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| 1 | 大气二氧化氮与每日总死亡率、心血管和呼吸系统疾病死亡率的短期关联:398个城市的多中心分析显示文摘目的:采用统一的分析方案,评估全球多个国家/地区的二氧化氮(NO_(2))与总死亡率、心血管和呼吸系统疾病死亡率之间的短期关联。研究设计:采用两阶段的时间序列分析方法、过度离散的广义线性模型和多水平meta分析。研究地点:22个低到高收入国家/地区的398个城市。主要结局指标:1973—2018年逐日总死亡人数(6280万人)、心血管疾病死亡人数(1970万人)和呼吸系统疾病死亡人数(550万人)。结果:平均而言,NO_(2)浓度在滞后1天(前1天)每增加10μg/m^(3),会导致总死亡率、心血管和呼吸系统疾病死亡率分别增加0.46%(95%可信区间0.36%~0.57%)、0.37%(0.22%~0.51%)、0.47%(0.21%~0.72%)。在对共污染物(PM_(10)、PM_(2.5)、臭氧、二氧化硫和一氧化碳)进行调整后,这些关联仍然很稳定。所有3种死因的暴露-反应曲线几乎是线性的,没有明显的阈值。在398个城市中,可归因于高过假定零水平的NO_(2)浓度造成的死亡比例为1.23%(95%可信区间0.96%~1.51%)。结论:这项多中心研究提供了关于NO_(2)短期暴露与总死亡率、心血管和呼吸系统死亡风险之间的独立和线性关联的关键证据,说明通过加强NO_(2)的控制和监管限制标准,可获得人群水平的健康收益。 | 孟夏 刘聪(校) 陈仁杰 郑湃(译) 阚海东(校) Francesco Sera Ana Vicedo-Cabrera Ai Milojevic Maria Guo Yuming Tong Shilu Micheline de Sousa Zanotti Stagliorio Coelh Paulo Hilario Nascimento Saldiva Eric Lavigne Patricia Matus Correa Nicolas Valdes Ortega Samuel Osorio Garcia Jan Kysely Ales Urban Hans Orru Marek Maasikmets Jouni J K Jaakkola Niilo Ryti Veronika Huber Alexandra Schneider Klea Katsouyanni Antonis Analitis Masahiro Hashizume Yasushi Honda Chris Fook Sheng Ng Baltazar Nunes João Paulo Teixeira Iulian Horia Holobaca Simona Fratianni Ho Kim Aurelio Tobias Carmeníniguez Bertil Forsberg ChristoferÅström Martina S Ragettli Yue-Liang Leon Guo Shih-Chun Pan Shanshan Li Michelle L Bell Antonella Zanobetti Joel Schwartz Tangchun Wu Antonio Gasparrini | 2021 | 英国医学杂志中文版2021，24，8： | 7 |
| 2 | Axitinib plus gemcitabine versus placebo plus gemcitabine in patients with advanced pancreatic adenocarcinoma: a double-blind randomised phase 3 study显示文摘 | Hedy L Kindler Tatsuya Ioka Dirk J Richel Jaafar Bennouna Richard Létourneau Takuji Okusaka Akihiro Funakoshi Junji Furuse Young Suk Park Shinichi Ohkawa Gregory M Springett Harpreet S Wasan Peter C Trask Paul Bycott Alejandro D Ricart Sinil Kim Eric Van | 2011 | Lancet Oncology2011，，3： | 4 |
| 3 | Radiation exposure from CT scans in childhood and subsequent risk of leukaemia and brain tumours: a retrospective cohort study显示文摘 | Mark S Pearce Jane A Salotti Mark P Little Kieran McHugh Choonsik Lee Kwang Pyo Kim Nicola L Howe Cecile M Ronckers Preetha Rajaraman Alan W Craft Louise Parker Amy Berrington de González | 2012 | The Lancet . 2012 (9840)2012，，： | 3 |
| 4 | Macrodiversity power control in hierarchical CDMA cellular systems显示文摘 | KIM J Y GORDON L S IAN F A | 2001 | IEEE Journal on Selected Areas in Commun2001，19，2： | 2 |
| 5 | Successful orthotopic liver transplanation forl amivudine-associated YMDD mutant hepatitis B virus显示文摘 | SAAB S KIM M WRIGHT T L | 2000 | Gastroenterology2000，119，5： | 2 |
| 6 | Low-copy plasmids can perform as weU as or better than high-copy plasmids for metabolic engineering of bacteria 显示文摘 | Jones K L Kim S W Keasling J D | 2000 | Metabolic Engineering2000，2，： | 1 |
| 7 | A novel transcription factor, T- bet, directs Thl lineage commitement显示文摘 | SZABO S J KIM S T COSTA G L | 2000 | Cell2000，100，6： | 1 |
| 8 | A transforming growth factor-beta receptor type Ⅱgene mutation common in colon and gastric but rare in endometrial cancer with microsatellite instability显示文摘 | PARSON S R KIM S J | 1995 | Cancer Res1995，55，23： | 1 |
| 9 | Inactivation of DFR (Dihydroflavonol 4-reductase) gene transcription results in blockage of anthocyanin production in yellow onions (Allium cepa)显示文摘 | KIM S G BINZEL M L PARK S H YOO K S PIKE L M | 2004 | Molecular Breeding2004，14，： | 1 |
| 10 | Efficacy and safety of sorafenib in patients in the Asia Pacific region with advanced hepatocellular carcinoma: a phase Ⅲ randomised,double-blind, placebo controlled trial显示文摘 | Cheng A L Kang Y K Chen Z Tsao C J Qin S Kim J S | 2009 | Lancet Oncol2009，10，： | 1 |
| 11 | Isolation and characterization of collagen from brown backed toadfish (Lagocephalus gloveri) skin显示文摘 | SENARATNE L S PARK P J KIM S K | 2006 | Bioresource Technology2006，97，： | 1 |
| 12 | A TGF-β receptor type Ⅱ gene mutation common in colon and gastric but rare in endometrial cancers with microsatel- lite instability显示文摘 | MYEROFF L PARSONS R KIM S J | 1995 | Cancer Res1995，55，： | 1 |
| 13 | Estimating Corn Leaf Chlorophyll Concentration from Leaf and Canopy Reflectance 显示文摘 | Daughtry C S T Wahhall C L Kim M S | 2000 | Remote Sensing of Environment2000，74，2： | 1 |
| 14 | Pituitary tumor transforming gene regulates multiple downstream angiogenic genes in thyroid cancer显示文摘 | KIM D S FRANKLYN J A STRATFORD A L | 2006 | J Clin Endocrinol Metab2006，91，3： | 1 |
| 15 | Safety and accuracy of bedside external ventricular drain placement 显示文摘 | Kakarla U K Kim L J Chang S W | 2008 | Neurosurgery2008，63，11： | 1 |
| 16 | Estimating corn leaf chlorophyll concentration from leaf and canopy reflectanc显示文摘 | Daughtry C S T Walthall C L Kim M S | 2000 | Remote Sens Environ2000，74，： | 1 |
| 17 | 5-HT2A receptor gene promoter polymorphism -1438A/G and bipolar disorder显示文摘 | Chee I S Lee S W Kim J L | 2001 | Psychiatr Genet2001，11，： | 1 |
| 18 | Mitochondrial permeability transition: a common pathway to necrosis and apoptosis显示文摘 | Kim J S He L Lemasters J J | 2003 | Biochem Biophys Res Commun2003，304，3： | 1 |
| 19 | TLR4 expression in cardiac myocytes in normal and failing myocardium显示文摘 | Frantz S kobzik L Kim Y | 1999 | J Clin Invest1999，104，： | 1 |
| 20 | Structure-antitumor and hemolytic activity relationships of synthetic peptides derived from cecropin A-magainin 2 and cecropin A-melittin hybrid peptides显示文摘 | Shin S Y Lee M K Kim K L | 1997 | J Pept Res1997，50，4： | 1 |
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