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| 1 | p53-mediated transcriptional regulation and activation of the actin cytoskeleton regulatory RhoC to LIMK2 signaling pathway promotes cell survival显示文摘响应 DNA 损坏的房间命运的中央仲裁人是 p53,它调整涉及房间周期拘捕,幸存和 apoptosis 的基因的表示。尽管 DNA 损坏开始的许多回答被描绘了,肌动朊细胞骨架管理者的角色大部分是未知的。我们现在显示出那 RhoC 和秘鲁利玛机场之代号 kinase (LIMK2 ) 2 是 genotoxic 代理人导致的直接 p53 目标基因。尽管 RhoC 和 LIMK2 在肌动朊细胞骨架规定有生长得很好的角色,我们的结果显示 LIMK2 的激活也有支持幸存的功能追随者 DNA 损坏。由调停 siRNA 的击倒或选择的药理学封锁的 LIMK 抑制敏化房间到无线电 -- 或化疗,以便当与 LIMK 抑制结合了时,当单身地管理了时,是尚不致命的治疗导致了房间死亡。我们的调查结果建议把 LIMK 禁止者与 genotoxic 治疗相结合能比单个代理人的管理更有效,并且加亮在肌动朊细胞骨架管理者和 DNA 之间的一个新奇连接导致损坏的房间幸存机制。 | Daniel R Croft Diane Crighton Michael S Samuel Filipe C Lourenco June Munro Jenifer Wood Karim Bensaad Karen H Vousden Owen J Sansom Kevin M Ryan Michael F Olson | 2011 | Cell Research2011，21，4： | 3 |
| 2 | Maintenance respiration and stand development in a subalpine lodgepole pine forest显示文摘 | Ryan M G Waring R H | 1992 | Ecology1992，73，： | 1 |
| 3 | Acute myocardial infarction: contrast-enhanced multi-detector row CT in a porcine model显示文摘 | Udo H Ryan M Christian E | 2004 | Radiology2004，231，3： | 1 |
| 4 | Design,operation,and motion characteristics of a precise piezoelectric linear motor 显示文摘 | KING F H RYAN V PINAR M | 2010 | Precision Engineering2010，34，2： | 1 |
| 5 | Availability and transformation of applied phosphorous in calcareous Lebanese soils显示文摘 | Ryan J Hasan B M Tabbara H S | 1985 | Soil Science Soci- ety of America Journal1985，49，： | 1 |
| 6 | Phase Ⅱ study of recombinant human endostatin in patients with advanced neuroendocrine tumors显示文摘 | KULKE M H BERGSLAND E K RYAN D P | 2006 | J Clin Oncol2006，24，22： | 1 |
| 7 | Stone retropulsion during holmium:YAG lithotripsy显示文摘 | LEE H RYAN T TEICHMAN J M | 2003 | J Urol2003，169，3： | 1 |
| 8 | SDS-inducedphenoloxidase activity of hemocyanins from Limulus polyphemus,Eurypelma californicum, and Cancer magister显示文摘 | Decker H Ryan M Jaenicke E | 2001 | JBiol Chem2001，276，17： | 1 |
| 9 | VEGF is required for growth and survival in neonatal mice显示文摘 | Gerber H P Hillan K J Ryan A M | 1999 | Development1999，126，6： | 1 |
| 10 | The heat shock response inhibits inducible nitric oxide synthase gene expression by blocking I -κB degradation and NF-κB nuclear translocation显示文摘 | Wong H R Ryan M Wispe J R | 1997 | Biochem Biophys Res Commun1997，231，： | 1 |
| 11 | 1999 update:ACC/AHA guidelines for the management of patients with acute myocardial infarction:a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Committee on Management of Acute Myocardial Infarction)显示文摘 | RYAN T J ANTMAN E M BROOKS N H | 1999 | J Am Coll Cardiol1999，34，： | 1 |
| 12 | Availability and transformation of applied phosphorous in calcareous Lebanese soils显示文摘 | RYAN J Hasan H M BASSINA | 1985 | Soil Sci Soc of Am J1985，49，： | 1 |
| 13 | SD Sinduced phenoloxidase activity of hemocyanins from Limuluspolyphemus, Eurypelma californicum, and Cancer magister 显示文摘 | Decker H Ryan M Jaenieke E | 2001 | J Blo Chem2001，276，： | 1 |
| 14 | Aging-dependent regulation of antioxidant enzymes and redox status in chronically loaded rat dorsiflexor muscles 显示文摘 | Ryan MJ Dudash H J Docherty M | 2008 | J Gerontol A Biol Sci Med Sci2008，63，10： | 1 |
| 15 | Characterization and cloning of GP50, a Taeaia solium antigen diagnostic for cysticercosis 显示文摘 | Kathy H Sowmya P Ryan M | 2004 | Molecular Biochemical Parasitology2004，133，： | 1 |
| 16 | Study of crumb rubber materials as paving asphalt modifiers显示文摘 | Daryl M Susanna H Ryan W | 2007 | Canadian Journal of Civil Engineering2007，34，10： | 1 |
| 17 | Systemic inflam- mation and ammonia in hepatic encephalopathy 显示文摘 | Tranah T H Vijay G K Ryan J M | 2013 | Metab Brain Dis2013，28，1： | 1 |
| 18 | Suis n sp (Apicomplexa:Cryptosporididae) in pigs (Susscrofa)显示文摘 | Ryan U M Monisp Enemark H L | 2004 | J Parasitol2004，90，4： | 1 |
| 19 | Bacterial phosphatidylinositol- specific phospholipase C : structure, function, and interaction with lipids 显示文摘 | GRIFFITH O H RYAN M | 1999 | Biochimica et Biophysica Acta1999，1441，2： | 1 |
| 20 | VEGF is required for growth and survival in neonatal mice显示文摘 | GERBER H P HILLAN K J RYAN A M | 1999 | Development1999，126，6： | 1 |
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