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| 1 | Hydrochemical characteristics and element contents of natural waters in Tibet, China显示文摘六十件水样品( 35 件地下水样品, 22 件表面水样品和三件温泉的水样品)在拉萨城市里从村庄和镇在 36 个点被收集, Nagchu ( Nagqu )府,到 hydrochemical 特征和元素天赋满足的学习的在 2013 的府(西藏)浇的阿里( Ngari )府和 Shigatse ( Xigaze )。元素的集中在水样品并且与在从另外的区域的水样品的集中相比是坚定的,例如东南 Qinghai,南方 Xinjiang,东方四川和西方西藏。在不同区域的 hydrochemical 种类也被学习。在西藏的大多数部分的水到达中国国家标准和世界健康组织的要求国际标准。水样品的 pH 价值从 6.75 ~ 8.21 ,为吝啬的全部的溶解固体的价值是 225.54 mg/L。从阿里府的水里的砷的集中超过了中国国家标准和国际标准的限制,从 Shuanghu 的水里的氟化物的集中超过了中国国家标准和国际标准的限制。西藏的水里的主要 hydrochemical 种类是 Ca (HCO < 潜水艇 class= “ a-plus-plus ” > 3 ) 2 。从南方到向北,水里的主要阳离子从 Ca 变化<啜class=“ a-plus-plus ”>2+到 Na <啜class=“ a-plus-plus ”>+,而水里的主要阴离子从 HCO 变化<潜水艇class=“ a-plus-plus ”> 3 <啜class=“ a-plus-plus ”>到 Cl <啜class=“ a-plus-plus ”>并且那么<潜水艇class=“ a-plus-plus ”> 4 <啜class=“ a-plus-plus ”> 2 。河的化学从冰和雪浇并且融化水被在他们的来源在场的岩石统治,而地下水的化学被许多因素影响。构造部门决定水里并且也的主要元素的集中影响在场的 hydrochemical 种类。 | TIAN Yuan YU Chengqun LUO Kunli ZHA Xinjie WU Jianshuang ZHANG Xianzhou NI Runxiang | 2015 | Journal of Geographical Sciences2015，25，6： | 5 |
| 2 | A preliminary analysis of the surface chemistry of atmospheric aerosol particles in a typical urban area of Beijing显示文摘Atmospheric aerosol particle samples were collected using an Ambient Eight Stage(Non-Viable) Cascade Impactor Sampler in a typical urban area of Beijing from 27 th Sep.to 5th Oct.,2009.The surface chemistry of these aerosol particles was analyzed using Static Time of Flight-Secondary Ion Mass Spectrometry(Static TOF-SIMS).The factors influencing surface compositions were evaluated in conjunction with the air pollution levels,meteorological factors,and air mass transport for the sampling period.The results show that a variety of organic ion groups and inorganic ions/ion groups were accumulated on the surfaces of aerosol particles in urban areas of Beijing;and hydrophobic organic compounds with short-or middle-chain alkyl as well as hydrophilic secondary inorganic compounds were observed.All these compounds have the potential to affect the atmospheric behavior of urban aerosol particles.PM1.1–2.1and PM3.3–4.7had similar elements on their surfaces,but some molecules and ionic groups demonstrated differences in Time of Flight-Secondary Ion Mass Spectrometry spectra.This suggests that the quantities of elements varied between PM1.1–2.1and PM3.3–4.7.In particular,more intense research efforts into fluoride pollution are required,because the fluorides on aerosol surfaces have the potential to harm human health.The levels of air pollution had the most significant influence on the surface compositions of aerosol particles in our study.Hence,heavier air pollution was associated with more complex surface compositions on aerosol particles.In addition,wind,rainfall,and air masses from the south also greatly influenced the surface compositions of these urban aerosol particles. | Zhengzheng Zhang Hong Li Hongyan Liu Runxiang Ni Jinjuan Li Liqun Deng Defeng Lu Xueli Cheng Pengli Duan Wenjun Li | 2016 | Journal of Environmental Sciences2016，28，9： | 5 |
| 3 | 槲皮素对人肺癌细胞株A549化疗药物增敏作用的实验研究(英文)显示文摘Objective: The present study was designed to investigate whether quercetin exerts increasing chemosensitivity on human lung adenocarcinoma cells when quercetin combined with cisplatin (DDP) and vincristine (VCR) in vitro respectively and its possible antitumor mechanism. To provide experimental proof for clinical combination application. Methods: Using intermittent administration of high dose VCR, human lung adenocarcinoma sensitive cell line (A549/S) was induced to VCR-resistant human lung adenocarcinoma cell line (A549/VCR). MTT assay was adapted for examing the 50% inhibition (IC50) value of DDP and VCR on A549/S and A549/VCR when quercetin combined with DDP and VCR respectively. Results: IC50 of DDP on A549/S and A549/VCR was 10.18 and 12.35 mg/L, and the IC50 of VCR on the two cell lines was 1.21 and 12.77 mg/L, respectively. The resistance fold of A549/VCR on VCR and DDP was 10.55 and 1.21, respectively. When quercetin at concentration of 50, 100 and 200 μmol/L in combination with DDP and VCR respectively, the IC50 of DDP and VCR on A549/S and A549/VCR were obvious decreased (P < 0.05 - P < 0.01). Conclusion: The experiment results suggested that quercetin could increase the chemosensitivity and partly revise the resistance of A549/VCR. | Xuejun Zhan Runxiang Zhang Yanping Xu Shuhua Yang Daze Xie Liwei Tan | 2012 | The Chinese-German Journal of Clinical Oncology2012，11，7： | 1 |
| 4 | FBXW7βloss-of-function enhances FASN-mediated lipogenesis and promotes colorectal cancer growth显示文摘Continuous de novo fatty acid synthesis is required for the biosynthetic demands of tumor.FBXW7 is a highly mutated gene in CRC,but its biological functions in cancer are not fully characterized.Here,we report that FBXW7β,a FBXW7 isoform located in the cytoplasm and frequently mutated in CRC,is an E3 ligase of fatty acid synthase(FASN).Cancer-specific FBXW7βmutations that could not degrade FASN can lead to sustained lipogenesis in CRC.COP9 signalosome subunit 6(CSN6),an oncogenic marker of CRC,increases lipogenesis via interacting with and stabilizing FASN.Mechanistic studies show that CSN6 associates with both FBXW7βand FASN,and antagonizes FBXW7β’s activity by enhancing FBXW7βautoubiquitination and degradation,which in turn prevents FBXW7β-mediated FASN ubiquitination and degradation,thereby regulating lipogenesis positively.Both CSN6 and FASN are positively correlated in CRC,and CSN6-FASN axis,regulated by EGF,is responsible for poor prognosis of CRC.The EGF-CSN6-FASN axis promotes tumor growth and implies a treatment strategy of combination of orlistat and cetuximab.Patient-derived xenograft experiments prove the effectiveness of employing orlistat and cetuximab combination in suppressing tumor growth for CSN6/FASN-high CRC.Thus,CSN6-FASN axis reprograms lipogenesis to promote tumor growth and is a target for cancer intervening strategy in CRC. | Wenxia Wei Baifu Qin Weijie Wen Boyu Zhang Haidan Luo Yuzhi Wang Hui Xu Xiaoshan Xie Sicheng Liu Xin Jiang Mengan Wang Qin Tang Jiayu Zhang Runxiang Yang Zongmin Fan Haiwen Lyu Junzhong Lin Kai Li Mong-Hong Lee | 2023 | Signal Transduction and Targeted Therapy2023，8，6： | 0 |
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