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| 1 | Regulation of the inflammatory cycle by a controllable release hydrogel for eliminating postoperative inflammation after discectomy显示文摘Surgery is the final choice for most patients with intervertebral disc degeneration(IDD).Operation-caused trauma will cause inflammation in the intervertebral disc.Serious inflammation will cause tissue defects and induce tissue degeneration,IDD recurrence and the occurrence of other diseases.Therefore,we proposed a scheme to treat recurrence after discectomy by inhibiting inflammation with an aspirin(ASP)-loaded hydrogel to restore the mechanical stability of the spine and relieve local inflammation.ASP-liposomes(ASP-Lips)were incorporated into a photocrosslinkable gelatin-methacryloyl(GelMA)via mixing.This material can effectively alleviate inflammation by inhibiting the release of high mobility group box 1(HMGB1)from the nucleus to the cytoplasm.We further assessed the expression of inflammatory cytokines,such as interleukin 6(IL-6)and tumor necrosis factor-α(TNF-α),and degeneration-related factors,such as type II collagen(COL-2),Aggrecan,matrix metallopeptidases-3(MMP-3),MMP-13,a disintegrin and metalloproteinase with thrombospondin motifs-4(ADAMTS-4)and ADAMTS-5 in rat nucleus pulpous cells.The level of IDD was analyzed through H&E,safranin-O staining and immunohistochemistry in rabbit samples.In vitro,we found that ASP-Lip@GelMA treatment significantly decreased inflammatory cytokines,MMP-3 and-13,and ADAMTS-4 and-5 and up-regulated COL-2 and Aggrecan via the inhibited release of HMGB-1 from the nucleus.In vivo,ASP-Lip@GelMA can effectively inhibit inflammation of local tissue after disc surgery and fill local tissue defects.This composite hydrogel system is a promising way to treat the recurrence of IDD after surgery without persistent complications. | Yu Liu Jiacheng Du Peng Peng Ruoyu Cheng Jiayi Lin Congxin Xu Huilin Yang Wenguo Cui Haiqing Mao Yuling Li Dechun Geng | 2021 | Bioactive Materials2021，6，1： | 6 |
| 2 | The molecular mechanisms supporting the homeostasis and activation of dendritic epidermal T cell and its role in promoting wound healing显示文摘The epidermis is the outermost layer of skin and the first barrier against invasion.Dendritic epidermal T cells(DETCs)are a subset ofT cells and an important component of the epidermal immune microenvironment.DETCs are involved in skin wound healing,malignancy and autoim-mune diseases.DETCs secrete insulin-like growth factor-1 and keratinocyte growth factor for skin homeostasis and re-epithelization and release inflammatory factors to adjust the inflammatory microenvironment of wound healing.Therefore,an understanding of their development,activation and correlative signalling pathways is indispensable for the regulation of DETCs to accelerate wound healing.Our review focuses on the above-mentioned molecular mechanisms to provide a general research framework to regulate and control the function of DETCs. | Cheng Chen Ziyu Meng He Ren Na Zhao Ruoyu Shang Weifeng He Jianlei Hao | 2021 | Burns & Trauma2021，9，1： | 2 |
| 3 | Advances in nanotechnology-based delivery systems for EGFR tyrosine kinases inhibitors in cancer therapy显示文摘Oral tyrosine kinase inhibitors(TKIs) against epidermal growth factor receptor(EGFR) family have been introduced into the clinic to treat human malignancies for decades. Despite superior properties of EGFR-TKIs as small molecule targeted drugs, their applications are still restricted due to their low solubility, capricious oral bioavailability, large requirement of daily dose, high binding tendency to plasma albumin and initial/acquired drug resistance. Nanotechnology is a promising tool to improve efficacy of these drugs. Through non-oral routes. Various nanotechnology-based delivery approaches have been developed for providing efficient delivery of EGFR-TKIs with a better pharmacokinetic profile and tissue-targeting ability. This review aims to indicate the advantage of nanocarriers for EGFR-TKIs delivery. | Xiaohan Zhou Kun Shi Ying Hao Chengli Yang Ruoyu Zha Cheng Yi Zhiyong Qian | 2020 | Asian Journal of Pharmaceutical Sciences2020，15，1： | 1 |
| 4 | Reduced graphene oxide-platinum nanoparticles composites based imprinting sensor for sensitively electrochemical analysis of 17β-estradiol显示文摘 | Tingting Wen Cheng Xue Yun Li Yang Wang Ruoyu Wang Junli Hong Xuemin Zhou Huijun Jiang | 2012 | Journal of Electroanalytical Chemistry2012，，： | 1 |
| 5 | Honeycomb-Like Hydrogel Microspheres for 3D Bulk Construction of Tumor Models显示文摘A two-dimensional(2D)cell culture-based model is widely applied to study tumorigenic mechanisms and drug screening.However,it cannot authentically simulate the threedimensional(3D)microenvironment of solid tumors and provide reliable and predictable data in response to in vivo,thus leading to the research ilusionis and failure of drug screening.In this study,honeycomb-like gelatin methacryloyl(GelMA)hydrogel microspheres are developed by synchronous photocrosslinking microluidic technique to construct a 3D model of osteosarcoma.The in vitro study shows that ostcosarcoma cells(K7M2)culured in 3D GelMA microspheres have stronger tumorous stemness。proliferation and migration abilitics,more osteoclastogenetic ability,and reistance to chemotherapeutic drugs(DOX)than that of cells in 2D cultures.More imporantly,the 3D-cultured K7M2 cells show more tumorigenicity in immunologically sound mice,characterized by shorter tumorigenesis time,larger tumor volumc,severe bone destruction,and higher mortality.In conclusion,honeycomb like porous microsphere scaffolds are constructed with uniform structure by micofluidic technology to massively produce tumor cells with original phenotypes.Those microspheres could recapitulate the physiology microenvironment of tumors.maintain ell-cell and cell-extracellular matrix interactions,and thus provide an efective and convenient strategy for tumor pathogenesis and drug screening research. | Jiachen He Chichi Chen Liang Chen Ruoyu Cheng Jie Sun Xingzhi Liu Lin Wang Can Zhu Sihan Hu Yuan Xue Jian Lu Huiling Yang Wenguo Cui Qin Shi | 2022 | Research2022，，2： | 1 |
| 6 | 果蝇帕金森氏病模型中网格脱包被分子GAK/auxilin介导渐进性运动障碍和多巴胺能神经元凋亡显示文摘文章简介帕金森氏病是一种常见的神经退行性疾病,其病人表现出运动能力的障碍及心理层次的变化。帕金森病人的病理特征是中脑黑质区域多巴胺能神经元的凋亡和脑中多处由α-Synuclein组成的路易氏小体(Lewy bodies)的聚集。 | Li Song Yijing He Jiayao Ou Yongbo Zhao Ruoyu Li Jingjing Cheng Chin-Hsien Lin 何淑君 | 2018 | 科学新闻2018，0，4： | 0 |
| 7 | Protein Secondary Structure Prediction with Dynamic Self-Adaptation Combination Strategy Based on Entropy显示文摘The algorithm based on combination learning usually is superior to a singleclassification algorithm on the task of protein secondary structure prediction. However,the assignment of the weight of the base classifier usually lacks decision-makingevidence. In this paper, we propose a protein secondary structure prediction method withdynamic self-adaptation combination strategy based on entropy, where the weights areassigned according to the entropy of posterior probabilities outputted by base classifiers.The higher entropy value means a lower weight for the base classifier. The final structureprediction is decided by the weighted combination of posterior probabilities. Extensiveexperiments on CB513 dataset demonstrates that the proposed method outperforms theexisting methods, which can effectively improve the prediction performance. | Yuehan Du Ruoyu Zhang Xu Zhang Antai Ouyang Xiaodong Zhang Jinyong Cheng Wenpeng Lu | 2019 | Journal of Quantum Computing2019，1，1： | 0 |
| 8 | SOX9-transactived long non-coding RNA NEAT1 promotes the self-renewal of liver cancer stem cells through PKA/Hippo signaling显示文摘Dear Editor,Hepatocellular carcinoma(HCC),the most common pathological type of primary liver cancer,ranks as the third deadliest cancer.Despite the progress of surgical resection in recent years,the 5-year survival of HCC patients is still unsatisfactory due to the frequent relapse and chemoresistance.Accumulating evidence has demonstrated that liver cancer stem cells(CSCs)are critical for HCC chemoresistance and recurrence.Nevertheless,the molecular mechanisms of liver CSC regulation remain unclear,which hampers the development of the therapeutic strategy that targets liver CSCs. | Zhuo Cheng Xijun Liang Cheng Zhang Ruoyu Wang Tingting Wei Beifang Ning Elzbieta Poreba Liang Li Hongyang Wang Jin Ding | 2021 | Signal Transduction and Targeted Therapy2021，6，3： | 0 |
| 9 | Fundamental Limits of Doppler Shift-Based, ToA-Based,and TDoA-Based Underwater Localization显示文摘Dear Editor,This paper is concerned with the underwater localization based on acoustic signals. Specifically, we will focus on the search of an underwater target that can constantly broadcast a beacon signal, such as a black box. Common measurements for localization are Doppler shift [1], time of arrival(ToA) [2]–[4], time difference of arrival(TDoA) [5], [6], angle of arrival(AoA) [7], etc. | Zijun Gong Cheng Li Ruoyu Su | 2023 | IEEE/CAA Journal of Automatica Sinica2023，10，7： | 0 |
| 10 | P311 promotes typeⅡtransforming growth factor-βreceptor mediated fibroblast activation and granulation tissue formation in wound healing显示文摘Background:P311,a highly conserved 8 kDa intracellular protein,has recently been reported to play an important role in aggravating hypertrophic scaring by promoting the differentiation and secretion of fibroblasts.Nevertheless,how P311 regulates the differentiation and function of fibroblasts to affect granulation tissue formation remains unclear.In this work,we studied the underlying mechanisms via which P311 affects fibroblasts and promotes acute skin wound repair.Methods:To explore the role of P311,both in vitro and in vivo wound-healing models were used.Full-thickness skin excisional wounds were made in wild-type and P311−/−C57 adult mice.Wound healing rate,re-epithelialization,granulation tissue formation and collagen deposition were measured at days 3,6 and 9 after skin injury.The biological phenotypes of fibroblasts,the expression of target proteins and relevant signaling pathways were examined both in vitro and in vivo.Results:P311 could promote the proliferation and differentiation of fibroblasts,enhance the ability of myofibroblasts to secrete extracellular matrix and promote cell contraction,and then facilitate the formation of granulation tissue and eventually accelerate skin wound closure.Importantly,we discovered that P311 acts via up-regulating the expression of type II transforming growth factor-βreceptor(TGF-βRII)in fibroblasts and promoting the activation of the TGF-βRII-Smad signaling pathway.Mechanistically,the mammalian target of rapamycin signaling pathway is closely implicated in the regulation of the TGF-βRII-Smad pathway in fibroblasts mediated by P311.Conclusions:P311 plays a critical role in activation of the TGF-βRII-Smad pathway to promote fibroblast proliferation and differentiation as well as granulation tissue formation in the process of skin wound repair. | Jue Wang Ruoyu Shang Jiacai Yang Zhihui Liu Yunxia Chen Cheng Chen Wenxia Zheng Yuanyang Tang Xiaorong Zhang Xiaohong Hu Yong Huang Han-Ming Shen Gaoxing Luo Weifeng He | 2022 | Burns & Trauma2022，10，1： | 0 |
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