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| 1 | Genetics of coronary artery disease and myocardial infarction显示文摘Atherosclerotic coronary artery disease(CAD) comprises a broad spectrum of clinical entities that include asymptomatic subclinical atherosclerosis and its clinical complications, such as angina pectoris, myocardial infarction(MI) and sudden cardiac death. CAD continues to be the leading cause of death in industrialized society. The long-recognized familial clustering of CAD suggests that genetics plays a central role in its development, with the heritability of CAD and MI estimated at approximately 50% to 60%. Understanding the genetic architecture of CAD and MI has proven to be difficult and costly due to the heterogeneity of clinical CAD and the underlying multi-decade complex pathophysiological processes that involve both genetic and environmental interactions. This review describes the clinical heterogeneity of CAD and MI to clarify the disease spectrum in genetic studies, provides a brief overview of the historical understanding and estimation of the heritability of CAD and MI, recounts major gene discoveries of potential causal mutations in familial CAD and MI, summarizes CAD and MIassociated genetic variants identified using candidate gene approaches and genome-wide association studies(GWAS), and summarizes the current status of the construction and validations of genetic risk scores for lifetime risk prediction and guidance for preventive strategies. Potential protective genetic factors against the development of CAD and MI are also discussed. Finally, GWAS have identified multiple genetic factors associated with an increased risk of in-stent restenosis following stent placement for obstructive CAD. This review will also address genetic factors associated with in-stent restenosis, which may ultimately guide clinical decision-making regarding revascularization strategies for patients with CAD and MI. | Xuming Dai Szymon Wiernek James P Evans Marschall S Runge | 2016 | World Journal of Cardiology2016，8，1： | 15 |
| 2 | Mitochondrial dysfunction in atherosclerosis显示文摘 | Madamanchi N R Runge M S | 2007 | Circ Res2007，100，4： | 1 |
| 3 | Cytotoxicity of solid lipid manoparticles as function of the lipid matrix and the surfactant显示文摘 | Muller R Ruhl D Runge S | 1997 | Pharm Res1997，14，4： | 1 |
| 4 | Tl-weighted imaging of the brain at 3 tesla using a 2-dimensional spoiled gradient echo technique显示文摘 | Runge V M Patel M C Baumann S S | 2006 | Invest Radiol2006，41，2： | 1 |
| 5 | Extraction of Traffic Flows and Surface Current Information Using Terrasar-X Along-Track Inte Rferometry Data显示文摘 | Suchandt S Runge H Kotenkov A | | 0，，： | 1 |
| 6 | Cardiac troponin T in chest pain unit patients without ischemic electrocardiographic changes: angiographic correlates and long-term clinical outcomes显示文摘 | Christopher R deFilippi Monica Tocchi Rohit J Parmar Salvatore Rosanio Gerard Abreo Marjorie A Potter Marschall S Runge Barry F Uretsky | 2000 | Journal of the American College of Cardiology2000，，7： | 1 |
| 7 | First Results of Ground Moving Target Analysis in TerraSAR-X Data显示文摘 | Suchandt S Runge H Eineder M | | 0，，： | 1 |
| 8 | Oxidative stress and vascular disease显示文摘 | Madamanchi N R Vendrov A Runge M S | 2005 | Arterioscler Thromb Vasc Biol2005，25，： | 1 |
| 9 | Oxidative stress and vascular disease 显示文摘 | MADAMANCHI N R VENDROV A RUNGE M S | 2005 | Arterioscler Thromb Vasc Biol2005，25，1： | 1 |
| 10 | SLN (solid lipid nanoparticles ) a novel formulation for the oral administration of drugs 显示文摘 | Runge S Mehnert W Muller RH | 1996 | Eur J Pharm Sci1996，4，1： | 1 |
| 11 | Automatic Extraction of Traffic Flows Using TerraSAR-X Along-rack Interferometry显示文摘 | Suchandt S Runge H Breit H | | 0，，02： | 1 |
| 12 | The futue of thrombolytic therapy显示文摘 | Runge M S | 1992 | Heart Dis and stroke1992，1，： | 1 |
| 13 | The futue of thrombolytic therapy显示文摘 | RUNGE M S | 1992 | Heart Dis and stroke1992，1，： | 1 |
| 14 | Dual breath- hold magnetic resonance cine evaluation of global and regional car- diac function显示文摘 | Wintersperger B J Sincleair S Runge VM | 2007 | Eur Radiol2007，17，1： | 1 |
| 15 | Oxidative stress and vascular disease 显示文摘 | Madamanchi N R Vendrov A Runge M S | 2005 | Arterioscler Thromb Vasc Biol2005，25，1： | 1 |
| 16 | Atherosclerosis is attenuated by limiting superoxide generation in both macrophages and vessel wall cells 显示文摘 | Vendrov A E Hakim Z S Madamanchi N R Rojas M Madamanchi C Runge M S | 2007 | Arterioscler Thromb Vasc Biol2007，27，： | 1 |
| 17 | Oral bioavailability of cyclosporine: solid lipid nanoparticles (SLN) versus drug nanocrystals 显示文摘 | Mailer RH Runge S Ravelli V | 2006 | Int J Pharm2006，317，1： | 1 |
| 18 | Oxidative stress and vascular disease显示文摘 | MADAMANCHI N R VENDROV A RUNGE M S | 2005 | Arterioscler Thromb Vase Biol2005，25，1： | 1 |
| 19 | Genetic variant near IRS1 is associated with type 2 diabetes,insulin resistance and hyperinsulinemia显示文摘 | Rung J Cauchi S Albrechtsen A | | 0，，： | 1 |
| 20 | Enhanced thrombolytic and antithrombotic potency of a fibrin-targeted plas- minogen activator in baboons 显示文摘 | Runge M S Harker L A Bode C | 1996 | Circulation1996，94，6： | 1 |
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