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| 1 | Helicobacter pylori and colorectal neoplasia:Is there acausal link?显示文摘Ever since Helicobacter pylori(H. pylori) was recognized as an infectious cause of gastric cancer, there has been increasing interest in examining its potential role in colorectal carcinogenesis. Data from casecontrol and cross-sectional studies, mostly relying on hospital-based samples, and several meta-analyses have shown a positive statistical relationship between H. pylori infection and colorectal neoplasia. However, the possibility exists that the results have been influenced by bias, including the improper selection of patients and disparities with respect to potential confounders. While the evidence falls short of a definitive causal link, it appears that infection with H. pylori /H. pylori-related gastritis is associated with an increased, although modest, risk of colorectal adenoma and cancer. The pathogenic mechanisms responsible for this association remain uncertain. H. pylori has been detected in colorectal malignant tissues; however, the possibility that H. pylori is a direct activator of colonic carcinogenesis remains purely hypothetical. On the other hand, experimental data have indicated a series of potential oncogenic interactions between these bacteria and colorectal mucosa, including induction and perpetuation of inflammatory responses, alteration of gut microflora and release of toxins and/or hormonal mediators, such as gastrin, which may contribute to tumor formation. | Vasilios Papastergiou Stylianos Karatapanis Sotirios D Georgopoulos | 2016 | World Journal of Gastroenterology2016，22，2： | 22 |
| 2 | Treatment of Helicobacter pylori infection:Meeting the challenge of antimicrobial resistance显示文摘Treatment of Helicobacter pylori(H.pylori)infection is paramount for the management of prevalent gastrointestinal disorders including peptic ulcer disease and gastric cancer.Due to the wide increase in prevalence of H.pylori resistance to antibiotics,clarithromycin-based triple therapies are not any more suitable for unconditional empiric use,and should not be recommended,unless local resistance to this antibiotic is low(<20%).Alternative strategies have been proposed to overcome the issue of increasing clarithromycin resistance,and some of them are already implemented in clinical practice.These comprise:(1)adoption of novel,more effective,empirical treatments:bismuth quadruple,sequential,non-bismuth quadruple(concomitant),dual-concomitant(hybrid),and levofloxacin-based regimens,the latter mainly designated as second-line/rescue options;(2)perspectives for a susceptibility-guided(tailored)therapeutic approach based on culture-free molecular testing methods;and(3)adjunct use of probiotics to improve eradication rates.The present article is aimed to provide a comprehensive overview of current and emerging strategies in the treatment of H.pylori infection,focusing on the challenge of antimicrobial resistance. | Vasilios Papastergiou Sotirios D Georgopoulos Stylianos Karatapanis | 2014 | World Journal of Gastroenterology2014，20，29： | 18 |
| 3 | Treatment of Helicobacter pylori infection: Past, present and future显示文摘Helicobacter pylori(H. pylori) is a major human patho-gen associated with significant morbidity and mortal-ity. However, after decades of efforts, treatment of H. pylori remains a challenge for physicians, as there is no universally effective regimen. Due to the rising prevalence of antimicrobial resistance, mainly to clar-ithromycin, efficacy of standard triple therapies has declined to unacceptably low levels in most parts of the world. Novel regimens, specifically experimented to improve the therapeutic outcome against antibiotic-resistant H. pylori strains, are now recommended as first-line empirical treatment options providing high ef-ficacy(reportedly > 90% in intention to treat analysis) even in high clarithromycin resistance settings. These include the bismuth quadruple, concomitant, sequential and hybrid therapies. Due to the rapid development of quinolone resistance, levofloxacin-based regimens should be reserved as second-line/rescue options. Adjunct use of probiotics has been proposed in order to boost eradication rates and decrease occurrence of treatment-related side effects. Molecular testing meth-ods are currently available for the characterization of H. pylori therapeutic susceptibility, including genotypic detection of macrolide resistance and evaluation of the cytochrome P450 2C19 status known to affect the me-tabolism of proton pump inhibitors. In the future, use of these techniques may allow for culture-free, non-invasive tailoring of therapy for H. pylori infection. | Vasilios Papastergiou Sotirios D Georgopoulos Stylianos Karatapanis | 2014 | World Journal of Gastrointestinal Pathophysiology2014，5，4： | 11 |
| 4 | Current options for the treatment of Helicobacter pylori显示文摘 | Sotirios D Georgopoulos Vasilios Papastergiou Stylianos Karatapanis | 2013 | Expert Opinion on Pharmacotherapy2013，，2： | 3 |
| 5 | Diet, physical exer- cise and Orlistat administration increase serum anti-Miillerian hor- motxe (AMID levels in women with polycystic ovary syndrome (PCOS) 显示文摘 | Vosnakis C Georgopoulos NA Rousso D | 2013 | Gynecol Endocrinol2013，29，3： | 1 |
| 6 | Patent-ventilator interaction显示文摘 | Kondili E Prinianakis G Georgopoulos D | | 0，，： | 1 |
| 7 | Patient-ventilator interaction显示文摘 | Kondili E Prinianakis G Georgopoulos D | 2003 | Br J Anaesth2003，91，1： | 1 |
| 8 | Diet, physical exercise and orlistat administration increase serum anti-Müllerian hormone(AMH) levels in women with polycystic ovary syndrome(PCOS)显示文摘 | Vosnakis C Georgopoulos NA Rousso D | 2013 | Gynecol Endocrinol2013，29，3： | 1 |
| 9 | Lung ultrasound in the intensive care unit: let's move forward 显示文摘 | Georgopoulos D Xirouchaki N Volpicelli G | 2014 | Intensive Cre Med2014，40，10： | 1 |
| 10 | Recombinant human erythropoietin therapy in critically ill patients: a dose-response study 显示文摘 | Georgopoulos D Matamis D Routsi C | 2005 | Crit Care2005，9，5： | 1 |
| 11 | The impact of oral contraceptives and metformin on anti - Mtillerian hormone serum lev- els in women with polycystic ovary syndrome and biochemical hy- perandrogenemia 显示文摘 | Panidis D Georgopoulos NA Piouka A | 2011 | Gynecol Endocrinol2011，27，8： | 1 |
| 12 | The Dnaj chaperone catalytically activates the Dnak chaperan to preferentiarry bind δ32 heat shock transcription regulational regulator显示文摘 | Liberek K Wall D Georgopoulos C | 1995 | Proc Natl Acad Sci USA1995，92，4： | 1 |
| 13 | Management of large traumatic zonular dialysis with phacoemulsification and IOL implantation using the capsular tension ring显示文摘 | Georgopoulos GT Papaconstantinou D Georgalas I | 2007 | Acta Ophthalmol Scand2007，85，6： | 1 |
| 14 | Hypergastrin- emia is associated with increased risk of distal colon adenomas显示文摘 | Georgopoulos SD Polymeros D Triantafyllou K | 2006 | Digestion2006，74，1： | 1 |
| 15 | Recombinant human erythropoietin therapy in critically ill patients: a dose-response study 显示文摘 | Georgopoulos D Matamis D Routsi C | 2005 | Crit Care2005，9，5： | 1 |
| 16 | Patient-ventilator interaction显示文摘 | Kondili E Prinianakis G Georgopoulos D | | 0，，01： | 1 |
| 17 | The rpoE gene encodingthe sigma E (sigma 24) heat shock sigma factor of Escherichia coli 显示文摘 | RAINA S MISSIAKAS D GEORGOPOULOS C | 1995 | EMBO1995，14，5： | 1 |
| 18 | Long - term alterations of respiratory function in adolescents wearing a brace for idiopathic scoliosis 显示文摘 | Korovessis P Filos KS Georgopoulos D | 1996 | Spine1996，17，： | 1 |
| 19 | Control of breathing in mechanically ventilated patients显示文摘 | Georgopoulos D Roussos C | 1996 | Eur Respir J1996，9，： | 1 |
| 20 | The IOP with myopia显示文摘 | Georgopoulos G Andreanos D Liokis N | 1997 | Eur J Ophthalmol1997，7，： | 1 |
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