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| 1 | A new caffeic ester from Incarvillea mairei var.granditlora (Wehrhahn) Grierson显示文摘新 cafferic 酉旨,(+)-2-(1-hydroxyl-4-oxocyclohexyl) 乙醇 caffeate,从 Incarvillea mairei var 的整个植物的 80% 乙醇摘录被孤立。granditlora (Wehrhahn ) Grierson。混合物的结构被分光镜的方法建立。 | Yong Qing Su Wei Dong Zhang Chuan Zhang Run Hui Liu Yun Heng Shen | 2008 | Chinese Chemical Letters2008，19，7： | 6 |
| 2 | Rational development of a human antibody cocktail that deploys multiple functions to confer Pan-SARS-CoVs protection显示文摘Structural principles underlying the composition and synergistic mechanisms of protective monoclonal antibody cocktails are poorly defined.Here,we exploited antibody cooperativity to develop a therapeutic antibody cocktail against SARS-CoV-2.On the basis of our previously identified humanized cross-neutralizing antibody H014,we systematically an a lyzed a fully human n aive antibody library and rationally identified a potent neutralizing antibody partner,P17,which confers effective protection in animal model.Cryo-EM studies dissected the nature of the P17 epitope,which is SARS-CoV-2 specific and distinctly different from that of HOI4.High-resolution structure of the SARS-CoV-2 spike in complex with HOM and P17,together with functional investigations revealed that in a two-antibody cocktail,synergistic neutralization was achieved by S1 shielding and conformational locking,thereby blocking receptor attachment and viral membrane fusion,conferring high potency as well as robustness against viral mutation escape.Furthermore,cluster analysis identified a hypothetical 3rd antibody partner for further reinforcing the cocktail as pan-SARS-CoVs therapeutics. | Hangping Yao Yao Sun Yong-Qiang Deng Nan Wang Yongcong Tan Na-Na Zhang Xiao-Feng Li Chao Kong Yan-Peng Xuc Qi Chen Tian-Shu Cao Hui Zhao Xintian Yan Lei Cao Zhe Lv Dandan Zhu Rui Feng Nanping Wu Wenhai Zhang Yuhao Hu Keda Chen Rong-Rong Zhang Qingyu Lv Shihui Sun Yunhua Zhou Run Yan Guan Yang Xinglu Chanjuan Liu Xiangyun Lu Linfang Cheng Hongying Qiu Xing-Yao Huang Tianhao Weng Danrong Shi Weidong Jiang Junbin Shao Lei Wang Jie Zhang Tao Jiang Guojun Lang Cheng-Feng Qinc Lanjuan Li Xiangxi Wang | 2021 | Cell Research2021，31，1： | 5 |
| 3 | A Steroidal Glycoside from Cynanchum versicolor Bunge显示文摘A new C21 steroidal glycoside,named cynanversicoside F (1),was isolated from the root of Cynanchum versicolor Bunge. Its structure was established as glaucogenin-A 3-O-β-D-digitoxopyranosyl-(1→4)-β-D-cymaropyranoside by spectroscopic and chemical methods. | Zhao Guang ZHENG Run Hui LIU Ling Yi KONG Wei Dong ZHANG | 2006 | Chinese Chemical Letters2006，17，7： | 2 |
| 4 | Valsartan inhibited HIF-1α pathway and attenuated renal interstitial fibrosis in streptozotocin-diabetic rats显示文摘 | Lin Tang Run Yi Bing Yang Hui Li Huijuan Chen Zhangsuo Liu | 2012 | Diabetes Research and Clinical Practice2012，，1： | 1 |
| 5 | Advances in nuclear detection and readout techniques显示文摘“A Craftsman Must Sharpen His Tools to Do His Job,”said Confucius.Nuclear detection and readout techniques are the foundation of particle physics,nuclear physics,and particle astrophysics to reveal the nature of the universe.Also,they are being increasingly used in other disciplines like nuclear power generation,life sciences,environmental sciences,medical sciences,etc.The article reviews the short history,recent development,and trend of nuclear detection and readout techniques,covering Semiconductor Detector,Gaseous Detector,Scintillation Detector,Cherenkov Detector,Transition Radiation Detector,and Readout Techniques.By explaining the principle and using examples,we hope to help the interested reader underst and this research field and bring exciting information to the community. | Rui He Xiao‑Yang Niu Yi Wang Hong‑Wei Liang Hong‑Bang Liu Ye Tian Hong‑Lin Zhang Chao‑Jie Zou Zhi‑Yi Liu Yun‑Long Zhang Hai‑Bo Yang Ju Huang Hong‑Kai Wang Wei‑Jia Han Bei Cao Gang Chen Cong Dai Li‑Min Duan Rui‑Rui Fan Fang‑Fa Fu Jian‑Hua Guo Dong Han Wei Jiang Xian‑Qin Li Xin Li Zhuo‑Dai Li Yu‑Tie Liang Shun Liao De‑Xu Lin Cheng‑Ming Liu Guo‑Rui Liu Jun‑Tao Liu Ze Long Meng‑Chen Niu Hao Qiu Hu Ran Xiang‑Ming Sun Bo‑Tan Wang Jia Wang Jin‑Xiang Wang Qi‑Lin Wang Yong‑Sheng Wang Xiao‑Chuan Xia Hao‑Qing Xie He‑Run Yang Hong Yin Hong Yuan Chun‑Hui Zhang Rui‑Guang Zhao Ran Zheng Cheng‑Xin Zhao | 2023 | Nuclear Science and Techniques2023，34，12： | 0 |
| 6 | A new coumarin glycoside from Daphne giraldii显示文摘A new coumarin glycoside was isolated from the ethanol extract of the barks of stem of Daphne giraldii Nitsche. Its structure was defined as daphnetin 8-O-b-D-glucopyranosyl-(1→6)-b-D-glucopyranoside on the basis of spectral evidences. | Juan Su Zhi Jun Wu Run Hui Liu Yun Heng Shen Chuan Zhang Hui Liang Li Wei Zhang Wei Dong Zhang | 2007 | Chinese Chemical Letters2007，18，7： | 0 |
| 7 | Proteomics Study on the Differentially Expressed Proteins in c-fos-silenced Cells Exposed to PM2.5显示文摘Objective To investigate the effect of c-fos gene silencing on differentially expressed proteins(DEPs) in human bronchial epithelial(HBE) cells after exposure to fine particulate matter(PM2.5).Methods HBE cells and c-fos-silenced HBE cells were exposed to 50 μg/mL PM2.5, LC-MS/MS and tandem mass tag(TMT) labeling methods were combined with bioinformatics methods, and DEPs and interaction networks were identified.Results In the HBE group, 414 DEPs were screened, of which 227 were up-regulated and 187 downregulated. In the c-fos silenced HBE group, 480 DEPs were screened, including 240 up-regulated proteins and 240 down-regulated proteins. KEGG annotations showed that DEPs in the HBE group are mainly concentrated in the glycolysis/gluconeogenesis pathway and those in the c-fos silenced group are concentrated mainly in endoplasmic reticulum and the processing of proteins. Additionally, the abnormal expression of GPRC5 C, DKK4, and UBE2 C was identified in top 15 DEPs. After constructing the protein interaction network, 20 Hub proteins including HNRNPA2 B1, HNRNPL, RPS15 A, and RPS25 were screened from the HBE group and the c-fos silenced HBE group.Conclusion c-fos gene affected the expression of cancer-related proteins. Our results provided a scientific basis for further study of PM2.5-induced carcinogenesis mechanism. | CAI Ying ZHENG Kai LI Run Bing YU Shu Yuan LIU Ning JI Jia Jia YANG Chen WU De Sheng QIN Shuang Jian LI Bo Ru ZHANG Zhao Hui XU Xin Yun | 2020 | Biomedical and Environmental Sciences2020，33，9： | 0 |
| 8 | Sebiferone,a New Triterpenoid from Stem Bark of Sapium sebiferum (L.)Roxb.显示文摘From the stem bark of Sapium sebiferum a new triterpenoid, named sebiferone (1), was isolated. The structure of the new compound was elucidated as 3β-acetoxy-D-friedoolen-14-en -1-one-28-oic acid on the basis of spectral and chemical methods. | Run Hui LIU, Ling Yi KONG* Department of Natural Medicinal Chemistry, China Pharmaceutical University, Nanjing 210038 | 2002 | Chinese Chemical Letters2002，13，11： | 0 |
| 9 | Insights on copper,manganese,and Nickel/ZSM-5 catalytic mechanisms for nitric oxides selective reduction with ammonia显示文摘The elucidation of the selective catalytic reduction mechanisms over state-of-the-art metal-promoted zeolites is essential for nitric oxides removal in automobile and stationary source applications.In this work,H/ZSM-5 catalysts modified with transition metals,including copper,manganese,and nickel,were prepared by using an incipient wetness impregnation method and were evaluated for the selective reduction of nitric oxides with ammonia.Results indicate that copper/ZSM-5 exhibits the highest catalytic activity,with>90%nitric oxide conversion at a broad operation temperature window(221–445◦C).The nitric oxide conversion profiles of nickel/ZSM-5 shows two peaks that correspond to weak activity among the catalysts;the low-temperature peak(290◦C)was induced by nickel clusters dispersed on the ZSM-5 surface,while the high-temperature peak(460◦C)was assigned to the bulk nickel oxides.The size of granular nickel monoxide crystallites with an exposed(202)plane is 2–30 nm,as confirmed by Scanning electron microscopy,X-ray diffraction,and Transmission electron microscope measurements.Temperature-programmed reductions with hydrogen results testified that the copper and nickel cations,as the main species contributing to selective catalytic reduction,were reduced via Cu^(2+)/Cu^(+)→Cu^(0) and Ni^(2+)→Ni^(0) for copper/ZSM-5 and nickel/ZSM-5,respectively,while for the manganese/ZSM5,the Mn3+species in manganese clusters were reduced to Mn^(2+) by hydrogen.Particularly,temperatureprogrammed desorption coupled with mass spectrometer(TPD-MS)and in situ diffuse reflectance infrared Fourier transform spectroscopy(DRIFTS)were comprehensively used to reveal the relationship between zeolite structure and catalysts’properties for improving selective catalytic reduction.These results confirm that the ammonia is adsorbed and activated on both Brønsted and Lewis acid sites.The nitrous oxide desorbs in two stages during nitric oxide-TPD-MS measurements,corresponding to the desorption of nitric oxide bounded to amorphous clusters and the nitric oxide strongly bounded to bulk metal oxides,respectively.The selective catalytic reduction process follows the L-H mechanism at low temperatures,in which nitric oxide and ammonia molecules were adsorbed and activated on the catalyst surface.The selective catalytic reduction rates reached the maximum value of 1.8×10^(8)(218◦C),6.4×10^(7)(227◦C),and 3.9×10^(7)s^(−1)(235◦C)for copper,manganese,and nickel/ZSM-5,respectively. | Cheng Liu Running Kang Feng Bin Xiaolin Wei Kwun Nam Hui Saravanan Kasipandi Kwan San Hui | 2022 | Carbon Resources Conversion2022，5，1： | 0 |
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