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| 1 | Somatosensory neuron types identified by high-coverage single-cell RNA-sequencing and functional heterogeneity显示文摘感觉神经原被不同发信号的网络和接受特征区分。因此,感觉神经原类型能被连接基于 transcriptome 的神经原与感觉显型打字定义。这里,我们分类老鼠的 somatosensory 神经原由高范围的单个房间的定序 RNA 的背面的根中心(DRG )(10 950 ±1 218 基因每神经原) 并且神经原基于尺寸的层次聚类。而且,对皮肤的刺激作出回应的单个 DRG 神经原被记录用一在里面 vivo 整个房间的补丁夹钳技术并且由神经原类型分类基因标记。小直径 DRG 神经原被分类进低阀值的 mechanoreceptor 的一种类型和 mechanoheat nociceptors (MHN ) 的五种类型。每 MHN 类型进一步被分成二种子类型。大 DRG 神经原被分成四种类型,包括表示联系 BAI1 的蛋白质 2-like 的 neurexophilin 1 快车 MHN 和机械 nociceptors (MN ) 1 (Baiap2l1 ) 。表示 trafficking 蛋白质粒子建筑群 3-like 和 Baiap2l1 显著的 MN 的 Mechanoreceptors 各被细分进二种子类型。这些结果为编目 somatosensory 神经原和他们的 transcriptome 数据库提供一个新系统。 | Chang-Lin Li Kai-Cheng Li Dan Wu Yan Chen Hao Luo Jing-Rong Zhao Sa-Shuang Wang Ming-Ming Sun Ying-Jin Lu Yan-Qing Zhong Xu-Ye Hu Rui Hou Bei-Bei Zhou Lan Bao Hua-Sheng Xiao Xu Zhang | 2016 | Cell Research2016，26，1： | 21 |
| 2 | Generating dense and super-resolution ISAR image by combining bandwidth extrapolation and compressive sensing显示文摘Recent developing compressive sensing (CS) theory indicates that it is possible to obtain precise recovery of a sparse signal from very limited measurements,which provides a new way for data acquisition and signal processing as nature signals usually involve some degree of sparsity.In this paper,we present an algorithm for inversed synthetic aperture radar (ISAR) imaging with super resolution by combining CS and bandwidth extrapolation (BWE) technique.For ISAR imaging,the backscattering field of target is usually contributed by a few strong scattering centers,whose number is much less than that of image pixels.Thus,CS is intuitively suitable for constructing super resolution ISAR image.According to CS theory,the number of extracted dominating scatterers relies on the signal length,which indicates that if only limited data is available,it is difficult to generate dense ISAR image robustly by CS,and some signal components tend to lose.To soften this constraint,BWE is combined with CS imaging to increase the degree of freedom of signal while preserving its coherence.A refined CS-based formation for ISAR image-resolution enhancement is then developed.Both real and simulated data experiments are performed to evaluate the proposed approach,and an example of using this technique demonstrates the enhanced image resolution in application of maneuvering target imaging. | QUAN YingHui ZHANG Lei GUO Rui XING MengDao BAO Zheng | 2011 | Science China(Information Sciences)2011，54，10： | 15 |
| 3 | Curative effect of radiotherapy at various doses on subcutaneous alveolar echinococcosis in rats显示文摘背景牙槽的包虫病(AE ) 是在人和动物的疾病,并且痊愈率是不能令人满意的。试图在感染包虫 multilocularis 的 rats.Methods 老鼠在牙槽的包虫病上调查局部地应用的放射疗法的不同剂量的药品功效的这研究随机各被划分成 4 组 15 只老鼠:低 -- ,中间 -- ,并且高照耀的组和控制组织。当在照耀组的老鼠分别地在 20 Gy/8 f, 40 Gy/8 f,和 60 Gy/8 f 收到了 6 兆电子伏放射疗法时,在控制组的老鼠没经历处理,一旦为 8 的一个总数的每 3 天预定。在放射疗法,湿重量和 AE 泡以后的一个月禁止的率在每个组的老鼠被检测。组织病理学说并且有 AE 损害的纸巾的 ultrastructural 观察是在处理组,的 performed.Results 明显的禁止的效果在 AE 老鼠被发现;禁止的率分别地是 50, 72,和 82。也与控制组(P 0.05 ) 相比在病理学的变化和损害的平均湿重量有统计差别。在处理组,各种各样的度的损害在超微结构被发现把压成薄片并且在 AE 的胶囊的墙中的幼芽的层,和损害在高剂量的 group.Conclusion 放射疗法是很严重的有一个剂量依赖者 AE 的生长上的禁止的效果。 | ZHANG Yue-fen XIE Zeng-ru NI Ya-qiong MAO Rui QI Hong-zhi YANG Yu-gang JIANG Tao BAO Yong-xing | 2011 | Chinese Medical Journal2011，，18： | 14 |
| 4 | SbHKT1;4, a member of the high‐affinity potassium transporter gene family from Sorghum bicolor, functions to maintain optimal Na^+/K^+ balance under Na^+ stress显示文摘In halophytic plants, the high‐affinity potassium transporter HKT gene family can selectively uptake Kt in the presence of toxic concentrations of Nat. This has so far not been well examined in glycophytic crops. Here, we report the characterization of SbHKT1;4, a member of the HKT gene family from Sorghum bicolor. Upon Nat stress, SbHKT1;4 expression was more strongly upregulated in salt‐tolerant sorghum accession, correlating with a better balanced Nat/ Kt ratio and enhanced plant growth. Heterogeneous expression analyses in mutants of Saccharomyces cerevisiae and Arabidopsis thaliana indicated that overexpressing SbHKT1;4 resulted in hypersensitivity to Nat stress, and such hypersensitivity could be alleviated with the supply of elevated levels of Kt, implicating that SbHKT1;4 may mediate Kt uptake in the presence of excessive Nat. Further electrophysiological evidence demonstrated that SbHKT1;4 could transport Nat and Kt when expressed in Xenopus laevis oocytes. The relevance of the finding that SbHKT1;4 functions to maintain optimal Nat/Kt balance under Nat stress to the breeding of salt‐tolerant glycophytic crops is discussed. | Tian‐Tian Wang Zhi‐Jie Ren Zhi‐Quan Liu Xue Feng Rui‐Qi Guo Bao‐Guo Li Le‐Gong Li Hai‐Chun Jing | 2014 | Journal of Integrative Plant Biology2014，56，3： | 11 |
| 5 | Comparison between the surface defects caused by Al_2O_3 and TiN inclusions in interstitial-free steel auto sheets显示文摘Al_2O_3 and TiN inclusions in interstitial-free(IF) steel deteriorate the properties of the steel. To decrease the defects of cold-rolled sheet, it is important to clearly distinguish between the degrees of damage caused by these two inclusions on the surface quality of the steel. In this study, a nanoindenter was used to test the mechanical properties of the inclusions, and the distribution and size of the inclusions were obtained by scanning electron microscopy(SEM). It was found that when only mechanical properties are considered, TiN inclusions are more likely to cause defects than Al_2O_3 inclusions of the same size during the rolling process. However, Al_2O_3 inclusions are generally more inclined to cause defects in the rolling process than TiN inclusions because of their distribution characteristic in the thickness direction. The precipitation of Al_2O_3 and TiN was obtained through thermodynamical calculations. The growth laws of inclusions at different cooling rates were calculated by solidification and segregation models. The results show that the precipitation regularity is closely related to the distribution law of the inclusions in IF slabs along the thickness direction. | Rui Wang Yan-ping Bao Zhi-jie Yan Da-zhao Li Yan Kang | 2019 | International Journal of Minerals,Metallurgy and Materials2019，26，2： | 11 |
| 6 | Micromanufacturing technologies of compact heat exchangers for hypersonic precooled airbreathing propulsion: A review显示文摘The Hypersonic Precooled Combined Cycle Engine(HPCCE), which introduces precooler into traditional hypersonic engine, is regarded as the most promising propulsion system for realizing a single-stage-to-orbit vehicle. The unique demands lead to the application of the compact heat exchangers, which can realize high thrust-to-weight ratio, sufficient specific impulse and high compression ratio. However, it is challenging to accurately manufacture the compact heat exchanger due to its extremely high heat dissipation capacity, remarkable compactness, superior adaptability and harsh operating condition. This review summarizes the precooling schemes of combined cycle propulsions and describes the demands and key issues in the fabrication of a compact heat exchanger for HPCCE. The investigation focuses on the application of various micromanufacturing methods of heat exchangers constructed from tubes of less than 1 mm in diameter and microchannels of less than 200 micrometers. Various micromanufacturing processes, which include microforming, micromachining, stereolithography, chemical etching, 3 D printing, joining and other advanced microfabricating processes, were reviewed. In addition, the technologies are compared in terms of dimensional tolerance, material compatibility, and process applicability. Furthermore, the boundaries of the micromanufacturing constraints are specified as references for the design of compact heat exchangers. Ultimately, the technological difficulties and development trends are discussed for the fabrication of compact heat exchangers for HPCCE. | Bao MENG Min WAN Rui ZHAO Zhengping ZOU Huoxing LIU | 2021 | Chinese Journal of Aeronautics2021，34，2： | 10 |
| 7 | Assessing the Effectiveness of a Cervical Cancer Screening Program in a Hospital-based Study显示文摘This study compared HPV testing and liquid-based cytology(LCT)as performance indicators for cervical cancer screening in a hospital-based study.A total of 61,193 outpatients were screened initially by LCT.Samples with screening results showing atypical squamous cells of undetermined significance(ASC-US)or worse were referred for colposcopy,and some | YANG Yi LANG Jing He WANG You Fang CHENG Xue Mei CAI Yu Pin LI Hui ZHU Bao Li ZHANG Rui Fen | 2015 | Biomedical and Environmental Sciences2015，28，1： | 10 |
| 8 | Possible influence of Arctic Oscillation on dust storm frequency in North China显示文摘这研究在 19612007 期间在春天季节在诺思中国在灰尘暴风雨频率上调查了北极摆动(AO ) 的影响。在灰尘暴风雨频率和 AO 之间有一个重要连接;一否定(积极) AO 阶段与有关一增加(减少) 在诺思中国的灰尘暴风雨频率。这种关系是仔细在蒙古与在寒冷的变化有关让活动通风。冷空气活动在灰尘暴风雨频率上施加大影响;在蒙古上的冷空气活动的频率断然不仅在诺思中国与灰尘暴风雨频率相关,而且显示出是为在诺思中国的灰尘暴风雨频率的长期的减少的一个重要原因的一个长期的减少趋势。AO 在蒙古上在冷空气活动的频率上有大影响;一否定(积极) AO 阶段是高度与有关一增加(减少) 寒冷的频率在蒙古上让活动通风,它导致一增加(减少) 在诺思中国的灰尘暴风雨频率。 | MAO Rui GONG Daoyi BAO Jingdong FAN Yida | 2011 | Journal of Geographical Sciences2011，21，2： | 9 |
| 9 | Improved approach to atrial septum puncture: experience in 539 cases显示文摘 | YAO Yan GUO Jun DING Li-gang BAO Jing-ru HUANG Wen SHI Rui WU Ling-min ZHANG Shu | 2012 | Chinese Medical Journal2012，，6： | 9 |
| 10 | Progressive failure analysis of slope with strain-softening behaviour based on strength reduction method显示文摘Based on the strength reduction method and strain-softening model,a method for progressive failure analysis of strain-softening slopes was presented in this paper.The mutation is more pronounced in strain-softening analysis,and the mutation of displacement at slope crest was taken as critical failure criterion.An engineering example was provided to demonstrate the validity of the present method.This method was applied to a cut slope in an industry site.The results are as follows:(1) The factor of safety and the critical slip surface obtained by the present method are between those by peak and residual strength.The analysis with peak strength would lead to non-conservative results,but that with residual strength tends to be overly conservative.(2) The thickness of the shear zone considering strain-softening behaviour is narrower than that with non-softening analysis.(3) The failure of slope is the process of the initiation,propagation and connection of potential failure surface.The strength parameters are mobilized to a non-uniform degree while progressive failure occurs in the slope.(4) The factor of safety increases with the increase of residual shear strain threshold and elastic modulus.The failure mode of slope changes from shallow slip to deep slip.Poisson's ratio and dilation angle have little effect on the results. | Ke ZHANG Ping CAO Rui BAO | 2013 | Journal of Zhejiang University-Science A(Applied Physics & Engineering)2013，14，2： | 9 |
| 11 | Switchable C02 electroreduction via engineering active phases of Pd nanoparticles显示文摘活跃阶段的工程定期被利用在异构的催化作用调节金属 nanoparticles (NP ) 的选择。然而,在 electrocatalysis 的活跃阶段的理解的缺乏为公司 2 electroreduction 妨碍了有效催化剂的发展。此处,我们报导 Pd NP 的活跃阶段的系统的工程,它被利用为公司 2 electroreduction 选择反应小径。在 situ X光检查吸收光谱学,在稀释的 situ 总计思考红外线的光谱学,并且密度功能的理论计算建议吸附氢的 Pd 的形成出现在混合物上-并且一个钯氢化物核心的阶段(在 0.2 V 上面的+ PdH x @PdH x )(对一个可逆的氢电极)经由 HCOO 便于甲酸盐生产*中间,而阶段 Pd 氢化物核心上的金属性的 Pd 表面的形成( PdH x @主要产品,是甲酸盐或公司,能有选择地与高 Faradaic 效率被生产(>90%) 并且在有可伸缩的申请的 0.05 ~ 0.9 V 的潜在的窗户中的集体活动示范。 | Dunfeng Gao Hu Zhou Fan Cai Dongniu Wang Yongfeng Hu Bei Jiang Wen-Bin Cai Xiaoqi Chen Rui Si Fan Yang Shu Miao Jianguo Wang Guoxiong wang Xinhe Bao | 2017 | Nano Research2017，10，6： | 8 |
| 12 | Influence of Low Load Truncation Level on Crack Growth for Al 2324-T39 and Al 7050-T7451显示文摘Tests with middle-crack tension(M(T)) specimens made of Al 2324-T39 and Al 7050-T7451 are conducted to investigate the influence of low load truncation level on fatigue crack growth.The six different truncated spectra are obtained by removing the small cycles of which amplitudes are less than the specified percentages of the maximum amplitude in the basic flight-by-flight loading spectrum and the remainder of the spectrum is untouched.The tests indicate that the mean level of fatigue crack growth life(FCGL) increases as the load truncation level is enhanced.Considering both the time saving and the influence on FCGL,there is an applicable choice(i.e.spectrum S2 or spectrum S3 in this investigation) for full scale fatigue test.The scatter of FCGL becomes much larger than that under the basic spectrum when the load truncation level is increased to a specified high level,mainly due to the occurrence of crack slanting and branching under the high level truncated loading spectra. | Tian Hailing Bao Rui Zhang Jianyu Zheng Xiaoling Fei Binjun | 2009 | Chinese Journal of Aeronautics2009，22，4： | 8 |
| 13 | Effects of closing and reopening live poultry markets on the epidemic of human infection with avian influenza A virus显示文摘Live poultry markets(LPMs) are crucial places for human infection of influenza A(H7N9 virus).In Yangtze River Delta,LPMs were closed after the outbreak of human infection with avian influenza A(H7N9) virus,and then reopened when no case was found.Our purpose was to quantify the effect of LPMs' operations in this region on the transmission of influenza A(H7N9) virus.We obtained information about dates of symptom onset and locations for all human influenza A(H7N9) cases reported from Shanghai,Jiangsu and Zhejiang provinces by May 31,2014,and acquired dates of closures and reopening of LPMs from official media.A two-phase Bayesian model was fitted by Markov Chain Monte Carlo methods to process the spatial and temporal influence of human cases.A total of 235 cases of influenza A(H7N9) were confirmed in Shanghai,Jiangsu and Zhejiang by May 31,2014.Using these data,our analysis showed that,after LPM closures,the influenza A(H7N9) outbreak disappeared within two weeks in Shanghai,one week in Jiangsu,and one week in Zhejiang,respectively.Local authorities reopened LPMs when there was no outbreak of influenza A(H7N9),which did not lead to reemergence of human influenza A(H7N9).LPM closures were effective in controlling the H7N9 outbreak.Reopening of LPM in summer did not increase the risk of human infection with H7N9.Our findings showed that LPMs should be closed immediately in areas where the H7N9 virus is confirmed in LPM.When there is no outbreak of H7N9 virus,LPMs can be reopened to satisfy the Chinese traditional culture of buying live poultry.In the long term,local authorities should take a cautious attitude in permanent LPM closure. | Jian Lu Wendong Liu Rui Xia Qigang Dai Changjun Bao Fenyang Tang Yefei Zhu Qiao Wang | 2016 | The Journal of Biomedical Research2016，30，2： | 7 |
| 14 | The biological effect of recombinant humanized collagen on damaged skin induced by UV-photoaging:An in vivo study显示文摘The application of medical devices to repair skin damage is clinically accepted and natural polymer enjoys an important role in this field,such as collagen or hyaluronic acid,etc.However,the biosafety and efficacy of these implants are still challenged.In this study,a skin damage animal model was prepared by UV-photoaging and recombinant humanized type Ⅲ collagen(rhCol Ⅲ)was applied as a bioactive material to implant in vivo to study its biological effect,comparing with saline and uncrosslinked hyaluronic acid(HA).Animal skin conditions were non-invasively and dynamically monitored during the 8 weeks experiment.Histological observation,specific gene expression and other molecular biological methods were applied by the end of the animal experiment.The results indicated that rhCol Ⅲ could alleviate the skin photoaging caused by UV radiation,including reduce the thickening of epidermis and dermis,increase the secretion of Collagen Ⅰ(Col Ⅰ)and Collagen Ⅲ(Col Ⅲ)and remodel of extracellular matrix(ECM).Although the cell-material interaction and mechanism need more investigation,the effect of rhCol Ⅲ on damaged skin was discussed from influence on cells,reconstruction of ECM,and stimulus of small biological molecules based on current results.In conclusion,our findings provided rigorous biosafety information of rhCol Ⅲ and approved its potential in skin repair and regeneration.Although enormous efforts still need to be made to achieve successful translation from bench to clinic,the recombinant humanized collagen showed superiorities from both safety and efficacy aspects. | Jing Wang He Qiu Yang Xu Yongli Gao Peijie Tan Rui Zhao Zhanhong Liu Yajun Tang Xiangdong Zhu Chongyun Bao Hang Wang Hai Lin Xingdong Zhang | 2022 | Bioactive Materials2022，7，5： | 7 |
| 15 | Discrete time transfer matrix method for dynamics analysis of complex weapon systems显示文摘Efficient, precise dynamic modeling and analysis for complex weapon systems have become more and more important in their dynamic design and performance optimizing. As a new method developed in recent years, the discrete time transfer matrix method of multibody system is highly efficient for multibody system dynamics. In this paper, taking a shipboard gun system as an example, by deducing some new transfer equations of elements, the discrete time transfer matrix method of multibody sys- tem is used to solve the dynamics problems of complex rigid-flexible coupling weapon systems successfully. This method does not need the global dynamic equations of system and has the low order of system matrix, high computational efficiency. The proposed method has advantages for dynamic design of complex weapon systems, and can be carried over straightforwardly to other complex mechanical systems. | RUI XiaoTing RONG Bao WANG GuoPing HE Bin | 2011 | Science China(Technological Sciences)2011，54，5： | 5 |
| 16 | Biological removal of antiandrogenic activity in gray wastewater and coking wastewater by membrane reactor process显示文摘A recombinant human androgen receptor yeast assay was applied to investigate the occurrence of antiandrogens as well as the mechanism for their removal during gray wastewater and coking wastewater treatment. The membrane reactor(MBR) system for gray wastewater treatment could remove 88.0% of antiandrogenic activity exerted by weakly polar extracts and 97.3% of that by moderately strong polar extracts, but only 32.5%of that contributed by strong polar extracts. Biodegradation by microorganisms in the MBR contributed to 95.9% of the total removal. After the treatment, the concentration of antiandrogenic activity in the effluent was still 1.05 μg flutamide equivalence(FEQ)/L, 36.2%of which was due to strong polar extracts. In the anaerobic reactor, anoxic reactor, and membrane reactor system for coking wastewater treatment, the antiandrogenic activity of raw coking wastewater was 78.6 mg FEQ/L, and the effluent of the treatment system had only 0.34 mg FEQ/L. The antiandrogenic activity mainly existed in the medium strong polar and strong polar extracts. Biodegradation by microorganisms contributed to at least 89.2%of the total antiandrogenic activity removal in the system. Biodegradation was the main removal mechanism of antiandrogenic activity in both the wastewater treatment systems. | Dehua Ma Lujun Chen Cong Liu Chenjun Bao Rui Liu | 2015 | Journal of Environmental Sciences2015，27，7： | 5 |
| 17 | Temperature dependent Raman and photoluminescence of vertical WS2/MoS2 monolayer heterostructures显示文摘Heterostructures from two-dimensional transition-metal dichalcogenides MX_2 have emerged as a hot topic in recent years due to their various fascinating properties. Here, we investigated the temperature dependent Raman and photoluminescence(PL) spectra in vertical stacked WS_2/MoS_2 monolayer heterostructures. Our result shows that both E_(2g)~1 and A_(1g) modes of WS_2 and MoS_2 vary linearly with temperature increasing from 300 to 642 K. The PL measurement also reveals strong temperature dependencies of the PL intensity and peak position. The activation energy of the thermal quenching of the PL emission has been found to be equal to 69.6 meV. The temperature dependence of the peak energy well follows the bandgap shrinkage of bulk semiconductor. | Zhijian Hu Yanjun Bao Ziwei Li Yongji Gong Rui Feng Yingdong Xiao Xiaochun Wu Zhaohui Zhang Xing Zhu Pulickel M. Ajayan Zheyu Fang | 2017 | Science Bulletin2017，62，1： | 5 |
| 18 | Subtype Identification of Avian Influenza Virus on DNA Microarray显示文摘We have developed a rapid microarray-based assay for the reliable detection of H5, H7 and H9 subtypes of avian influenza virus (AIV). The strains used in the experiment were A/Goose/Guangdong/1/96 (H5N1), A/African starling/983/79 (H7N1) and A/Turkey/Wiscosin/1/66 (H9N2). The capture DNAs clones which encoding approximate 500-bp avian influenza virus gene fragments obtained by RT-PCR, were spotted on a slide-bound microarray. Cy5-labeled fluorescent cDNAs, which generated from virus RNA during reverse transcription were hybridized to these capture DNAs. These capture DNAs contained multiple fragments of the hemagglutinin and matrix protein genes of AIV respectively, for subtyping and typing AIV. The arrays were scanned to determine the probe binding sites. The hybridization pattern agreed approximately with the known grid location of each target. The results show that DNA microarray technology provides a useful diagnostic method for AIV. | WANG Xiu-rong YU Kang-zhen DENG Guo-hua SHI Rui LIU Li-ling QIAO Chuan-ling BAO Hong-mei KONG Xian-gang CHEN Hua-lan | 2005 | Agricultural Sciences in China2005，4，9： | 5 |
| 19 | Effect of slag composition on steel cleanliness in interstitial-free steel显示文摘Ladle slag affects steel cleanliness at the end of the Ruhrstahl-Hereaeus(RH)and holding process.The relationship between composition of ladle slag,total oxygen(TO)and inclusions was investigated using X-ray fluorescence(XRF),infrared absorption,and SEM+EDS methods.The results indicate that TO in steel at the end of RH increases linearly with increasing FeO content in slag.TO is lower when wCaO/wAlO(C/A)=1.5-2.0than4under23 that of C/A=1.0-1. an approximate content of FeO.During the holding process,irregular Al_2O_3 inclusions are newly generated due to slag reoxidation.Additionally,Al_2O_3-Ti_xO inclusions are newly generated in the steel when the content of FeO is higher.By combining experimental and thermodynamic calculation results,it is determined that the slag has a good melting property within the zone of C/A=1.2-1.8and adsorption capacity of Al_2O_3 when the content of SiO_2 in slag is controlled at 4%-6%.The increase in the C/A ratio and the decrease of FeO content in slag can slow down the reoxidation rate. | Rui Wang Yan-ping Bao Yi-hong Li Tai-quan Li Di Chen | 2017 | Journal of Iron and Steel Research(International)2017，24，6： | 5 |
| 20 | Consensus on the digestive endoscopic tunnel technique显示文摘With the digestive endoscopic tunnel technique(DETT), many diseases that previously would have been treated by surgery are now endoscopically curable by establishing a submucosal tunnel between the mucosa and muscularis propria(MP). Through the tunnel, endoscopic diagnosis or treatment is performed for lesions in the mucosa, in the MP, and even outside the gastrointestinal(GI) tract.At present, the tunnel technique application range covers the following:(1)Treatment of lesions originating from the mucosal layer, e.g., endoscopic submucosal tunnel dissection for oesophageal large or circular early-stage cancer or precancerosis;(2) treatment of lesions from the MP layer, per-oral endoscopic myotomy, submucosal tunnelling endoscopic resection, etc.; and(3) diagnosis and treatment of lesions outside the GI tract, such as resection of lymph nodes and benign tumour excision in the mediastinum or abdominal cavity. With the increasing number of DETTs performed worldwide, endoscopic tunnel therapeutics, which is based on DETT, has been gradually developed and optimized. However, there is not yet an expert consensus on DETT to regulate its indications, contraindications, surgical procedure, and postoperative treatment.The International DETT Alliance signed up this consensus to standardize the procedures of DETT. In this consensus, we describe the definition, mechanism,and significance of DETT, prevention of infection and concepts of DETTassociated complications, methods to establish a submucosal tunnel, and application of DETT for lesions in the mucosa, in the MP and outside the GI tract(indications and contraindications, procedures, pre-and postoperative treatments, effectiveness, complications and treatments, and a comparison between DETT and other operations). | Ning-Li Chai Hui-Kai Li En-Qiang Linghu Zhao-Shen Li Shu-Tian Zhang Yu Bao Wei-Gang Chen Philip WY Chiu Tong Dang Wei Gong Shu-Tang Han Jian-Yu Hao Shui-Xiang He Bing Hu1 Bing Hu2 Xiao-Jun Huang Yong-Hui Huang Zhen-Dong Jin Mouen A Khashab James Lau Peng Li Rui Li De-Liang Liu Hai-Feng Liu Jun Liu Xiao-Gang Liu Zhi-Guo Liu Ying-Cai Ma Gui-Yong Peng Long Rong Wei-Hong Sha Pateek Sharma Jian-Qiu Sheng Shui-Sheng Shi Dong Wan Seo Si-Yu Sun Gui-Qi Wang Wen Wang Qi Wu Hong Xu Mei-Dong Xu Ai-Ming Yang Fang Yao Hong-Gang Yu Ping-Hong Zhou Bin Zhang Xiao-Feng Zhang Ya-Qi Zhai | 2019 | World Journal of Gastroenterology2019，25，7： | 5 |
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