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| 1 | Sex-specific differences in white matter microvascular integrity after ischaemic stroke显示文摘background and purpose Functional outcomes after ischaemic stroke are worse in women,despite adjusting for differences in comorbidities and treatment approaches.White matter microvascular integrity represents one risk factor for poor long-term functional outcomes after ischaemic stroke.The aim of the study is to characterise sex-specific differences in microvascular integrity in individuals with acute ischaemic stroke.Methods A retrospective analysis of subjects with acute ischaemic stroke and brain MRI with diffusion-weighted(DWI)and dynamic-susceptibility contrast-enhanced(DSC)perfusion-weighted imaging obtained within 9 hours of last known well was performed.In the hemisphere contralateral to the acute infarct,normal-appearing white matter(NAWM)microvascular integrity was measured using the K_(2) coefficient and apparent diffusion coefficient(ADC)values.Regression analyses for predictors of K_(2) coefficient,DWI volume and good outcome(90-day modified Rankin scale(mRS)score<2)were performed.results 105 men and 79 women met inclusion criteria for analysis.Despite no difference in age,women had increased NAWM K_(2) coefficient(1027.4 vs 692.7×10^(-6)/s;p=0.006).In women,atrial fibrillation(β=583.6;p=0.04)and increasing NAWM ADC(β=4.4;p=0.02)were associated with increased NAWM K_(2) coefficient.In multivariable regression analysis,the K_(2) coefficient was an independent predictor of DWI volume in women(β=0.007;p=0.01)but not men.Conclusions In women with acute ischaemic stroke,increased NAWM K_(2) coefficient is associated with increased infarct volume and chronic white matter structural integrity.Prospective studies investigating sex-specific differences in white matter microvascular integrity are needed. | Mark R Etherton Ona Wu Pedro Cougo Svetlana Lorenzano Hua Li Lisa Cloonan Mark J R J Bouts Arne Lauer Ken Arai Eng H Lo Steve K Feske Karen L Furie Natalia S Rost | 2019 | Stroke & Vascular Neurology2019，4，4： | 2 |
| 2 | Advances of a spatial sine testing system显示文摘 | Severyn A J Barney P S Rost W Brown D L | 1989 | International Modal Analysis Conference Las Vegas Nevada1989，，： | 1 |
| 3 | Alterations in semen parameters in men with epilepsy treated with valproate or carbamazepine monotherapy 显示文摘 | Roste L S Tauboll E Haugen T B | 2003 | Eur J Neuro12003，10，： | 1 |
| 4 | Sr2RhO4: A new, clean correlated electron metal 显示文摘 | Perry R S Baumberger F Balicas L Kikugawa N Ingle N J C Rost A Mercure J F Maeno Y Sehn Z X Mackenzie A P | 2006 | New J Phys2006，8，： | 1 |
| 5 | Apical organization and maturation of the cortex and vascular cylinder in Arabidopsis thaliana ( Brassicaceae ) roots 显示文摘 | Baum S F Dubrovsky J G Rost T L | 2002 | American Journal of Botany2002，89，6： | 1 |
| 6 | Brain natriuretic pep- tide predicts functional outcome in ischemic stroke 显示文摘 | Rost N S Biffi A Cloonan L | 2012 | Stroke2012，43，2： | 1 |
| 7 | Determinate root growth and meristem maintenance in Angiosperms显示文摘 | Shishkova S Rost T L Dubrovsky J G | 2008 | Annals of Botany2008，101，： | 1 |
| 8 | Successful percutaneous drainage of a giant hydatid cyst in the liver显示文摘CASE REPORTA 35-year-old female was hospitalized for abdominal pain,bloating, and vomiting. Plain X-ray pictures exhibitedbowel obstruction for which she underwent emergencysurgery. On the second postoperative day, she started tocomplain about dull right upper quadrant abdominal painand bloating. Abdominal CT scans revealed very largecystic lesion with an inhomogeneous fluid content. Thecyst occupied the whole right lobe of the liver compressingthe surrounding organs and dislocating the left lobe ofthe liver towards the left hypocbondrium (Figure 1).Additionally, several more cysts of various sizes were | István Battyány Zsuzsanna Herbert Tamás Rostás ron Vincze Adrien Fülp Zoltán Harmat Beáta Gasztony | 2006 | World Journal of Gastroenterology2006，12，5： | 0 |
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