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| 1 | New Lower Bounds for the Least Common Multiples of Arithmetic Progressions显示文摘For relatively prime positive integers u_0 and r,and for 0≤k≤n,define u_k:=u_0+kr.Let L_n:=1cm(u_0,u_1,…,u_n)and let a,l≥2 be any integers.In this paper,the authors show that,for integersα≥a,r≥max(a,l-1)and n≥lar,the following inequality holds L_n≥u_0r^((l-1)α+a-l)(r+1)~n.Particularly,letting l=3 yields an improvement on the best previous lower bound on L_n obtained by Hong and Kominers in 2010. | Rongjun WU Qianrong TAN Shaofang HONG | 2013 | Chinese Annals of Mathematics,Series B2013，34，6： | 1 |
| 2 | PGAM5-Mediated PHB2 Dephosphorylation Contributes to Diabetic Cardiomyopathy by Disrupting Mitochondrial Quality Surveillance显示文摘Disruption of the mitochondrial quality surveillance(MQS)system contributes to mitochondrial dysfunction in diabetic cardiomyopathy(DCM).In this study,we observed that cardiac expression of phosphoglycerate mutase 5(PGAM5),a mitochondrial Ser/Thr protein phosphatase,is upregulated in mice with streptozotocin-induced DCM.Notably,DCM-related cardiac structural and functional deficits were negated in cardiomyocyte-specific Pgam5 knockout(Pgam5^(CKO))mice.Hyperglycemic stress impaired adenosine triphosphate production,reduced respiratory activity,and prolonged mitochondrial permeability transition pore opening in acutely isolated neonatal cardiomyocytes from control Pgam5^(f/f) mice,and these effects were markedly prevented in cardiomyocytes from Pgam5^(CKO) mice.Likewise,three main MQS-governed processes—namely,mitochondrial fission/fusion cycling,mitophagy,and biogenesis—were disrupted by hyperglycemia in Pgam5^(f/f),but not in Pgam5^(CKO),cardiomyocytes.On the basis of bioinformatics prediction of interaction between PGAM5 and prohibitin 2(PHB2),an inner mitochondrial membrane-associated scaffolding protein,co-immunoprecipitation,and immunoblot assays demonstrated that PGAM5 dephosphorylates PHB2 on Ser91.Transfection of cardiomyocytes with phosphodefective or phosphomimetic Ser91 mutants of PHB2 confirmed a critical role for PGAM5-mediated dephosphorylation of PHB2 in mitochondrial dysfunction associated with hyperglycemic stress.Furthermore,knockin mice expressing phosphomimetic PHB2^(S91D) were resistant to diabetes-induced cardiac dysfunction.Our findings highlight the PGAM-PHB2 axis as a novel and critical regulator of mitochondrial dysfunction in DCM. | Rongjun Zou Jun Tao Jie He Chaojie Wang Songtao Tan Yu Xia Xing Chang Ruibing Li Ge Wang Hao Zhou Xiaoping Fan | 2023 | Research2023，，3： | 0 |
| 3 | Combined spatial-temporal energy harvesting and relay selection for cognitive wireless powered networks显示文摘In order to improve the Energy Efficiency(EE)and spectrum utilization of Cognitive Wireless Powered Networks(CWPNs),a combined spatial-temporal Energy Harvesting(EH)and relay selection scheme is proposed.In the proposed scheme,for protecting the Primary User(PU),a two-layer guard zone is set outside the PU based on the outage probability threshold of the PU.Moreover,to increase the energy of the CWPNs,the EH zone in the two-layer guard zone allows the Secondary Users(SUs)to spatially harvest energy from the Radio Frequency(RF)signals of temporally active PUs.To improve the utilization of the PU spectrum,the guard zone outside the EH zone allows for the constrained power transmission of SUs.Moreover,the relay selection transmission is designed in the transmission zone of the SU to improve the EE of the CWPNs.In addition to the EE of the CWPNs,the outage probabilities of the SU and PU are derived.The results reveal that the setting of a two-layer guard zone can effectively reduce the outage probability of the PU and improve the EE of CWPNs.Furthermore,the relay selection transmission decreases the outage probabilities of the SUs. | Yuan Gao Haixia He Rongjun Tan Junho Choi | 2021 | Digital Communications and Networks2021，7，2： | 0 |
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