|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | An epigenomic approach to therapy for tamoxifen-resistant breast cancer显示文摘Tamoxifen 是为雌激素受体 alpha 的前线治疗(ERα) 在绝经前的女人的积极的胸肿瘤。然而,到 tamoxifen 的抵抗发生在许多病人。嗯仍然与获得的 tamoxifen 抵抗在乳癌房间的生长起一个关键作用,建议那 ERα为治疗仍然是一个有效目标 tamoxifen 抵抗(Tam-R ) 乳癌。以识别 ERα 的新奇管理者;发信号,通过对 histone 甲基修饰词的一幅小规模的 siRNA 屏幕,我们发现了 WHSC1, histone H3K36 methyltransferase, ERα 的一个积极管理者;在乳癌房间发信号。我们证明 WHSC1 被招募到 ERα由 BET 蛋白质 BRD3/4 的基因,并且便于 ERα基因表示。小分子的赌注蛋白质禁止者 JQ1 potently 压制了经典 ERα发信号的小径和在文化的 Tam-R 乳癌房间的生长。用一个 Tam-R 乳癌异种皮移植老鼠模型,我们与 JQ1 和 ER degrader fulvestrant 由 JQ1 和联合治疗的强壮的长持续的效果在 vivo 反胸癌症活动示威了。一起拿,我们提供 epigenomic 蛋白质 BRD3/4 和 WHSC1 是雌激素受体发信号的必要管理者并且是为 Tam-R 乳癌的治疗的新奇治疗学的目标的证据。 | Qin Feng Zheng Zhang Martin J Shea Chad J Creighton Cristian Coarfa Susan G Hilsenbeck Rainer Lanz Bin He Lei Wang Xiaoyong Fu Agostina Nardone Yongcheng Song James Bradner Nicholas Mitsiades Constantine S Mitsiades C Kent Osborne Rachel Schiff Bert W O'Malley | 2014 | Cell Research2014，24，7： | 10 |
| 2 | First performance evaluation of a dual-source CT (DSCT) system显示文摘 | Thomas G. Flohr Cynthia H. McCollough Herbert Bruder Martin Petersilka Klaus Gruber Christoph Sü? Michael Grasruck Karl Stierstorfer Bernhard Krauss Rainer Raupach Andrew N. Primak Axel Küttner Stefan Achenbach Christoph Becker Andreas Kopp Bernd M. Ohnes | 2006 | European Radiology2006，，6： | 3 |
| 3 | Preoperative chemoradiotherapy and postoperative chemotherapy with fluorouracil and oxaliplatin versus fluorouracil alone in locally advanced rectal cancer: initial results of the German CAO/ARO/AIO-04 randomised phase 3 trial显示文摘 | Claus R?del Torsten Liersch Heinz Becker Rainer Fietkau Werner Hohenberger Torsten Hothorn Ullrich Graeven Dirk Arnold Marga Lang-Welzenbach Hans-Rudolf Raab Heiko Sülberg Christian Wittekind Sergej Potapov Ludger Staib Clemens Hess Karin Weigang-K?hler G | 2012 | Lancet Oncology2012，，7： | 2 |
| 4 | Product configuration frameworks-a survey显示文摘 | DANIEL S RAINER W | 1998 | IEEE Expert1998，，78： | 1 |
| 5 | The influence of EDDS on the uptake of heavy metal in hydroponically grown sunflowers显示文摘 | Susan T Rainer S Bemd N | 2006 | Chemosphere2006，62，： | 1 |
| 6 | Discovering functional gene expression patterns in the metabolic network of Escherichia coli with wavelets transforms 显示文摘 | RAINER K GUNNAR S MARCUS O | 2006 | BMC Bioinformatics2006，7，： | 1 |
| 7 | Congenital Anomalies of the Coronary Arteries:Imaging with Ckontrastenhanced,Multidetector computed Tomography显示文摘 | Rainer S Steffen F Juergen B | 2005 | Eur Radiol2005，15，6： | 1 |
| 8 | Expression of indoleamine 2, 3- dioxygenase in tumor endothelial cells correlates with Long-term survival of patients with renal cell carcinoma 显示文摘 | Rainer R Christoph W Oliver S | 2007 | Clin Cancer Res2007，13，23： | 1 |
| 9 | Scientists'Transition to Academic Entrepreneurship显示文摘 | MAXIMILIAN G MART1N O RAINER K S | 2012 | Economic and Psychological Determinants2012，，7： | 1 |
| 10 | Differential Evolution - A Simple and Efficient Heuristic for Global Optimization Over Continuous Spaces显示文摘 | S Rainer K Price | 1997 | J of Global Optimization1997，11，4： | 1 |
| 11 | Cardiac fibrosis in human transplanted hearts is mainly driven by cells of intracardiac origin 显示文摘 | Piehler M Rainer P P Schauer S | 2012 | J Am Coil Cardiol2012，59，11： | 1 |
| 12 | Column extraction of heavy metals from soils using biodegradable chelating agent EDDS显示文摘 | Lukas H Susan T Rainer S | 2005 | Environ Sci Technol2005，39，17： | 1 |
| 13 | Deletion screening of the Duchenne muscular dystrophy locus via multiplex DNA am- plification 显示文摘 | Chamberlain J S Gibbs R A Rainer J E | 1988 | Nucleic Acids Res1988，16，11： | 1 |
| 14 | First performance evaluation of a dual-source CT (DSCT) system显示文摘 | Thomas G. Flohr Cynthia H. McCollough Herbert Bruder Martin Petersilka Klaus Gruber Christoph Süβ Michael Grasruck Karl Stierstorfer Bernhard Krauss Rainer Raupach Andrew N. Primak Axel Küttner Stefan Achenbach Christoph Becker Andreas Kopp Bernd M. Ohnes | 2006 | European Radiology2006，，2： | 1 |
| 15 | Transcrip- tion analysis of arabidopsis membrane transporters and hormone pathways during developmental and induced leaf senescence 显示文摘 | Graaff V D G Rainer S Ania S | 2006 | Plant Physiology2006，141，2： | 1 |
| 16 | Assessment of optic disk blood flow in patients with open-angle glaucoma显示文摘 | Findl O Rainer G Dallinger S | 2000 | Am J Ophthalmol2000，130，5： | 1 |
| 17 | Inducible expression of tissue factor in small-cell lung cancer:impact on morphology and matrix met alloproteinase secretion显示文摘 | NICOLE H MARGARETHE II RAINER S | 2012 | Canner Res Clin Onca12012，138，4： | 1 |
| 18 | Differential Evolution-A Simple and Efficient Heuristic for Global Optimization over Continuous Spaces 显示文摘 | Rainer S Price K | 1997 | Journal of Global Optimization (S0925-5001 )1997，11，4： | 1 |
| 19 | Coronary Microembolization 显示文摘 | Rainer S Dietrich B | 2001 | Progress In Cardiovascular Dieases2001，44，： | 1 |
| 20 | Polymeric surfactants from styrene - co - maleic - anhydride copolymers 显示文摘 | DIETRICH B RAINER S GOETZ P | 2001 | Macromolecular Symposia2001，163，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员