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| 1 | Recent advances of wearable and flexible piezoresistivity pressure sensor devices and its future prospects显示文摘The human skin inspired soft electronic devices have attracted broadly research attention in the past decades as the promising potential applications in health monitoring and diagnosis,robotics,and prosthetics.The soft wearable piezoresistivity pressure sensor is one of the most attractive candidates for the development of advanced electronic skin for its simple mechanism,compact structure,low cost and power energy consumption and ease of signal acquisition and transforms advantages.In this review,we will explore the recent progress and achievements in the field of piezoresistivity pressure sensor,focusing on the fundamentals of the piezoresistivity pressure sensor and the materials related to the devices,including active materials,substrate materials,and electrode materials.Subsequently,the challenges and outlook are discussed.We list several current challenges perspectives on the development of pressure sensors.Several critical topics for the optimization of the sensitivity and working range of sensing devices toward practical applications are discussed.Finally,perspectives on the slip and force vectors sensors,the developing technologies for multi-function and high-resolution sensor systems and signals process technologies are examined to highlight the near future development tendency in piezoresistivity pressure sensor research field. | Jiang He Yufei Zhang Runhui Zhou Lirong Meng Tao Chen Wenjie Mai Caofeng Pan | 2020 | Journal of Materiomics2020，6，1： | 9 |
| 2 | Breaking or following the membrane-targeting mechanism:Exploring the antibacterial mechanism of host defense peptide mimicking poly(2-oxazoline)s显示文摘Peptides exert important biological functions but their application is hindered by their susceptibility to proteolysis and poor stability in vivo.Thus,functional peptide mimics have drawn a great deal of attention to address this challenge.Poly(2-oxazoline)s,a class of biocompatible and proteolysis-resistant polymer,can work as host defense peptide mimics without following the general membrane-targeting mechanism as shown in our previous work.This observation encouraged us to figure out if poly(2-oxazoline)s are special and break the general membrane-targeting mechanism of host defense peptides and their mimics.In this study,we aimed at the connection between structure and antibacterial mechanism of poly(2-oxazoline)s.A new γ-aminobutyric acid(GABA)-pendent poly(2-oxazoline)was synthesized and investigated to compare with glycine-pendent poly(2-oxazoline)in our previous study,with the former polymer has two extra CH2 groups in the sidechain to increase the hydrophobicity and amphiphilicity.Membrane depolarization assay suggested that incorporating two more CH2 groups into the sidechain of poly(2-oxazoline)resulted in a mechanism switch from DNA-targeting to membrane-targeting,which was supported by the slow time-kill kinetics and slightly distorted and sunken membrane morphology.Besides,GABA-pendent poly(2-oxazoline)showed potent activity against methicillin-resistant S.aureus and low hemolysis on human red blood cells.Moreover,repeated use of the antimicrobial poly(2-oxazoline)did not stimulate bacteria to obtain resistance,which was an obvious advantage of membrane-targeting antimicrobial agents. | Chengzhi Dai Min Zhou Weinan Jiang Ximian Xiao Jingcheng Zou Yuxin Qian Zihao Cong Zhemin Ji Longqiang Liu Jiayang Xie Zhongqian Qiao Runhui Liu | 2020 | Journal of Materials Science & Technology2020，59，24： | 1 |
| 3 | Alkali-metal hexamethyldisilazide initiated polymerization on alpha-amino acid N-substituted N-carboxyanhydrides for facile polypeptoid synthesis显示文摘Polypeptoids have been explored as mimics of polypeptides,owing to polypeptoids'superior stability upon proteolysis.Polypeptoids can be synthesized from one-pot ring-opening polymerization of amino acid N-substituted N-carboxyanhydrides(NNCAs).However,the speed of polymerization of NNCAs can be very slow,especially for NNCAs bearing a bulky N-substitution group.This hindered the exploration on polypeptoids with more diverse structures and functions.Therefore,it is in great need to develop advanced strategies that can accelerate the polymerization on inactive NNCAs.Hereby,we report that lithium/sodium/potassium hexamethyldisilazide(Li/Na/KHMDS)initiates a substantially faster polymerization on NNCAs than do commonly used amine initiators,especially for NNCAs with bulky N-substitution group.This fast NNCA polymerization will increase the structure diversity and application of polypeptoids as synthetic mimics of polypeptides. | Yueming Wu Min Zhou Kang Chen Sheng Chen Ximian Xiao Zhemin Ji Jingcheng Zou Runhui Liu | 2021 | Chinese Chemical Letters2021，32，5： | 1 |
| 4 | Recent advances in ultrathin materials and their applications in e-skin显示文摘Intelligent technologies based on artificial intelligence and big data hold great potential for health monitoring and human–machine capability enhancement.However,electronics must be connected to the human body to realize this vision.Thus,tissue or skin-like electronics with high stretchability and low stiffness mechanical properties are highly desirable.Ultrathin materials have attracted significant attention from the research community and the industry because of their high performance and flexibility.Over the past few years,considerable progress has been made in flexible ultrathin sensors and devices based on ultrathin materials.Here,we review the developments in this area and examine representative research progress in ultrathin materials fabrication and device construction.Strategies for the fabrication of stretchable ultrathin materials and devices are considered.The relationship between the thin-film structure and performance is emphasized and highlighted.Finally,the current capabilities and limitations of ultrathin devices were explored. | Wenchao Gao Jiaoya Huang Jiang He Runhui Zhou Zemin Li Ziyu Chen Yufei Zhang Caofeng Pan | 2023 | InfoMat2023，5，8： | 1 |
| 5 | Therapeutic strategies against bacterial biofilms显示文摘The emergence of multi-drug resistance makes bacterial infection a major threat to public health and economy.The formation of bacterial biofilms is one of the main reasons of bacterial resistance.The complexity of chemical composition and physical structure makes the elimination of mature biofilms a difficult problem.The highly antibiotic resistant property of biofilms urgently calls for potent antimicrobial agents and novel antibiofilm strategies.Researchers have made a lot of efforts in this field.Here we review the current strategies to eliminate mature biofilms and progress in related drug delivery nanosystems,with the aim of inspiring researchers to design new antibiofilm systems. | Yufang Bi Guixue Xia Chao Shi Jianglin Wan Longqiang Liu Yuan Chen Yueming Wu Wenjing Zhang Min Zhou Hongyan He Runhui Liu | 2021 | Fundamental Research2021，1，2： | 1 |
| 6 | Host-Defense-Peptide-Mimickingβ-Peptide Polymer Acting as a Dual-Modal Antibacterial Agent by Interfering Quorum Sensing and Killing Individual Bacteria Simultaneously显示文摘Host defense peptides(HDPs)are one of the potentially promising agents for infection diseases due to their broad spectrum and low resistance rate,but their clinical applications are limited by proteolytic instability,high-cost,and complicated synthesis process.Here,we report a host-defense-peptidemimickingβ-peptide polymer that resists proteolysis to have enhanced the activity under physiological conditions,excellent antimicrobial efficiency even at high density of bacteria,and low cost for preparation.Theβ-peptide polymer demonstrated quorum sensing(QS)interference and bactericidal effect against both bacterial communities and individual bacterium to simultaneously block bacterial communication and disrupt bacterial membranes.The hierarchical QS network was suppressed,and main QS signaling systems showed considerably down-regulated gene expression,resulting in excellent biofilm eradication and virulence reduction effects.The dual-modal antibacterial ability possessed excellent therapeutic effects in Pseudomonas aeruginosa pneumonia,which could inhibit biofilm formation and exhibit better antibacterial and anti-inflammatory efficiency than clinically used antibiotics,levofloxacin.Furthermore,theβ-peptide polymer also showed excellent therapeutic effect Escherichia coli pyogenic liver abscess.Together,we believed that theβ-peptide polymer had a feasible clinical potential to treat bacterial infection diseases. | Wanlin Li Ximian Xiao Yuchen Qi Xiuhui Lin Huiqun Hu Minqi Shi Min Zhou Weinan Jiang Longqiang Liu Kang Chen Kai Wang Runhui Liu Min Zhou | 2023 | Research2023，，4： | 0 |
| 7 | Controllable Polymerization of N-Substituted β-Alanine N-Thiocarboxyanhydrides for Convenient Synthesis of Functional Poly(β-peptoid)s显示文摘Poly(β-peptoid)is a class of polypeptide mimics that possesses excellent biocompatibility and resistance to proteolysis.However,the synthesis of poly(β-peptoid)s with functionalities is a long-standing challenge that greatly hinders the functional study and application of poly(β-peptoid)s.We report a controllable and easy synthesis of poly(β-peptoid)s bearing diverse functionalities via the ring-opening polymerization on N-substitutedβ-alanine N-thiocarboxyanhydrides(β-NNTAs).The polymerization can be carried out in openvesselsundermildconditions usingaminesas the initiators to provide poly(β-peptoid)s with targeted molecular weights,narrow dispersities,and diverse functionalities in the side chains and termini.Theβ-NNTAs polymerization is even compatible with initiators bearing unprotected hydroxyl groups.The amphiphilic/cationic poly(β-peptoid)s exhibit a broad spectrum and potent antibacterial activities against multidrug-resistant bacteria.In addition,the highly favored stability ofβ-NNTAmonomers for purification and storage highlights the advantages of thisβ-NNTA polymerization strategy for poly(β-peptoid)s synthesis,functional study,and application as a synthetic mimic of polypeptides. | Ximian Xiao Min Zhou Zihao Cong Longqiang Liu Jingcheng Zou Zhemin Ji Ruxin Cui Yueming Wu Haodong Zhang Sheng Chen Maoquan Li Runhui Liu | 2023 | CCS Chemistry2023，5，4： | 0 |
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