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| 1 | 帕博利珠单抗治疗伴脑转移NSCLC患者的一项非随机、开放Ⅱ期试验的长期随访结果和生物标志物分析显示文摘背景与目的我们开展了一项帕博利珠单抗用于伴未治疗脑转移的非小细胞肺癌(non-small cell lung cancer,NSCLC)或黑色素瘤患者的疗效和安全性的II期试验,旨在评估程序性死亡受体1(programmed cell death 1,PD-1)抑制剂在中枢神经系统(central nervous system,CNS)中的疗效。中期结果已发表,现报道对NSCLC队列的更新分析结果。方法这是一项开放性、单中心、II期试验。纳入标准:年龄≥18岁,诊断为晚期NSCLC并伴有≥1个5 mm-20 mm脑转移病灶,既往从未治疗或之前放疗后进展,无神经系统症状,不需要激素治疗且美国东部肿瘤协作组(Eastern Cooperative Oncology Group,ECOG)<2分。患者每2周接受一次帕博利珠单抗(10 mg/kg)治疗。队列1为程序性死亡配体1(programmed cell death ligand 1,PD-L1)≥1%的患者,队列2为PD-L1<1%或未评估的患者。主要终点是脑转移患者缓解比例。所有经治患者均纳入疗效与安全性终点的分析。该研究已结束入组,并于Clinicaltrials.gov登记注册,注册号为NCT02085070。结果2014年3月31日-2018年5月21日,共42例患者接受治疗。中位随访时间为8.3个月(IQR:4.5个月-26.2个月)。队列1的37例患者中11例有脑转移缓解[29.7%(95%CI:15.9%-47.0%)]。队列2未观察到缓解。治疗相关的3级-4级不良事件(adverse events,AEs)包括2例肺炎、1例全身症状、1例结肠炎、1例肾上腺皮质功能不全、1例高血糖症和1例低钾血症。6例(14%)患者发生了治疗相关的严重不良事件,包括肺炎、急性肾损伤、低钾血症和肾上腺皮质功能不全。没有观察到治疗相关死亡病例。结论帕博利珠单抗治疗PD-L1≥1%的NSCLC伴脑转移患者有效,且对所有纳入的未经治疗的脑转移患者安全。需要进一步探索免疫治疗用于NSCLC合并CNS转移。 | Sarah B GOLDBERG Kurt A SCHALPER Scott N GETTINGER Amit MAHAJAN Roy S HERBST Anne C CHANG Rogerio LILENBAUM Frederick H WILSON Sacit Bulent OMAY James B YU Lucia JILAVEANU Thuy TRAN Kira PAVLIK Elin ROWEN Heather GERRSH Annette KOMLO Richa GUPTA Hailey WYATT Matthew RIBEIRO Yuval KLUGER Geyu ZHOU Wei WEI Veronica L CHANG Harriet M KLUGER 董晓荣(翻译/校对) | 2021 | 中国肺癌杂志2021，24，9： | 34 |
| 2 | Polymorphisms of MTHFD,plasma homocysteine levels, and risk of gastric cancer in ahigh-risk Chinese population显示文摘Purpose:Accumulative evidence suggests that folate has a protective effect on gastric cancer. The methylenetetrahyd-rofolate dlehydrogenase(MTHFD) plays an important role in folate and homocysteine metabolisms, and polymorphisms of MTHFD may result in disturbance of the folate-mediated homocysteine pathway. The aim of this study is to test the hypothesis that genetic variants of MTHFD and plasma homocysteine levels are associated with risk of gastric cancer and modulated by genotypes of methylenetetrahydrofolate reductase(MTHFR). Experimental Design: We genotyped G1958A and T401C in MTHFD and C677T in MTHFR and detected total plasma homocysteine(tHcy) levels in a case-control study of 589 gastric cancer cases and 635 cancer-free controls in a high-risk Chinese population. Results:The variant genotypes of MTHFD 1958AA and 401CC were associated with a significantly increased risk of gastric canceradjusted odds ratio(OR), 2.05; 95% confidence interval(95% CI),1.34-3.13 for 1958AA; adjusted OR,1.43; 95% CI,1.14-1.80 for 401CC compared with 1958GG/GA and 401TT/TC genotypes, respectively. Both of the effects were more evident in the subjects carrying MTHFR 677CT/TT genotypes. The average tHcy level was significantly higher in gastric cancer cases than in controls(P < 0.01), and the upper quartile of tHcy (> 13.6 mu mol/L) was associated with an 82% significantly increased risk of gastric cancer, compared with the lowest quartile of tHcy(<= 8.0 pmol/L;adjusted OR,1.82; 95% CI,1.20-2.75). Conclusions:The strong associations between MTHFD variants and the plasma tHcy levels and gastric cancer risk suggest, for the first time, a possible gene-environment interaction between genetic variants of folate-metabolizing genes and high tHcy levels in gastric carcinogenesis. | Wang, L. N Ke, Q Chen, W. S Wang, J. M Tan, Y. F Zhou, Y Hua, Z. L Ding, W. L Niu, J. Y Shen, J Zhang, Z. F Wang, X. R Xu, Y. H Shen, H. B Yi Xing | 2007 | 南京医科大学学报(自然科学版)2007，27，7： | 10 |
| 3 | Genetic transformation of wheat mediated by Agrobacterium tumefaciens显示文摘 | Cheng M Fry J E Pang S Zhou H Hironaka C M Duncan D R Conner T W Wan Y | 1997 | Plant Physiol1997，，： | 2 |
| 4 | Corner-Cube Retroreflectors based on Structure-Assisted Assembly for Free-Space Optical Communication显示文摘 | Lixia Zhou Joseph M Kahn Dristofer S J Pister | 2003 | Journal of Microelectromechanical Systems2003，12，3： | 2 |
| 5 | A simple and sensitive resonance scattering spectral method for determination of hydroxyl radical in Fenton system using rhodamineS and its application to screening the antioxidant显示文摘 | Liang A H Zhou S M Jiang Z L | 2006 | Talanta2006，70，： | 1 |
| 6 | Polyamide thin film composite membrane prepared from m-phenylenediamine and m-phenylenediamine-5-sulfonic acid 显示文摘 | Zhou Y Yu S C Liu M H | 2006 | Journal of Membrane Science2006，270，12： | 1 |
| 7 | Soil heavy-metal distribution and transference to soybeans surrounding an etectroplating factory显示文摘 | Hans X S Wang H Y Zhou J M | 2010 | Acta Asriculturae Scandinavica Section B-Soil & Plant Science2010，160，： | 1 |
| 8 | Long-term subthreshold electrical stimulation of the left stellate ganglion and a canine model of sudden cardiac death 显示文摘 | Swissa M Zhou S Gonzalez GI | 2004 | J Am Coll Cardiol2004，43，： | 1 |
| 9 | The detection and quantification of retinopathy using digital angiograms 显示文摘 | ZHOU L RZESZOTARSKI M S SINGERMAN L J | 1994 | IEEE Transactions on Medical Imaging1994，13，4： | 1 |
| 10 | Effects of Zn-complexes on zinc uptake by wheat(Triticum aestivttm) roots:A comprehensive consideration of physical, chemical and biological processes on bio-uptake显示文摘 | Wang P Zhou D M Luo X S | 2009 | Plant Soil2009，316，： | 1 |
| 11 | Correlation betw een myopia and major biometric parameters of the eye:a retrospective clinical study显示文摘 | Xie R Zhou XT Lu F Chen M Xue A Chen S | 2009 | Optom Vis Sci2009，86，5： | 1 |
| 12 | Nitrogen transformations and balance in a constructed wetland for nutrient-polluted river water treatment using forage rice in Japan 显示文摘 | ZHOU S HOSOMI M | 2008 | Ecological Engineering2008，32，2： | 1 |
| 13 | Molecular chain movements and transitions of SEBS above room temperature studied by move- window two-dimensional correlation infrared spectroscopy 显示文摘 | Zhou T Zhang A M Zhao C S | 2007 | Macromoleeules2007，40，25： | 1 |
| 14 | Antigen synthetic strategy and immunoassay development for detection of acrylamide in foods 显示文摘 | Zhou S Zhang C Wang D Zhao M P | 2008 | Analyst2008，133，： | 1 |
| 15 | Variations in satellitederivedphenology in China's temperate vegetation显示文摘 | Piao S L Fang J Y Zhou L M | | 0，，： | 1 |
| 16 | Stimulation of stellate cells by injured acinar cells : a model of acute pancreatitis in- duced by alcohol and fat (VLDL) 显示文摘 | SIECH M ZHOU Z ZHOU S | 2009 | Am J Physiol Gas- trointest Liver Physiol2009，297，6： | 1 |
| 17 | IrrE, a global regulator of extreme radiation resistance inDeinococcus radiodurans, enhances salt tolerance in Escherichia coli and Brassica napus显示文摘 | Pan J Wang J Zhou Z Yan Y Zhang W Lu W Ping S Dai Q Yuan M Feng B Hou X Zhang Y Ma R Liu T Feng L Wang L Chen M Lin M | 2009 | PloS One2009，4，2： | 1 |
| 18 | Reduction of voltage gated sodium channelprotein in DRG by vector mediated miRNA reduces pain in rats with painful diabetic neuropathy 显示文摘 | Chattopadhyay M Zhou Z Hao S Mata M Fink D J | 2012 | Mol Pain2012，8，： | 1 |
| 19 | Interannual variations of monthly and seasonal normalized difference vegetation index(NDVI) in China from 1982 to 1999显示文摘 | Piao S L Fang J Y Zhou L M | 2003 | Journal of Geophysical Research2003，108，14： | 1 |
| 20 | Collaborative filtering with diffusion-based similarity on tripartite graphs显示文摘 | Shang M S Zhang Z K Zhou T | 2010 | Physi- ca A: Statistical Mechanics and Its Applications2010，389，6： | 1 |
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