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| 1 | Responsive changes of rumen microbiome and metabolome in dairy cows with different susceptibility to subacute ruminal acidosis显示文摘Subacute ruminal acidosis(SARA)represents one of the most important digestive disorders in intensive dairy farms,and dairy cows are individually different in the severity of SARA risk.The objectives of the current study were to investigate differences in the ruminal bacterial community and metabolome in dairy cattle with different susceptibility to SARA.In the present study,12 cows were initially enrolled in the experiment.Based on average ruminal pH,4 cows with the lowest ruminal pH were assigned to the susceptible group(SUS,pH=5.76,n=4)and 4 cows with the highest ruminal pH assigned to the tolerant group(TOL,pH=6.10,n=4).Rumen contents from susceptible(SUS,n=4)and tolerant(TOL,n=4)dairy cows were collected through rumen fistula to systematically reveal the rumen microbial and metabolic alterations of dairy cows with different susceptibility to SARA using multi-omics approaches(16S and 18S rRNA gene sequencing and metabolome).The results showed that despite being fed the same diet,SUS cows had lower ruminal pH and higher concentrations of total volatile fatty acids(VFA)and propionate than TOL cows(P<0.05).No significant differences were observed in dry matter intake,milk yield,and other milk compositions between the SUS and TOL groups(P>0.05).The principal coordinates analysis based on the analysis of molecular variance indicated a significant difference in bacterial composition between the two groups(P=0.01).More specifically,the relative abundance of starch-degrading bacteria(Prevotella spp.)was greater(P<0.05),while the proportion of fiber-degrading bacteria(unclassified Ruminococcaceae spp.,Ruminococcus spp.,Papillibacter,and unclassified Family_-XIII)was lower in the rumen of SUS cows compared with TOL cows(P<0.05).Community analysis of protozoa showed that there were no significant differences in the diversity,richness,and community structure(P>0.05).Metabolomics analysis revealed that the concentrations of organic acids(such as lactic acid),biogenic amines(such as histamine),and bacterial degradation products(such as hypoxanthine)were significantly higher in the SUS group compared to the TOL group(P<0.05).These findings revealed that the higher proportion of starch-degrading bacteria/lower fiber-degrading bacteria in the rumen of SUS cows resulted in higher VFA-producing capacity,in particular propionate.This caused a disruption in metabolic homeostasis in the rumen which might be the reason for the higher susceptibility to SARA.Overall,these findings enhanced our understanding of the ruminal microbiome and metabolic changes in cows susceptible to SARA. | Tao Zhang Yingyu Mu Ruiyang Zhang Yanfeng Xue Changzheng Guo Wangpan Qi Jiyou Zhang Shengyong Mao | 2022 | Animal Nutrition2022，，1： | 4 |
| 2 | The emerging role of MMP14 in brain tumorigenesis and future therapeutics显示文摘 | Ilya Ulasov Ruiyang Yi Donna Guo Purvaba Sarvaiya Charles Cobbs | 2014 | BBA - Reviews on Cancer2014，，： | 1 |
| 3 | Assessing the ecological risk of soil irrigated with wastewater using in vitro cell bioassays显示文摘 | Guo Yu Ruiyang Xiao Donghong Wang Jun Zhou Zijian Wang | 2008 | Journal of Environmental Science and Health Part A2008，，14： | 1 |
| 4 | INDEPENDENTLY-TUNED CONCURRENT DUAL-BAND BRANCH-LINE COUPLER USING VARACTOR显示文摘This paper presents a concurrent dual-band branch-line coupler with an independently tunable center frequency. In the proposed architecture, the quarter-wavelength lines, which work at two separated bands concurrently and can be tuned in one of them, are key components. Based on the analysis of ABCD-matrix, a novel hybrid structure and a pair of varactors topology are utilized to achieve concurrent dual-band operation and independent tunability, respectively. Using this configuration, it is convenient to tune the center frequency of the upper band, while the responses of the lower band remain unaltered. To verify the proposed idea, a demonstration is implemented and the simulated results are presented. | Guo Xiaofeng Ye Yan Liu Taijun Xu Qian Li Ruiyang | 2014 | Journal of Electronics(China)2014，31，4： | 1 |
| 5 | 3D magnetic field guided sunflower-like nanocatalytic active swarm targeting patients-derived organoids显示文摘Nanocatalytic medicine triggering in situ catalytic reactions has been considered as a promising strategy for tumor-selective therapeutics.However,the targeted distribution of nanocatalysts was still low,considering the absence of targeting propulsion capability.Here,encouraged by the fast-developing controllable microrobotics for targeting delivery,a sunflower-like nanocatalytic active swarm(SNCAS)controlled by a three-dimensional(3D)magnetic field was proposed for synergistic tumorselective and magnetic-actively tumor-targeting therapeutics.Furthermore,a patient-derived renal cancer cell 3D organoid was utilized for the verification of the effective tumor therapeutic outcomes.Under the targeted control of 3D magnetic field,the multiple cascade catalytic efficiency of SNCAS based on Fenton reaction was evaluated,resulting in efficient tumor cell apoptosis and death.For the patient-derived organoid treatment,the SNCAS presented significant lethality toward 3D organoid structure to induce cell apoptosis with the collapse of organoid morphology.The targeting efficiency was further enhanced under the magnetic-controllable of SNCAS.Overall,empowered by the magnetic control technology,the synergistic therapeutic strategy based on controllable swarm combined active targeting and tumor-specific catalytic nanomedicine has provided a novel way for advanced cancer therapy.Meanwhile,3D patient-derived organoids were proved as a powerful tool for the effectiveness verification of nanocatalytic medicine. | Dong Liu Ruirui Guo Shuangshuang Mao Yanjie Huang Bin Wang Zijian Wu Xuanjie Xia Jian Dong Yu Xin Ruiyang Xie Jianzhong Shou Wei Sun Yuan Pang Yuan Lu | 2023 | Nano Research2023，16，1： | 0 |
| 6 | Simulated Reflectance of Apple Trees in Canopy Level Based on the PROSAIL Model and HJ-1A-HSI Data显示文摘Using the PROSAIL radiation transfer model and HJ-1A-HSI data to simulate the canopy reflectivity of apple trees, this study lays the foundation for the inversion of canopy parameters. Taking Qixia City of Yantai City, Shandong Province as the research area, the apple tree was taken as the research object, and the hyperspectral reflectance, LAI and sample GPS of apple canopy were measured in the field. The parameters required for the PROSAIL model were obtained by experimental methods. The model simulates the reflectivity;the HSI image data is preprocessed, and the canopy reflectivity is extracted by GPS coordinates. The PROSAIL model and the HSI image simulated reflectance were fitted to the measured apple canopy reflectivity. The decisive factor (R2) of the simulated reflectance and the measured reflectance of the PROSAIL model was 0.9944, and the relative error (RE%)was 0.1845. The HSI data simulated reflectance and measured reflectance. The coefficient of determination is 0.9714 and the relative error is 0.6202. Both have achieved good fitting effects and can be used for inversion studies of apple canopy parameters. | Xiaoyan Guo Xicun Zhu Jingling Xiong Ruiyang Yu Xueyuan Bai Yuanmao Jiang Dongsheng Gao Guijun Yang | 2019 | 遥感科学(中英文版)2019，7，1： | 0 |
| 7 | Experimental and modeling study of surface topography generation considering tool-workpiece vibration in high-precision turning显示文摘High-precision turning(HPT)is a main processing method for manufacturing rotary high-precision components,especially for metallic parts.However,the generated vibration between tool tip and workpiece during turning may seriously deteriorate the surface integrity.Therefore,exploring the effect of vibration on turning surface morphology and quality of copper parts using 3D surface topography regeneration model is crucial for predicting HPT performance.This developed model can update the machined surface topology in real time.In this study,the effects of tool arc radius,feed rate,radial vibration,axial vibration and tangential vibration on the surface topography and surface roughness were explored.The results show that the effect of radial vibration on surface topography is greater than that of axial vibration and tangential vibration.The radial vibration frequency is also critical.When vibration frequency changes,the surface topography profile presents three different types:the standard sinusoidal curve,the sinusoidal curve whose lowfrequency signal envelopes high-frequency signal,and the oscillation curve whose low-frequency signal superimposes high-frequency signal.In addition,HPT experiment was carried out to validate the developed model.The surface roughness obtained in the experiment was Ra=53 nm,while the roughness obtained by the simulation was Ra=46 nm,achieving a prediction accuracy of 86.7%.Received 4 September 2022;revised 3 October 2022;accepted 17 October 2022. | Xingying ZHOU Henan LIU Tianyu YU Ruiyang GUO Guangzhou WANG Yazhou SUN Mingjun CHEN | 2023 | Chinese Journal of Aeronautics2023，36，7： | 0 |
| 8 | Prediction Model of Nitrogen Content in Apple Leaves based on Ground Imaging Spectroscopy显示文摘A prediction model of apple leaf nitrogen content based on ground imaging spectroscopy was established to rapidly and nondestructively detect nitrogen content in apple leaves.SOC710VP hyperspectral imager was used to obtain the imaging spectral information of apple leaves,and the average spectral curve of interest region was extracted.The study is to analyze the characteristics of imaging spectral curves of apple leaves with different nitrogen content.On the basis of the SG smoothing and first derivative pretreatment of the spectral curve,the maximum sensitive band with nitrogen content is screened and the spectral parameters are constructed.Three modeling methods of BP,SVM and RF were used to establish the prediction model of nitrogen content in apple leaves.The results showed that in the visible range,the nitrogen content of apple leaves was negatively correlated with the reflectance of the spectral curve,and was most obvious in the green range.The R2 of BP,SVM and RF of apple leaf nitrogen content prediction model were 0.7283,0.8128,0.9086,RMSE were 0.9359,0.7365,0.5368,the R2 of test model were 0.6260,0.7294,0.6512,RMSE were 0.9460,0.7350,0.9024.Comparing the prediction results of the three models,the optimal prediction model is SVM model,which can well predict the nitrogen content of apple leaves. | Baichao LI Xicun ZHU Ruiyang YU Xiaoyan GUO Shujing CAO Huansan ZHAO | 2018 | 遥感科学(中英文版)2018，6，1： | 0 |
| 9 | Nitrogen Estimation Model of Apple Leaves Based on Imaging Spectroscopy显示文摘Imaging spectrometer was used to measure the spectral data of apple leaves.The spectral reflectance of apple leaves was extracted.The nitrogen content of apple leaves was correlated with the spectral reflectance after SG smoothing first-order differential treatment.The sensitive wavelengths were selected and nitrogen content prediction models were founded.The results showed that the spectral of apple leaves with different concentration gradients were obvious.The higher nitrogen content was,the lower spectral reflectance was.Established estimation models by using the selected SG smooth first-order differential spectral sensitive wavelengths SG-FDR403,SG-FDR469,SG-FDR525,SG-FDR566,SG-FDR650,SG-FDR696,SG-FDR781,SG-FDR851,SG-FDR933.The determined coefficient(R^2)of the partial least squares model was 0.5202.The root mean square error(RMSE)of that was 2.19 and the relative error(RE)of that was 5.89%.The R^2 of the support vector machine(SVM)model was 0.724.The RMSE of that was 1.94,and the RE of that was 5.13%.It is indicated that the SVM model can estimate the nitrogen content of apple leaves effectively. | Xin Wen Xicun Zhu Shujing Cao Xiaoyan Guo Ruiyang Yu Jingling Xiong Dongsheng Gao | 2018 | 遥感科学(中英文版)2018，6，1： | 0 |
| 10 | Genetic polymorphisms of 21 STR loci of Goldeneye^(TM) DNA ID 22NC kit in five ethnic groups of China显示文摘Dear Editor,Short tandem repeats(STRs),polymorphic DNA regions with a variable number of repeated units(2–6 base pairs),are attractive to forensic applications such as human identification and parentage testing[1].Nowadays,most of the commercial STR kits are designed based on STRs from the combined DNA index system(CODIS),European Standard Set(ESS),expanded CODIS,and extended ESS[2].In this study,we evaluated 21 STRs from GoldeneyeTM DNA ID 22NC kit(PeopleSpot Inc.,Beijing,China),which including 20 polymorphic non-CODIS STR loci(i.e.D1S1656,D2S441,D3S1744,D3S3045,D4S2366,D5S2500,D6S477,D7S1517,D7S3048,D8S1132,D10S1248,D10S1435,D11S2368,D13S325,D14S608,D15S659,D17S1290,D18S535,D19S253,D22GATA198B05)and a CODIS STR locus(D3S1358),in five ethnic groups(i.e.Eastern Han,Ningxia Hui,Xinjiang Uygur,Xizang Tibetan,and Inner Mongolia Mongolian)of China.The forensic genetic investigation of above loci may provide more genetic information in complex kinship testing and population studies[3,4]. | Jiashuo Zhang Yun Bao Ruiyang Tao Fei Guo Xiang Sheng Yingnan Bian Xiling Liu Suhua Zhang Chengtao Li | 2019 | Forensic Sciences Research2019，4，4： | 0 |
| 11 | Genomic,transcriptomic,and epigenomic analysis of a medicinal snake,Bungarus multicinctus,to provides insights into the origin of Elapidae neurotoxins显示文摘The many-banded krait,Bungarus multicinctus,has been recorded as the animal resource of JinQianBaiHuaShe in the Chinese Pharmacopoeia.Characterization of its venoms classified chief phyla of modern animal neurotoxins.However,the evolutionary origin and diversification of its neurotoxins as well as biosynthesis of its active compounds remain largely unknown due to the lack of its high-quality genome.Here,we present the 1.58 Gbp genome of B.multicinctus assembled into 18 chromosomes with contig/scaffold N50 of 7.53 Mbp/149.8 Mbp.Major bungarotoxin-coding genes were clustered within genome by family and found to be associated with ancient local duplications.The truncation of glycosylphosphatidylinositol anchor in the 3'-terminal of a LY6E paralog released modern three-finger toxins(3FTxs)from membrane tethering before the Colubroidea divergence.Subsequent expansion and mutations diversified and recruited these 3FTxs.After the cobra/krait divergence,the modern unit-B ofβ-bungarotoxin emerged with an extra cysteine residue.A subsequent point substitution in unit-A enabled theβ-bungarotoxin covalent linkage.The B.multicinctus gene expression,chromatin topological organization,and histone modification characteristics were featured by transcriptome,proteome,chromatin conformation capture sequencing,and ChIP-seq.The results highlighted that venom production was under a sophisticated regulation.Our findings provide new insights into snake neurotoxin research,meanwhile will facilitate antivenom development,toxin-driven drug discovery and the quality control of JinQianBaiHuaShe. | Jiang Xu Shuai Guo Xianmei Yin Mingqian Li He Su Xuejiao Liao Qiushi Li Liang Le Shiyu Chen Baosheng Liao Haoyu Hu Juan Lei Yingjie Zhu Xiaohui Qiu Lu Luo Jun Chen Ruiyang Cheng Zhenzhan Chang Han Zhang Nicholas Chieh Wu Yiming Guo Dianyun Hou Jin Pei Jihai Gao Yan Hua Zhihai Huang Shilin Chen | 2023 | Acta Pharmaceutica Sinica B2023，13，5： | 0 |
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