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| 1 | 血管性认知障碍的诊断标准:国际血管性行为与认知障碍学会的申明显示文摘长期以来,脑血管病(CVD)就被认为是认知损害的一个重要原因,但是有关脑血管病后认知障碍的概念化却有着一段多变的历史。'动脉变硬'或脑的动脉粥样硬化是'老化'的原因,是存在已久的观点,在20世纪60年代受到了来自英格兰纽卡斯尔的神经病理学研究的质疑。这些研究表明,血管性痴呆(vascular dementia,Va D)与超过一定程度的多发性脑梗死有关。 | 徐岩 郭起浩 Sachdev P Kalaria R O'Brien J Skoog I Alladi S Black SE Blacker D Blazer DG Chen C Chui H Ganguli M Jellinger K Jeste DV Pasquier F Paulsen J Prins N Rockwood K Roman G Scheltens P | 2014 | 神经病学与神经康复学杂志2014，11，3： | 19 |
| 2 | Nat Biotechnol:将人星形胶质细胞重编程为多巴胺能神经元,有助治疗帕金森病显示文摘帕金森病是一种主要影响运动系统的神经退行性疾病。它的特征在于大脑中的多巴胺能神经元(dopaminergic neuron)渐进性丧失。尽管当前的疗法旨在补充多巴胺水平,但是没有一种疗法能够恢复这些丢失的细胞。如今。在一项新的研究中,来自瑞典、奥地利、西班牙和美国的研究人员开发出一种方法:将神经胶质细胞(glialcell)转化为活性的多巴胺能神经元,并且所产生的多巴胺能神经元能够部分恢复帕金森病模式小鼠的运动功能。这项概念验证研究可能为开发出一种治疗这种疾病的新方法铺平道路。 | Pia Rivetti di Val Cervo, Elisa Martín-Montañez, Enrique M Toledo, Gioele La Manno, Sara Padrell Sánchez, Sten Linnarsson Ernest Arenas Roman A Romanov, Christian Pifl Tibor Harkany Roman A Romanov, Giada Spigolon, Débora Masini, Michael Feyder, Tibor Harkany Gilberto Fisone Elisa Martín-Montañez Yi-Han Ng Marius Wernig | 2017 | 现代生物医学进展2017，17，17： | 11 |
| 3 | High-flow nasal oxygen availability for sedation decreases the use of general anesthesia during endoscopic retrograde cholangiopancreatography and endoscopic ultrasound显示文摘AIM To examine whether high-flow nasal oxygen(HFNO) availability influences the use of general anesthesia(GA) in patients undergoing endoscopic retrograde cholangiopancreatography(ERCP) and endoscopic ultrasound(EUS) and associated outcomes.METHODS In this retrospective study, patients were stratified into 3 eras between October 1, 2013 and June 30, 2014 based on HFNO availability for deep sedation at the time of their endoscopy. During the first and last 3-mo eras(era 1 and 3), no HFNO was available, whereas it was an option during the second 3-mo era(era 2). The primary outcome was the percent utilization of GA vs deep sedation in each period. Secondary outcomes included oxygen saturation nadir during sedation between periods, as well as procedure duration, and anesthesia-only time between periods and for GA vs sedation cases respectively.RESULTS During the study period 238 ERCP or EUS cases were identified for analysis. Statistical testing was employed and a P < 0.050 was significant unless the Bonferroni correction for multiple comparisons was used. General anesthesia use was significantly lower in era 2 compared to era 1 with the same trend between era 2 and 3(P = 0.012 and 0.045 respectively). The oxygen saturation nadir during sedation was significantly higher in era 2 compared to era 3(P < 0.001) but not between eras 1 and 2(P = 0.028) or 1 and 3(P = 0.069). The procedure time within each era was significantly longer under GA compared to deep sedation(P ≤ 0.007) as was the anesthesia-only time(P ≤ 0.001).CONCLUSION High-flow nasal oxygen availability was associated with decreased GA utilization and improved oxygenation for ERCP and EUS during sedation. | Roman Schumann Nikola S Natov Klifford A Rocuts-Martinez Matthew D Finkelman Tom V Phan Sanjay R Hegde Robert M Knapp | 2016 | World Journal of Gastroenterology2016，22，47： | 9 |
| 4 | Effect of reaction conditions on the properties and behavior of wood cellulose nanocrystal suspensions显示文摘 | Beck-Candanedo S Roman M Gray D G | 2005 | Biomacromolecules2005，6，2： | 1 |
| 5 | Efficacy and tolerability of donepezil in vascular dementia: positive results of a 24- week, multicenter, international, randomized, placebo-controlled clinical trial显示文摘 | BLACK S ROMAN G C GELDMACHER D S | 2003 | Stroke2003，34，10： | 1 |
| 6 | Effect of reaction conditions on the properties and behavior of wood cellulose nanocrystal suspensions显示文摘 | Beck-Candanedo S Roman M Gray D G | 2005 | Biomacromolecules2005，6，2： | 1 |
| 7 | Cardiac MRI of the normal and hypertrophied mouse heart 显示文摘 | Slawson S E Roman B B Williams D S | 1998 | Magn Reson Med1998，39，： | 1 |
| 8 | Disparity for the minor histocompatibility antigen HA-1 is associated with an increased risk of acute graft-versus-host disease(GvHD)but it does not affect chronic GvHD incidence,disease-free survival or overall survival after allogeneic human leucocyte antigen-identical sibling donor transplantation显示文摘 | Arostegui JI Balas A Torres A Caballero D Carreras E Brunet S Jimenez A Mataix R Serrano D Vallejo C Sanz G Solano C Rodriguez-Luaces M Marin J Baro J Sanz C Roman J Gonzalez M Martorell J Sierra J Martin C de la Camara R Granena A | 2001 | Br J Haematol2001，114，4： | 1 |
| 9 | Carbon nanotubes based nanocomposites for photocurrent improvement显示文摘 | CANESTRARO C D SCHNITZLER M C ZARBIN A J G DALUZ M G E ROMAN L S | | 0，，15： | 1 |
| 10 | Effect of reaction conditions on the properties and behavior of wood cellulose nanocrystal suspensions显示文摘 | Beck-Candanedo S Roman M Gray D G | 2005 | Biomacromolecules2005，6，： | 1 |
| 11 | Pelvic examination,tumor marker level,and gray-scale and Doppler sonography in the prediction of pelvic cancer显示文摘 | Roman L D Muderspach L I Stein S M | 1997 | Obstet Gynecol1997，89，4： | 1 |
| 12 | Optical band-edge absorption of oxide compound SnO2显示文摘 | L S Roman R Valaski C D Canestraro | 2006 | Applied Surface Science2006，252，： | 1 |
| 13 | Effect of reaction condi-tions on the properties and behavior of wood cellulose nanocrystalsuspensions显示文摘 | Candanedo S B Roman M Gray D G | 2005 | Biomacromolecules2005，6，2： | 1 |
| 14 | Expression and regulation of retinoic acid receptor in human breast cancer cells 显示文摘 | Roman S D Clarke C L Hall R E | 1992 | Cancer Res1992，52，： | 1 |
| 15 | Rough set approach to multiple criteria classification with imprecise evaluations and assignments显示文摘 | Krzysztof D Greco S Roman S | 2009 | European Journal of Operational Research2009，198，2： | 1 |
| 16 | Population structure and cryptic evolutionary units in the alligator snapping turtle显示文摘 | Roman J Santhuff S D Moler P E | 1999 | Conservation Biology1999，13，1： | 1 |
| 17 | Spatial and temporal variability in factors affecting zooplankton dynamics in Chespeake Bay: Evidence from biomass size spectra显示文摘 | KIMMEL D G ROMAN M R ZHANG X S | 2006 | Limnol Oceanogr2006，51，1： | 1 |
| 18 | Deregulation,privatization and competition:transmission planning under uncertainty显示文摘 | TORRE T D FELTES J W ROMAN J W G S | 1999 | IEEE Trans PWRS1999，14，2： | 1 |
| 19 | Treatment of non-small- cell lung cancer with erlotinib or gefitinib 显示文摘 | Vince D C Don L G Roman P S | 2011 | N Engl J Med2011，364，10： | 1 |
| 20 | Rough set approach to multiple criteria classification with imprecise evaluations and assignments显示文摘 | Krzysztof D Salvatore G Roman S | 2009 | European Journal of Operational Research2009，198，2： | 1 |
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