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| 1 | Combined hepatocellular-cholangiocarcinoma:An update on epidemiology,classification,diagnosis and management显示文摘Background:Combined hepatocellular-cholangiocarcinoma(CHC)is a rare subtype of primary hepatic malignancies,with variably reported incidence between 0.4%–14.2%of primary liver cancer cases.This study aimed to systematically review the epidemiological,clinicopathological,diagnostic and therapeutic data for this rare entity.Data sources:We reviewed the literature of diagnostic approach of CHC with special reference to its clinical,molecular and histopathological characteristics.Additional analysis of the recent literature in order to evaluate the results of surgical and systemic treatment of this entity has been accomplished.Results:The median age at CHC’s diagnosis appears to be between 50 and 75 years.Evaluation of tumor markers[alpha fetoprotein(AFP),carbohydrate antigen 19–9(CA19–9)and carcinoembryonic antigen(CEA)]along with imaging patterns provides better opportunities for CHC’s preoperative diagnosis.Reported clinicopathologic prognostic parameters possibly correlated with increased tumor recurrence and grimmer survival odds include advanced age,tumor size,nodal and distal metastases,vascular and regional organ invasion,multifocality,decreased capsule formation,stem-cell features verification and increased GGT as well as CA19–9 and CEA levels.In case of inoperable or recurrent disease,combinations of cholangiocarcinoma-directed systemic agents display superior results over sorafenib.Liver-directed methods,such as transarterial chemoembolization(TACE),percutaneous ethanol injection(PEI),hepatic arterial infusion chemotherapy(HAIC),radioembolization and ablative therapies,demonstrate inferior efficacy than in cases of hepatocellular carcinoma(HCC)due to CHC’s common hypovascularity.Conclusions:CHC demonstrates an overlapping clinical and biological pattern between its malignant ingredients.Natural history of the disease seems to be determined by the predominant tumor element.Gold standard for diagnosis is histology of surgical specimens.Regarding therapeutic interventions,major hepatectomy is acknowledged as the cornerstone of treatment whereas minor hepatectomy and liver transplantation may be applied in patients with advanced cirrhosis.Despite all therapeutic attempts,prognosis of CHC remains dismal. | Dimitrios Schizas Aikaterini Mastoraki Eleni Routsi Michail Papapanou Dimitrios Tsapralis Pantelis Vassiliu Konstantinos Toutouzas Evangelos Felekouras | 2020 | Hepatobiliary & Pancreatic Diseases International2020，19，6： | 14 |
| 2 | Association between infections caused by multidrug-resistant gram-negative bacteria and mortality in critically ill patients显示文摘The incidence of gram-negative multidrug-resistant(MDR) bacterial pathogens is increasing in hospitals and particularly in the intensive care unit(ICU) setting. The clinical consequences of infections caused by MDR pathogens remain controversial. The purpose of this review is to summarize the available data concerning the impact of these infections on mortality in ICU patients. Twenty-four studies, conducted exclusively in ICU patients, were identified through Pub Med search over the years 2000-2015. Bloodstream infection was the only infection examined in eight studies, respiratory infections in four and variable infections in others. Comparative data on the appropriateness of empirical antibiotic treatment were provided by only seven studies. In ten studies the presence of antimicrobial resistance was not associated with increased mortality; on the contrary, in other studies a significant impact of antibiotic resistance on mortality was found, though, sometimes, mediated by inappropriate antimicrobial treatment. Therefore, a direct association between infections due to gram-negative MDR bacteria and mortality in ICU patients cannot be confirmed. Sample size, presence of multiple confounders and other methodological issues may influence the results. These data support the need for further studies to elucidate the real impact of infections caused by resistant bacteria in ICU patients. | Elisabeth Paramythiotou Christina Routsi | 2016 | World Journal of Critical Care Medicine2016，5，2： | 3 |
| 3 | Application of the sequential organ failure assessment (SOFA) score to bacteremic ICU patients显示文摘 | Routsi C Pratikaki M Sotiropoulou C | 2007 | Infection2007，35，4： | 1 |
| 4 | Recombinant human erythropoietin therapy in critically ill patients: a dose-response study 显示文摘 | Georgopoulos D Matamis D Routsi C | 2005 | Crit Care2005，9，5： | 1 |
| 5 | Carbapenem - resistant versus carbapenem - susceptible Acinetobacter baumannii bacteremia in a Greek intensive care unit: risk factors, clinical features and out- comes显示文摘 | Routsi C Pratikaki M Platsouka E | 2010 | Infection2010，38，3： | 1 |
| 6 | Nitroglycerin can facilitate weaning of difficult-to-wean chronic obstructive pulmonary disease patients:a prospective interventional non-randomized study显示文摘 | Routsi C Stanopoulos I Zakynthinos E | 2010 | Crit Care2010，14，6： | 1 |
| 7 | Aspergillus bronchitis causing ateleetasis and acute respiratory failure in an immunocompromised patient显示文摘 | Routsi C Platsouka E Prekates A Rontogianni D Paniara O Roussos C | 2001 | Infection2001，29，： | 1 |
| 8 | Recombinant human erythropoietin therapy in critically ill patients: a dose-response study 显示文摘 | Georgopoulos D Matamis D Routsi C | 2005 | Crit Care2005，9，5： | 1 |
| 9 | Electrical muscle stimulation prevents critical illness polyneuromyopathy:a randomized parallel intervention trial显示文摘 | Routsi C Gerovasili V Vasileiadis I | | 0，，： | 1 |
| 10 | A comparative study of the Reaction Level Scale(RLS85) with Glasgow Coma Scale (GCS) and Edinburgh-2 Coma Scale(modified) (E2CS(M))显示文摘 | Teaseris J Pantazidis N Routsi C | 1991 | Acta Neurochir1991，110，12： | 1 |
| 11 | Does soluble triggering receptor expressed on myeloid cells - I play any role in the pathogenesis of septic shock 显示文摘 | Routsi C Giamarellos - Bourboulis E J Antonopoulou A | 2005 | Clin Exp Immunol2005，142，1： | 1 |
| 12 | Electrical muscle stimulation prevents critical illnesspolyneuromyopathy ; a randomized parallel intervention trial显示文摘 | ROUTSI C GEROVASIL1 V VAS1LE1AD1S I | 2010 | Crit Care2010，14，2： | 1 |
| 13 | Increased levels of senrum S100B protein in critically ill patients without brain injury显示文摘 | Stamataki E Nanas S | 2006 | Shock2006，26，： | 1 |
| 14 | Application of the Sequential Organ Failure Assessment(SOFA) Score to Bacteremic ICU Patients显示文摘 | Routsi C Pratikaki M Sotiropoulou C | 2007 | Infection2007，35，4： | 1 |
| 15 | Does soluble triggering receptor expressed on mycloid ccUs- 1 play any role in the pathogcncsis of septic shock显示文摘 | Routsi C GiamarcUos-Bourboulis E J Antonopoulou A ct al | 2005 | Clin Exp lmmunol2005，142，1： | 1 |
| 16 | Carbapenem-resistant versus carbapenem-susceptible Acinetobacter baumannii bacteremia in a Greek intensive care unit:risk factors,clinical features and outcomes显示文摘 | Routsi C Pratikaki M Platsouka E | 2010 | Infection2010，38，3： | 1 |
| 17 | Community-acquired methicillin-resistant Staphylococcus aureus carrying Panton-Valentine leukocidin genes: A lethal cause of pneumonia in an adult immunocompetent patient显示文摘 | Magira EE Zervakis D Routsi C | 2007 | ScandJlnfect Dis2007，39，5： | 1 |
| 18 | Carbapenem-re- sistant versus carbape-nem-susceptible Acinetobacter bauman- nil bacteremia in a Greek intensive care unit: risk factors, clinical features and outcomes 显示文摘 | Routsi C Pratikaki M Platsouka E | 2010 | Infection2010，38，： | 1 |
| 19 | Community-acquired methicillin-resistant Staphylococcus aureus carrying Panton-Valentine leukocidin genes:a lethal cause of pneumonia in an adult immunocompetent patient显示文摘 | Magira EE Zervakis D Routsi C | 2007 | Scand J Infect Dis2007，39，5： | 1 |
| 20 | Community acquired methieillin-resistant Staphylococcus aureus carrying Panton-Valentine leukocidin genes:A lethal cause of pneumonia in an adult immunocompetent patient 显示文摘 | Eleni E Magira Dimitrios Zervakis Christina Routsi | 2007 | Scandinavian Journal of Infectious Diseases2007，39，5： | 1 |
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