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| 1 | Fecal lactoferrin accurately reflects mucosal inflammation in inflammatory bowel disease显示文摘BACKGROUND Studies have demonstrated a potential role for fecal biomarkers such as fecal calprotectin(FC)and fecal lactoferrin(FL)in monitoring inflammatory bowel diseases(IBD)-Crohn's disease(CD)and ulcerative colitis(UC).However,their correlation to endoscopic scores,disease severity and affected intestinal surface has not been extensively investigated.AIM To correlate FL,and for comparison white blood cell(WBC)and C-reactive protein(CRP),with endoscopic scores,disease extent and location in CD and UC.METHODS Retrospective analysis in 188 patients who had FL,CRP and WBC determined within 30 d of endoscopy.Disease location,disease extent(number of intestinal segments involved),disease severity(determined by endoscopic scores),timing of FL testing in relation to colonoscopy,as well as the use of effective fast acting medications(steroids and biologics)between colonoscopy and FL measurement,were recorded.RESULTS In 131 CD and 57 UC patients,both CRP and FL-but not WBC-distinguished disease severity(inactive,mild,moderate,severe).In patients receiving fastacting(steroids or biologics)treatment in between FL and colonoscopy,FL showed a higher correlation to endoscopic scores when tested before vs after the procedure(r=0.596,P<0.001,vs r=0.285,P=0.15 for the Simple Endoscopic Score for CD;and r=0.402,P=0.01 vs r=0.054 P=0.84 for Disease Activity Index).Finally,FL was significantly correlated with the diseased mucosal surface(colon-ileocolon>small bowel)and the number of inflamed colon segments.CONCLUSION FL and CRP separated disease severity categories with FL showing lower discriminating P-values.FL showed a close correlation with the involved mucosal surface and with disease extent and was more closely correlated to endoscopy when determined before the procedure–this indicating that inflammatory activity changes associated with therapy might be rapidly reflected by FL levels.FL can accurately and timely characterize intestinal inflammation in IBD. | Marrieth G Rubio Kofi Amo-Mensah James M Gray Vu Q Nguyen Sam Nakat Douglas Grider Kim Love James H Boone Dario Sorrentino | 2019 | World Journal of Gastrointestinal Pathophysiology2019，10，5： | 4 |
| 2 | Germanene: a novel two-dimensional germanium allotrope akin to graphene and silicene显示文摘 | M E Dávila L Xian S Cahangirov A Rubio G Le Lay | 2014 | New Journal of Physics2014，，： | 3 |
| 3 | Ep2/Ep4 mediated PGE2 signalling induces the synthesis of osteoprotegerin (OPG) and receptor activator of NF - kappa b ligand (RANKL) in human osteoarthritic chondrocytes in culture 显示文摘 | Moreno - Rubio J Herrero - Beaumont G Tardio L | 2007 | Osteoarthritis Cartilage2007，3，： | 1 |
| 4 | Reboxetine ad-junct for partial or nonresponders to antidepressant treat-ment显示文摘 | Rubio G San L Lapez-Mu oz F | 2004 | J Affect Disord2004，81，1： | 1 |
| 5 | Application of new control strategy for sun tracking显示文摘 | Rubio F R Ortega M G Gordillo F | 2007 | Energy Conversion and Management2007，48，7： | 1 |
| 6 | The A1 allele of the DRD2 gene(TaqI A polymorphisms) is associated with antisocial personality in a sample of alcohol-dependent patients显示文摘 | Ponce G Jimenez-Arriero MA Rubio G | 2003 | Eur Psychiatry2003，18，7： | 1 |
| 7 | 5-ALA-PDT induces RIP3-dependent necrosis in glioblastoma显示文摘 | Coupienne I Fettweis G Rubio N | 2011 | Photochem Photobiol Sci2011，10，12： | 1 |
| 8 | Applicationof new control strategy for sun tracking显示文摘 | Rubio F R Ortega M G Gordillo F | 2007 | Energy Con-version and Management2007，48，7： | 1 |
| 9 | Stability and band gap constancy of boron nitride nanotubes 显示文摘 | BLASE X RUBIO A LOUIE S G | 1994 | Eur Phys Lett1994，28，： | 1 |
| 10 | Stability Studies of Carbonate Pesticides and Analysis by Gas Chroma- tography with Flame Ionization and Nitrogen - phosphorus Detection 显示文摘 | SANTOS M J D RUBIO B S FERNONDEZ -TOSTADO G T | 2001 | J Chromatography2001，921，： | 1 |
| 11 | Selective control ofSIRP-alpha-positive airway dendritic cell trafficking throughCD47 is critical for the development of T ( H ) 2-mediatedallergic inflammation显示文摘 | Raymond M Rubio M Fortin G | 2009 | J Allergy Clin Immunol2009，1246，： | 1 |
| 12 | Allometric relations for biomass partitioning of Nothofagus antarctica trees of different crown classes over a site quality gradient显示文摘 | GARGAGLIONE V PERI P L RUBIO G | 2010 | Forest Ecology of Management2010，259，6： | 1 |
| 13 | Down-regulation of astroglial proteins in the rat cerebellum after portacaval anastomosis 显示文摘 | Suarez I Bodega G Rubio M | 2005 | Neuropathol Appl Neurobiol2005，31，2： | 1 |
| 14 | Stability and band gap constancy of boron nitride nanotubes 显示文摘 | Blase X Rubio A Louie S G | 1994 | Europhys Lett1994，28，： | 1 |
| 15 | Systematic design of weighting matrices for the H infinity mixed sensitivity problem显示文摘 | ORTEGA M G RUBIO F R | 2004 | Journal of Process Control2004，14，： | 1 |
| 16 | Autoregresive conditional volatility, skewness and kurtosis 显示文摘 | Leon A Rubio G Serna G | 2005 | The Quarterly Review of Economics and Finance2005，45，45： | 1 |
| 17 | Regulation of mprF by antisense RNA restores daptomycin susceptibility to daptomycin-resistant isolates of Staphylococcus aureus显示文摘 | Rubio A Conrad M Haselbeck RJ G CK Brown-Driver V Finn J Silverman JA | | 0，，： | 1 |
| 18 | Imatinib resistance in multidrug-resistant K562 human leukemic cells显示文摘 | Assef Y Rubio F Colo G | 2009 | Leuk Res2009，33，5： | 1 |
| 19 | Autoregresive conditional volatility,skewness and kurtosis显示文摘 | Leon A Rubio G Serna G | 2005 | The Quarterly Review of Economics and Finance2005，45，： | 1 |
| 20 | An integral predictive/nonlinear control structure for a Quadrotor heli- copter显示文摘 | RAFFO G V ORTEGA M G RUBIO F R | 2010 | Automatica2010，46，1： | 1 |
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