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| 1 | Screening for gastric cancer in China:Advances,challenges and visions显示文摘Gastric cancer(GC)is one of the major cancers in China and all over the world.Most GCs are diagnosed at an advanced stage with unfavorable prognosis.Along with some other countries,China has developed the government-funded national screening programs for GC and other major cancers.GC screening has been shown to effectively decrease the incidence of and mortality from GC in countries adopting nationwide screening programs(Japan and Korea)and in studies based on selected Chinese populations.The screening of GC relies mostly on gastroendoscopy,the accuracy,reliability and safety of which have been indicated by previous studies.However,considering its invasive screening approach,requirements on skilled endoscopists and pathologists,and a high cost,developing noninvasive methods to amend endoscopic screening would be highly needed.Numerous studies have examined biomarkers for GC screening and the combination of biomarkers involving pepsinogen,gastrin,and Helicobacter pylori antibodies has been proposed for risk stratification,seeking to narrow down the high-risk populations for further endoscopy.Despite all the achievements of endoscopic screening,evidence on appropriate screening age,intervals for repeated screening,novel biomarkers promoting precision prevention,and health economics need to be accumulated to inform policymakers on endoscopic screening in China.With the guide of Health China 2030 Planning Outline,we have golden opportunities to promote prevention and control of GC.In this review,we summarize the characteristics of screening programs in China and other East Asian countries and introduce the past and current approaches and strategies for GC screening,aiming for featuring the latest advances and key challenges,and illustrating future visions of GC screening. | Xiaohan Fan Xiangxiang Qin Yang Zhang Zhexuan Li Tong Zhou Jingying Zhang Weicheng You Wenqing Li Kaifeng Pan | 2021 | Chinese Journal of Cancer Research2021，33，2： | 21 |
| 2 | Ductile deformation within Upper Himalaya Crystalline Sequence and geological implications,in Nyalam area,Southern Tibet显示文摘The South Tibet Detachment System(STDS) is a flat normal fault that separates the Upper Himalaya Crystalline Sequence(UHCS) below from the Tethyan Sedimentary Sequence(TSS) above.Timing of deformations related to the STDS is critical to understand the mechanism and evolution of the Himalaya collision zone.The Nyalam detachment(ND)(~86°E) locates in the middle portion of STDS(81°-89°E).Dating of deformed leucocratic dykes that are most probably syntectonic at different depth beneath the ND,allow us to constrain the timing of deformation.(1) Dyke T11N37 located ~3500 m structurally below the ND emplaced at 27.4± 0.2 Ma;(2) Dyke T11N32 located ~1400 m structurally below the ND emplaced at 22.0±0.3 Ma;(3) T11N25 located within the top to the north STD shear zone,~150 m structurally below the ND,emplaced at 17.1±0.2 Ma.Combining ND footwall cooling history and T11N25 deformation temperature,we indicate a probable onset of top to the north deformation at ~16 Ma at this location.These results show an upward younging of the probable timing of onset of the deformation at different structural distance below the ND.We then propose a new model for deformation migration below the ND with deformation starting by pure shear deformation at depth prior to ~27.5 Ma that migrates upward at a rate of ~ 0.3 mm/a until ~18 Ma when deformation switches to top to the north shearing in the South Tibet Detachment shear zone(STDsz).As deformation on the ND stops at 14-13 Ma this would imply that significant top to the North motion would be limited to less than 5 Ma and would jeopardize the importance of lower channel flow. | LIU XiaoBing LIU XiaoHan LELOUP P.H. MAHEO G. PAQUETTE J.L. ZHANG XinGang ZHOU XueJun | 2012 | Chinese Science Bulletin2012，57，26： | 14 |
| 3 | Petrology and ^(40)Ar/^(39)Ar iso-topic ages of blueschists in Gangmar, central Qiangtang, northern Tibet显示文摘The petrology and mineral assemblages of blueschists in the Gangmar, central Qiangtang, northern Tibet were examined, which indicates that the metamorphic condition is high-pressure low-temperature. In this note, we reported the 40Ar/39Ar dating results of glaucophane from two blueschist samples. Their apparent ages are (275.0±1.3) Ma and (287.6±2.3) Ma and similar isochron ages are (275.0±0.9) Ma and (282.4±0.8) Ma, respectively. These iso-topic datings show the high-pressure metamorphism occurring in Lower Permian. The ages also coincide with the evolution of Palaeo-Tethys ocean in Late Palaeozoic. | DENG Xiguang, DING Lin, LIU Xiaohan & ZHOU YongLaboratory of Lithospheric Tectonic Evolution, Institute of Geology and Geophysics, Chinese Academy of Sciences, Beijing 100029, China | 2001 | Chinese Science Bulletin2001，46，5： | 13 |
| 4 | Neuroprotective effects of Ginkgo biloba extract and GinkgoUde B against oxygen-glucose deprivation/reoxygenation and glucose injury in a new in vitro multicellular network model显示文摘 | Xiaohan Yang Tiezheng Zheng Hao Hong Nan Cai Xiaofeng Zhou Changkai Sun Liying Wu Shuhong Liu Yongqi Zhao Lingling Zhu Ming Fan Xuezhong Zhou Fengxie Jin | 2018 | Frontiers of Medicine2018，12，3： | 12 |
| 5 | Economic Optimization Dispatching Strategy of Microgrid for Promoting Photoelectric Consumption Considering Cogeneration and Demand Response显示文摘A system combining photovoltaic power generation and cogeneration is proposed to improve the photoelectric absorption capacity. First, a time-of-use price strategy is adopted to guide users to change their electricity consumption habits for participation in the demand response, and a demand response model is established. Then, particle swarm optimization(PSO)is used with the aim of minimizing the operation cost of the microgrid to achieve economic dispatching of the microgrid. This considers power balance equation constraints, unit operation constraints, energy storage constraints, and heat storage constraints. Finally, the simulation results show the improved level of photoelectric consumption using the proposed scheme and the economic benefits of the microgrid. | Chunxia Dou Xiaohan Zhou Tengfei Zhang Shiyun Xu | 2020 | Journal of Modern Power Systems and Clean Energy2020，8，3： | 10 |
| 6 | Palynological evidence sheds new light on the age of the Liuqu Conglomerates in Tibet and its geological significance显示文摘The Liuqu Conglomerates consist of a suit of terrestrial molasse deposits formed in a foreland basin of the Himalaya-Tibet orogenic belt before the collision of India and Eurasia.These deposits record considerable geological information regarding the late tectonic evolution of the Neotethyan ocean.The palynological study of interlayers of mudstone and mud-sandstones indicates an Oligocene age.The palynological assemblage consists mainly of deciduous broad-leaved angiosperms,with some coniferous gymnosperms and evergreen broad-leaved angiosperms.The deposits reflect a broad-leaved deciduous forest or mixed with conifer-broad-leaved forest ecotypes,showing a warm-temperate or temperate zone climatic environment.This work provides significant new information about the tectonic evolution,paleogeography,and paleoenvironment of southern Tibet during the Cenozoic. | WEI LiJie LIU XiaoHan YAN FuHua MAI XueShun LI GuangWei LIU XiaoBing ZHOU XueJun | 2011 | Science China Earth Sciences2011，54，6： | 5 |
| 7 | Cyanobacteria-based near-infrared light-excited self-supplying oxygen system for enhanced photodynamic therapy of hypoxic tumors显示文摘Tumor hypoxia has been considered to induce tumor cell resistance to radiotherapy and anticancer chemotherapy,as well as predisposing for increased tumor metastases.Therefore,strategies for the eradication of the hypoxic tumor are highly desirable.Photodynamic therapy(PDT)is a new technique that can be used to treat tumors using laser irradiation to photochemically activate a photosensitizer.Compared to traditional radiotherapy and chemotherapy,photodynamic therapy has many advantages,such as good selectivity,low toxicity,and less trauma and resistance.However,PDT is oxygen-dependent,and the lack of oxygen in hypoxic tumors renders photodynamic therapy ineffective.Cyanobacteria,the earliest photosynthetic oxygen-generating organisms,can utilize water as an electron donor to reduce CO_(2) into organic carbon compounds along with continuously releasing oxygen under sunlight.Inspired by this,herein,cyanobacteria were used as a living carrier of photosensitizer conjugated upconversion nanoparticles(UCNP)to construct a self-supplying oxygen PDT system.Improvement in the PDT efficiency for hypoxic tumors can be achieved as a result of in situ oxygen production by cyanobacteria under near-infrared(NIR)light using UCNP as a light harvesting antenna.A successful demonstration of this concept would be of great significance and could open the door to a new generation of carrier systems in the field of hypoxia-targeted drug transport platforms. | Yinghua Zhang Huifang Liu Xinyue Dai Hang Li Xiaohan Zhou Shizhu Chen Jinchao Zhang Xing-Jie Liang Zhenhua Li | 2021 | Nano Research2021，14，3： | 4 |
| 8 | Hybrid Field-Effect Transistors and Photodetectors Based on Organic Semiconductor and CsPbI_3 Perovskite Nanorods Bilayer Structure显示文摘The outstanding performances of nanostructured allinorganic CsPbX_3(X = I, Br, Cl) perovskites in optoelectronic applications can be attributed to their unique combination of a suitable bandgap, high absorption coefficient, and long carrier lifetime, which are desirable for photodetectors. However, the photosensing performances of the CsPbI_3 nanomaterials are limited by their low charge-transport efficiency. In this study, a phototransistor with a bilayer structure of an organic semiconductor layer of 2,7-dioctyl [1] benzothieno[3,2-b] [1] benzothiophene and CsPbI_3 nanorod layer was fabricated. The high-quality CsPbI_3 nanorod layer obtained using a simple dip-coating method provided decent transistor performance of the hybrid transistor device.The perovskite layer efficiently absorbs light, while the organicsemiconductor layer acts as a transport channel for injected photogenerated carriers and provides gate modulation. The hybrid phototransistor exhibits high performance owing to the synergistic function of the photogating effect and field effect in the transistor,with a photoresponsivity as high as 4300 A W^(-1), ultra-high photosensitivity of 2.2 9 106, and excellent stability over 1 month.This study provides a strategy to combine the advantages of perovskite nanorods and organic semiconductors in fabrication of high-performance photodetectors. | Yantao Chen Xiaohan Wu Yingli Chu Jiachen Zhou Bilei Zhou Jia Huang | 2018 | Nano-Micro Letters2018，10，4： | 4 |
| 9 | The Crisis of Global COVID-19 Governance and the Challenge of Liberalism From Error-Tolerantism显示文摘The crisis of COVID-19 governance in Western countries has demonstrated inherent defects of the concept of freedom defined by liberalists.Error-Tolerantism integrating liberalism with China’s cultures divides the right to freedom into two categories:The right to freedom in the innovative fields is the right to be wrong as an original right;and those to freedom in the non-innovative fields are the subordinate rights.Rights come from mutual empowerment between people.The right theory of Error-Tolerantism called error-tolerant rights paradigm is the right to be wrong as an original right and mutual empowerment theory.The first defect of liberalism is that the Western media criticized China’s right to be wrong as an original right in the governance of COVID-19 by turning to the rights to freedom at the subordinate level in the context of non-COVID-19.The second defect is its failure to realize that the rational implementation of the right to be wrong as an original right will produce new subordinate rights.The number of people infected with COVID-19 in Wuhan dropping to zero indicates that new subordinate rights to freedom,such as keeping social distance,wearing face masks in public places,showing health codes,etc.,have been formed and confirmed.Error-Tolerantism holds that the definition of freedom by liberalists lacks dynamics,leading to the confusion in understanding the idea of freedom and various illegal actions endangering public security,such as traveling,gathering,or demonstrating without wearing masks during the pandemic. | ZHOU Zhifa TAN Xiaohan LIU Yanhong | 2020 | Journal of Philosophy Study2020，10，9： | 4 |
| 10 | METTL3-mediated m^(6)A RNA methylation regulates dorsal lingual epithelium homeostasis显示文摘The dorsal lingual epithelium,which is composed of taste buds and keratinocytes differentiated from K14^(+)basal cells,discriminates taste compounds and maintains the epithelial barrier.N6-methyladenosine(m^(6)A)is the most abundant mRNA modification in eukaryotic cells.How METTL3-mediated m^(6)A modification regulates K14^(+)basal cell fate during dorsal lingual epithelium formation and regeneration remains unclear.Here we show knockout of Mettl3 in K14^(+)cells reduced the taste buds and enhanced keratinocytes.Deletion of Mettl3 led to increased basal cell proliferation and decreased cell division in taste buds.Conditional Mettl3 knock-in mice showed little impact on taste buds or keratinization,but displayed increased proliferation of cells around taste buds in a protective manner during post-irradiation recovery.Mechanically,we revealed that the most frequent m^(6)A modifications were enriched in Hippo and Wnt signaling,and specific peaks were observed near the stop codons of Lats1 and FZD7.Our study elucidates that METTL3 is essential for taste bud formation and could promote the quantity recovery of taste bud after radiation. | Qiuchan Xiong Caojie Liu Xin Zheng Xinyi Zhou Kexin Lei Xiaohan Zhang Qian Wang Weimin Lin Ruizhan Tong Ruoshi Xu Quan Yuan | 2022 | International Journal of Oral Science2022，14，3： | 2 |
| 11 | Special interstitial route can transport nanoparticles to the brain bypassing the blood-brain barrier显示文摘Nowadays,nanoparticles(NPs)are considered to be ideal tools for bioimaging and drug delivery.Although increasing research has focused on NP biodistribution,transportation in the interstitial architecture has been neglected.The entire body is connected by the interstitial architecture,which can provide a long-range and direct pathway for NP biodistribution in a nonvascular system.In this study,we report that 10-nm gold NPs injected directly into the interstitial architecture of the tarsal tunnel of rats(intervaginal space injection(ISI))were delivered to the brain without crossing the blood-brain barrier.Furthermore,NaGdF4 nanoparticles were used to explore the transportation route by magnetic resonance imaging.The results demonstrated that,after ISI,the NaGdF4 nanoparticles were transported through the perivascular interstitial space of the carotid arteries and brain vessels to the brain.This is a special nonvascular transportation route like a stream based on the interstitial architecture that provides an alternative pathway for NP biodistribution. | Nan Hu Xiaoli Shi Qiang Zhang Wentao Liu Yuting Zhu Yuqing Wang Yi Hou Yinglu Ji Yupeng Cao Qian Zeng Zhuo Ao Quanmei Sun Xiaohan Zhou Xiaochun Wu Dong Han | 2019 | Nano Research2019，12，11： | 2 |
| 12 | Preparation of a novel anion exchange group modified hyper-crosslinked resin for the effective adsorption of both tetracycline and humic acid显示文摘与一个阴离子交换组一起修改的新奇的超树脂(MENQ ) 经由四步作为 comonomers 用 divinylbenzene (DVB ) 和甲基 acrylate (麻省) 被准备:暂停聚合, crosslinking 以后, ammonolysis 和完化反应。获得的树脂两个都有一个高特定的表面区域(793.34 m < 啜 class= “ a-plus-plus ” > 2 | Qing ZHOU Mengqiao WANG Aimin LI Chendong SHUANG Mancheng ZHANG Xiaohan LIU Liuyan WU | 2013 | Frontiers of Environmental Science & Engineering2013，7，3： | 2 |
| 13 | Novel directions of precision oncology:circulating microbial DNA emerging in cancer-microbiome areas显示文摘Microbiome research has extended into the cancer area in the past decades.Microbes can affect oncogenesis,progression,and treatment response through various mechanisms,including direct regulation and indirect impacts.Microbiota-associated detectionmethods and agents have been developed to facilitate cancer diagnosis and therapy.Additionally,the cancermicrobiome has recently been redefined.The identification of intra-tumoral microbes and cancer-related circulating microbial DNA(cmDNA)has promoted novel research in the cancer–microbiome area.In this review,we define the human system of commensal microbes and the cancer microbiome from a brand-new perspective and emphasize the potential value of cmDNA as a promising biomarker in cancer liquid biopsy.We outline all existing studies on the relationship between cmDNA and cancer and the outlook for potential preclinical and clinical applications of cmDNA in cancer precision medicine,as well as critical problems to be overcome in this burgeoning field. | Liting You Juan Zhou Zhaodan Xin J.Spencer Hauck Feifei Na Jie Tang Xiaohan Zhou Zichen Lei Binwu Ying | 2022 | Precision Clinical Medicine2022，5，1： | 2 |
| 14 | Cybertwin-Assisted Mode Selection in Ultra-Dense LEO Integrated Satellite-Terrestrial Network显示文摘Ultra-dense low earth orbit(LEO)integrated satellite-terrestrial network(ULISTN)has become an emerging paradigm to support massive access of Internet of things(IoT)in beyond fifth generation mobile networks(B5G).In ULISTN,there are two communication modes:cellular mode and satellite mode,where IoT users assessing terrestrial small base stations(TSBSs)and terrestrial-satellite terminals(TSTs)respectively.However,how to optimize the network performance and guarantee self-interests of the operator and IoT users in ULISTN is a challenging issue.In this paper,we propose a cybertwin-assisted joint mode selection and dynamic pricing(JMSDP)scheme for effective network management in ULISTN,where cybertwin serves as the intelligent agent.In JMSDP,the operator determines optimal access prices of TSBSs and TSTs,while each user selects the access mode according to access prices.Specifically,the operator conducts the Stackelberg game aiming at maximizing average throughput depending on the mode selection results of IoT users.Meanwhile,IoT users as followers adopt the evolutionary game to choose an access mode based on the access prices provided by the operator.Simulation results show that the proposed JMSDP can improve the average throughput and reduce the delay effectively,comparing with random access(RA)and maximum rate access. | Xin Zhang Bo Qian Xiaohan Qin Ting Ma Jiachen Chen Haibo Zhou Xuemin(Sherman)Shen | 2022 | Journal of Communications and Information Networks2022，7，4： | 1 |
| 15 | Mapping of wheat stripe rust resistance gene Yr041133 by BSR-Seq analysis显示文摘Puccinia striiformis Westend. f. sp. tritici(Pst) pathotype CYR34 is widely virulent and prevalent in China.Here, we report identification of a strpie rust resistance(Yr) gene, designated Yr041133, in winter wheat line 041133. This line produced a hypersensitive reaction to CYR34 and conferred resistance to 13 other pathotypes. Resistance to CYR34 in line 041133 was controlled by a single dominant gene. Bulked segregant RNA sequencing(BSR-Seq) was performed on a pair of RNA bulks generated by pooling resistant and susceptible recombinant inbred lines. Yr041133 was mapped to a 1.7 c M genetic interval on the chromosome arm 7 BL that corresponded to a 0.8 Mb physical interval(608.9–609.7 Mb) in the Chinese Spring reference genome. Based on its unique physical location Yr041133 differred from the other Yr genes on this chromosome arm. | Yahui Li Ruiming Lin Jinghuang Hu Xiaohan Shi Dan Qiu Peipei Wu Gebremedhin Habteab Goitom Siqi Wang Hongjun Zhang Li Yang Hongwei Liu Qiuhong Wu Jingzhong Xie Yang Zhou Zhiyong Liu Hongjie Li | 2022 | The Crop Journal2022，10，2： | 1 |
| 16 | Mesh puppetry显示文摘 | Xiaohan Shi Kun Zhou Yiying Tong Mathieu Desbrun Hujun Bao Baining Guo | 2007 | ACM Transactions on Graphics (TOG)2007，，3： | 1 |
| 17 | Subspace gradient domain mesh deformation显示文摘 | Jin Huang Xiaohan Shi Xinguo Liu Kun Zhou Li-Yi Wei Shang-Hua Teng Hujun Bao Baining Guo Heung-Yeung Shum | 2006 | ACM Transactions on Graphics (TOG)2006，，3： | 1 |
| 18 | Advances in nanotechnology-based delivery systems for EGFR tyrosine kinases inhibitors in cancer therapy显示文摘Oral tyrosine kinase inhibitors(TKIs) against epidermal growth factor receptor(EGFR) family have been introduced into the clinic to treat human malignancies for decades. Despite superior properties of EGFR-TKIs as small molecule targeted drugs, their applications are still restricted due to their low solubility, capricious oral bioavailability, large requirement of daily dose, high binding tendency to plasma albumin and initial/acquired drug resistance. Nanotechnology is a promising tool to improve efficacy of these drugs. Through non-oral routes. Various nanotechnology-based delivery approaches have been developed for providing efficient delivery of EGFR-TKIs with a better pharmacokinetic profile and tissue-targeting ability. This review aims to indicate the advantage of nanocarriers for EGFR-TKIs delivery. | Xiaohan Zhou Kun Shi Ying Hao Chengli Yang Ruoyu Zha Cheng Yi Zhiyong Qian | 2020 | Asian Journal of Pharmaceutical Sciences2020，15，1： | 1 |
| 19 | Asymmetric Synthesis of Chiral a-Substituted Mercaptoglycine Derivatives via α-Sulfenylation of Ni(ll) Complex of Glycine and S-Substituted 4-Methylbenzenesulfonothioate显示文摘有代替 S 的 4-methylbenzenesulfonothioate 的 glycine 的 Ni (II ) 建筑群的不对称的 -sulfenylation 被报导。由于温和、简单的反应条件,这不对称的反应与各种各样的功能的组兼容。 | Jia Li Xiaohan Song Shengbin Zhou Jiang Wang Hong Liu | 2017 | Chinese Journal of Chemistry2017，35，9： | 1 |
| 20 | Associations of insulin resistance and beta-cell function with abnormal lipid profile in newly diagnosed diabetes显示文摘Background:Abnormal lipids are strong predictors of cardiovascular disease in type 1 diabetes mellitus(T1DM)and type 2 diabetes mellitus(T2DM).However,the potential associations of insulin resistance(IR)and beta-cell function(BCF)with abnormal lipids in newly diagnosed T1DM or T2DM patients are not fully understood.Methods:A cross-sectional survey of 15,928 participants was conducted.Homeostasis model assessment and postprandial C-peptide levels were used to estimate IR and BCF.A restricted cubic spline(RCS)nested in binary logistic regression was used to examine the associations of IR and BCF with abnormal lipids.Results:High triglyceride(TG),low high-density lipoprotein cholesterol,and high low-density lipoprotein cholesterol(LDL-C)accounted for 49.7%,47.8%,and 59.2%of the participants,respectively.In multivariable analysis,high IR was associated with an increased risk of high TGs(P for trend<0.001)in T1DM and is associated with an elevated risk of high TG and low HDL-C(all P for trend<0.01)in T2DM.Low BCF was not associated with risks of dyslipidemia in patients with T1DM or T2DM after adjustment for potential confounders.Conclusion:High IR had different associations with the risk of dyslipidemia in newly diagnosed T1DM and T2DM patients,suggesting that early treatment that improves IR may benefit abnormal lipid metabolism. | Xiaohan Tang Xiang Yan Houde Zhou Gan Huang Xiaohong Niu Hongwei Jiang Heng Su Xilin Yang Xia Li Zhiguang Zhou | 2022 | Chinese Medical Journal2022，135，21： | 1 |
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