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| 1 | Methanogenic community dynamics in anaerobic co-digestion of fruit and vegetable waste and food waste显示文摘A lab-scale continuously-stirred tank reactor (CSTR), used for anaerobic co-digestion of fruit and vegetable waste (FVW) and food waste (FW) at different mixture ratios, was operated for 178 days at the organic loading rate of 3 kg VS (volatile solids)/(m3·day). The dynamics of the Archaeal community and the correlations between environmental variables and methanogenic community structure were analyzed by polymerase chain reactions-denaturing gradient gel electrophoresis (PCR-DGGE) and redundancy analysis (RDA), respectively. PCR-DGGE results demonstrated that the mixture ratio of FVW to FW altered the community composition of Archaea. As the FVW/FW ratio increased, Methanoculleus, Methanosaeta and Methanosarcina became the predominant methanogens in the community. Redundancy analysis results indicated that the shift of the methanogenic community was significantly correlated with the composition of acidogenic products and methane production yield. Different mixture ratios of substrates led to different compositions of intermediate metabolites, which may affect the methanogenic community. These results suggested that the analysis of microbial communities could be used to diagnose anaerobic processes. | Jia Lin Jiane Zuo Ruofan Ji Xiaojie Chen Fenglin Liu Kaijun Wang Yunfeng Yang | 2012 | Journal of Environmental Sciences2012，24，7： | 4 |
| 2 | A metabolite from commensal Candida albicans enhances the bactericidal activity of macrophages and protects against sepsis显示文摘The gut microbiome is recognized as a key modulator of sepsis development.However,the contribution of the gut mycobiome to sepsis development is still not fully understood.Here,we demonstrated that the level of Candida albicans was markedly decreased in patients with bacterial sepsis,and the supernatant of Candida albicans culture significantly decreased the bacterial load and improved sepsis symptoms in both cecum ligation and puncture(CLP)-challenged mice and Escherichia coli-challenged pigs.Integrative metabolomics and the genetic engineering of fungi revealed that Candida albicans-derived phenylpyruvate(PPA)enhanced the bactericidal activity of macrophages and reduced organ damage during sepsis.Mechanistically,PPA directly binds to sirtuin 2(SIRT2)and increases reactive oxygen species(ROS)production for eventual bacterial clearance.Importantly,PPA enhanced the bacterial clearance capacity of macrophages in sepsis patients and was inversely correlated with the severity of sepsis in patients.Our findings highlight the crucial contribution of commensal fungi to bacterial disease modulation and expand our understanding of the host-mycobiome interaction during sepsis development. | Peng Gu Ruofan Liu Qin Yang Li Xie Rongjuan Wei Jiaxin Li Fengyi Mei Tao Chen Zhenhua Zeng Yan He Hongwei Zhou Hongjuan Peng Kutty Selva Nandakumar Huikuan Chu Yong Jiang Wei Gong Ye Chen Bernd Schnabl Peng Chen | 2023 | Cellular & Molecular Immunology2023，20，10： | 0 |
| 3 | Aptamer-based cell-free detection system to detect target protein显示文摘Biomarkers of disease,especially protein,show great potential for diagnosis and prognosis.For detecting a certain protein,a binding assay implementing antibodies is commonly performed.However,antibodies are not thermally stable and may cause false-positive when the sample composition is complicated.In recent years,a functional nucleic acid named aptamer has been used in many biochemical analysis cases,which is commonly selected from random sequence libraries by using the systematic evolution of ligands by exponential enrichment(SELEX)techniques.Compared to antibodies,the aptamer is more thermal stable,easier to be modified,conjugated,and amplified.Herein,an Aptamer-Based Cell-free Detection(ABCD)system was proposed to detect target protein,using epithelial cell adhesion molecule(EpCAM)as an example.We combined the robustness of aptamer in binding specificity with the signal amplification ability of CRISPR-Cas12a′s trans-cleavage activity in the ABCD system.We also demonstrated that the ABCD system could work well to detect target protein in a relatively low limit of detection(50-100 nM),which lay a foundation for the development of portable detection devices.This work highlights the superiority of the ABCD system in detecting target protein with low abundance and offers new enlightenment for future design and development. | Junhong Chen Xiaoyan Zhuang Jiyang Zheng Ruofan Yang Fei Wu Aihui Zhang Baishan Fang | 2021 | Synthetic and Systems Biotechnology2021，6，3： | 0 |
| 4 | Corrigendum to“Aptamer-based cell-free detection system to detect target protein”[Synth Syst Biotechnol 6(3)(2021)209–215]显示文摘The authors regret that following the publication of the original article,the authors noticed that the“Affiliation a”were incorrect.It should be“XMU-China Team,College of Chemistry and Chemical Engineering,Xiamen University,Xiamen,361005,PR China”. | Junhong Chen Xiaoyan Zhuang Jiyang Zheng Ruofan Yang Fei Wu Aihui Zhang Baishan Fang | 2023 | Synthetic and Systems Biotechnology2023，8，2： | 0 |
| 5 | Relationship between thyroid hormones and metabolic syndrome in a normal thyroid function population in Western China:a cross-sectional study based on both epidemiological and genetic analysis显示文摘To the Editor:Metabolic syndrome(MetS)is defined as a set of metabolic disorders including abdominal obesity,hyperglycemia,hypertension,and dyslipidemia.[1]As thyroid hormones are essential for cellular energy homeostasis and regulation,the levels of serum thyroid hormones are considered to be associated with various metabolic parameters.Over the past decade,the association between thyroid hormones and MetS has been extensively studied in euthyroid subjects,leading to inconsistent results.Some studies suggested that a high level of thyrotropin(TSH)contributed to the increased incidence of MetS or unfavorable metabolic parameters,whereas other studies found no such correlation.Moreover,some researches have shown that free thyroxin(FT4)levels were inversely proportional to various unfavorable metabolic parameters or MetS,while other studies suggested that FT4 levels have no such association or even a positive association with some unfavorable metabolic components after adjustment.These conflicting results may result from different designs,settings,race,exclusion criteria,adjustments,statistical analyses,and definitions of MetS and population iodine intake.Based on these,our study aimed to evaluate the association and causal relationship between thyroid hormones and MetS in people with normal thyroid function through standard epidemiological and Mendelian randomization analysis. | Shengru Liang Jing Cai Yang Yang Lei Zhang Peter Taylor Jie Ming Xinwen Yu Ruofan Hu Jie Zhou Colin M.Da-Yan Qiuhe Ji | 2022 | Chinese Medical Journal2022，，3： | 0 |
| 6 | Current-Induced Magnetic Switching in an L1_(0) FePt Single Layer with Large Perpendicular Anisotropy Through Spin–Orbit Torque显示文摘In this study,current-induced partial magnetization-based switching was realized through the spin–orbit torque(SOT)in single-layer L1_(0) FePt with a perpendicular anisotropy(K_(u⊥))of 1.19×10^(7) erg·cm^(-3)(1 erg·cm^(-3)=0.1 J·m^(-3)),and its corresponding SOT efficiency(βDL)was 8×10^(-6) Oe·(A·cm^(-2))^(-1)(1 Oe=79.57747 A·m^(-1)),which is several times higher than that of the traditional Ta/CoFeB/MgO structure reported in past work.The SOT in the FePt films originated from the structural inversion asymmetry in the FePt films since the dislocations and defects were inhomogeneously distributed within the samples.Furthermore,the FePt grown on MgO with a granular structure had a larger effective SOT field and effi-ciency than that grown on SrTiO_(3)(STO)with a continuous structure.The SOT efficiency was found to be considerably dependent on not only the sputtering temperature-induced chemical ordering but also the lattice mismatch-induced evolution of the microstructure.Our findings can provide a useful means of efficiently electrically controlling a magnetic bit that is highly thermally stable via SOT. | Kaifeng Dong Chao Sun Laizhe Zhu Yiyi Jiao Ying Tao Xin Hu Ruofan Li Shuai Zhang Zhe Guo Shijiang Luo Xiaofei Yang Shaoping Li Long You | 2022 | Engineering2022，8，5： | 0 |
| 7 | Improving the device performances of two-dimensional semiconducting transition metal dichalcogenides: Three strategies显示文摘Two-dimensional(2D)semiconductors are emerging as promising candidates for the next-generation nanoelectronics.As a type of unique channel materials,2D semiconducting transition metal dichalcogenides(TMDCs),such as MoS2 and WS2,exhibit great potential for the state-of-the-art fieldeffect transistors owing to their atomically thin thicknesses,dangling-band free surfaces,and abundant band structures.Even so,the device performances of 2D semiconducting TMDCs are still failing to reach the theoretical values so far,which is attributed to the intrinsic defects,excessive doping,and daunting contacts between electrodes and channels.In this article,we review the up-to-date three strategies for improving the device performances of 2D semiconducting TMDCs:(i)the controllable synthesis of wafer-scale 2D semiconducting TMDCs single crystals to reduce the evolution of grain boundaries,(ii)the ingenious doping of 2D semiconducting TMDCs to modulate the band structures and suppress the impurity scatterings,and(iii)the optimization design of interfacial contacts between electrodes and channels to reduce the Schottky barrier heights and contact resistances.In the end,the challenges regarding the improvement of device performances of 2D semiconducting TMDCs are highlighted,and the further research directions are also proposed.We believe that this review is comprehensive and insightful for downscaling the electronic devices and extending the Moore’s law. | Mo Cheng Junbo Yang Xiaohui Li Hui Li Ruofan Du Jianping Shi Jun He | 2022 | Frontiers of physics2022，17，6： | 0 |
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