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| 1 | Multiphase computed tomography radiomics of pancreatic intraductal papillary mucinous neoplasms to predict malignancy显示文摘BACKGROUND Intraductal papillary mucinous neoplasms(IPMNs)are non-invasive pancreatic precursor lesions that can potentially develop into invasive pancreatic ductal adenocarcinoma.Currently,the International Consensus Guidelines(ICG)for IPMNs provides the basis for evaluating suspected IPMNs on computed tomography(CT)imaging.Despite using the ICG,it remains challenging to accurately predict whether IPMNs harbor high grade or invasive disease which would warrant surgical resection.A supplementary quantitative radiological tool,radiomics,may improve diagnostic accuracy of radiological evaluation of IPMNs.We hypothesized that using CT whole lesion radiomics features in conjunction with the ICG could improve the diagnostic accuracy of predicting IPMN histology.AIM To evaluate whole lesion CT radiomic analysis of IPMNs for predicting malignant histology compared to International Consensus Guidelines.METHODS Fifty-one subjects who had pancreatic surgical resection at our institution with histology demonstrating IPMN and available preoperative CT imaging were included in this retrospective cohort.Whole lesion semi-automated segmentation was performed on each preoperative CT using Healthmyne software(Healthmyne,Madison,WI).Thirty-nine relevant radiomic features were extracted from each lesion on each available contrast phase.Univariate analysis of the 39 radiomics features was performed for each contrast phase and values were compared between malignant and benign IPMN groups using logistic regression.Conventional quantitative and qualitative CT measurements were also compared between groups,viaχ2(categorical)and Mann Whitney U(continuous)variables.RESULTS Twenty-nine subjects(15 males,age 71±9 years)with high grade or invasive tumor histology comprised the'malignant'cohort,while 22 subjects(11 males,age 70±7 years)with low grade tumor histology were included in the'benign'cohort.Radiomic analysis showed 18/39 precontrast,19/39 arterial phase,and 21/39 venous phase features differentiated malignant from benign IPMNs(P<0.05).Multivariate analysis including only ICG criteria yielded two significant variables:thickened and enhancing cyst wall and enhancing mural nodule<5 mm with an AUC(95%CI)of 0.817(0.709-0.926).Multivariable post contrast radiomics achieved an AUC(95%CI)of 0.87(0.767-0.974)for a model including arterial phase radiomics features and 0.834(0.716-0.953)for a model including venous phase radiomics features.Combined multivariable model including conventional variables and arterial phase radiomics features achieved an AUC(95%CI)of 0.93(0.85-1.0)with a 5-fold cross validation AUC of 0.90.CONCLUSION Multi-phase CT radiomics evaluation could play a role in improving predictive capability in diagnosing malignancy in IPMNs.Future larger studies may help determine the clinical significance of our findings. | Stuart L Polk Jung W Choi Melissa J McGettigan Trevor Rose Abraham Ahmed Jongphil Kim Kun Jiang Yoganand Balagurunathan Jin Qi Paola T Farah Alisha Rathi Jennifer B Permuth Daniel Jeong | 2020 | World Journal of Gastroenterology2020，26，24： | 5 |
| 2 | Not interferon, but interleukin‐6 controls early gene expression in hepatitis B virus infection显示文摘 | Marianna H?sel Maria Quasdorff Katja Wiegmann Dennis Webb Uta Zedler Mathias Broxtermann Raindy Tedjokusumo Knud Esser Silke Arzberger Carsten J. Kirschning Anja Langenkamp Christine Falk Hildegard Büning Stefan Rose‐John Ulrike Protzer | 2009 | Hepatology2009，，6： | 3 |
| 3 | 站立30s后直立性低血压与老年抑郁之间的纵向关系显示文摘直立性低血压(orthostatic hypotension,OH)与老年抑郁之间存在明确的横向联系。该观察性研究的目的是为了阐明基线症状性OH(symptomatic OH,sOH-30)与抑郁症之问的纵向关系。该样本包含无基线抑郁症的老年人(平均年龄62岁)〉3000名。 | Robert B Daniel C Sean PK Rose AK 刘青 叶鹏 | 2018 | 中华高血压杂志2018，26，5： | 2 |
| 4 | 遗传性肥胖与心房颤动的关系显示文摘观察性研究已经确定了体质量指数(body mass index,BMI)与心房颤动之间的关联。然而,从观察性研究中推断因果关系会受到混杂因素、逆因果关系和偏倚的影响。该研究的主要目的是应用BMI的遗传学预测因子评估BMI与心房颤动之间的因果关系。方法:纳入1987-2002年期间在美国、冰岛和荷兰实施的7个前瞻性人群队列研究中基线无心房颤动的欧洲血统个体51 646人, | 刘莉 叶鹏 Chatterjee NA Giulianini F Geelhoed B Lunetta KL Misialek JR Niemeijer MN Rienstra M Rose LM Smith AV Arking DE Ellinor PT Heeringa J Lin H Lubitz SA Soliman EZ Verweij N Alonso A Benjamin EJ Gudnason V Stricker BH van der Harst P Chasman DI Albert CM | 2017 | 中华高血压杂志2017，25，2： | 2 |
| 5 | A method for the solubilization of a (1→3)-β-D-glucan isolated from Saccharomyces cerevisiae显示文摘 | Williams David L McNamee Rose B Jones Ernest L | 1991 | Carbohydrate Research1991，219，： | 1 |
| 6 | Photocatalytic oxidation of organics in water using pure and silver-modifiedtitanium dioxide particles 显示文摘 | Veronica V Rose A Donia B | 2002 | Journal of Photochemistry and Photobiology A: Chemistry2002，148，： | 1 |
| 7 | Caesium-137 profiles in the sediments of a partial-meromictic lake on Great Sandy Island (Fraser Island),Queensland,Australia显示文摘 | LONGMORE M E O'LEARY B M ROSE C W | 1983 | Hydrobiologia1983，103，： | 1 |
| 8 | Verbs and Adverbs:Multidimensional Motion Interpolation 显示文摘 | Rose C E Cohen M Bodenheimer B | 1998 | IEEE Computer Graphics & Application (S0272-1716)1998，18，5： | 1 |
| 9 | 显示文摘 | Rose J B | 1974 | Polymer1974，15，： | 1 |
| 10 | Restenosis following coronary artery angioplasty,pattems,recognition,and results of repeat angioplasty显示文摘 | Rose B | 1988 | Cardiovas Clin1988，19，： | 1 |
| 11 | The I- Cluster Cloud: distributed management of idle resources for intense computing 显示文摘 | Richard B Maillard N De Rose CAF | 2005 | Parallel Computing2005，89，31： | 1 |
| 12 | The mGluR7 allosteric agonist AMN082 produces antidepressant-like effects by modulating glutamatergic signaling显示文摘 | Stefania R Bradley Jason M Uslaner Rose B Flick | 2012 | Pharmacol Biochem Behav2012，101，1： | 1 |
| 13 | Preparation of amino-functionalized silica in aqueous conditions显示文摘 | Cuoq F Masion A Labille J Rose J Ziarelli F Prelot B Bottero J Y | 2013 | Applied Surface Science2013，266，： | 1 |
| 14 | What is 'emerging'? 显示文摘 | Field J A Johnson C A Rose J B | 2006 | Environmental Science & Technology2006，40，23： | 1 |
| 15 | In vitro differentiation of a cloned bovine mammary epithelial cell显示文摘 | ROSE B T ASO H YONEKURA S | 2002 | Journal of Dairy Research2002，69，3： | 1 |
| 16 | The heterogeneous evolution of multidrug-resistant Mycobacterium tuberculosis显示文摘 | Moller B Borrell S Rose G | 2013 | Trends Genet2013，29，3： | 1 |
| 17 | Cryptosporidium parvum and Cyclospora cayetanensis : A review of laboratory methods for detection of these waterborne parasites 显示文摘 | QUINTERO-BETANCOURT W PEELE E R ROSE J B | 2002 | Journal of Microbiological Methods2002，49，3： | 1 |
| 18 | Physiological levels of pro- and anti-inflammatory mediators in cerebrospinal fluid and plasma:a normative study显示文摘 | Maier B Laurer HL Rose S | 2005 | J Neurotrauma2005，22，7： | 1 |
| 19 | Rituximab: mechanism of action and resistance 显示文摘 | Maloney D G Smith B Rose A | 2002 | Semin Oncol2002，29，12： | 1 |
| 20 | Blood levels and serum protein binding of cis-platinum (Ⅱ) complexed to carboxymethyl-dextran显示文摘 | Schechter B Rosing MA Wilchek M | 1989 | Cancer Chemother Pharmacol1989，24，： | 1 |
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