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您的检索式：作者名="Ruixue Cai"
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| 1 | Microenvironment regulation of M-N-C single-atom catalysts towards oxygen reduction reaction显示文摘The development of cost-effective,robust,and durable electrocatalysts to replace the expensive Pt-based catalysts towards oxygen reduction reaction(ORR)is the trending frontier research topic in renewable energy and electrocatalysis.Particular attention has been paid to metal-nitrogen-carbon(M-N-C)single atom catalysts(SACs)due to their maximized atom utilization efficiency,biomimetic active site,and distinct electronic structure.More importantly,their catalytic properties can be further tailored by rationally regulating the microenvironment of active sites(i.e.,M-N coordination number,heteroatom doping and substitution.Herein,we present a comprehensive summary of the recent advancement in the microenvironment regulation of MN-C SACs towards improved ORR performance.The coordination environment manipulation regarding central metal and coordinated atoms is first discussed,focusing on the structure-function relationship.Apart from the near-range coordination,longrange substrate modulation including heteroatom doping,defect engineering is discussed as well.Besides,the synergy mechanism of nanoparticles and single atom sites to tune the electron cloud density at the active sites is summarized.Finally,we provide the challenges and outlook of the development of M-N-C SACs. | Li Zhang Qinglei Meng Ruixue Zheng Liuqing Wang Wei Xing Weiwei Cai Meiling Xiao | 2023 | Nano Research2023，16，4： | 2 |
| 2 | The relationships between step count and all-cause mortality and cardiovascular events:A doseresponse meta-analysis显示文摘Background:A goal of 10,000 steps per day is widely advocated,but there is little evidence to support that goal.Our purpose was to examine the doseresponse relationships between step count and all-cause mortality and cardiovascular disease risk.Methods:Cochrane Central Register of Controlled Trials,EMBASE,OVID,PubMed,Scopus,and Web of Science databases were systematically searched for studies published before July 9,2021,that evaluated the association between daily steps and at least 1 outcome.Results:Sixteen publications(12 related to all-cause mortality,5 related to cardiovascular disease;and 1 article contained 2 outcomes:both allcause death and cardiovascular events)were eligible for inclusion in the meta-analysis.There was evidence of a nonlinear doseresponse relationship between step count and risk of all-cause mortality or cardiovascular disease(p=0.002 and p=0.014 for nonlinearity,respectively).When we restricted the analyses to accelerometer-based studies,the third quartile had a 40.36%lower risk of all-cause mortality and a 35.05%lower risk of cardiovascular event than the first quartile(all-cause mortality:Q1=4183 steps/day,Q3=8959 steps/day;cardiovascular event:Q1=3500 steps/day,Q3=9500 steps/day;respectively).Conclusion:Our meta-analysis suggests inverse associations between higher step count and risk of premature death and cardiovascular events in middle-aged and older adults,with nonlinear doseresponse patterns. | Mingxin Sheng Junyue Yang Min Bao Tianzhi Chen Ruixue Cai Na Zhang Hongling Chen Minqi Liu Xueyu Wu Bowen Zhang Yiting Liu Jianqian Chao | 2021 | Journal of Sport and Health Science2021，10，6： | 0 |
| 3 | Lgr5^+ intestinal stem cell sorting and organoid culture显示文摘Intestinal epithelial stem cells (IESCs) are one of the most rapidly self‐renewing and proliferating adult stem cells. The IESCs reside at the bottom of intestinal and colonic crypts, giving rise to all intestinal epithelial lineages and maintaining intestinal epithelial replenishment. The technique of three‐dimensional culture based upon intestinal stem cell biology has been recently developed to study gastrointestinal development and disease pathogenesis. Here, we summarize the techniques used to isolate Lgr5‐ positive IESCs to form the enteroids from intestine or colonoids from colon, and present the means to examine these organoid functions. This study will provide a simple and practical way for producing intestinal tissues in the laboratory. | Ruixue Liu Haifeng Li Juan Cai Qiang Wei Xiaonan Han | 2019 | Animal Models and Experimental Medicine2019，2，2： | 0 |
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