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| 1 | Self-microemulsifying drug delivery system for improving the bioavailability of huperzine A by lymphatic uptake显示文摘Huperzine A(Hup-A) is a poorly water-soluble drug with low oral bioavailability. A selfmicroemulsifying drug delivery system(SMEDDS) was used to enhance the oral bioavailability and lymphatic uptake and transport of Hup-A. A single-pass intestinal perfusion(SPIP) technique and a chylomicron flow-blocking approach were used to study its intestinal absorption, mesenteric lymph node distribution and intestinal lymphatic uptake. The value of the area under the plasma concentration–time curve(AUC) of Hup-A SMEDDS was significantly higher than that of a Hup-A suspension(P <0.01).The absorption rate constant(K_a) and the apparent permeability coefficient(P_(app)) for Hup-A in different parts of the intestine suggested a passive transport mechanism, and the values of K_a and P_(app) of Hup-A SMEDDS in the ileum were much higher than those in other intestinal segments. The determination of Hup-A concentration in mesenteric lymph nodes can be used to explain the intestinal lymphatic absorption of Hup-A SMEDDS. For Hup-A SMEDDS, the values of AUC and maximum plasma concentration(C_(max)) of the blocking model were significantly lower than those of the control model(P<0.05). The proportion of lymphatic transport of Hup-A SMEDDS and Hup-A suspension were about 40% and 5%,respectively, suggesting that SMEDDS can significantly improve the intestinal lymphatic uptake and transport of Hup-A. | Fang Li Rongfeng Hu Bin Wang Yun Gui Gang Cheng Song Gao Lei Ye Jihui Tang | 2017 | Acta Pharmaceutica Sinica B2017，7，3： | 15 |
| 2 | Development of antimony sulfide–selenide Sb2(S,Se)3-based solar cells显示文摘Antimony sulfide–selenide Sb_2(S,Se)_3,including Sb_2S_3and Sb_2Se_3,can be regarded as binary metal chalcogenides semiconductors since Sb_2S_3and Sb_2Se_3are isomorphous.They possess abundant elemental storage,nontoxicity,good stability with regard to moisture at elevated temperatures and suitable physical parameters for light absorption materials in solar cells.To date,quite a few attempts have been conducted in the materials synthesis,photovoltaic property investigation and device fabrication.Benefiting from previous investigation in thin film solar cells and new generation nanostructured solar cells,this class of materials has been applied in either sensitized-architecture or planar heterojunction solar cells.Decent power conversion efficiencies from 5%to 7.5%have been achieved.Apparently,further improvement on the efficiency is required for future practical applications.To give an overview of this research field,this paper displays some typical researches regarding the methodologies toward the antimony sulfide–selenide synthesis,development of interfacial materials and device fabrications,during which we highlight some critical findings that promote the efficiency enhancement.Finally,this paper proposes some outstanding issue regarding fundamental understanding of the materials,some viewpoints for the efficiency improvement and their future challenges in solar cell applications. | Xiaomin Wang Rongfeng Tang Chunyan Wu Changfei Zhu Tao Chen | 2018 | Journal of Energy Chemistry2018，27，3： | 10 |
| 3 | Abscisic Acid Antagonizes Ethylene Production through the ABI4-Mediated Transcriptional Repression of ACS4 and ACS8 in Arabidopsis显示文摘增加的证据表明了 abscisic 酸(骆驼毛的织物) 否定地调制乙烯生合成,尽管内在的机制仍然保持不清楚。为了识别因素,包含了,我们在 Arabidopsis 与改变的乙烯生产为骆驼毛的织物感觉迟钝的异种进行了一幅屏幕。ABI4 的主导的等位基因, abi4-152,在 ABI4 的 C 终点与 16-amino-acid 截断生产通常认为的蛋白质,减少乙烯生产。由对比, ABI4 的二后退的猛烈等位基因, abi4-102 和 abi4-103,导致增加的乙烯进化,显示 ABI4 否定地调整乙烯生产。进一步的分析证明乙烯生合成基因 ACS4, ACS8,和 ACO2 的 thatexpression 显著地在 abi4-152 被减少,但是在猛烈异种增加了,与骆驼毛的织物上的部分依赖。染色质 immunoprecipitation 量的 PCR 试金证明 ABI4 直接绑这些乙烯生合成基因的倡导者,那件骆驼毛的织物提高这个相互作用。包含截断的 ABI4-152 肽的熔化蛋白质在转基因的植物比它的全身的对应物积累了到高水平,建议 ABI4 被它的 C 终点使动摇。因此,我们的结果证明那件骆驼毛的织物否定地在 Arabidopsis 通过乙烯生合成基因 ACS4 和 ACS8 的调停 ABI4 的 transcriptional 压抑调整乙烯生产。 | Zhijun Dong Yanwen Yu Shenghui Li Juan Wang Saijun Tang Rongfeng Huang | 2016 | Molecular Plant2016，9，1： | 9 |
| 4 | Effect of Ti substitution on hydrogen storage properties of Zr_(1-x)Ti_xCo (x = 0, 0.1, 0.2, 0.3) alloys显示文摘Zr1-xTixCo(x = 0, 0.1, 0.2, 0.3) alloys were prepared by arc-melting method and the effect of Ti substitution on hydrogen storage properties was studied systematically. Hydrogen desorption pressure-composition-temperature(PCT) measurements were carried out using Sievert's type volumetric apparatus for ZrCo(at 473 K, 573 K and 673 K) and Zr1-xTixCo alloys(at 673 K), respectively. Products after dehydrogenation were characterized by X-ray diffraction(XRD). In addition, the kinetics of Zr1-xTixCo hydride was investigated at 473 K and 673 K,respectively, under hydrogen pressure of 5 MPa. Results showed that Ti substitution for Zr did not change the crystal structure of ZrCo phase.With the increase of temperature from 473 K to 673 K, the extent of disproportionation for ZrCo alloy increased. With Ti content increasing at 673 K, the desorption equilibrium pressure of Zr1-xTixCo-H2 systems elevated and the disproportionation reaction of Zr1-xTixCo alloys was inhibited effectively. Ti substitution decreased the kinetics rate and the effective hydrogen storage capacity of Zr1-xTixCo alloys slightly.Generally speaking, it was found that Zr0.8Ti0.2Co alloy had better anti-disproportionation property with less decrease of effective hydrogen storage capacity which was beneficial to tritium application in the International Thermonuclear Experimental Reactor(ITER). | Yamin Zhao Rongfeng Li Ruihe Tang Boyan Li Ronghai Yu Wei Liu Huaqin Kou Jianbo Meng | 2014 | Journal of Energy Chemistry2014，23，1： | 6 |
| 5 | Adhesive anastomosis for organ transplantation显示文摘The recent development of tough tissue adhesives has stimulated intense interests among material scientists and medical doctors.However,these adhesives have seldom been tested in clinically demanding surgeries.Here we demonstrate adhesive anastomosis in organ transplantation.Anastomosis is commonly conducted by dense sutures and takes a long time,during which all the vessels are occluded.Prolonged occlusion may damage organs and even cause death.We formulate a tough,biocompatible,bioabsorbable adhesive that can sustain tissue tension and pressurized flow.We expose the endothelial surface of vessels onto a gasket,press two endothelial surfaces to the adhesive using a pair of magnetic rings,and reopen the bloodstream immediately.The time for adhesive anastomosis is shortened compared to the time for sutured anastomosis.We have achieved adhesive anastomosis of a great vein in transplanting the liver of a pig.After the surgery,the adhesive is absorbed,the vein heals,and the pig lives for over one month. | Kang Liu Hang Yang Gaobo Huang Aihua Shi Qiang Lu Shanpei Wang Wei Qiao Haohua Wang Mengyun Ke Hongfan Ding Tao Li Yanchao Zhang Jiawei Yu Bingyi Ren Rongfeng Wang Kailing Wang Hui Feng Zhigang Suo Jingda Tang Yi Lv | 2022 | Bioactive Materials2022，7，7： | 3 |
| 6 | Composition engineering of Sb_2S_3 film enabling high performance solar cells显示文摘Sb_2S_3 is a kind of stable light absorption materials with suitable band gap, promising for practical applications. Here we demonstrate that the engineering on the composition ratio enables significant improvement in the device performance. We found that the co-evaporation of sulfur or antimony with Sb_2S_3 is able to generate sulfur-or antimony-rich Sb_2S_3. This composition does not generate essential influence on the crystal structure, optical band and film formability, while the carrier concentration and transport dynamics are considerably changed. The device investigations show that sulfur-rich Sb_2S_3 film is favorable for efficient energy conversion, while antimony-rich Sb_2S_3 leads to greatly decreased device performance. With optimizations on the sulfur-rich Sb_2S_3 films, the final power conversion efficiency reaches5.8%, which is the highest efficiency in thermal evaporation derived Sb_2S_3 solar cells. | Yiwei Yin Chunyan Wu Rongfeng Tang Chenhui Jiang Guoshun Jiang Weifeng Liu Tao Chen Changfei Zhu | 2019 | Science Bulletin2019，64，2： | 2 |
| 7 | Recent progress on the hydrogen storage properties of ZrCo-based alloys applied in International Thermonuclear Experimental Reactor(ITER)显示文摘Under the development of International Thermonuclear Experimental Reactor(ITER) system aimed at realizing the controllable fusion reaction to solve the energy crisis fundamentally, there is an urgent need to find an appropriate material for tritium handling. ZrCo alloy is considered to be a promising candidate for the storage and delivery of hydrogen isotopes due to the favorable characteristics such as low plateau pressure for absorption, high dissociation pressure at moderate temperature and better ability of trapping ~3He. However, the hydrogen induced disproportionation and the slower recovery/deliverty rate of ZrCo-based alloys have limited their further application in ITER system. This review summarizes the efforts towards enhancing the hydrogen storage properties of ZrCo-based alloys including element substitution, surface modification, disproportionation mechanism investigation and the isotope effect study. Element substitution and surface modification play positive role to improve the anti-disproportionation ability and kinetic property of the alloys. However, the ZrCo-based alloys require to be further modified by more attempts such as new composition, novelty modification method or catalyst addition in order to better satisfy the application demands for tritium handling. Moreover, new insight for further understanding the inner disproportionation mechanisms of this material is needed by combining the advance characterization and theoretical analysis, which is in favor of addressing the disproportionation problem of the ZrCo-based alloys essentially. | Feng Wang Rongfeng Li Cuiping Ding Wukui Tang Yibo Wang Shimeng Xu Ronghai Yu Ying Wu | 2017 | Progress in Natural Science:Materials International2017，27，1： | 1 |
| 8 | Engineering microstructures for efficient Sb_(2)(S_(x)Se1−x)_(3) solar cells显示文摘To realize solar-to-electrical energy conversion,several kinds of solar technologies have been developed since the in-vention of silicon solar cells.Recently,antimony selenosulf-ide Sb_(2)(S,Se)_(3)(including Sb_(2)S_(3) and Sb_(2)Se_(3))has been con-sidered one of the promising emerging materials for solar cell applications due to simple chemical composition,abund-ant elemental storage and excellent stability[1]. | Rongfeng Tang Tao Chen Liming Ding | 2021 | Journal of Semiconductors2021，42，7： | 0 |
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