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| 1 | The neuroprotective mechanism of brain ischemic preconditioning显示文摘大脑局部缺血是死亡的最普通的原因和在世界上的成年残疾的领先的原因之一。大脑 ischemic preconditioning (BIP ) 指导致忍耐到以后的、不那样致命的、服的局部缺血的短暂、尚不致命的局部缺血。许多尝试被做了理解位于 neuroprotection 下面的分子、细胞的机制由 ischemic preconditioning 出现了。许多研究证明了 neuroprotective 机制可以包括 N-methyl-D-aspartate (NMDA ) 和腺苷受体的激活包含一系列分子的规章的小径;象 mitogen 那样的细胞内部的发信号的小径的激活激活蛋白质 kinases (MAPK ) 和另外的蛋白质 kinases;Bcl-2 和热吃惊蛋白质(HSP ) 的 upregulation;并且 ubiquitin-proteasome 小径和 autophagic-lysosomal 小径的激活。在击以后以及 BIP 由免于大脑 ischemic 侮辱的内长的 neuroprotective 机制导致房间死亡的过程的更好的理解能帮助为这破坏开发新治疗学的策略神经病学的疾病。现在的评论的目的是总结 BIP 的 neuroprotective 机制并且为局部缺血的预防处理作为新策略讨论 mimicking ischemic preconditioning 的可能性。 | Xiao-qian LIU RuiSHENG Zheng-hong QIN | 2009 | Acta Pharmacologica Sinica2009，30，8： | 34 |
| 2 | New incompatible pair of TCM:Epimedii Folium combined with Psoraleae Fructus induces idiosyncratic hepatotoxicity under immunological stress conditions显示文摘Epimedii Folium(EF)combined with Psoraleae Fructus(PF)is a common modern preparation,but liver injury caused by Chinese patent medicine preparations containing EF and PF has been frequently reported in recent years.Zhuangguguanjiewan pills(ZGW),which contain EF and PF,could induce immune idiosyncratic liver injury according to clinical case reports and a nonhepatotoxic dose of lipopolysaccharide(LPS)model.This present study evaluated the liver injury induced by EF or PF alone or in combination and investigated the related mechanism by using the LPS model.Liver function indexes and pathological results showed that either EF or PF alone or in combination led to liver injury in normal rats;however,EF or PF alone could lead to liver injury in LPS-treated rats.Moreover,EF combined with PF could induce a greater degree of injury than that caused by EF or PF alone in LPS-treated rats.Furthermore,EF or PF alone or in combination enhanced the LPS-stimulated inflammatory cytokine production,implying that IL-1β,which is processed and released by activating the NLRP3 inflammasome,is a specific indicator of EF-induced immune idiosyncratic hepatotoxicity.Thus,EF may induce liver injury through enhancing the LPS-mediated proinflammatory cytokine production and activating the NLRP3 inflammasome.In addition,the metabolomics analysis results showed that PF affected more metabolites in glycerophospholipid and sphingolipid metabolic pathways compared with EF in LPS model,suggesting that PF increased the responsiveness of the liver to LPS or other inflammatory mediators via modulation of multiple metabolic pathways.Therefore,EF and PF combination indicates traditional Chinese medicine incompatibility,considering that it induces idiosyncratic hepatotoxicity under immunological stress conditions. | Yuan Gao Zhilei Wang Jinfa Tang Xiaoyi Liu Wei Shi Nan Qin Xiaoyan Wang Yu Pang Ruisheng Li Yaming Zhang Jiabo Wang Ming Niu Zhaofang Bai Xiaohe Xiao | 2020 | Frontiers of Medicine2020，14，1： | 32 |
| 3 | Lubricating a bright future:Lubrication contribution to energy saving and low carbon emission显示文摘Both the academic society and the industry are hunting for new energy forms for the future.However,the world should not forget the conventional technologies that contribute to the sustainable society by technical innovations.Among them,lubrication plays a significant role in energy saving and in low CO2emission by increasing the fuel efficiency and by prolonging the service life of machines.With the advance of novel synthetic approaches,and nanoscience and technologies,novel lubrication oils and additives and their formulations are being developed to reduce friction and wear,and novel surface treatment routes and surface coatings are invented and provide more efficient lubrication.These technologies create tremendous chances for machines to work more efficiently with low energy consumption.Here we review the recent progresses and challenges associated with some novel lubrication techniques that include novel surface treatment(such as texturing,high-performance nanocomposite coatings,adapting coating),tribology design(solid and liquid lubrication),energy-conserving engine oil and novel lubricants and formula(such as ionic liquids,low S,P content additives)which are to be adopted to enhance the fuel efficiency to achieve energy saving and low carbon emission.There is increased demand to replace fossil lubricants by degradable green lubricants.Specially designed coatings can reduce drag significantly during navigation of both airplanes and ships.All these aspects will be also reviewed in the paper. | CAI MeiRong GUO RuiSheng ZHOU Feng LIU WeiMin | 2013 | Science China(Technological Sciences)2013，56，12： | 22 |
| 4 | T cell–associated immunoregulation and antiviral effect of oxymatrine in hydrodynamic injection HBV mouse model显示文摘Although oxymatrine(OMT) has been shown to directly inhibit the replication of hepatitis B virus(HBV) in vitro, limited research has been done with this drug in vivo. In the present study, the antiviral effect of OMT was investigated in an immunocompetent mouse model of chronic HBV infection.The infection was achieved by tail vein injection of a large volume of DNA solution. OMT(2.2, 6.7 and20 mg/kg) was administered by daily intraperitoneal injection for 6 weeks. The efficacy of OMT was evaluated by the levels of HBV DNA, hepatitis B surface antigen(HBs Ag), hepatitis B e antigen(HBe Ag)and hepatitis B core antigen(HBc Ag). The immunoregulatory activity of OMT was evaluated by serum ELISA and flow cytometry. Results shows that OMT at 20 mg/kg inhibited HBV replication, and it was more efficient than entecavir(ETV) in the elimination of serum HBs Ag and intrahepatic HBc Ag. Inaddition, OMT accelerated the production of interferon-γ(IFN-γ) in a dose-dependent manner in CD4^+T cells. Our findings demonstrate the beneficial effects of OMT on the enhancement of immunological function and in the control of HBV antigens. The findings suggest this drug to be a good antiviral therapeutic candidate for the treatment of HBV infection. | Xiuxiu Sang Ruilin Wang Yanzhong Han Cong’en Zhang Honghui Shen Zhirui Yang Yin Xiong Huimin Liu Shijing Liu Ruisheng Li Ruichuang Yang Jiabo Wang Xuejun Wang Zhaofang Bai Xiaohe Xiao | 2017 | Acta Pharmaceutica Sinica B2017，7，3： | 20 |
| 5 | Cardamonin from a medicinal herb protects against LPS-induced septic shock by suppressing NLRP3 inflammasome显示文摘Aberrant activation of NLRP3 inflammasome has been implicated in the pathogenesis of diverse inflammation-related diseases, and pharmacological molecules targeting NLRP3 inflammasome are of considerable value to identifying potential therapeutic interventions. Cardamonin(CDN), the major active ingredient of the traditional Chinese medicinal herb Alpinia katsumadai, has exerted an excellent anti-inflammatory activity, but the mechanism underlying this role is not fully understood. Here, we show that CDN blocks canonical and noncanonical NLRP3 inflammasome activation triggered by multiple stimuli. Moreover, the suppression of CDN on inflammasome activation is specific to NLRP3, not to NLRC4 or AIM2 inflammasome. Besides, the inhibitory effect is not dependent on the expression of NF-κB-mediated inflammasome precursor proteins. We also demonstrate that CDN suppresses the NLRP3 inflammasome through blocking ASC oligomerization and speckle formation in a dose-dependent manner.Importantly, CDN improves the survival of mice suffering from lethal septic shock and attenuates IL-1βproduction induced by LPS in vivo, which is shown to be NLRP3 dependent. In conclusion, our results identify CDN as a broad-spectrum and specific inhibitor of NLRP3 inflammasome and a candidate therapeutic drug for treating NLRP3 inflammasome-driven diseases. | Zhilei Wang Guang Xu Yuan Gao Xiaoyan Zhan Nan Qin Shubin Fu Ruisheng Li Ming Niu Jiabo Wang Youping Liu Xiaohe Xiao Zhaofang Bai | 2019 | Acta Pharmaceutica Sinica B2019，9，4： | 19 |
| 6 | Raman tensor of AlN bulk single crystal显示文摘The angle dependence of optical phonon modes of an AlN bulk single crystal from the m-plane(1100) and c-plane(0001) surfaces, respectively, is investigated by polarized Raman spectroscopy in a backscattering configuration at room temperature. Corresponding Raman selection rules are derived according to measured scattering geometries to illustrate the angle dependence. The angle-dependent intensities of phonon modes are discussed and compared to theoretical scattering intensities, yielding the Raman tensor elements of A1(TO), E22, E1(TO), and A1(LO) phonon modes and the relative phase difference between the two complex elements of A1(TO). Furthermore, the Raman tensor of wurtzite AlN is compared with that of wurtzite ZnO reported in previous work, revealing the intrinsic differences of lattice vibration dynamics between AlN and ZnO. | Wei Zheng Ruisheng Zheng Feng Huang Honglei Wu Fadi Li | 2015 | Photonics Research2015，3，2： | 9 |
| 7 | Bavachin enhances NLRP3 inflammasome activation induced by ATP or nigericin and causes idiosyncratic hepatotoxicity显示文摘Psoraleae Fructus(PF)is a well-known traditional herbal medicine in China,and it is widely used for osteoporosis,vitiligo,and other diseases in clinical settings.However,liver injury caused by PF and its preparations has been frequently reported in recent years.Our previous studies have demonstrated that PF could cause idiosyncratic drug-induced liver injury(IDILI),but the mechanism underlying its hepatotoxicity remains unclear.This paper reports that bavachin isolated from PF enhances the specific stimuli-induced activation of the NLRP3 inflammasome and leads to hepatotoxicity.Bavachin boosts the secretion of IL-ip and caspase-1 caused by ATP or nigericin but not those induced by poly(I:C),monosodium urate crystal,or intracellular lipopolysaccharide.Bavachin does not affect AIM2 or NLRC4 inflammasome activation.Mechanistically,bavachin specifically increases the production of nigericin-induced mitochondrial reactive oxygen species among the most important upstream events in the activation of the NLRP3 inflammasome.Bavachin increases the levels of aspartate transaminase and alanine aminotransferase in serum and hepatocyte injury accompanied by the secretion of IL-ip via a mouse model of lipopolysaccharide-mediated susceptibility to IDILI.These results suggest that bavachin specifically enhances the ATP-or nigericin-induced activation of the NLRP3 inflammasome.Bavachin also potentially contributes to PF-induced idiosyncratic hepatotoxicity.Moreover,bavachin and PF should be evaded among patients with diseases linked to the ATP-or nigericin-mediated activation of the NLRP3 inflammasome,which may be a dangerous factor for liver injury. | Nan Qin Guang Xu Yan Wang Xiaoyan Zhan Yuan Gao Zhilei Wang Shubin Fu Wei Shi Xiaorong Hou Chunyu Wang Ruisheng Li Yan Liu Jiabo Wang Haiping Zhao Xiaohe Xiao Zhaofang Bai | 2021 | Frontiers of Medicine2021，15，4： | 9 |
| 8 | Combined prostaglandin E1 and lithium exert potent neuroprotection in a rat model of cerebral ischemia显示文摘 | RuiSHENG Li-sha ZHANG Rong HAN Bo GAO Xiao-qian LIU Zheng-hong QIN | 2011 | Acta Pharmacologica Sinica2011，32，3： | 8 |
| 9 | 激光焊接中的等离子体变化规律及气孔缺陷快速测试方法--检测信号整体分析方法显示文摘文中通过对激光焊接过程中等离子体面积信号线性轨迹和其整体分布情况的研究,发现其整体信号的分布特征与实际激光焊接条件密切相关.并由此提出了一种针对激光等离子体面积信号的整体分析方法,建立了激光等离子体面积信号整体分布特征模型.结果表明,该方法可有效去除激光等离子体信号中的随机干扰信号及信号波动对检测数据分析产生的不利影响,具有较好的可重复性及易识别特点,能够对激光焊接等离子体形态变化特征进行快速、准确的识别. | 王旭友 孙谦 王威 李小宇 Huang Ruisheng | 2016 | 焊接学报2016，37，3： | 6 |
| 10 | In situ zircon Hf isotopic, U-Pb age and trace element study of monzonite xenoliths from Pingquan and Fuxin basalts: Tracking the thermal events of 169 Ma and 107 Ma in Yanliao area显示文摘K-Ar ages of the Mesozoic (92-100 Ma) Fuxin alkalic basalts (western Liaoning Province) and the Tertiary (23-45 Ma) Pingquan alkalic basalts (eastern Hebei Province), and the results of in situ zircon U-Pb dating, Hf isotope and the trace elements from three monzonite xenoliths carried in the alkalic basalts are reported. The crust-mantle interaction occurring in the Yanshan intracontinental orogenic belt is also discussed. Fuxin zircons show highly uniform U-Pb age ((1693) Ma). More than 95% Pingquan zircons display the age of (107?0) Ma except two are 2491 Ma and 513 Ma respectively. Zircons with the ages of (169?) Ma have eHf close to zero. eHf of the zircons with the ages of (10710) Ma are mainly at -11.5--16.3, showing the crustal derivation. Fuxin zircons contain low Nb, Ta, Sr, Th, U contents, low and narrow Hf model ages (0.87-1.00 Ga), which reflect that the source materials of the monzonite xenoliths are young to Pingquan (focus at (1.280.08) Ga). High contents of the incompatible elements, and wide range of Hf model ages (0.89-2.56 Ga) in Pingquan zircons suggest a more complex source and the highly crustal maturity in their petrogenesis. Comprehensive information including the published data indicates that J3-K1 is the key period of the deep processes and shallow tectonic reverse in the Yanliao area. However, the processes were highly heterogeneous in spatial and in temporal. | ZHENG Jianping ZHANG Ruisheng YU Chunmei TANG Huayun ZHANG Pei | 2004 | Science China Earth Sciences2004，47，z2： | 6 |
| 11 | Preparation of lignin/TiO2 nanocomposites and their application in aqueous polyurethane coatings显示文摘A simple method using a water soluble lignin quaternary ammonium salt (LQAS) and TiO2 has been developed for the preparation of lignin/TiO2 nanocomposites in an aqueous medium under mild conditions. The LQAS/TiO2 nanocomposites contain well-dispersed small particles with excellent ultraviolet (UV) shielding abilities and good compatibilities with waterborne polyurethane (WPU). When the LQAS/TiO2 nanocomposites were blended with WPU, the UV absorbance and the tensile ductility of the WPU increased significantly. The composite WPU hybrid film containing 6 wt-% LQAS/TiO2 nanocomposite had the highest visible light transmittance and had excellent ultraviolet aging properties. After 192 h of UV light irradiation, the tensile strength of the composite film was above 8 MPa and the elongation at break was 800%. This work highlights new possibilities for the utilization of alkali lignin. | Dongjie Yang Shengyu Wang Ruisheng Zhong Weifeng Liu Xueqing Qiu | 2019 | Frontiers of Chemical Science and Engineering2019，13，1： | 5 |
| 12 | Monthly Variation in Crustacean Assemblage(Decapod and Stomatopod) and Its Relationships with Environmental Variables in Laizhou Bay,China显示文摘In this study,we investigated the community structure of crustaceans(decapod and stomatopod) inhabiting the sandy mud bottoms of Laizhou Bay(northeastern China) monthly from May 2011 to April 2012.Investigation was stopped from December 2011 to February 2012 because of the extreme weather and sea ice.A total of 205,057 specimens belonging to 31 species(shrimp,15;crab,15;and stomatopod,1) were collected in 148 hauls.From 2011 to 2012,Oratosquilla oratoria was the dominant biomass species(47.80%),followed by Charybdis japonica(15.49%),Alpheus japonicas(12.61%),Portunus trituberculatus(6.46%),and Crangon spp.(4.19%).Crangon spp.was the most dominant species by individual(32.55%).O.oratoria was the most-frequently encountered species(81.76%),followed by Palaemon gravieri(70.95%),C.japonica(65.54%),A.japonicas(62.16%),and P.trituberculatus(54.73%).The biomass density increased from August to September 2011 and decreased from March 2012 to April 2012.The dynamics of the ecological indices evolve in a similar manner,with high values of diversity and evenness and rich species from May to June 2011 and low values from September to October 2011.O.oratoria,C.japonica,and P.trituberculatus differed by biomass data between groups I(samples obtained from September to October 2011) and II(samples in other months).These species contributed more than 70% to the similarity of the crustacean community structure.Furthermore,the subsets of environmental variables that best matched the crustacean-assemblage structure were as follows:water depth(WD) in summer(June to August);sea surface temperature(SST),dissolved oxygen(DO),and WD in autumn(September to November);and DO,salinity,and WD in spring(March to May).The calculated correlation coefficients and significance level were higher in the period of July to August 2011 than in other months.Comparing 2011 to 2012 with 1982 to 1983,the species composition remained stable.However,the dominant species changed significantly.High value and large species,such as F.chinensis,P.trituberculatus,and T.curvirostris,have been replaced by low value and small species(i.e.,Crangon spp.,P.gravieri,and C.japonica). | WU Qiang WANG Jun ZHANG Bo CHEN Ruisheng JIN Xianshi | 2016 | Journal of Ocean University of China2016，15，2： | 4 |
| 13 | An MID-Based Load Balancing Approach for Topic-Based Pub-Sub Overlay Construction显示文摘A large proportion of Internet of Things (IoT) applications are internally publish/subscribe in nature,and traditional architecture cannot support them efficiently and flexibly.In essence,supporting efficient publish/subscribe systems requires data-oriented naming and efficient multicast.Since deployment of native IP-based multicast has failed,overlay-based multicast has become the practical choice.Since load balancing between heterogeneous nodes is an important issue,designing an optimal load balancing overlay network for publish/subscribe systems is a necessary endeavor.This study focuses on the optimal load balancing overlay design problem for topic-based publish/subscribe systems in a heterogeneous environment (in terms of node processing power,bandwidth,and reachability).The Minimum Idle Degree (MID) model is introduced to capture the heterogeneity of overlay nodes.Based on the MID model,new node load measures are defined that can accommodate heterogeneous server capacities and capture the node load in publish/subscribe systems more accurately than traditional measures.A new optimization problem,Maximum Minimum Idle Degree Topic-Connected Overlay (MMID-TCO),is established.This problem is NP-complete and a constant approximation algorithm does not exist for this problem (unless P=NP).Based on MID metrics,the Maximum Minimum Idle Degree Overlay Design Algorithm (MMID-ODA),which has polynomial time,is introduced.To improve performance,an approach that breaks down the problem into several small-scale problems by exploiting the potential inherent disjoint characteristic in the subscription table is presented.Simulation results show that the proposed algorithm is able to achieve better load balance than Min-Max-ODA in a heterogeneous environment. | Ruisheng Shi Fuqiang Liu Yang Zhang Bo Cheng Junliang Chen | 2011 | Tsinghua Science and Technology2011，16，6： | 4 |
| 14 | A Robust Real-time Low-frequency Oscillation Detection and Analysis (LFODA) System with Innovative Ensemble Filtering显示文摘Low-frequency oscillations are hazardous to power system operation,and can lead to cascading failures if not detected and mitigated in a timely manner.This paper presents a robust and automated real-time monitoring system for detecting grid oscillations and analyzing their mode shapes using PMU measurements.A novel Extended Kalman Filtering(EKF)based approach is introduced to detect and analyze oscillations.To further improve the accuracy and efficiency of the presented software system,the EKF approach takes advantages of three effective signal processing methods(including Prony’s Method,Hankel Total Least Square(HTLS)Method,EKF)and adopts a novel voting schema to significantly reduce the computation cost.Results from these methods are processed through a timeseries filter to ensure the consistency of detected oscillations and reduce the number of false alarms.The Density-based Spatial Clustering of Applications with Noise(DBSCAN)method is used to accurately classify oscillation modes and the PMU measurement channels.The LFODA system has been functioning well in the State Grid Jiangsu Electric Power Company with 176 PMUs and 1000+channels since February 2018,demonstrating outstanding performance in reducing false alarms with much less computational cost. | Desong Bian Zhe Yu Di Shi Senior Ruisheng Diao Zhiwei Wang | 2020 | CSEE Journal of Power and Energy Systems2020，6，1： | 3 |
| 15 | Active control of EIT-like response in a symmetry-broken metasurface with orthogonal electric dipolar resonators显示文摘The active control of electromagnetic response in metamaterial and mutual coupling between resonant building blocks is of fundamental importance in realizing high-quality metamaterials. In this work, we propose and experimentally demonstrate the tunabilities of symmetry-broken metasurfaces made of orthogonal electric dipolar resonators. The metasurface with vertical and horizontal wires is integrated with a PIN diode for active control.It is found that the electromagnetically induced transparency(EIT)-like spectrum appears due to the destructive or constructive interferences between the two electric dipolar modes when the structural symmetry broken is introduced to the metasurface. Different from previous works on the EIT-like effect, there is only electric dipole response in our metasuface. The microscopic response of the metasurface is numerically calculated to illustrate the mode coupling between the orthogonal electric dipolar resonators. By applying temporal coupled-mode theory,the interaction between the electromagnetic wave and the symmetry-broken metasurface is described, and the characteristic parameters of the resonator system, which determine the electromagnetic response of the metasurface, are acquired. | RUISHENG YANG QUANHONG FU YUANCHENG FAN WEIQI CAI KEPENG QIU WEIHONG ZHANG FULI ZHANG | 2019 | Photonics Research2019，7，9： | 3 |
| 16 | The influence of stochastic dispersion on quantum key distribution system显示文摘By theoretical calculation and analysis, this paper studies the influence of stochastic fiber dispersion on interference stability and erroneous detected rate of quantum key distribution (QKD) system receiver, and analyses its effects on quantum key generation rates of decoy states QKD. The result shows that the interference contrast and erroneous detected rate of the system will be affected by real part only but not by imaginary part only. However, when the real part exists, the imaginary part will have an effect on the interference contrast and erroneous detected rate. | JIN Wei ZHENG LiMing WANG FaQiang LIANG RuiSheng | 2013 | Science China(Information Sciences)2013，56，9： | 3 |
| 17 | Power quality enhancement and engineering application with high permeability distributed photovoltaic access to low-voltage distribution networks in Australia显示文摘Considering power quality problems such as overvoltage and three-phase unbalance caused by high permeability distributed photovoltaic access in low-voltage distribution networks,this paper proposes a comprehensive control scheme using a static var.generator(SVG),electric energy storage(EES),a phase switching device(PSD)and an intelligent terminal controller.The control strategies of transformer overload,bus over/under voltage,anticountercurrent,storage battery state of charge(SOC)maintenance,and three-phase unbalance are studied.The engineering application in the Greenvale low-voltage distribution networks in Australia with high permeability distributed photovoltaics is discussed.The results show that the intelligent terminal controller is able to improve the power quality of low-voltage distribution networks through coordination with EES,SVG and PSD. | Ruisheng Li Peter Wong Kun Wang Bin Li Fangfang Yuan | 2020 | Protection and Control of Modern Power Systems2020，5，1： | 2 |
| 18 | Effects of novel Fufang Biejia Ruangan Tablets with sheep placenta as substitute for Hominis Placenta on CCl4-induced liver fibrosis显示文摘Objective:Fufang Biejia Ruangan Tablet(FBRT) is widely used for the treatment of liver fibrosis.However,Hominis Placenta(HP),as an important adjuvant of FBRT,has been restricted for medicinal using due to the limited availability,ethical controversy and safety issues.The present study aimed to investigate the therapeutic effects of novel FBRT(N-FBRT) with sheep placenta(SP) as substitute for HP on liver fibrosis and explore its possible mechanisms.Different dosages of SP in N-FBRT were also evaluated.Methods:Rats were subcutaneously injected with CCl_(4)to induce liver fibrosis and then treated with NFBRT and FBRT.The anti-hepatic fibrosis effect was determined based on biomarkers analysis of liver function and hepatic fibrosis,and the liver pathology was visualized by H&E staining and Masson staining.The oxidative stress and inflammatory cytokines were also detected.Immunohistochemical staining of a-SMA,real time PCR and Western blotting were performed to evaluate hepatic stellate cells(HSCs)activation and TGF-β1/Smad signaling pathway.Results:N-FBRT and FBRT could ameliorate CCl_(4)-induced liver fibrosis and improve liver function,as evidenced by lowering serum biomarkers levels of liver function and hepatic fibrosis,and decreasing hepatic Hyp content and collagen deposition,and improving the hepatic morphology and architecture changes.Moreover,the anti-liver fibrosis effect was better when the dosage of SP used in N-FBRT was 1/2 of HP in FBRT.Administration of N-FBRT markedly alleviated oxidative stress and inflammatory cytokines,and inhibited a-SMA expression.Furthermore,the mRNA expression of Col Ⅰ,Col Ⅲ,a-SMA and TGF-β1,and proteins expression of a-SMA,TGF-β1,Smad2/3 and p-Smad2/3 were significantly down-regulated by N-FBRT treatment.Conclusion:SP can be used as substitute for HP to prepare N-FBRT for the treatment of liver fibrosis and the anti-liver fibrosis effect of N-FBRT is achieved by eliminating oxidative stress and inflammation,and inhibiting HSCs activation and ECM production by blocking TGF-β1/Smad signaling pathway. | Baode Shen Li Deng Yuan Liu Ruisheng Li Chengying Shen Xiao Liu Yinchao Li Hailong Yuan | 2022 | Chinese Herbal Medicines2022，14，1： | 2 |
| 19 | Phytolith carbon sequestration in bamboos of different ecotypes:a case study in China显示文摘Occlusion of carbon(C) within phytoliths(Phyt OC) is becoming one of the most promising terrestrial C sequestration mechanisms. This study explored the production of Phyt OC within 35 bamboo species belonging to three ecotypes using methods of microwave digestion. The aim of this study is to explore the present and potential C sequestration rate within phytoliths of bamboo species from three ecotypes. Phyt OC content in bamboos of three ecotypes ranges from 0.07 % to 0.42 %. The mean Phyt OC production flux decreases as: clustered bamboo(0.050 ±0.016 t CO2ha-1a-1) & mixed bamboo(0.049 ± 0.016 t CO2ha-1a-1) [ scattered bamboo(0.038 ± 0.020 t CO2ha-1a-1). The phytolith carbon sequestration in Chinese bamboo is estimated to be 0.293 ± 0.127 Tg(1 Tg =1012g) CO2a-1; approximately 75 %, 3 %, and 22 % of which is contributed from scattered, mixed and clustered bamboo, respectively. Taking the Phyt OC production flux of 0.18 ± 0.12 t CO2ha-1a-1and current annual area increasing rate of 3 %, global bamboo phytoliths wouldsequester 11.9 ± 7.9 Tg CO2a-1by 2050. Consequently,bamboo forests have significant potential to mitigate the increasing concentration of atmospheric CO2 by maximizing Phyt OC production flux and expanding bamboos. | Beilei Li Zhaoliang Song Hailong Wang Fengshan Guo Renyi Gui Xiaomin Yang Ruisheng Song | 2014 | Chinese Science Bulletin2014，59，34： | 2 |
| 20 | The multiple-kinase inhibitor lenvatinib inhibits the proliferation of acute myeloid leukemia cells显示文摘Background:Current chemotherapy for acute myeloid leukemia(AML)mainly involves cytotoxic agents such as doxorubicin(DNR),mitoxantrone(Mito)or 2‐aminopurine‐6‐thiol(6‐TG).However,because these agents are relatively ineffective,discovering other more effective drugs for AML treatment would be valuable.Methods:The in vitro antitumor effect of lenvatinib on AML cells was examined using the colorimetric MTT assay for assessing cell metabolic activity.AML cells mixed with Poloxamer 407 were injected into nude mice to form subcutaneous tumors.Tumorbearing mice received lenvatinib by oral administration.The antitumor effect of lenvatinib was established by measuring tumor volumes and weights.Results:Lenvatinib inhibited the growth of AML cells in a dose‐dependent manner.We used AML cells to establish subcutaneous tumor tissues by mixing the cell suspension with Poloxamer 407.Poloxamer 407 alone did not influence the subcutaneous growth of AML cells.Treatment of lenvatinib inhibited in vivo tumor growth of AML cells.Conclusion:The multiple‐kinase inhibitor lenvatinib inhibits the in vitro proliferation of AML cells,and restricts the in vivo growth of AML tumors. | Fan Feng Xiaojuan Li Ruisheng Li Boan Li | 2019 | Animal Models and Experimental Medicine2019，2，3： | 2 |
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