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| 1 | Immunohistochemical analysis of p53,cyclinD1,RB1,c-fos and N-ras gene expression in hepatocellular carcinoma in Iran显示文摘AIM: To study the effect of some genes especially those involved in cell cycle regulation on hepatocellular carcinoma. METHODS: Paraffin-embedded tissue samples of 25 patients (18 males and 7 females) with hepatocellular carcinoma were collected from 22 pathology centers in Tehran during 2000-2001, and stained using immunohistochemistry method (avidin-biotin-peroxidase) for detection of p53, cyclinD1, RB1, c-fos and N-ras proteins. RESULTS: Six (24%), 5 (20%), 12 (48%) and 2 samples (8%) were positive for p53, cyclinD1, C-fos and N-ras expression, respectively. Twenty-two (88%) samples had alterations in the G1 cell-cycle checkpoint protein expression (RB1 or cyclinD1). P53 positive samples showed a higher (9 times) risk of being positive for RB1 protein than p53 negative samples. Loss of expression of RB1 in association with p53 over-expression was observed in 4 (66.7%) of 6 samples. Loss of expression of RB1 was seen in all cyclinD1 positive, 20 (90.9%) N-ras negative, and 11 (50%) C-fos positive samples, respectively. CyclinD1 positive samples showed a higher (2.85 and 4.75 times) risk of being positive for c-fos and N-ras expression than cyclinD1 negative samples. CONCLUSION: The expression of p53, RB1 and c-fos genes appears to have a key role in the pathogenesis of hepatocellular carcinoma in Iran. Simultaneous overexpression of these genes is significantly associated with their loss of expression during development of hepatocellular carcinoma. | SJ Moghaddam EN Haghighi S Samiee N Shahid AR Keramati S Dadgar MR Zali | 2007 | World Journal of Gastroenterology2007，13，4： | 73 |
| 2 | Small ubiquitin-like modifier(SUMO)modification of the androgen receptor attenuates polyglutamine-mediated aggregation显示文摘 | Mukherjee S Thomas M Dadgar N | 2009 | J Biol Chem2009，284，21： | 1 |
| 3 | Comparison of soybean meal and cottonseed meal variety pak (CSMP) on growth and feed using in rainbow trout (Oncorhynchus mykiss)显示文摘 | Dadgar S Saad C R B Alimon A R | 2010 | Iran J Fish Sci2010，9，1： | 1 |
| 4 | Broiler chicken thigh and breast muscle responses to cold stress during simulated transport before slaughter 显示文摘 | Dadgar S Crowe T G Classen H L | 2012 | Poultry Science2012，91，6： | 1 |
| 5 | Road transport of cattle, swine and poultry in North America and its impact on animal welfare, carcass and meat quality: a review显示文摘 | SCHWARTZKOPF-GENSWE1N K S FAUCITANO L DADGAR S | 2012 | Meat Science2012，92，3： | 1 |
| 6 | Inhibition of HIV-1 virus replication using small soluble Tat peptides显示文摘 | AGBOTTAH E ZHANG N DADGAR S | 2006 | Virology2006，345，2： | 1 |
| 7 | Laser-interference lithography tailored for highly symmetrically arranged Zn0 nanowire arrays显示文摘 | Kim D S Ji R Fan H J Bertram F Scholz R Dadgar A Nielsch K Krost A Christen J.Gosele U Zacharias M | | 0，，01： | 1 |
| 8 | Effects of high sugar diets on renal fluid,electrolyte and mineral han-dling in rats:Relationship to blood pressure显示文摘 | Preuss H G Memon S Dadgar A | | 0，，01： | 1 |
| 9 | Inhibition of HIV-1 virus replication using small soluble Tat peptides 显示文摘 | Agbottah E Zhang N Dadgar S et ai | 2006 | Viroiogy2006，345，： | 1 |
| 10 | Road transport of cattle,swine and poultry in North America and its impact on animal welfare,carcass and meat quality:A review显示文摘 | Schwartzkopf-Genswein K S Faucitano L Dadgar S et a/ | 2012 | Meat science2012，92，3： | 1 |
| 11 | Laser-interference lithography tailored for highly symmetrically arranged ZnO nanowire arrays显示文摘 | Kim D S Ji R Fan H J Bertram F Scholz R Dadgar A Nielsch K Krost A Christen J G(o)sele U Zacharias M | | 0，，01： | 1 |
| 12 | Cathodoluminescenee of epitaxial GaN and ZnO thin films for scintillator appli- cations 显示文摘 | Schenk H P D Borenstain S I Berezin A Schon A Cheifetz E Dadgar A Krost A | 2009 | Journal of Crystal Growth2009，311，16： | 1 |
| 13 | Broiler chicken thigh and breast muscle responses to cold stress during simulated trans- port before slaughter显示文摘 | Dadgar S Crowe T G Classen H L | 2012 | Poultry Science2012，91，6： | 1 |
| 14 | Road transport of cattle, swine and poultry in North America and its impact on animal welfare, carcass and meat quality: A review显示文摘 | Schwartzkopf-Genswein K Faucitano L Dadgar S | 2012 | Meat science2012，92，3： | 1 |
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