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| 1 | A study of pulmonary embolism after abdominal surgery in patients undergoing prophylaxis显示文摘AIM:To determine risk factors for pulmonary embolism and estimate effects and benefits of prophylaxis.METHODS:We included 78 patients who died subsequently to a pulmonary embolism after major abdomi nal surgery from 1985 to 2003.A first,retrospective analysis involved 41 patients who underwent elective surgery between 1985 and 1990 without receiving any prophylaxis.In the prospectively evaluated subgroup,37 patients undergoing major surgery between 1991 and 2003 were enrolled:all of them had received a prophylaxis consisting in low-molecular weight heparin,given subcutaneously at a dose of 2850 IU AXa/0.3 mL(body weight < 50 kg) or 5700 IU AXa/0.6 mL(body weight ≥ 50 kg).RESULTS:A higher incidence of thromboembolism(43.9% and 46.34% in the two groups,respectively) was found in older patients(> 60 years).The incidence of pulmonary embolism after major abdominal surgery in patients who had received the prophylaxis was signifi cantly lower compared to the subjects with the same condition who had not received any prophylaxis(P < 0.001,OR = 2.825;95% CI,1.811-4.408).Furthermore,the incidence of pulmonary embolism after colorectal cancer surgery was signifi cantly higher compared to incidence of pulmonary embolism after other abdominal surgical procedures.Finally,the incidence of pulmonary embolism after colorectal cancer surgery among the patients who had received the prophylaxis(11/4316,0.26%) was significantly lower compared to subjects undergoing a surgical procedure for the same indication but without prophylaxis(10/1562,0.64%)(P < 0.05,OR = 2.522;95% CI,1.069-5.949).CONCLUSION:Prophylaxis with low molecular weight heparin is highly recommended during the preoperative period in patients with diagnosis of colorectal cancer due to high risk of pulmonary embolism after elective surgery. | Mirko D Kerkez Dorde M ulafi Dragana D Mija Vitomir I Rankovi Nebja S Leki Dejan Z Stefanovi | 2009 | World Journal of Gastroenterology2009，15，3： | 14 |
| 2 | 橄榄石微量元素原位分析的现状及其应用显示文摘随着高精度EMPA和LA-ICP-MS分析技术的发展和矿物微量元素测试精度的提高,利用橄榄石中的微量元素示踪地幔部分熔融、地幔交代作用、岩浆早期结晶过程等地质问题成为近年来一个新兴的研究方向。一系列开拓性的研究发现也被陆续的发表,主要涉及橄榄石中Ni、Co、Al、Cr、Zn、Ti、Li、V、Sc、Mn、Ca和P等元素的示踪使用。一些卓有成效的示踪方法为:Ca、Al、Ti、Ni及Mn能够很好的用于区分橄榄石捕掳晶和斑晶;橄榄石-尖晶石地幔演化趋势线(OSMA:olivine-spinel mantle array)图解可以用于表征岩浆源区的亏损程度;玄武岩中橄榄石斑晶的Li同位素及Li含量可以很有效地指示岩浆源区是否存在地壳物质再循环及地幔交代作用;橄榄石斑晶中Ni、Ca、Mn、Cr和Al协变关系图解可以识别岩浆的辉石岩源区;利用橄榄石捕掳晶中Zr和Sc的含量差异特征可将橄榄岩中三种最主要的类型(尖晶石橄榄岩、石榴石橄榄岩以及尖晶石-石榴石橄榄岩)区分开来;一些元素的比值或组合(例如Ni/Co、Fe/Mn、V/Sc、Zr和Sc、Ca和Ti)可以指示源区交代作用、岩浆作用过程及氧化状态;基于橄榄石中Al、Cr及Ca的地质温度计可以为推算地幔热状态提供新方法;基于橄榄石分离结晶Fo-NiO演化线的原始岩浆计算模型可以较好的推算原始岩浆成分;利用橄榄石的环带及微量元素的扩散机制可以判别更多岩石成因信息,如识别交代介质、熔体类型以及地质构造背景等。基于上述最新研究的相关资料和已有成果,本文对橄榄石微量元素的地球化学示踪方法做系统性的归纳整理,并对橄榄石微量元素赋存状况、橄榄石微量元素测试方法、橄榄石微量元素的使用条件及需注意的问题等进行讨论,为读者在做相关研究时提供参考。 | 张柳毅 李霓 Dejan PRELEVIC | 2016 | 岩石学报2016，32，6： | 11 |
| 3 | The role of Epstein-Barr virus in multiple sclerosis:from molecular pathophysiology to in vivo imaging显示文摘Multiple sclerosis(MS) is a disease of the central nervous system characterized by inflammation, demyelination, and neuronal damage. Environmental and genetic factors are associated with the risk of developing MS, but the exact cause still remains unidentified. Epstein-Barr virus(EBV), vitamin D, and smoking are among the most well-established environmental risk factors in MS. Infectious mononucleosis, which is caused by delayed primary EBV infection, increases the risk of developing MS. EBV may also contribute to MS pathogenesis indirectly by activating silent human endogenous retrovirus-W. The emerging B-cell depleting therapies, particularly anti-CD20 agents such as rituximab, ocrelizumab, as well as the fully human ofatumumab, have shown promising clinical and magnetic resonance imaging benefit. One potential effect of these therapies is the depletion of memory B-cells, the primary reservoir site where EBV latency occurs. In addition, EBV potentially interacts with both genetic and other environmental factors to increase susceptibility and disease severity of MS. This review examines the role of EBV in MS pathophysiology and summarizes the recent clinical and radiological findings, with a focus on B-cells and in vivo imaging. Addressing the potential link between EBV and MS allows the better understanding of MS pathogenesis and helps to identify additional disease biomarkers that may be responsive to B-cell depleting intervention. | Yi Guan Dejan Jakimovski Murali Ramanathan Bianca Weinstock-Guttman Robert Zivadinov | 2019 | Neural Regeneration Research2019，14，3： | 8 |
| 4 | Systemic review and network meta-analysis:Prophylactic antibiotic therapy for spontaneous bacterial peritonitis显示文摘BACKGROUND Spontaneous bacterial peritonitis(SBP)is an important prognostic factor for outcomes in patients with cirrhosis.Antibiotic prophylaxis is recommended in patients at high risk for developing SBP,but the choice of antibiotics remains unclear.AIM To evaluate the efficacy of various antibiotics for prophylaxis of SBP based on randomized control trials(RCTs).METHODS Electronic databases were searched through November 2018 for RCTs evaluating the efficacy of therapies for primary or secondary prophylaxis of SBP.The primary outcome was the development of SBP.Sensitivity analyses limited to studies of primary or secondary prophylaxis and studies reported after 2010 were performed.The secondary outcome was the risk of all-cause mortality or transplant.The outcomes were assessed by rank of therapies based on network meta-analyses.Individual meta-analyses were also performed.RESULTS Thirteen RCTs(1742 patients)including norfloxacin,ciprofloxacin,rifaximin,trimethoprim-sulfamethoxazole(TMP-SMX),or placebo/no comparator were identified.Individual meta-analyses showed superiority of rifaximin over norfloxacin as well as norfloxacin and TMP-SMX over placebo.Network metaanalysis demonstrated the rank of efficacy in reducing the risk of SBP as:Rifaximin,ciprofloxacin,TMP-SMX,norfloxacin,and placebo/no comparator.Rifaximin ranked highest in sensitivity analyses limited to studies of primary or secondary prophylaxis and studies reported after 2010.Similarly,rifaximin ranked highest in reducing the risk of death/transplant.CONCLUSION The present comprehensive network meta-analysis provides RCT based evidence for superior efficacy of rifaximin compared to other antibiotics for the prophylaxis of SBP and reducing risk of death/transplant.Further RCTs are warranted to confirm our findings. | Nolan Faust Akihiro Yamada Haider Haider Yuga Komaki Fukiko Komaki Dejan Micic Atsushi Sakuraba | 2020 | World Journal of Hepatology2020，12，5： | 3 |
| 5 | An Application of the Shark Skin Denticle Geometry for Windbreak Fence Design and Fabrication显示文摘在开、城市的区域的防风林篱笆能被用来有效地减少风速度。在这份报纸,我们检验防风林篱笆的几何形状怎么能最佳地减轻风速度。我们基于鲨鱼皮肤小齿几何学的一个仿生的参量的模型为防风林篱笆设计建议一条途径,它改进风速度的减小在附近并且在防风林篱笆后面。生产模型被用来在篱笆面板的参数由变化估计改进几何形状,由鲨鱼皮肤小齿启发了。篱笆表面用鲨鱼皮肤启发了,这比扁平、弄皱的表面更好执行的分析显示的计算液体动力学(CFD ) 的结果。考虑表面的复杂几何学由鲨鱼皮肤小齿启发了,我们用多孔塑料泡沫(EPS ) 建议一个制造过程材料,与一个热电线的工具使用一只工业机器人手臂创造。为鲨鱼皮肤小齿面板创造 EPS 模子允许在最后的设计要过去常的更富有的变化材料,带两个到更高的效率和一个更吸引人的图案。 | Ivana Bajsanski Vesna Stojakovic Bojan Tepavcevic Marko Jovanovic Dejan Mitov | 2017 | Journal of Bionic Engineering2017，14，3： | 3 |
| 6 | Radical abdominal trachelectomy in the 19th gestation week in patients with early invasive cervical carcinoma: case study and overview of literalure显示文摘 | Aljosa M Petar N Dejan N | 2009 | Am J Obstet Gynecol2009，201，： | 1 |
| 7 | Effects of hull-less barley flour and flakes on bread nutritional composition and sensory properties显示文摘 | Biljana ?krbi? Sne?ana Milovac Dejan Dodig Bojana Filip?ev | 2009 | Food Chemistry2009，，3： | 1 |
| 8 | Sublethal effects of spirodiclofen on life history andlifetable parameters of twospotted spider mite (Tetranychusurticae)显示文摘 | Dejan Marcic | 2007 | Experimental & Applied Acaro- logy2007，42，： | 1 |
| 9 | Methylmercury induces oxidantive injurys, alterations in permeability and glutamine transpot in cultures astrocytes 显示文摘 | Zhaobao Yin Dejan Milatovic Judy L | 2007 | Brain Research2007，，1131： | 1 |
| 10 | Perforated midgut diverticulitis:Revisited显示文摘AIM:To study and provide data on the evolution of medical procedures and outcomes of patients suffering from perforated midgut diverticulitis. METHODS:Three data sources were used:the Medline and Google search engines were searched for case reports on one or more patients treated for perforated midgut diverticulitis (Meckel's diverticulitis excluded) that were published after 1995. The inclusion criterion was sufficient individual patient data in the article. Both indexed and non-indexed journals were used. Patients treated for perforated midgut diverticulitis at Vestfold Hospital were included in this group. Data on symptoms, laboratory and radiology results, treatment modalities, surgical access, procedures, complications and outcomes were collected. The Norwegian patient registry was searched to find patients operated upon for midgut diverticulitis from 1999 to 2007. The data collected were age, sex, mode of access, surgical procedure performed and number of patients per year. Historical controls were retrieved from an article published in 1995 containing pertinent individual patient data. Statistical analysis was done with SPSS software.RESULTS:GroupⅠ:106 patients (48 men) were found. Mean age was 72.2 ± 13.1 years (mean ± SD). Age or sex had no impact on outcomes (P = 0.057 and P = 0.771, respectively). Preoperative assessment was plain radiography in 53.3% or computed tomography (CT) in 76.1%. Correct diagnosis was made in 77.1% with CT, 5.6% without (P = 0.001). Duration of symptoms before hospitalization was 3.6 d (range:1-35 d), but longer duration was not associated with poor outcome (P = 0.748). Eighty-six point eight percent of patients underwent surgery, 92.4% of these through open access where 90.1% had bowel resection. Complications occurred in 19.2% of patients and 16.3% underwent reoperation. Distance from perforation to Treitz ligament was 41.7 ± 28.1 cm. At surgery, no peritonitis was found in 29.7% of patients, local peritonitis in 47.5%, and diffuse peritonitis in 22.8%. Peritonitis grade correlated with the reoperation rate (r = 0.43). Conservatively treated patients had similar hospital length of stay as operated patients (10.6 ± 8.3 d vs 10.7 ± 7.9 d, respectively). Age correlated with hospital stay (r = 0.46). No difference in outcomes for operated or nonoperated patients was found (P = 0.814). Group Ⅱ:113 patients (57 men). Mean age 67.6 ± 16.4 years (range: 21-96 years). Mean age for men was 61.3 ± 16.2 years, and 74.7 ± 12.5 years for women (P = 0.001). Number of procedures per year was 11.2 ± 0.9, and bowel resection was performed in 82.3% of patients. Group Ⅲ: 47 patients (21 men). Patient age was 65.4 ± 14.4 years. Mean age for men was 61.5 ± 17.3 years and 65.3 ± 14.4 years for women. Duration of symptoms before hospitalization was 6.9 d (range: 1-180 d). No patients had a preoperative diagnosis, 97.9% of patients underwent surgery, and 78.3% had multiple diverticula. Bowel resection was performed in 67.4% of patients, and suture closure in 32.6%. Mortality was 23.4%. There was no difference in length of history or its impact on survival between Groups Ⅰ and Ⅲ (P = 0.241 and P = 0.198, respectively). Resection was more often performed in Group Ⅰ (P = 0.01). Mortality was higher in Group Ⅲ (P = 0.002). CONCLUSION: In cases with contained perforation, conservative treatment gives satisfactory results, laparosco-py with lavage and drainage can be attempted and continued with a conservative course. | Milan Spasojevic Jens Marius Naesgaard Dejan Ignjatovic | 2012 | World Journal of Gastroenterology2012，18，34： | 1 |
| 11 | Tactical Scheduling of Rail Operations: The SCAN Ⅰ System显示文摘 | Dejan J Patrick T Harker | 1991 | Transportation Science1991，25，1： | 1 |
| 12 | Dependability as criteria for bucket wheel excavator revilization 显示文摘 | MILOS T DEJAN I DRAGAN I | 2011 | Journal of Sci- entific and Industrial Research2011，70，1： | 1 |
| 13 | Predicting pork water-holding capacity with NIR spectroscopy in relation to different reference methods显示文摘 | Maja Prevolnik Marjeta Candek-Potokar Dejan Skorjanc | 2010 | Journal of Food Engineering2010，98，3： | 1 |
| 14 | Electrochemical Behavior and Antioxidant and Prooxidant Activity of Natural Phenolics显示文摘 | Aleksandra S Dragan M Dejan S | 2007 | Molecules2007，12，： | 1 |
| 15 | Separation of water-in-oil emulsions by freeze/thaw method and microwave radiation显示文摘 | Vladana Rajakovic Dejan Skala | 2006 | Separation and Purification Technology2006，49，： | 1 |
| 16 | Mixed steroidal tetraoxanes induce apoptotic cell death in tumor cells显示文摘 | ?eljko ?i?ak Zorica Jurani? Dejan Opsenica Bogdan A. ?olaja | 2009 | Investigational New Drugs2009，，5： | 1 |
| 17 | An improvement of Hardy Cross method applied on looped spatial natural gas distribution networks显示文摘 | Dejan B | | 0，，7： | 1 |
| 18 | Computation of Working Life Consumption of a Steam Turbine Rotor 显示文摘 | Dejan Mitrovic Dragoljub Zivkovic | 2010 | Journal of Pressure Vessel Technology2010，132，1： | 1 |
| 19 | Disturbance history and dynamics of an old-growth mixed species mounta in forest in the Slovenian Alps 显示文摘 | Dejan F Thomas A N Jurij D | 2009 | Forest Ecology and Management2009，257，： | 1 |
| 20 | Co(II)-substituted Haemophilus influenzae β-carbonic anhydrase: Spectral evidence for allosteric regulation by pH and bicarbonate ion显示文摘 | Katherine M. Hoffmann Dejan Samardzic Katherine van den Heever Roger S. Rowlett | 2011 | Archives of Biochemistry and Biophysics2011，，1： | 1 |
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