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11篇 您的检索式:作者名="Rommel F"
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1Value of a newly sequenced bacterial genome显示文摘Next-generation sequencing(NGS) technologies have made high-throughput sequencing available to medium- and small-size laboratories, culminating in a tidal wave of genomic information. The quantity of sequenced bacterial genomes has not only brought excitement to the field of genomics but also heightened expectations that NGS would boost antibacterial discovery and vaccine development. Although many possible drug and vaccine targets have been discovered, the success rate of genome-based analysis has remained below expectations. Furthermore, NGS has had consequences for genome quality, resulting in an exponential increase in draft(partial data) genome deposits in public databases. If no further interests are expressed for a particular bacterial genome, it is more likely that the sequencing of its genome will be limited to a draft stage, and the painstaking tasks of completing the sequencing of its genome and annotation will not be undertaken. It is important to know what is lost when we settle for a draft genome and to determine the 'scientific value' of a newly sequenced genome. This review addresses the expected impact of newly sequenced genomes on antibacterial discovery and vaccinology. Also, it discusses the factors that could be leading to the increase in the number of draft deposits and the consequent loss of relevant biological information.Eudes GV Barbosa Flavia F Aburjaile Rommel TJ Ramos Adriana R Carneiro Yves Le Loir Jan Baumbach Anderson Miyoshi Artur Silva Vasco Azevedo 2014World Journal of Biological Chemistry2014,5,2:7
2Performance evaluation of the 'large SMADES' autonomous desalination solar-driven membrane distillation plant in Aqaba, Jordan 显示文摘Banat F Jwaied N Rommel M 2007Desalination2007,217,13:1
3Desalination by a 'compact SMADES' autonomous solar powered membrane distillation unit 显示文摘Banat F Jwaied N Rommel M Koschikowski J Wieghuas M 2007Desalination2007,217,:1
4In vitro test - system for chemo- and thermosensitivity: an analysis of survival fractions and cell -cycle distributions in human Ewing's sarcomas as a modelfor tumor in pediatric oncology 显示文摘Debes A Rommel F Breise M 2002Klinische Padiatrie2002,214,4:1
5Performance evaluation of the 'large SMADES' autonomous desalination solar-driven membrane distillation plant in Aqaba, Jordan 显示文摘Banat F Jwaied N Rommel M Koschikowski J Wieghaus M 2007Desalination2007,217,:1
6In vitro test-system for chemo-and thermosensitivity: An analysis of survival fractions and cell-cycle distributions in human Ewing's sarcomas as a model for tumors in pediatric oncology显示文摘Debes A Rommel F Breise M 2002Kiln Padiatr2002,214,4:1
7Desalination by a 'compact SMADES' autonomous solar powered menabmne distillation unit显示文摘Banat F Jwaied N Rommel M 2007Desalination2007,217,13:1
8Control of susceptibilityrelated image contrast by spin-lock techniques显示文摘Martirosian P Rommel E Sohick F 2008Magn Reson Imaging2008,26,10:1
9The treatment of gross bleeding with Finasteride显示文摘Sieber P R Rommel F M Huffnagle H W 1998J Urol1998,159,:1
10The orphan nuclear recep tor HNF4c determines PXR2- and CAR2-mediated xenobiotic in- duction of CYP3A4 显示文摘Rommel G LeeW Brenda F 2003Nat Med2003,9,2:1
11The orphan nuclear receptor HNF4αdetermines PXR- and CAR-mediated xenobiotic induction of CYP3A4 显示文摘Rommel G Lee W Brenda F 2003Nat Med2003,9,:1
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