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| 1 | Influence of order degree of coaly graphite on its structure change during preparation of graphene oxide显示文摘Coaly graphite is an important natural graphite resource that derived from coal under a natural process that associated with igneous intrusion.Flake graphite is usually used for the chemical synthesis of graphene oxide(GO),the main precursor for preparation of graphene,but few papers pay attention to preparing GO using coaly graphite.In this paper,four kinds of natural coaly graphite with different graphitization degrees were exposed to a modified Hummer’s oxidation method to prepare GO.The flake graphite sample was also used for comparison.The results showed that the structural change process from graphite to GO were significantly affected by the graphitization degree of the original coaly graphite.The relationship between yields of GO and graphitization degrees of the coaly graphite was explored.The mechanism of why the graphite with low graphitization degrees cannot be totally oxidized was proposed.Coaly graphite with a graphitization degree of higher than 80% was easier to be oxidized and yielded the same amount of GO as the flake graphite did,suggesting it is the potential substitute for the flake graphite to produce GO in bulk quantities. | Dandan Hou Kuo Li Rujia Ma Qinfu Liu | 2020 | Journal of Materiomics2020，6，3： | 2 |
| 2 | On-Surface Synthesis of Na-Porphyrins Using NaCl as a Convenient Na Source显示文摘Metallo-porphyrins with different metal centers display unique properties and are essential in various biological and chemical processes.Enormous efforts have been devoted to enriching the family of metallo-porphyrins on surfaces mainly through metalation processes within porphyrins and exogenous pure metals or intrinsic surface adatoms,which have focused on transition elements.However,less attention has been paid to the synthesis of alkali-metal-based porphyrins on a surface.Herein,by a combination of scanning tunneling microscopy(STM)imaging/manipulations and density functional theory(DFT)calculations,we report the fabrication of Na-porphyrins on Au(111)by introducing NaCl,i.e.,two double-layered Na-centered porphyrins.Moreover,the interconversion between them was realized by precise STM manipulations.Our results demonstrate the feasibility of metalation by applying inorganic salt,which would serve as a promising strategy to embed intramolecular metal components into porphyrins for further functionalization and modification. | Zewei Yi Chi Zhang Zhaoyu Zhang Rujia Hou Yuan Guo Wei Xu | 2023 | Precision Chemistry2023，1，4： | 0 |
| 3 | LncRNA NKILA inhibits HBV replication by repressing NF-κB signalling activation显示文摘Hepatitis B virus(HBV)infection results in liver cirrhosis and hepatocellular carcinoma(HCC).HBx/nuclear factor(NF)-κB pathway plays a role in HBV replication.However,whether NF-κB-interacting long noncoding RNA(NKILA),a suppressor of NF-κB activation,regulates HBV replication remains largely unknown.In this study,gain-and-loss experiments showed that NKILA inhibited HBV replication by inhibiting NF-κB activity.In turn,HBV infection down-regulated NKILA expression.In addition,expression levels of NKILA were lower in the peripheral blood-derived monocytes(PBMCs)of HBV-positive patients than in healthy individuals,which were correlated with HBV viral loads.And a negative correlation between NKILA expression level and HBV viral loads was observed in blood serum from HBV-positive patients.Lower levels of endogenous NKILA were also observed in HepG2 cells expressing a 1.3-fold HBV genome,HBV-infected HepG2-NTCP cells,stable HBV-producing HepG2.2.15 and HepAD38 cells,compared to those HBV-negative cells.Furthermore,HBx was required for NKILA-mediated inhibition on HBV replication.NKILA decreased HBx-induced NF-κB activation by interrupting the interaction between HBx and p65,whereas NKILA mutants lack of essential domains for NF-κB inhibition,lost the ability to inhibit HBV replication.Together,our data demonstrate that NKILA may serve as a suppressor of HBV replication via NF-κB signalling. | Xi Zhang Yuanyuan Li Chen Huan Yubao Hou Rujia Liu Hongyun Shi Peng Zhang Baisong Zheng Yingchao Wang Hong Wang Wenyan Zhang | 2024 | Virologica Sinica2024，39，1： | 0 |
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