|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | -765G > C COX-2 polymorphism may be a susceptibility marker for gastric adenocarcinoma in patients with atrophy or intestinal metaplasia显示文摘AIM: To investigate the relationship between the -765G > C COX-2 polymorphism and the development of different gastric lesions: atrophy or intestinal metaplasia and gastric adenocarcinoma. METHODS: A cross-sectional study was performed involving 320 Portuguese individuals (210 without evidence of neoplastic disease, 73 patients with gastric adenocarcinomas and 37 with atrophy or intestinal metaplasia) using a PCR-RFLP method. RESULTS: -765C allele was overrepresented in the patients with gastric adenocarcinoma (51%) when compared either with the control group (38%) or patients with atrophy or intestinal metaplasia (27%). Callele was found to be very common in our population (0.22), and a multivariate logistic regression analysis revealed nearly 3-fold increased risk for the progression to gastric adenocarcinoma in patients with atrophy or intestinal metaplasia carrying the -765C allele (OR = 2.67, 95% CI = 1.03-6.93; P = 0.04).considered as another susceptibility marker for gastric adenocarcinoma development in patients with atrophy or intestinal metaplasia. | Carina Pereira Hugo Sousa Paula Ferreira Maria Fragoso Luís Moreira-Dias Carlos Lopes Rui Medeiros Mário Dinis-Ribeiro | 2006 | World Journal of Gastroenterology2006，12，34： | 16 |
| 2 | Animal models of acute gastric mucosal injury: Macroscopic and microscopic evaluation显示文摘Acute gastric mucosal injury is a common disorder of the gastrointestinal tract and the search for new therapeutics is ongoing. The aim of this study is to update and expand the information related to the most widely used rat models of acute gastric ulcer, the ethanol‐induced ulcer and the indomethacin‐induced ulcer. These two models are compared in terms of macroscopic and microscopic features. Experimentally, ethanol was given orally in a single dose and indomethacin was subcutaneously injected into male Wistar rats. After ulcerative challenges, the stomachs were removed and visually inspected. Anti‐ulcerative drugs were used to validate the models. Histological analysis of the stomachs determined the microscopic score. The methodology used for model evaluation applied to macroscopic and microscopic gastric lesions. With these methods it was possible to induce lesions in the gastric mucosa. Microscopic evaluation permitted assessment of the inflammatory and apoptotic impact in the mucosa not observable by macroscopic evaluation. Groups of animals were treated with two standard drugs: sulcralfate suspension or lansoprazole solution. Both drugs reduced macroscopic and microscopic lesions, particularly the hemorrhagic ones. Both models induced acute gastric mucosal injury and no single evaluation method can address all the aspects of the pathology of gastric lesions. As a complement to macroscopic evaluation, microscopy appears to be a relevant tool to selectively identify specific aspects of the development of mucosal injury, quantify the extent of lesions, and contribute to an appropriate interpretation of results. The score systems established here offer a reliable method for testing antiulcer drugs. | Sandra Simoes Rui Lopes Maria Celeste Dias Campos Maria Joao Marruz Maria Eugenia Meirinhos da Cruz Luisa Corvo | 2019 | Animal Models and Experimental Medicine2019，2，2： | 7 |
| 3 | Gastric cancer in a Caucasian population: Role of pepsinogen C genetic variants显示文摘瞄准:在胃蛋白酶原 C (PGC ) 基因学习插入 / 删除多型性的角色,为胃粘膜的终端区别的一个有效标记,在到胃的损害的开发的危险性。方法:没有肿瘤的疾病的证据,学习与已知的胃的损害的 99 件样品和 127 件样品被执行。PCR 被采用, 6 多态的等位基因被放大:等位基因 1 (510 bp ) ,等位基因 2 (480 bp ) ,等位基因 3/4 (450/460 bp ) ,等位基因 5 (400 bp ) 并且等位基因 6 (310 bp ) 。结果:我们的结果表明等位基因 6 搬运人似乎对任何胃的损害的发展有保护(或 = 0.34;P<0.001 ) ,与象萎缩或肠的组织变形那样的胃的腺癌联系的 non-dysplastic 损害(或 = 0.28;P<0.001 ) 或侵略 GC (或 = 0.39;P = 0.004 ) 。结论:我们的学习表明等位基因 6 搬运人地位在胃的损害的发展有一个保护的角色,可能由于它有 PGC 的更高的表示的协会。而且,在控制组的等位基因 6 搬运人的频率比在亚洲人口获得了高是远的,它可能代表在白种人和亚洲人口之间的基因差距。 | Ana L Pinto-Correia Hugo Sousa Maria Fragoso Luís Moreira-Dias Carlos Lopes Rui Medeiros Mário Dinis-Ribeiro | 2006 | World Journal of Gastroenterology2006，12，31： | 6 |
| 4 | Helicobacter pylori Induces Increased Expression of Toll‐Like Receptors and Decreased Toll‐Interacting Protein in Gastric Mucosa that Persists Throughout Gastric Carcinogenesis显示文摘 | Pedro Pimentel‐Nunes Nádia Gon?alves Inês Boal‐Carvalho Luís Afonso Paula Lopes Roberto Roncon‐Albuquerque Rui Henrique Luís Moreira‐Dias Adelino F. Leite‐Moreira Mário Dinis‐Ribeiro | 2012 | Helicobacter2012，，1： | 2 |
| 5 | Towards curative therapy in gastric cancer:Faraway, so close!显示文摘Although recent diagnostic and therapeutic advances have substantially improved the survival of patients with gastric cancer(GC), the overall prognosis is still poor. Surgery is the only curative treatment and should be performed in experienced centers. Due to high relapse following surgery, complementary and systemic treatment aimed at eradicating micrometastasis should be performed in most cases. Cytotoxic treatments are effective in downstaging locally advanced cancer, but different sensitivities and toxicities probably exist in different GC subtypes. Current treatment protocols are based primarily on clinical data and histological features, but molecular biomarkers that would allow for the prediction of treatment responses are urgently needed. Understanding how host factors are responsible for inter-individual variability of drug response or toxicity will also contribute to the development of more effective and less toxic treatments. | Marília Cravo Catarina Fidalgo Rita Garrido Tania Rodrigues Gon?alo Luz Carolina Palmela Marta Santos Fábio Lopes Rui Maio | 2015 | World Journal of Gastroenterology2015，21，41： | 2 |
| 6 | Detection of colon cancer by terahertz techniques显示文摘 | Faustino Wahaia Gintaras Valusis Luis M. Bernardo Abílio Almeida Joaquim A. Moreira Patricia C. Lopes Jan Macutkevic Irmantas Kasalynas Dalius Seliuta Ramunas Adomavicius Rui Henrique Machado Lopes | 2011 | Journal of Molecular Structure2011，，1： | 1 |
| 7 | Co-expression of monocarboxylate transporter 1 (MCT1) and its chaperone (CD147) is associated with low survival in patients with gastrointestinal stromal tumors (GISTs)显示文摘 | Ant?nio Talvane Torres Oliveira Céline Pinheiro Adhemar Longatto-Filho Maria Jose Brito Olga Martinho Delcio Matos André Lopes Carvalho Vinícius Lima Vazquez Thiago Buosi Silva Cristovam Scapulatempo Sarhan Sydney Saad Rui Manuel Reis Fátima Baltazar | 2012 | Journal of Bioenergetics and Biomembranes2012，，1： | 1 |
| 8 | Co-expression of monocarboxylate transporter 1 (MCT1) and its chaperone (CD147) is associated with low survival in patients with gastrointestinal stromal tumors (GISTs)显示文摘 | Ant?nio Talvane Torres Oliveira Céline Pinheiro Adhemar Longatto-Filho Maria Jose Brito Olga Martinho Delcio Matos André Lopes Carvalho Vinícius Lima Vazquez Thiago Buosi Silva Cristovam Scapulatempo Sarhan Sydney Saad Rui Manuel Reis Fátima Baltazar | 2012 | Journal of Bioenergetics and Biomembranes2012，，1： | 1 |
| 9 | Effect of cooking methods on fatty acids, conjugated isomers of linoleic acid and nutritional quality of beef intramuscular fat显示文摘 | Cristina M.M. Alfaia Susana P. Alves Anabela F. Lopes Maria J.E. Fernandes Ana S.H. Costa Carlos M.G.A. Fontes Matilde L.F. Castro Rui J.B. Bessa José A.M. Prates | 2009 | Meat Science2009，，4： | 1 |
| 10 | Synthesis and characterization of N-modified titania nanotubes for photocatalytic applications显示文摘 | Ricardo A. R. Monteiro Filipe V. S. Lopes Rui A. R. Boaventura Adrián M. T. Silva Vítor J. P. Vilar | 2015 | Environmental Science and Pollution Research2015，，： | 1 |
| 11 | Adsorption of CO2,CH4, and N2 in activated carbon honeycomb monolith 显示文摘 | Rui P Ribeiro Ticiane P Sauer Filipe V Lopes | 2008 | Journal of Chemical & Engineering Data2008，53，10： | 1 |
| 12 | Polypharmacy in Elderly Patients in a Community Pharmacy显示文摘Introduction:The definition of polypharmacy is not consensual,but all authors refer it as the simultaneous use and the chronic way,of several drugs by the same person.Polypharmacy affects mainly the elderly and it is due to the high number of chronic diseases in this population and consequent need to take medications to control them.Aims:Characterization and quantification of polypharmacy in a rural elderly population.Materials and Methods:It carried out an observational,retrospective,transversal and analytical study in Farmácia Popular(Pombal).Total of 230 individuals aged 65 years old or more were surveyed and the data collection was made through a questionnaire prepared for this purpose,in time between February and April 2017.Results:The elderly took,on mean,6.20 drugs daily.The prevalence of Major polypharmacy(≥5 medications)was 70.4%.The most prescribed pharmacotherapeutics groups were cardiovascular and central nervous system.There were statistically significant differences between age and number of medicaments taken,as well between number of drugs and the way to identify the medication,the knowledge of the therapeutics indications,the occurrence of mistakes or take outside advised time,and the self-perception of health state(p≤0.05).Conclusion:In view of the obtained results,it concludes that polypharmacy is very high in Portuguese population in study.It is the persons most aged who consume a greater number of drugs.The elderly with less academic qualifications are those who have more difficulty in identifying medication and respective therapeutics indications.It is necessary to adopt strategies in order to reduce polypharmacy,with the prescriber and the professionals of pharmacy a preponderant role in this task. | Sonia Lopes Clara Rocha Rui Cruz | 2019 | Journal of Pharmacy and Pharmacology2019，7，2： | 0 |
| 13 | 比较饮食摄取l-卡尼汀和dl-卡尼汀对氨中毒和肝代谢的作用(英文)显示文摘AIM: To compare the effects of chronic supplementationwith l-carnitine (LCT) and dl-carnitine (DLC) on am-monia toxicity and hepatic metabolism. METHODS:Three groups of male adult rats were studied: 1) supple-mented with LCT (1.2 mmol·kg-1·d-1 ), 2) supple-mented with DLC (1.2 mmol·kg-1·d-1 ), and 3) con-trol froup (COG) not supplemented. RESULTS: Thetreatment with LCT decreased the toxicity to ammonia.However, the supplementation with DLC did not showany significant effect. In contrast, the effects of thesupplementation with LCT and DLC on hepaticmetabolism were quite similar, ie, both groups showed:(a) intensified ammonia uptake and decreased urea pro- | Vilma A F G GAZOLA Gisele LOPES Rose M M DIAS Rui CURI Roberto B BAZOTTE | 2001 | Acta Pharmacologica Sinica2001，22，4： | 0 |
| 14 | Exosomal glypican-1 is elevated in pancreatic cancer precursors and can signal genetic predisposition in the absence of endoscopic ultrasound abnormalities显示文摘BACKGROUND Individuals within specific risk groups for pancreatic ductal adenocarcinoma(PDAC)[mucinous cystic lesions(MCLs),hereditary risk(HR),and new-late onset diabetes mellitus(NLOD)]represent an opportunity for early cancer detection.Endoscopic ultrasound(EUS)is a premium image modality for PDAC screening and precursor lesion characterization.While no specific biomarker is currently clinically available for this purpose,glypican-1(GPC1)is overexpressed in the circulating exosomes(crExos)of patients with PDAC compared with healthy subjects or those harboring benign pancreatic diseases.AIM To evaluate the capacity of GPC1+crExos to identify individuals at higher risk within these specific groups,all characterized by EUS.METHODS This cross-sectional study with a prospective unicentric cohort included 88 subjects:40 patients with MCL,20 individuals with HR,and 20 patients with NLOD.A control group(CG)was submitted to EUS for other reasons than pancreatic pathology,with normal pancreas and absence of hereditary risk factors(n=8).The inclusion period was between October 2016 and January 2019,and the study was approved by the Ethics Committee of Centro Hospitalar Universitário de São João,Porto,Portugal.All patients provided written informed consent.EUS and blood tests for quantification of GPC1+crExos by flow cytometry and carbohydrate antigen 19-9(CA 19-9)levels by ELISA were performed in all subjects.EUS-guided tissue acquisition was done whenever necessary.For statistical analysis,SPSS®27.0(IBM Corp.,Armonk,NY,United States)version was used.All graphs were created using GraphPad Prism 7.00(GraphPad Software,San Diego,CA,United States).RESULTS Half of MCLs harbored worrisome features(WF)or high-risk stigmata(HRS).Pancreatic abnormalities were detected by EUS in 10.0%and 35.0%in HR and NLOD individuals,respectively,all considered non-malignant and“harmless.”Median levels of GPC1+crExos were statistically different:MCL[99.4%,interquartile range(IQR):94.9%-99.8%],HR(82.0%,IQR:28.9%-98.2%),NLOD(12.6%,IQR:5.2%-63.4%),and CG(16.2%,IQR:6.6%-20.1%)(P<0.0001).Median levels of CA 19-9 were within the normal range in all groups(standard clinical cut-off of 37 U/mL).Within HR,individuals with a positive history of cancer had higher median levels of GPC1+crExos(97.9%;IQR:61.7%-99.5%),compared to those without(59.7%;IQR:26.3%-96.4%),despite no statistical significance(P=0.21).Pancreatic cysts with WF/HRS were statistically associated with higher median levels of GPC1+crExos(99.6%;IQR:97.6%-99.8%)compared to those without(96.5%;IQR:81.3%-99.5%)(P=0.011),presenting an area under the receiver operating characteristic curve value of 0.723(sensitivity 75.0%and specificity 67.7%,using a cutoff of 98.5%;P=0.012).CONCLUSION GPC1+crExos may act as biomarker to support the diagnosis and stratification of PDAC precursor lesions,and in signaling individuals with genetic predisposition in the absence of EUS abnormalities. | Pedro Moutinho-Ribeiro Ines A Batista Sofia T Quintas Bárbara Adem Marco Silva Rui Morais Armando Peixoto Rosa Coelho Pedro Costa-Moreira Renato Medas Susana Lopes Filipe Vilas-Boas Manuela Baptista Diogo Dias-Silva Ana L Esteves Filipa Martins Joanne Lopes Helena Barroca Fátima Carneiro Guilherme Macedo Sonia A Melo | 2022 | World Journal of Gastroenterology2022，28，31： | 0 |
| 15 | 食物中添加ι-卡尼汀对大鼠肝代谢ι-丙氨酸的作用(英文) | Vilma A F G GAZOLA, Gisele LOPES, Daniel M LIMEIRA, Ricardo GALLETTO, Sebastiao GAZOLA, Rui CURI, Roberto B BAZOTTE (State University of Maringa, SUM, Department of Pharmacy and Pharmacology, Maringa, PR, 87020-900 University of Sao Paulo, Sao Paulo, SP, 05508-900, Brazil) | 2002 | Acta Pharmacologica Sinica2002，23，4： | 0 |
| 16 | Comparative acute effects of l-carnitine and dl-carnitine on hepatic catabolism of l-alanine and l-glutamine in rats显示文摘AIM: To compare the acute effects of l-carnitine (LCT) and dl-carnitine (DLC) on hepatic catabolism of l-alanine and l-glutamine in rats. METHODS: Livers from 24 h fasted and fed rats were perfused in situ. The substrates l-alanine (5 mmol/L) and l-glutamine (5 mmol/L) were employed. The gluconeogenic and ureogenic activity was measured as the difference between the rates of glucose and urea released during and before the infusion of l-glutamine or l-alanine. RESULTS: LCT (60 μmol/L) but not DLC (60 μmol/L and 120 μmol/L) increased the production of glucose and urea from l-glutamine. However, neither LCT (60 μmol/L and 120 μmol/L) nor DLC (60μmol/L and 240 μmol/L) showed any significant effect on hepatic glucose and urea production from l-alanine. CONCLUSION: The results showed a different acute effect of LCT and DLC on the activation of hepatic gluconeogenesis and ureagenesis promoted by l-glutamine, reinforcing the idea that DLC could not replace LCT. | Gisele LOPES Vilma A F G GAZOLA Sharize B GALENDE Wilson ALVES-DO-PRADO Rui CURI Roberto B BAZOTTE | 2004 | Acta Pharmacologica Sinica2004，25，10： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员