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| 1 | Characterization of monocarboxylate transporter activity in hepatocellular carcinoma显示文摘AIM: To assess the immunoexpression of hypoxiarelated markers in samples from cirrhosis and primary and metastatic hepatocellular carcinoma(HCC).METHODS: From a total of 5836 autopsies performed at the Pathology Department- University of Sao Paulo School of Medicine Hospital- from 2003 to 2009, 188 presented primary liver tumors. Immunohistochemical reactivity for monocarboxylate transporters(MCTs)-1, 2 and 4, CD147 and glucose transporter-1(GLUT1)was assessed in necropsies from 80 cases of HCC. Data were stored and analyzed using the IBM SPSS statistical software(version 19, IBM Company, Armonk, NY). All comparisons were examined for statistical significance using Pearson's χ2 test and Fisher's exact test(when n < 5). The threshold for significant P values was established as P < 0.05.RESULTS: Plasma membrane expression of MCT4 and overall expression of GLUT1 showed progressively higher expression from non-neoplastic to primary HCC and to metastases. In contrast, overall expression of MCT2 was progressively decreased from non-neoplastic to primary HCC and to metastases. MCT1(overall and plasma membrane expression), MCT2 and CD147 plasma membrane expression were associated with absence of cirrhosis, while plasma membrane expression of CD147 was also associated with absence of HBV infection. MCT2 overall expression was associated with lower liver weight, absence of metastasis and absence of abdominal dissemination. Additionally, MCT4 plasma membrane positivity was strongly associated with Ki-67 expression. CONCLUSION: MCT4 and GLUT1 appear to play a role in HCC progression, while MCT2 is lost during progression and associated with better prognosis. | Venncio AF Alves Céline Pinheiro Filipa Morais-Santos Aloisio Felipe-Silva Adhemar Longatto-Filho Fátima Baltazar | 2014 | World Journal of Gastroenterology2014，20，33： | 11 |
| 2 | Role of endoglin and VEGF family expression in colorectal cancer prognosis and anti-angiogenic therapies显示文摘Colorectal cancer(CRC)is one of the cancer models and most of the carcinogenic steps are presently well understood.Therefore,successful preventive measures are currently used in medical practice.However,CRC is still an important public health problem as it is the third most common cancer and the fourth most frequent cause of cancer death worldwide.Nowadays,pathologic stage is a unique and well-recognized prognostic indicator,however,more accurate indicators of the biologic behavior of CRC are expected to improve the specificity of medical treatment.Angiogenesis plays an important role in the growth and progression of cancer but its role as a prognostic factor is still controversial.Probably the most important clinical implication of tumor angiogenesis is the development of anti-angiogenic therapy.The goal of this review is to critically evaluate the role of angiogenic markers,assessed by either endoglin-related microvessel density or expression of vascular endothelial growth factor family members in the CRC setting and discuss the role of these angiogenic markers in antiangiogenic therapies. | Sandra F Martins Rui M Reis Antonio Mesquita Rodrigues Fátima Baltazar Adhemar Longatto Filho | 2011 | World Journal of Clinical Oncology2011，2，6： | 9 |
| 3 | Dietary supplementation with free methionine or methionine dipeptide mitigates intestinal oxidative stress induced by Eimeria spp. challenge in broiler chickens显示文摘Background: This study evaluated the effects of Eimeria spp. challenge and dietary supplementation with free methionine or methionine dipeptide on animal performance;expression of genes associated with the immune system, antioxidant system, and amino acid transport in the jejunum;and redox status of the jejunum of broiler chickens.Methods: A randomized, 2 × 3 factorial design was used, in which Eimeria spp. challenge was the first factor(Eimeria-challenged, EC, or unchallenged, UC, broilers) and methionine supplementation was the second factor(non-supplemented, NS;free DL-methionine, DL-Met;and methionine dipeptide, DL-methionyl-DL-methionine, DLMMet). At 14 days of age, chickens were inoculated orally with sporulated oocysts of Eimeria acervulina, Eimeria praecox, Eimeria maxima, and Eimeria mitis. Birds were killed by cervical dislocation 144 h post-inoculation(PI), and the jejunum was collected for biochemical and molecular analyses.Results: EC broilers had a 13% lower feed intake(FI), 37% lower body weight gain(BWG), and 39% higher feed conversion ratio(FCR) than UC broilers. Chickens fed the DL-Met diet had higher BWG(about 12% higher) and better FCR(about 12% lower) than chickens fed the NS diet. EC chickens had lower relative weight of the bursa of Fabricius(51.8%) and higher relative weights of the spleen and whole intestine(53.6% and 26.3%, respectively) than UC chickens. Eimeria spp. challenge led to an increase in the levels of oxidative substances, such as nitrite and thiobarbituric acid reactive substances(TBARS), in the jejunum of chickens 144 h PI. Among UC chickens, those fed the DL-Met diet had higher total antioxidant capacity(TAC) and lower catalase(CAT) and superoxide dismutase(SOD) activities. EC chickens that received the NS diet had higher carbonylated protein content(CP). This result was associated with their lower TAC and catalase activity. The lower TAC in EC chickens might have been due to reduced expression of catalase(CAT) and superoxide dismutase 1(SOD1) genes. Chickens fed the DL-Met and DLMMet diets had lower nitrite content. Eimeria spp. challenge suppressed neutral amino acid transporter 1(B0 AT1),peptide transporter 1(PEPT1), toll-like receptor 5(TLR5), interleukin 2(IL2), and occludin(OCLN) gene expression and enhanced cationic amino acid transporter 1(CAT-1) and interferon gamma(IFNG) gene expression. The highest PEPT1 expression level was observed in broilers fed the DL-MMet diet, and the lowest TLR5 expression level was found in broilers fed the NS diet.Conclusion: Our results show for the first time that supplementation with methionine as free amino acid or dipeptide helps protect the intestinal cells of broilers under Eimeria spp. challenge from the oxidative damage induced by free radicals, mainly through modulation of the antioxidant system. | Angélica de Souza Khatlab Ana Paula Del Vesco Adhemar Rodrigues de Oliveira Neto Roberta Pereira Miranda Fernandes Eliane Gasparino | 2019 | Journal of Animal Science and Biotechnology2019，10，4： | 6 |
| 4 | Generalized cross validation for wavelet thresholding显示文摘 | Maarten Jansen Maurits Malfait Adhemar Bultheel | 1997 | Signal Processing1997，，1： | 2 |
| 5 | The growing importance of materials that prevent microbial adhesion: antimicrobial effect of medical devices containing silver显示文摘 | Douglas Roberto Monteiro Luiz Fernando Gorup Aline Satie Takamiya Adhemar Colla Ruvollo-Filho Emerson Rodrigues de Camargo Debora Barros Barbosa | 2009 | International Journal of Antimicrobial Agents2009，，2： | 1 |
| 6 | Co-expression of monocarboxylate transporter 1 (MCT1) and its chaperone (CD147) is associated with low survival in patients with gastrointestinal stromal tumors (GISTs)显示文摘 | Ant?nio Talvane Torres Oliveira Céline Pinheiro Adhemar Longatto-Filho Maria Jose Brito Olga Martinho Delcio Matos André Lopes Carvalho Vinícius Lima Vazquez Thiago Buosi Silva Cristovam Scapulatempo Sarhan Sydney Saad Rui Manuel Reis Fátima Baltazar | 2012 | Journal of Bioenergetics and Biomembranes2012，，1： | 1 |
| 7 | VEGFR-3 expression in breast cancer tissue is not restricted to lymphatic vessels显示文摘 | Adhemar Longatto Filho Albino Martins Sandra Maria Araujo Costa | 2005 | Pathology-Research and Practice2005，201，2： | 1 |
| 8 | Expression of Monocarboxylate Transporters 1, 2, and 4 in Human Tumours and Their Association with CD147 and CD44显示文摘 | Céline Pinheiro Rui M. Reis Sara Ricardo Adhemar Longatto-Filho Fernando Schmitt Fátima Baltazar Anne Hamburger | 2010 | Journal of Biomedicine and Biotechnology2010，，： | 1 |
| 9 | The prognostic value of CD147/EMMPRIN is associated with monocarboxylate transporter 1 co-expression in gastric cancer显示文摘 | Céline Pinheiro Adhemar Longatto-Filho Kleber Sim?es Carlos Eduardo Jacob Cláudio José Caldas Bresciani Bruno Zilberstein Ivan Cecconello Venancio Avancini Ferreira Alves Fernando Schmitt Fátima Baltazar | 2009 | European Journal of Cancer2009，，13： | 1 |
| 10 | Computation of the fractional Fourier transform显示文摘 | Adhemar Bultheel Héctor E. Mart??nez Sulbaran | 2004 | Applied and Computational Harmonic Analysis2004，，3： | 1 |
| 11 | Therapy with adjunctive doxycycline local delivery in patients with type 1 diabetes mellitus and periodontitis显示文摘 | Antonio FernandoMartorelli de Lima Cmila CristinaCury Daniela BazanPalioto Adhemar MendesDuro Robert Carvalho daSilva Larry F.Wolff | 2004 | Journal of Clinical Periodontology2004，，8： | 1 |
| 12 | Co-expression of monocarboxylate transporter 1 (MCT1) and its chaperone (CD147) is associated with low survival in patients with gastrointestinal stromal tumors (GISTs)显示文摘 | Ant?nio Talvane Torres Oliveira Céline Pinheiro Adhemar Longatto-Filho Maria Jose Brito Olga Martinho Delcio Matos André Lopes Carvalho Vinícius Lima Vazquez Thiago Buosi Silva Cristovam Scapulatempo Sarhan Sydney Saad Rui Manuel Reis Fátima Baltazar | 2012 | Journal of Bioenergetics and Biomembranes2012，，1： | 1 |
| 13 | Generalized cross validation for wavelet thresholding显示文摘 | Maarten Jansen Maurits Malfait Adhemar Buhheel | 1997 | Signal Processing1997，56，： | 1 |
| 14 | Kinetics of cisplatin in an anuric patient undergoing hemofihration dialysis 显示文摘 | Gouyette A Lemoine R Adhemar JP | 1981 | Cancer Treat Rep1981，65，： | 1 |
| 15 | Expression of Monocarboxylate Transporters 1, 2, and 4 in Human Tumours and Their Association with CD147 and CD44显示文摘 | Céline Pinheiro Rui M. Reis Sara Ricardo Adhemar Longatto-Filho Fernando Schmitt Fátima Baltazar Anne Hamburger | 2010 | Journal of Biomedicine and Biotechnology2010，，： | 1 |
| 16 | Lithium prevents stress-induced reduction of vascular endothelium growth factor levels显示文摘 | Rui Silva Luís Martins Adhemar Longatto-Filho Osborne F.X. Almeida Nuno Sousa | 2007 | Neuroscience Letters2007，，1： | 1 |
| 17 | How useful is the assessment of lymphatic vascular density in oral carcinoma prognosis显示文摘 | Adhemar LF Tiago GO Celine P | 2007 | World J Surgical Oncology2007，5，： | 1 |
| 18 | Smoking worsens the prognosis of mild abnormalities in cervical cytology显示文摘 | Sarian Luis Otavio Hammes Luciano Serpa Longatto Filho Adhemar | | 0，，05： | 1 |
| 19 | 沙漠星轨显示文摘智利的阿塔卡玛沙漠远离城市,是理想的观星之地.这是摄影师Adhemar M.Duro Jr在阿塔卡玛沙漠拍摄的照片。摄影师采用了延时摄影的方法,拍摄星星围绕南天极旋转几个小时在天空中划出的路径。在照片中,这些路径最终形成明亮的弧线和圆圈。由于星星的亮度不同,因此它们共同创造了一个神奇的景像——许多条明亮程度不同、颜色不同的光轨。而在照片的左上角.我们可以看到一小段横切光轨的明亮光线,这是一颗流星进入大气层时燃烧的痕迹。 | Adhemar M.Duro Jr | 2016 | 大科技(科学之谜)(A)2016，0，12： | 0 |
| 20 | 大自然幼儿园显示文摘在斯堪的纳维亚的幼儿园里,大自然是最伟大的老师。 | Anna Adhemar 沐阳(译) | 2012 | 英语学习(天下少年)2012，，11： | 0 |
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