|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Angiogenesis in hepatocellular carcinoma:mechanisms and anti-angiogenic therapies显示文摘Hepatocellular carcinoma(HCC)is the fourth leading cause of cancer-associated death worldwide.Angiogenesis,the process of formation of new blood vessels,is required for cancer cells to obtain nutrients and oxygen.HCC is a typical hypervascular solid tumor with an aberrant vascular network and angiogenesis that contribute to its growth,progression,invasion,and metastasis.Current anti-angiogenic therapies target mainly tyrosine kinases,vascular endothelial growth factor receptor(VEGFR),and plateletderived growth factor receptor(PDGFR),and are considered effective strategies for HCC,particularly advanced HCC.However,because the survival benefits conferred by these anti-angiogenic therapies are modest,new anti-angiogenic targets must be identified.Several recent studies have determined the underlying molecular mechanisms,including pro-angiogenic factors secreted by HCC cells,the tumor microenvironment,and cancer stem cells.In this review,we summarize the roles of pro-angiogenic factors;the involvement of endothelial cells,hepatic stellate cells,tumor-associated macrophages,and tumor-associated neutrophils present in the tumor microenvironment;and the regulatory influence of cancer stem cells on angiogenesis in HCC.Furthermore,we discuss some of the clinically approved anti-angiogenic therapies and potential novel therapeutic targets for angiogenesis in HCC.A better understanding of the mechanisms underlying angiogenesis may lead to the development of more optimized anti-angiogenic treatment modalities for HCC. | Changyu Yao Shilun Wu Jian Kong Yiwen Sun Yannan Bai Ruhang Zhu Zhuxin Li Wenbing Sun Lemin Zheng | 2023 | Cancer Biology & Medicine2023，20，1： | 3 |
| 2 | The signaling mechanism of Arabidopsis CRY1 involves direct interaction with COP1显示文摘 | YANG Hongquan TANG Ruhang CASHMORE A R | 2001 | Plant Cell2001，13，12： | 1 |
| 3 | Cardiomyocyte-specific p65 NF-κB deletion protects the injured heart by preservation of calcium handling显示文摘 | Xiu Q. Zhang Ruhang Tang Ling Li Amanda Szucsik Hadi Javan Noriko Saegusa Ken W. Spitzer Craig H. Selzman | 2013 | AJP: Heart and Circulatory Physiology2013，，7： | 1 |
| 4 | Current status,future po tentials and challenges of renewable energy De-velopment in Gansu province (North west Chi-na)显示文摘 | Wu Yunna Xu Ruhang | | 0，，18： | 1 |
| 5 | Government Investment Projects Collusion Supervision Based on the Prospect Theo- ry显示文摘 | Yunna Wu Yisheng Yang Tiantian Feng Lirong Liu Ruhang Xu | 2011 | ICIC Express Letters Part B: Applications2011，2，6： | 1 |
| 6 | Influence of Temperature Conditions on Dynamic Young’s Modulus Testing显示文摘The Young’s modulus was measured at high temperatures by impulse excitation of vibration method,and the effects of heating rate,holding time and temperature cycle on the test results were analyzed.The results show that the heating rate has obvious effect on the high temperature Young’s modulus of the green body,but has no obvious effect on that of the sintered products;the holding time of the heating process has no regular effect on the Young’s modulus,and the effect varies with the different products at a certain temperature;the method can also be used to test the Young’s modulus during cooling process. | SONG Yanyan HU Piao LI Ruhang LI Xiaorui | 2019 | China's Refractories2019，28，3： | 0 |
| 7 | High Temperature Gas Permeability Tester for Refractories and Its Application显示文摘In this paper,an ideal structural model and a scientific and practical mathematical model of high temperature permeability testing technology were established based on the formula of gas permeability at room temperature according to Darcy’s equation and Forchheimer equation and combined with the basic law of gas mechanics and the resistance loss of gas movement process at high temperatures.Through a gas heater,the safe heating of gas from room temperature to the test temperature was realized;the pressure sealing of high temperature permeability test technology was studied using high temperature resistant flexible material instead of silica gel material and combining preloading with system expansion and continuous loading.Based on the above research,a high temperature gas permeability tester for refractories has been developed and the test temperature can be up to 1000℃.The equipment was applied to research refractories,showing well using effects. | HU Piao SONG Yanyan WANG Zhanmin LI Ruhang LI Xiaorui | 2020 | China's Refractories2020，29，1： | 0 |
| 8 | Roles of light transmission aggregometry and CYP2C19 genotype in predicting ischaemic complications during interventional therapy for intracranial aneurysms显示文摘Background and purpose Light transmission aggregometry(LTA)and CYP2C19 genotype analysis are commonly used to evaluate the antiplatelet effects of clopidogrel during the interventional treatment of intracranial aneurysms.The aim of this study was to determine which test can predict ischaemic events during these treatments.Methods Patient demographic information,imaging data,laboratory data and ischaemic complications were recorded.LTA and CYP2C19 genotype results were compared,and multiple linear regression was performed to examine factors related to platelet reactivity.Multivariate regression analysis was performed to determine whether LTA and CYP2C19 could predict ischaemic complications and to identify other clinical risk factors.Receiver operating characteristic curve analysis was conducted to calculate the cut-off value for predicting ischaemic complications.A subgroup analysis was also performed for different CYP2C19 genotype metabolisers,as well as for patients with flow diverters and traditional stents.Results A total of 379 patients were included,of which 22 developed ischaemic events.Maximum platelet aggregation induced by ADP(ADP-MPA)could predict ischaemic events(p<0.001;area under the curve,0.752(95%CI 0.663 to 0.842)),and its cut-off value was 41.5%.ADP-MPA(p=0.001)and hypertension duration>10 years(p=0.022)were independent risk factors for ischaemic events,while the CYP2C19 genotype was not associated with ischaemic events.In the subgroup analysis,ADP-MPA could predict ischaemic events in fast metabolisers(p=0.004)and intermediate metabolisers(p=0.003).The cut-off value for ischaemic events was lower in patients with flow diverters(ADP-MPA=36.4%)than in patients with traditional stents(ADP-MPA=42.9%).Conclusions ADP-MPA can predict ischaemic complications during endovascular treatment of intracranial aneurysms.Patients with flow diverters require stronger antiplatelet medication than patients with traditional stents. | Yangyang Zhou Wenqiang Li Chao Wang Ruhang Xie Yongnan Zhu Qichen Peng Limin Zhang Hongqi Zhang Yuxiang Gu Shiqing Mu Jian Liu Xinjian Yang | 2023 | Stroke & Vascular Neurology2023，8，4： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员