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| 1 | Reduced hemoglobin and increased C-reactive protein are associated with upper gastrointestinal bleeding显示文摘AIM: To investigate the early upper gastrointestinal endoscopy(endoscopy) significantly reduces mortality resulting from upper gastrointestinal(GI) bleeding. METHODS: Upper GI bleeding was defined as 1a, 1b, 2a, and 2b according to the Forrest classification. The hemoglobin(Hb), and C-reactive protein(CRP) were examined at around the day of endoscopy and 3 mo prior to endoscopy. The rate of change was calculated as follows:(the result of blood examination on the day of endoscopy- the results of blood examination 3 mo prior to endoscopy)/(results of blood examination 3 mo prior to endoscopy). Receiver operating characteristic curves were created to determine threshold values. RESULTS: Seventy-nine men and 77 women were enrolled. There were 17 patients with upper GI bleeding: 12 with a gastric ulcer, 3 with a duodenal ulcer, 1 with an acute gastric mucosal lesion, and 1 with gastric cancer. The area under the curve(AUC), threshold, sensitivity, and specificity of Hb around the day of endoscopy were 0.902, 11.7 g/dL, 94.1%, and 77.1%, respectively, while those of CRP were 0.722, 0.5 mg/dL, 70.5%, and 73%, respectively. The AUC, threshold, sensitivity, and specificity of the rate of change of Hb were 0.851,-21.3%, 76.4%, and 82.6%, respectively, while those of CRP were 0.901, 100%, 100%, and 82.5%, respectively. CONCLUSION: Predictors for upper GI bleeding were Hb < 11.7 g/dL, reduction rate in the Hb > 21.3% and an increase in the CRP > 100%, 3 mo before endoscopy. | Minoru Tomizawa Fuminobu Shinozaki Rumiko Hasegawa Akira Togawa Yoshinori Shirai Noboru Ichiki Yasufumi Motoyoshi Takao Sugiyama Shigenori Yamamoto Makoto Sueishi | 2014 | World Journal of Gastroenterology2014，20，5： | 13 |
| 2 | Patient characteristics with high or low blood urea nitrogen in upper gastrointestinal bleeding显示文摘AIM: To examine characteristics of patients with blood urea nitrogen(BUN) levels higher and lower than the normal limit.METHODS: Patient records between April 2011 and March 2014 were analyzed retrospectively. During this time, 3296 patients underwent upper endoscopy. In total, 50 male(69.2 ± 13.2 years) and 26 female(72.3 ± 10.2 years) patients were assessed. Patients were divided into two groups based on BUN levels: higher than the normal limit(21.0 mg/d L)(H) and lower thanthe normal limit(L). One-way analysis of variance was performed to reveal differences in the variables between the H and L groups. Fisher's exact test was used to compare the percentage of patients with gastric ulcer or gastric cancer in the H and L groups.RESULTS: White blood cell count was higher in the H group than in the L group(P = 0.0047). Hemoglobin level was lower in the H group than in the L group(P = 0.0307). Glycated hemoglobin was higher in the H group than in the L group(P = 0.0264). The percentage of patients with gastric ulcer was higher in the H group(P = 0.0002). The H group contained no patients with gastric cancer.CONCLUSION: Patients with BUN ≥ 21 mg/d L might have more severe upper gastrointestinal bleeding. | Minoru Tomizawa Fuminobu Shinozaki Rumiko Hasegawa Yoshinori Shirai Yasufumi Motoyoshi Takao Sugiyama Shigenori Yamamoto Naoki Ishige | 2015 | World Journal of Gastroenterology2015，21，24： | 8 |
| 3 | The Possible Role of Hydrogen Sulfide as an Endogenous Smooth Muscle Relaxant in Synergy with Nitric Oxide显示文摘 | Rumiko Hosoki Norio Matsuki Hideo Kimura | 1997 | Biochemical and Biophysical Research Communications1997，，3： | 3 |
| 4 | The significance of virulence factors in H elicobacter pylori显示文摘 | Seiji Shiota Rumiko Suzuki Yoshio Yamaoka | 2013 | Journal of Digestive Diseases2013，，7： | 3 |
| 5 | Sulforaphane-rich broccoli sprout extract improves hepatic abnormalities in male subjects显示文摘AIM: To evaluate effects of dietary supplementation of sulforaphane(SF)-rich broccoli sprout(BS) extract on hepatic abnormalities in Japanese male participants.METHODS: In a randomized,placebo-controlled,double blind trial,male participants with fatty liver received either BS capsules containing glucoraphanin [GR; a precursor of SF(n = 24)] or placebo(n = 28) for 2 mo. Liver function markers,serum levels of aspartate and alanine aminotransferases(AST and ALT,respectively) and γ-glutamyl transpeptidase(γ-GTP) and an oxidative stress marker,urinary levels of 8-hydroxydeoxyguanosine(8-OHd G),were measured and compared in participants before and after the trial period. In an animal model,chronic liver failure was induced in Sprague-Dawley rats by successive intraperitoneal injection with N-nitrosodimethylamine(NDMA) for 4 wk. Concomitantly,rats received AIN-76 diets supplemented with or without BS extract. Thereafter,rats were sacrificed,and their sera and livers were collected to measure serum liver function markers and hepatic levels of thiobarbituric acid reactive substances(TBARS) levels and hepatic glutathione S-transferase(GST) activity,a prototypical phase 2 antioxidant enzyme.RESULTS: Dietary supplementation with BS extract containing SF precursor GR for 2 mo significantly decreased serum levels of liver function markers,ALT [median(interquartile range),before: 54.0(34.5-79.0) vs after supplementation: 48.5(33.3-65.3) IU/L,P < 0.05] and γ-GTP [before: 51.5(40.8-91.3) vs after: 50.0(37.8-85.3) IU/L,P < 0.05],as well as the alkali phosphatase activity. Placebo showed no significant effects on the markers. The urinary level of 8-OHd G,an established oxidative stress marker,was significantly reduced in participants who had received BS capsules but not the placebo [before: 6.66(5.51-9.03) vs after: 5.49(4.89-6.66) ng/mg-creatinine,P < 0.05]. The reduction of urinary 8-OHd G was significantly correlated with decreased levels of both ALT and γ-GTP [?8-OHd G and ?ALT: Spearman r(r) 0.514 and P = 0.012,?8-OHd G and ?γ-GTP: r = 0.496 and P = 0.016]. Intake of BS extract prevented NDMA-induced chronic liver failure in rats,which was attributable to the suppression of the increase in TBARS through induction of hepatic phase 2 antioxidant enzymes including hepatic GST(86.6 ± 95.2 vs 107.8 ± 7.7 IU/g,P < 0.01).CONCLUSION: Dietary supplementation with BS extract containing the SF precursor GR is likely to be highly effective in improving liver function through reduction of oxidative stress. | Masahiro Kikuchi Yusuke Ushida Hirokazu Shiozawa Rumiko Umeda Kota Tsuruya Yudai Aoki Hiroyuki Suganuma Yasuhiro Nishizaki | 2015 | World Journal of Gastroenterology2015，21，43： | 3 |
| 6 | Stable carbon, nitrogen, and oxygen isotope analysis as a potential tool for verifying geographical origin of beef显示文摘 | Rumiko Nakashita Yaeko Suzuki Fumikazu Akamatsu Yoshiko Iizumi Takashi Korenaga Yoshito Chikaraishi | 2008 | Analytica Chimica Acta2008，，1： | 2 |
| 7 | Rupture of a Small Hepatocellular Carcinoma in a Stable Disease State in a Patient Receiving Sorafenib Treatment显示文摘 | Rumiko Tsuboi Takeharu Asano Katsuhiko Matsuora Shinichi Asabe Hirosato Mashima | 2018 | Chinese Medical Journal2018，，8： | 2 |
| 8 | Molecular epidemiology, population genetics, and pathogenic role of Helicobacter pylori显示文摘 | Rumiko Suzuki Seiji Shiota Yoshio Yamaoka | 2011 | Infection Genetics and Evolution2011，，2： | 2 |
| 9 | Pathomorphologic study on the mechanism of fatty change in small hepatocellular carcinoma of humans显示文摘 | Rumiko Kutami Yutaka Nakashima Osamu Nakashima Koji Shiota Masamichi Kojiro | 2000 | Journal of Hepatology2000，，2： | 2 |
| 10 | Laboratory test variables useful for distinguishing upper from lower gastrointestinal bleeding显示文摘AIM: To distinguish upper from lower gastrointestinal(GI) bleeding. METHODS: Patient records between April 2011 and March 2014 were analyzed retrospectively(3296 upper endoscopy, and 1520 colonoscopy). Seventysix patients had upper GI bleeding(Upper group) and 65 had lower GI bleeding(Lower group). Variables were compared between the groups using one-way analysis of variance. Logistic regression was performed to identify variables significantly associated with the diagnosis of upper vs lower GI bleeding. Receiveroperator characteristic(ROC) analysis was performed to determine the threshold value that could distinguish upper from lower GI bleeding. RESULTS: Hemoglobin(P = 0.023), total protein(P = 0.0002), and lactate dehydrogenase(P = 0.009) were significantly lower in the Upper group than in the Lower group. Blood urea nitrogen(BUN) was higher in the Upper group than in the Lower group(P = 0.0065). Logistic regression analysis revealed that BUN was most strongly associated with the diagnosis of upper vslower GI bleeding. ROC analysis revealed a threshold BUN value of 21.0 mg/d L, with a specificity of 93.0%.CONCLUSION: The threshold BUN value for distinguishing upper from lower GI bleeding was 21.0 mg/d L. | Minoru Tomizawa Fuminobu Shinozaki Rumiko Hasegawa Yoshinori Shirai Yasufumi Motoyoshi Takao Sugiyama Shigenori Yamamoto Naoki Ishige | 2015 | World Journal of Gastroenterology2015，21，20： | 2 |
| 11 | LINE-1 Hypomethylation in a Choline-Deficiency-Induced LiverCancer in Rats: Dependence on Feeding Period显示文摘 | Kiyoshi Asada Yashige Kotake Rumiko Asada Deborah Saunders Robert H. Broyles Rheal A. Towner Hiroshi Fukui Robert A. Floyd | 2006 | Journal of Biomedicine and Biotechnology2006，，： | 1 |
| 12 | Adipocyte-derived microvesicles contain RNA that is transported into macrophages and might be secreted into blood circulation显示文摘 | Rumiko Ogawa Chie Tanaka Masahiro Sato Haruka Nagasaki Kazuto Sugimura Katsuzumi Okumura Yoshimi Nakagawa Naohito Aoki | 2010 | Biochemical and Biophysical Research Communications2010，，4： | 1 |
| 13 | A novel treatment system of wastewater contaminated with copper by a moss显示文摘 | Fumihisa Kobayashi Rumiko Kofuji Yuya Yamashita | 2006 | Biochemical Engineering Joumal2006，28，6： | 1 |
| 14 | Prospective studies on mental status and quality of life in patients with head and neck cancer treated by radiation显示文摘 | RUMIKO K TEMPEI O YUKA K | 2005 | Psycho-Oncology2005，14，1： | 1 |
| 15 | Cell bioassay for paralytic shellfish poisoning (PSP) : Comparison with postcolumn derivatization liquid chromatographic analysis and application to the monitoring of PSP in shellfish 显示文摘 | Rumiko Hayashi Hiroshi Saito Masanao Okumura | 2006 | Agricuhural Food Chem2006，54，： | 1 |
| 16 | Practical continuous resolution of u-amino-e-caprolaetam by diastereomeric salt formation using a single resolving agent with a solvent switch method 显示文摘 | Kenichi S Rumiko S Atsushi Y | 2003 | Tetrahedron Asymmetry2003，14，： | 1 |
| 17 | Allocation of nursing time at university hospitals in Japan显示文摘 | Katsuya Kanda Mieko Ozawa Rumiko Irimura | 2002 | J Nurs Studies NCNJ2002，1，1： | 1 |
| 18 | Hydroxypropylmodified potato starch increases fecal bile acid excretion in rats显示文摘 | KIYOSHI E RUMIKO S KAZUHIRO O | 1998 | Journal of Nutrition1998，128，5： | 1 |
| 19 | Expression of Osteopontin in Kupffer Cells and Hepatic Macrophages and Stellate Cells in Rat Liver after Carbon Tetrachloride Intoxication: A Possible Factor for Macrophage Migration into Hepatic Necrotic Areas显示文摘 | Rumiko Kawashima Satoshi Mochida Atsushi Matsui YuSuFu YouLuTuZ Keiko Ishikawa Keiko Toshima Fumio Yamanobe Mie Inao Hitoshi Ikeda Akihiko Ohno Sumiko Nagoshi Toshimitsu Uede Kenji Fujiwara | 1999 | Biochemical and Biophysical Research Communications1999，，3： | 1 |
| 20 | Fern constituents: triterpenoids isolated from the leaves of Cheiropleuria bicuspis 显示文摘 | Rumiko K Yoshiko T Rie H | 1990 | Chem Pharm Bull1990，38，8： | 1 |
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