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| 1 | -765G > C COX-2 polymorphism may be a susceptibility marker for gastric adenocarcinoma in patients with atrophy or intestinal metaplasia显示文摘AIM: To investigate the relationship between the -765G > C COX-2 polymorphism and the development of different gastric lesions: atrophy or intestinal metaplasia and gastric adenocarcinoma. METHODS: A cross-sectional study was performed involving 320 Portuguese individuals (210 without evidence of neoplastic disease, 73 patients with gastric adenocarcinomas and 37 with atrophy or intestinal metaplasia) using a PCR-RFLP method. RESULTS: -765C allele was overrepresented in the patients with gastric adenocarcinoma (51%) when compared either with the control group (38%) or patients with atrophy or intestinal metaplasia (27%). Callele was found to be very common in our population (0.22), and a multivariate logistic regression analysis revealed nearly 3-fold increased risk for the progression to gastric adenocarcinoma in patients with atrophy or intestinal metaplasia carrying the -765C allele (OR = 2.67, 95% CI = 1.03-6.93; P = 0.04).considered as another susceptibility marker for gastric adenocarcinoma development in patients with atrophy or intestinal metaplasia. | Carina Pereira Hugo Sousa Paula Ferreira Maria Fragoso Luís Moreira-Dias Carlos Lopes Rui Medeiros Mário Dinis-Ribeiro | 2006 | World Journal of Gastroenterology2006，12，34： | 16 |
| 2 | Land Surface Displacement Geohazards Monitoring Using Multi-temporal InSAR Techniques显示文摘China has been affected by some of the world’s most serious geological disasters and experiences high economic damage every year.Geohazards occur not only in remote areas but also in highly populated cities.In the framework of the Dragon-432365 Project,this paper presents the main results and the major conclusions derived from an extensive exploitation of Sentinel-1,ALOS-2(Advanced Land Observing Satellite 2),GF-3(Gao Fen Satellite 3),and latest launched SAR(Synthetic Aperture Radar),together with methods that allow the evaluation of their importance for various geohazards.Therefore,in the scope of this project,the great benefits of recent remote sensing data(wide spatial and temporal coverage)that allow a detailed reconstruction of past displacement events and to monitor currently occurring phenomena are exploited to study different areas and geohazards problems,including:surface deformation of mountain slopes;identification and monitoring of ground movements and subsidence;landslides;ground fissure;and building inclination studies.Suspicious movements detected in the different study areas were cross validated with different SAR sensors and truth data. | Guang LIU Perski ZBIGNIEW Salvi STEFANO Thiebes BENNI Lixin WU Jinghui FAN Shibiao BAI Lianhuan WEI Shiyong YAN Rui SONG Bignami CHRISTIAN Tolomei CRISTIANO Stefan SCHNEIDERBAUER Joao Sousa JOAQUIM 无 | 2021 | Journal of Geodesy and Geoinformation Science2021，4，1： | 13 |
| 3 | Clinical and pathological characterization of epstein-barr virus-associated gastric carcinomas in portugal显示文摘AIM To determine the prevalence of epstein-barr virus(eb V)-associated gastric carcinomas in the North Region of Portugal and to study its clinicopathological characteristics. METHODS We have performed a retrospective study including a total of 179 consecutive patients with gastric cancer(GC) submitted to gastrectomy during 2011 at the Portuguese Oncology Institute of Porto. Clinical and pathological data was collected from individual clinical records and inserted on a database with unique codification. Tumour tissues were collected from the institutional tumour bank. eb V was detected by in situ hybridization for the detection of eb V-encoded small RNAs(ebe Rs) and eb V latent proteins(LMP1 and LMP2 A) were detected by immunohistochemistry.RESULTS The analysis showed that eb V-associated gastric carcinomas(eb Va GC) represents 8.4%(15/179) of all GC cases, with a significant differential distribution among histological types(P < 0.001): 100%(3/3) of medullary carcinomas, 100%(1/1) of adenosquamous carcinoma, 8.7%(8/92) of tubular adenocarcinomas, 8.0%(2/25) of mixed carcinomas and 2%(1/51) in poorly cohesive carcinomas. The analysis revealed a higher predominance of eb Va GC in the upper third and middle(cardia, fundus and body) of the stomach(P = 0.041), a significant lower number of regional lymph nodes invasion(P = 0.025) and a tendency for better prognosis(P = 0.222). eb V latent protein expression revealed that all eb Va GC cases were LMP1-negative, nevertheless 6 cases(40%) expressed LPM2 A, which reveals that these cases show a distinct eb V-Latency profile(latency II-like).CONCLUSION eb Va GC represents 8.4% of all GC in the North Region of Portugal. The eb V-infected patients have specific clinic-pathological features that should be further explored to develop new strategies of management and treatment. | Joana Ribeiro Andreia Oliveira Mariana Malta Claudia Oliveira Fernanda Silva Ana Galaghar Luís Pedro Afonso Maria Cassiano Neves Rui Medeiros Pedro Pimentel-Nunes Hugo Sousa | 2017 | World Journal of Gastroenterology2017，23，40： | 9 |
| 4 | Gastric cancer in a Caucasian population: Role of pepsinogen C genetic variants显示文摘瞄准:在胃蛋白酶原 C (PGC ) 基因学习插入 / 删除多型性的角色,为胃粘膜的终端区别的一个有效标记,在到胃的损害的开发的危险性。方法:没有肿瘤的疾病的证据,学习与已知的胃的损害的 99 件样品和 127 件样品被执行。PCR 被采用, 6 多态的等位基因被放大:等位基因 1 (510 bp ) ,等位基因 2 (480 bp ) ,等位基因 3/4 (450/460 bp ) ,等位基因 5 (400 bp ) 并且等位基因 6 (310 bp ) 。结果:我们的结果表明等位基因 6 搬运人似乎对任何胃的损害的发展有保护(或 = 0.34;P<0.001 ) ,与象萎缩或肠的组织变形那样的胃的腺癌联系的 non-dysplastic 损害(或 = 0.28;P<0.001 ) 或侵略 GC (或 = 0.39;P = 0.004 ) 。结论:我们的学习表明等位基因 6 搬运人地位在胃的损害的发展有一个保护的角色,可能由于它有 PGC 的更高的表示的协会。而且,在控制组的等位基因 6 搬运人的频率比在亚洲人口获得了高是远的,它可能代表在白种人和亚洲人口之间的基因差距。 | Ana L Pinto-Correia Hugo Sousa Maria Fragoso Luís Moreira-Dias Carlos Lopes Rui Medeiros Mário Dinis-Ribeiro | 2006 | World Journal of Gastroenterology2006，12，31： | 6 |
| 5 | Epstein-Barr virus is associated with gastric carcinoma: The question is what is the significance?显示文摘AIM: To examine the possible role of the Epstein- Barr Virus (EBV) in the development of gastric adenocarcinoma (GC). It is unclear whether EBV is involved in GC development or is a consequence of gastric inflammation secondary to immunosuppressive treatments. METHODS: A systematic review was carried out of all published observational studies on the temporal association between EBV and GC, with a view to determine a causal relationship. RESULTS: The present study showed that the worldwide crude prevalence of EBV in gastric adenocarcinoma was 8.29%. The prevalence varied from 7.08% for intestinal type and 9.82% for diffuse type of GC. It was observed that Western and Central Asian countries had a significantly higher frequency of EBV positive cases compared to South-Eastern countries. America had the highest EBV-GC prevalence whereas Europe had the lowest. CONCLUSION: The present review has demonstrated a high prevalence of EBV in gastric adenocarcinoma. However, studies designed to assess a temporal relationship and histological association using sensitive techniques should be carried out to establish the role of EBV in GC carcinogenesis. | Hugo Sousa Ana L Pinto-Correia Rui Medeiros Mario Dinis-Ribeiro | 2008 | World Journal of Gastroenterology2008，14，27： | 4 |
| 6 | An Archi- tecture for Adaptive Fuzzy Control in Industrial Environ- ment 显示文摘 | MENDES Jerome ARAUJO Rui SOUSA Pedro | 2011 | Computers in Industry2011，62，： | 1 |
| 7 | Mesenchymal Stem Cells in the Umbilical Cord: Phenotypic Characterization, Secretome and Applications in Central Nervous System Regenerative Medicine显示文摘 | Miguel M. Carvalho Fabio G. Teixeira Rui L. Reis Nuno Sousa Antonio J. Salgado | 2011 | Current Stem Cell Research and Therapy2011，，3： | 1 |
| 8 | Fatigue analysis of box - girder webs subjected to in - plane shear and transverse bonding induced by railway traffic 显示文摘 | Carlos Sousa Joao Francisco Rocha Rui Calcada Afonso Serra Neves | 2013 | Engineering Structures2013，54，： | 1 |
| 9 | Chaperone proteins as ameliorators of α-synuclein-induced synaptic pathologies: insights into Parkinson’s disease显示文摘α-Synuclein accumulation causes synaptic vesicle trafficking defects and may underlie neurodegenerative disorders:Neurodegenerative disorders,such as Parkinson’s disease(PD)and other synucleinopathies,impact the lives of millions of patients and their caregivers.Synucleinopathies include PD,dementia with Lewy Bodies(DLB),multiple system atrophy,and several Alzheimer’s Disease variants.They are clinically characterized by intracellular inclusions called Lewy Bodies,which are rich in atypical aggregates of the protein α-synuclein.While dopaminergic neurons in the substantia nigra are particularly susceptible toα-synuclein-induced aggregation and neurodegeneration,glutamatergic neurons in other brain regions(e.g.cortex)are also frequently affected in PD and other synucleinopathies(Schulz-Schaeffer 2010). | Susan M.L.Banks Audrey T.Medeiros Rui Sousa Eileen M.Lafer Jennifer R.Morgan | 2021 | Neural Regeneration Research2021，16，6： | 1 |
| 10 | The enhancement of the mechanical properties of a high-density polyethylene显示文摘 | Gurhan Kalay Rui A Sousa | 1999 | Journal of Applied Polymer Science1999，73，： | 1 |
| 11 | Reforestation of burned stands: The effect of ectomycorrhizal fungi on Pinus pinaster establishment显示文摘 | Nadine R. Sousa Albina R. Franco Miguel A. Ramos Rui S. Oliveira Paula M.L. Castro | 2011 | Soil Biology and Biochemistry2011，，10： | 1 |
| 12 | Identification of DNA markers linked to an induced mutated gene conferring resistance to powdery mildew in pea ( Pisum sativum L.)显示文摘 | Gra?a Pereira Cátia Marques Rui Ribeiro Sandra Formiga Mafalda Damaso M. Tavares Sousa Mário Farinhó José M. Leit?o | 2010 | Euphytica2010，，3： | 1 |
| 13 | Renal denervation in patients with resistant hypertension: Six-month results显示文摘 | Hélder Dores Manuel de Sousa Almeida Pedro de Araújo Gon?alves Patrícia Branco Augusta Gaspar Henrique Sousa Angela Canha Gomes Maria Jo?o Andrade Maria Salomé Carvalho Rui Campante Teles Luís Raposo Henrique Mesquita Gabriel Francisco Pereira Machado Mig | 2014 | Revista Portuguesa de Cardiologia (English Edition)2014，，： | 1 |
| 14 | The enhancement of the mechanical properties of a high-density polyethylene 显示文摘 | Gurhan Kalay Rui A Sousa | 1999 | Journal of Apphed Polymer Science1999，73，： | 1 |
| 15 | Bioinert, biodegradable and injectable polymeric matrix composites for hard tissue replacement: state of the art and recent developments显示文摘 | Joao F Mano Rui A Sousa Luciano F Boesel | 2004 | Composites Science and Technology2004，64，6： | 1 |
| 16 | Fatigue analysis of box-girder webs subjected to in-plane shear and transverse bending induced byrailway traffic显示文摘 | Carlos Sousa Joo Francisco Rocha Rui Calada | 2013 | Engineering Structures2013，54，9： | 1 |
| 17 | Development of silk-based scaffolds for tissue engineering of bone from human adipose-derived stem cells显示文摘 | Cristina Correia Sarindr Bhumiratana Le-Ping Yan Ana L. Oliveira Jeffrey M. Gimble Danielle Rockwood David L. Kaplan Rui A. Sousa Rui L. Reis Gordana Vunjak-Novakovic | 2012 | Acta Biomaterialia2012，，7： | 1 |
| 18 | Quality management revistited:a reflective review and agenda for future research显示文摘 | Rui Sousa Christopher A Voss | 2002 | Journal of Operation Manageemt2002，，20： | 1 |
| 19 | Plasma-induced polymerization as a tool for surface functionalization of polymer scaffolds for bone tissue engineering: An in vitro study显示文摘 | Paula M. López-Pérez Ricardo M.P. da Silva Rui A. Sousa Iva Pashkuleva Rui L. Reis | 2010 | Acta Biomaterialia2010，，9： | 1 |
| 20 | An archi- tecture for adaptive fuzzy control in industrial environments 显示文摘 | MENDES Jerome RUI Araujo SOUSA Pedro | 2011 | Computers in Industry2011，62，3： | 1 |
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