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| 1 | Clinical and pathological characterization of epstein-barr virus-associated gastric carcinomas in portugal显示文摘AIM To determine the prevalence of epstein-barr virus(eb V)-associated gastric carcinomas in the North Region of Portugal and to study its clinicopathological characteristics. METHODS We have performed a retrospective study including a total of 179 consecutive patients with gastric cancer(GC) submitted to gastrectomy during 2011 at the Portuguese Oncology Institute of Porto. Clinical and pathological data was collected from individual clinical records and inserted on a database with unique codification. Tumour tissues were collected from the institutional tumour bank. eb V was detected by in situ hybridization for the detection of eb V-encoded small RNAs(ebe Rs) and eb V latent proteins(LMP1 and LMP2 A) were detected by immunohistochemistry.RESULTS The analysis showed that eb V-associated gastric carcinomas(eb Va GC) represents 8.4%(15/179) of all GC cases, with a significant differential distribution among histological types(P < 0.001): 100%(3/3) of medullary carcinomas, 100%(1/1) of adenosquamous carcinoma, 8.7%(8/92) of tubular adenocarcinomas, 8.0%(2/25) of mixed carcinomas and 2%(1/51) in poorly cohesive carcinomas. The analysis revealed a higher predominance of eb Va GC in the upper third and middle(cardia, fundus and body) of the stomach(P = 0.041), a significant lower number of regional lymph nodes invasion(P = 0.025) and a tendency for better prognosis(P = 0.222). eb V latent protein expression revealed that all eb Va GC cases were LMP1-negative, nevertheless 6 cases(40%) expressed LPM2 A, which reveals that these cases show a distinct eb V-Latency profile(latency II-like).CONCLUSION eb Va GC represents 8.4% of all GC in the North Region of Portugal. The eb V-infected patients have specific clinic-pathological features that should be further explored to develop new strategies of management and treatment. | Joana Ribeiro Andreia Oliveira Mariana Malta Claudia Oliveira Fernanda Silva Ana Galaghar Luís Pedro Afonso Maria Cassiano Neves Rui Medeiros Pedro Pimentel-Nunes Hugo Sousa | 2017 | World Journal of Gastroenterology2017，23，40： | 9 |
| 2 | 葡萄牙松材线虫与其媒介昆虫之间的互作显示文摘对松材线虫与其在葡萄牙和欧洲的媒介昆虫樟子松墨天牛(Monochamus galloprovincialis)进行了首次研究。在病死木中发现,松材线虫在天牛刚羽化时聚集在蛹室中,线虫主要集中在天牛的后胸部。天牛羽化后6周内,松材线虫主要在天牛成虫补充营养时进入新寄主树,其次在天牛产卵时也会进入寄主树。总的看来,松材线虫在欧洲与其携带天牛之间互作与其在亚洲与松墨天牛及在北美与卡来罗纳墨天牛之间的关系十分相似。经研究,影响线虫与天牛携带关系的因子有内源和外源两类因子,如化学气味和各种信号。但是,其他多数因子尚未了解。研究影响线虫与天牛携带关系的因子将有助于了解两种生物密切关系的内在机制,并有助于研发出新的防控方法。 | Pedro Miguel Naves Luís Bonifácio Edmundo Sousa | 2011 | 南京林业大学学报(自然科学版)2011，35，4： | 2 |
| 3 | An Archi- tecture for Adaptive Fuzzy Control in Industrial Environ- ment 显示文摘 | MENDES Jerome ARAUJO Rui SOUSA Pedro | 2011 | Computers in Industry2011，62，： | 1 |
| 4 | An energy balance of the 200 m front crawl race显示文摘 | PEDRO FIGUEIREIX) PAOLA ZAMPARO ANA SOUSA | 2011 | Eur J Appl Physiol2011，111，： | 1 |
| 5 | SJES14110700184569显示文摘 | Di?go P. Bezerra Francisco W.M. da Silva Pedro A.S. de Moura Allyson G.S. Sousa Rodrigo S. Vieira Enrique Rodriguez-Castellon Diana C.S. Azevedo | 2014 | Applied Surface Science2014，，： | 1 |
| 6 | Multidimensional optimization of promising antitumor xanthone derivatives显示文摘 | Carlos M.G. Azevedo Carlos M.M. Afonso Diana Sousa Raquel T. Lima M. Helena Vasconcelos Madalena Pedro Jo?o Barbosa Arlene G. Corrêa Salette Reis Madalena M.M. Pinto | 2013 | Bioorganic & Medicinal Chemistry2013，，11： | 1 |
| 7 | TLR4 and CD14 receptors expressed in rat pineal gland trigger NFKB pathway显示文摘 | SanserayDa Silveira Cruz‐Machado Claudia EmanueleCarvalho‐Sousa Eduardo KojiTamura LucianaPinato ErikaCecon Pedro Augusto Carlos MagnoFernandes Maria Christina WerneckDe Avellar Zulma SilvaFerreira Regina PekelmannMarkus | 2010 | Journal of Pineal Research2010，，2： | 1 |
| 8 | Optimization of the culture medium composition using response surface methodology for new recombinant cyprosin B production in bioreactor for cheese production显示文摘 | Pedro N. Sampaio Cecília R. C. Calado Lisete Sousa David C. Bressler Maria Salomé Pais Luís Pina Fonseca | 2010 | European Food Research and Technology2010，，2： | 1 |
| 9 | Renal denervation in patients with resistant hypertension: Six-month results显示文摘 | Hélder Dores Manuel de Sousa Almeida Pedro de Araújo Gon?alves Patrícia Branco Augusta Gaspar Henrique Sousa Angela Canha Gomes Maria Jo?o Andrade Maria Salomé Carvalho Rui Campante Teles Luís Raposo Henrique Mesquita Gabriel Francisco Pereira Machado Mig | 2014 | Revista Portuguesa de Cardiologia (English Edition)2014，，： | 1 |
| 10 | Contrast-induced nephropathy following percutaneous coronary intervention: case report显示文摘 | Sousa CS Pedro MM Pinto FJ | 2009 | Rev PortCardiol2009，28，3： | 1 |
| 11 | Social vulnerability assessment to seismic risk using multicriteria analysis:the case study of Vila Franca do Campo (S(a) Miguel Island,Azores,Portugal)显示文摘 | Nuno Martins Delta Sousa e Silva Pedro Cabral | | 0，，： | 1 |
| 12 | An archi- tecture for adaptive fuzzy control in industrial environments 显示文摘 | MENDES Jerome RUI Araujo SOUSA Pedro | 2011 | Computers in Industry2011，62，3： | 1 |
| 13 | Low rectal cancer显示文摘 | Angelita Habr-Gama Pedro M. Santinho B. Souza Ulysses Ribeiro Wladimir Nadalin René Gansl Afonso H. S. Sousa Fábio Guilherme Campos Joaquim Gama-Rodrigues | 1998 | Diseases of the Colon & Rectum1998，，： | 1 |
| 14 | Liver haemangioma: common and uncommon findings and how to improve the differential diagnosis显示文摘 | Filipe Caseiro-Alves Jorge Brito Antonio Eiras Araujo Pedro Belo-Soares Henrique Rodrigues Augusta Cipriano Daniel Sousa Didier Mathieu | 2007 | European Radiology2007，，6： | 1 |
| 15 | Liver haemangioma: common and uncommon findings and how to improve the differential diagnosis显示文摘 | Filipe Caseiro-Alves Jorge Brito Antonio Eiras Araujo Pedro Belo-Soares Henrique Rodrigues Augusta Cipriano Daniel Sousa Didier Mathieu | 2007 | European Radiology2007，，6： | 1 |
| 16 | Antispasmodic effect of Mentha piperita essential oil on tracheal smooth muscle of rats显示文摘 | Albertina Antonielly Sydney de Sousa Pedro Marcos Gomes Soares Arisa Nara Saldanha de Almeida Alana Rufino Maia Emmanuel Prata de Souza Ana Maria Sampaio Assreuy | 2010 | Journal of Ethnopharmacology2010，，： | 1 |
| 17 | MicroRNAs expression dynamics reveal post-transcriptional mechanisms regulating seed development in Phaseolus vulgaris L.显示文摘The knowledge on post-transcriptional regulation mechanisms implicated in seed development(SD)is still limited,particularly in one of the most consumed grain legumes,Phaseolus vulgaris L.We explore for the first time the miRNA expression dynamics in P.vulgaris developing seeds.Seventy-two known and 39 new miRNAs were found expressed in P.vulgaris developing seeds.Most of the miRNAs identified were more abundant at 10 and 40 days after anthesis,suggesting that late embryogenesis/early filling and desiccation were SD stages in which miRNA action is more pronounced.Degradome analysis and target prediction identified targets for 77 expressed miRNAs.While several known miRNAs were predicted to target HD-ZIP,ARF,SPL,and NF-Y transcription factors families,most of the predicted targets for new miRNAs encode for functional proteins.MiRNAs-targets expression profiles evidenced that these miRNAs could tune distinct seed developmental stages.MiRNAs more accumulated at early SD stages were implicated in regulating the end of embryogenesis,postponing the seed maturation program,storage compound synthesis and allocation.MiRNAs more accumulated at late SD stages could be implicated in seed quiescence,desiccation tolerance,and longevity with still uncovered roles in germination.The miRNAs herein described represent novel P.vulgaris resources with potential application in future biotechnological approaches to modulate the expression of genes implicated in legume seed traits with impact in horticultural production systems. | Jose Ricardo Parreira Michela Cappuccio Alma Balestrazzi Pedro Fevereiro Susana de Sousa Araujo | 2021 | Horticulture Research2021，8，1： | 1 |
| 18 | Low rectal cancer显示文摘 | Dr. Angelita Habr-Gama M.D. Pedro M. Santinho B. Souza M.D. Ulysses Ribeiro M.D. Wladimir Nadalin M.D. René Gansl M.D. Afonso H. S. Sousa M.D. Fábio Guilherme Campos M.D. Joaquim Gama-Rodrigues M.D | 1998 | Diseases of the Colon & Rectum1998，，9： | 1 |
| 19 | Enabling heterogeneous mobility in android devices显示文摘 | SILVA Ricardo CARVALHO Paulo SOUSA Pedro | | 0，，04： | 1 |
| 20 | Contrast-inducednephropathy following percutaneous coronary intervention: case report显示文摘 | Sousa CS Pedro MM Pinto FJ | 2009 | Rev Port Cardiol2009，28，30： | 1 |
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