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| 1 | Robotic Knee Tracking Control to Mimic the Intact Human Knee Profile Based on Actor-Critic Reinforcement Learning显示文摘We address a state-of-the-art reinforcement learning(RL)control approach to automatically configure robotic pros-thesis impedance parameters to enable end-to-end,continuous locomotion intended for transfemoral amputee subjects.Specifically,our actor-critic based RL provides tracking control of a robotic knee prosthesis to mimic the intact knee profile.This is a significant advance from our previous RL based automatic tuning of prosthesis control parameters which have centered on regulation control with a designer prescribed robotic knee profile as the target.In addition to presenting the tracking control algorithm based on direct heuristic dynamic programming(dHDP),we provide a control performance guarantee including the case of constrained inputs.We show that our proposed tracking control possesses several important properties,such as weight convergence of the learning networks,Bellman(sub)optimality of the cost-to-go value function and control input,and practical stability of the human-robot system.We further provide a systematic simulation of the proposed tracking control using a realistic human-robot system simulator,the OpenSim,to emulate how the dHDP enables level ground walking,walking on different terrains and at different paces.These results show that our proposed dHDP based tracking control is not only theoretically suitable,but also practically useful. | Ruofan Wu Zhikai Yao Jennie Si He(Helen)Huang | 2022 | IEEE/CAA Journal of Automatica Sinica2022，9，1： | 1 |
| 2 | Aptamer-based cell-free detection system to detect target protein显示文摘Biomarkers of disease,especially protein,show great potential for diagnosis and prognosis.For detecting a certain protein,a binding assay implementing antibodies is commonly performed.However,antibodies are not thermally stable and may cause false-positive when the sample composition is complicated.In recent years,a functional nucleic acid named aptamer has been used in many biochemical analysis cases,which is commonly selected from random sequence libraries by using the systematic evolution of ligands by exponential enrichment(SELEX)techniques.Compared to antibodies,the aptamer is more thermal stable,easier to be modified,conjugated,and amplified.Herein,an Aptamer-Based Cell-free Detection(ABCD)system was proposed to detect target protein,using epithelial cell adhesion molecule(EpCAM)as an example.We combined the robustness of aptamer in binding specificity with the signal amplification ability of CRISPR-Cas12a′s trans-cleavage activity in the ABCD system.We also demonstrated that the ABCD system could work well to detect target protein in a relatively low limit of detection(50-100 nM),which lay a foundation for the development of portable detection devices.This work highlights the superiority of the ABCD system in detecting target protein with low abundance and offers new enlightenment for future design and development. | Junhong Chen Xiaoyan Zhuang Jiyang Zheng Ruofan Yang Fei Wu Aihui Zhang Baishan Fang | 2021 | Synthetic and Systems Biotechnology2021，6，3： | 0 |
| 3 | Corrigendum to“Aptamer-based cell-free detection system to detect target protein”[Synth Syst Biotechnol 6(3)(2021)209–215]显示文摘The authors regret that following the publication of the original article,the authors noticed that the“Affiliation a”were incorrect.It should be“XMU-China Team,College of Chemistry and Chemical Engineering,Xiamen University,Xiamen,361005,PR China”. | Junhong Chen Xiaoyan Zhuang Jiyang Zheng Ruofan Yang Fei Wu Aihui Zhang Baishan Fang | 2023 | Synthetic and Systems Biotechnology2023，8，2： | 0 |
| 4 | Long and Covalently Conjugated Branched DNA Structures for in Situ Gelation in Vivo显示文摘DNA nanotechnology has been widely employed for biomedical applications.However,most DNA nanomaterials rely on noncovalent complementary base pairing of short single-stranded DNA oligonucleotides.Herein,we describe a general strategy to construct a long and covalently conjugated branched DNA structure for fast and in situ gelation in vivo.In our design,a short and covalently conjugated branched DNA structure can normally be employed as the DNA primer in the terminal deoxynucleotidyl transferase-dependent enzymatic polymerization system.After enzymatic extension,the DNA aptamer-modified branched DNA structures with the sequences of poly T or poly A can immediately coassemble for in situ encapsulation of the target protein and tumor cell.The fast and in situ gelation system can function in a murine model of local tumor recurrence for targeting residual tumor cells to achieve long-term drug release for efficient tumor inhibition in vivo.This rationally developed DNA self-assembly strategy provides a new avenue for the development of multifunctional DNA nanomaterials. | Xuehe Lu Hong Wang Ruofan Chen Tiantian Wu Xiaohui Wu Yingxu Shang Yuang Wang Wantao Tang Dongsheng Liu Jianbing Liu Baoquan Ding | 2023 | CCS Chemistry2023，5，9： | 0 |
| 5 | For more and purer hydrogen-the progress and challenges in water gas shift reaction显示文摘The water gas shift(WGS) reaction is a standard reaction that is widely used in industrial hydrogen production and removal of carbon monoxide. The improved catalytic performance of WGS reaction also contributes to ammonia synthesis and other reactions. Advanced catalysts have been developed for both high and low-temperature reactions and are widely used in industry. In recent years, supported metal nanoparticle catalysts have been researched due to their high metal utilization. Low-temperature catalysts have shown promising results, including high selectivity, high shift rates, and higher activity potential. Additionally, significant progress has been made in removing trace CO through the redox reaction in electrolytic cell. This paper reviews the development of WGS reaction catalysts, including the reaction mechanism, catalyst design, and innovative research methods. The catalyst plays a crucial role in the WGS reaction, and this paper provides an instant of catalyst design under different conditions. The progress of catalysts is closely related to the development of advanced characterization techniques.Furthermore, modifying the catalyst surface to enhance activity and significantly increase reaction kinetics is a current research direction. This review goals to stimulate a better understanding of catalyst design, performance optimization, and driving mechanisms, leading to further progress in this field. | Limin Zhou Yanyan Liu Shuling Liu Huanhuan Zhang Xianli Wu Ruofan Shen Tao Liu Jie Gao Kang Sun Baojun Li Jianchun Jiang | 2023 | Journal of Energy Chemistry2023，，8： | 0 |
| 6 | Engineering Vacancy-Atom Ensembles to Boost Catalytic Activity toward Hydrogen Evolution显示文摘The dissociation of water is the rate-determining step of several energy-relating reactions due to high energy barrier in homolysis of H-O bond.Herein,engineering vacancy-atom ensembles via injecting oxygen vacancy(V O)into single facet-exposed TiO_(2)-Pd catalyst to form V_(O)-Pd ensemble is proposed and implemented.The outstanding activity of as-prepared catalyst,1.5-PdTV_(O),toward water dissociation is established with a turnover frequency of 240 min^(−1) in ammonia borane hydrolysis at 298 K.Density functional theory simulation suggests that the V_(O)-Pd ensemble is responsible for the high intrinsic catalytic activity.Water molecules tend to be dissociated on V_(O) sites and ammonia borane molecules on Pd atoms.Those H atoms from water dissociation on V_(O) combine with H atoms from ammonia borane on Pd atoms to generate H_(2).This insights into engineering vacancy-atom ensembles catalysis provide a new avenue to design catalytic materials for important energy chemical reactions. | Ruofan Shen Yanyan Liu Hao Wen Xianli Wu Zhikun Peng Sehrish Mehdi Tao Liu Huanhuan Zhang Shuyan Guan Erjun Liang Baojun Li | 2023 | Energy & Environmental Materials2023，6，1： | 0 |
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