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| 1 | Adenovirus-mediated gene delivery:Potential applications for gene and cell-based therapies in the new era of personalized medicine显示文摘With rapid advances in understanding molecular pathogenesis of human diseases in the era of genome sciences and systems biology,it is anticipated that increasing numbers of therapeutic genes or targets will become available for targeted therapies.Despite numerous setbacks,efficacious gene and/or cell-based therapies still hold the great promise to revolutionize the clinical management of human diseases.It is wildly recognized that poor gene delivery is the limiting factor for most in vivo gene therapies.There has been a long-lasting interest in using viral vectors,especially adenoviral vectors,to deliver therapeutic genes for the past two decades.Among all currently available viral vectors,adenovirus is the most efficient gene delivery system in a broad range of cell and tissue types.The applications of adenoviral vectors in gene delivery have greatly increased in number and efficiency since their initial development.In fact,among over 2000 gene therapy clinical trials approved worldwide since 1989,a significant portion of the trials have utilized adenoviral vectors.This review aims to provide a comprehensive overview on the characteristics of adenoviral vectors,including adenoviral biology,approaches to engineering adenoviral vectors,and their applications in clinical and preclinical studies with an emphasis in the areas of cancer treatment,vaccination and regenerative medicine.Current challenges and future directions regarding the use of adenoviral vectors are also discussed.It is expected that the continued improvements in adenoviral vectors should provide great opportunities for cell and gene therapies to live up to its enormous potential in personalized medicine. | Cody S.Lee Elliot S.Bishop Ruyi Zhang Xinyi Yu Evan M.Farina Shujuan Yan Chen Zhao Zongyue Zeng Yi Shu Xingye Wu Jiayan Lei Yasha Li Wenwen Zhang Chao Yang Ke Wu Ying Wu Sherwin Ho Aravind Athiviraham Michael J.Lee Jennifer Moriatis Wolf Russell R.Reid Tong-Chuan He | 2017 | Genes & Diseases2017，4，2： | 19 |
| 2 | 光动力疗法辅助龈下刮治和根面平整对不同性别牙周病病人的疗效观察显示文摘目的:以随机化、控制性、盲法设计分析一种新型光动力疗法治疗牙周疾病病人时存在的潜行性的性别差异。方法:本研究经伦理委员会同意后,入选45例病人(每位病人至少有4个以上≥5mm的牙周袋并分布在两个以上区域内)。所有病人在接受基础检查、龈下刮治和根面平整(subgingival scaling and rootplanning)治疗后,随机分为3组,其中A组在SRP之后接受一次PERIOWAVE光动力治疗,B组在SRP后接受一次PERIOWAVE治疗以及在6周后再一次接受激光治疗,而C组仅接受SRP治疗。在6周以及12周来访中检查牙周袋深度、附着丧失,以Mann-Whitney秩和检验分析疗效的性别差异。结果:SRP组、A组均为8位男性7位女性,B组为7位男性8位女性。在6周、12周时,各组CAL均增加>1.1mm,6周时CAL增加无明显差异,然而12周时B组男性CAL平均增加2.06mm,明显高于女性组(1.61mm)(P=0.031),与女性组相比,接受两次激光治疗的男性CAL增加27.4%。结论:在本研究条件下,牙周袋深度≥5mm的男性牙周炎病人在接受两次光动力治疗后CAL增加超过女性病人27.4%。 | 王莹 林芝 张秀华 丁熙 陈宏 朱形好 王靖虓 李一鸣 S.LEE J.KIM 邓辉 | 2008 | 牙体牙髓牙周病学杂志2008，18，1： | 6 |
| 3 | 中草药牙膏对变形链球菌抑制作用的实验研究显示文摘目的:评估5种国产中草药牙膏对变形链球菌(S.mutants)的抑制作用。方法:运用扩散法来评估5种国产中草药牙膏——美加净复合中草药牙膏(MAX)、洁银中药牙膏(JY)、田七特效中药牙膏(TQ)、中华中草药牙膏(ZH)、高露洁草本美白牙膏(ColgateH)对口腔变形链球菌的抑菌作用。结果:阳性对照组对变形链球菌产生明显抑菌区域,而阴性对照组未见产生抑菌区域。5种国产中草药牙膏对变形链球菌均有明显的抑菌作用。膏状状态下的抑菌区域比稀释状态下有显著的增大(P<0.05)。结论:5种国产中草药牙膏对变形链球菌均有明显的抑菌作用。目的:评估5种国产中草药牙膏对变形链球菌(S.mutants)的抑制作用。方法:运用扩散法来评估5种国产中草药牙膏——美加净复合中草药牙膏(MAX)、洁银中药牙膏(JY)、田七特效中药牙膏(TQ)、中华中草药牙膏(ZH)、高露洁草本美白牙膏(ColgateH)对口腔变形链球菌的抑菌作用。结果:阳性对照组对变形链球菌产生明显抑菌区域,而阴性对照组未见产生抑菌区域。5种国产中草药牙膏对变形链球菌均有明显的抑菌作用。膏状状态下的抑菌区域比稀释状态下有显著的增大(P<0.05)。结论:5种国产中草药牙膏对变形链球菌均有明显的抑菌作用。 | 陈宏 丁熙 王莹 W.ZHANG Y.LI S.LEE | 2008 | 实用医学杂志2008，24，6： | 5 |
| 4 | Accuracy of Diagnostic Tests for Helicobacter pylori in Patients with Peptic Ulcer Bleeding显示文摘 | Yoon J.Choi NayoungKim JihwanLim So Y.Jo Cheol M.Shin Hye S.Lee Sang H.Lee Young S.Park Jin‐HyeokHwang Jin‐WookKim Sook‐HyangJeong Dong H.Lee Hyun C.Jung | 2012 | Helicobacter2012，，2： | 4 |
| 5 | The effect of acute aerobic exercise on central arterial stiffness,wave reflections,and hemodynamics in adults with diabetes:A randomized cross-over design显示文摘Background:Individuals with diabetes have greater central arterial stiffness,wave reflections,and hemodynamics,all of which promote the accelerated cardiovascular pathology seen in this population.Acute aerobic exercise has been shown to be an effective strategy for reducing central arterial stiffness,wave reflections,and hemodynamics in healthy individuals;however,the effects of acute aerobic exercise in reducing these outcomes is not well established in people with diabetes.Recently,implementation of high-intensity interval exercise(HIIE)has shown superior improvements in cardiovascular health outcomes when compared to traditional aerobic exercise.Yet,the effect of HIIE on the aforementioned outcomes in people with diabetes is not known.The purpose of this study was to(i)describe the central arterial stiffness,wave reflections,and hemodynamic responses to a bout of HIIE and moderate-intensity continuous exercise(MICE)in adults with diabetes;and(ii)compare the effects of HIIE and MICE on the aforementioned outcomes.Methods:A total of 24 adult men and women(aged 29-59 years old)with type 1(n=12)and type 2(n=12)diabetes participated in a randomized cross-over study.All participants completed the following protocols:(i)HIIE:cycling for 4×4 min at 85%-95%of heart rate peak(HR_(peak)),interspersed with 3 min of active recovery at 60%-70%HR_(peak);(ii)MICE:33 min of continuous cycling at 60%-70%HR_(peak);and(iii)control(CON):lying quietly in a supine position for 30 min.Results:A significant group￡time effect was found for changes in central systolic blood pressure(F=3.20,p=0.01)with a transient reduction for the HIIE group but not for the MICE or CON groups.There was a significant group￡time effect for changes in augmentation index at a heart rate of 75 beats/min(F=2.32,p=0.04)with a decrease following for HIIE and MICE but not for CON.For all other measures of central arterial stiffness and hemodynamics,no significant changes were observed(p>0.05).Conclusion:A bout of HIIE appears to lead to a greater transient reduction in central systolic blood pressure than the reduction observed following MICE;however,both HIIE and MICE improved augmentation index at a heart rate of 75 beats/min in people with diabetes.There was no significant difference in response to HIIE and MICE in all outcomes.This provides preliminary evidence on the role of HIIE on such outcomes in people with diabetes. | Kimberley L.Way Angela S.Lee Stephen M.Twigg Nathan A.Johnson | 2021 | Journal of Sport and Health Science2021，10，4： | 4 |
| 6 | Prognostic markers in triple‐negative breast cancer显示文摘 | Emad A.Rakha Maysa E.El‐Sayed Andrew R.Green Andrew H. S.Lee John F.Robertson Ian O.Ellis | 2006 | Cancer2006，，1： | 4 |
| 7 | 全球聚酯产业链的最新发展显示文摘2019年,聚酯产业链充满挑战,不得不面对整个产业链上不同程度的产能过剩问题。此外,由于上游工序压缩成本,导致价格螺旋式上升,因而利润率受到挤压甚至基本没有利润。全球经济形势进一步挑战了经历艰难一年的市场参与者的极限。然而,供应链的恢复力——尤其是聚酯行业供应链的恢复力值得关注。不仅聚酯产量没有大幅下降,中国还引领全球聚酯在下游市场取得了令人信服的成绩。在低迷的经济形势下,这给市场参与者带来了一线希望,那就是2020年可能不会像之前担心的那样糟糕。 | S.Lee 宋清泉(译) 于俊荣(校) | 2020 | 国际纺织导报2020，48，11： | 4 |
| 8 | Refractory ascites: pathogenesis, definition and therapy of a severe complication in patients with cirrhosis显示文摘 | FrancescoSalerno MonicaGuevara MauroBernardi RichardMoreau FlorenceWong PaoloAngeli GuadalupeGarcia‐Tsao Samuel S.Lee | 2010 | Liver International2010，，7： | 3 |
| 9 | Prognostic markers in triple‐negative breast cancer显示文摘 | Emad A.Rakha Maysa E.El‐Sayed Andrew R.Green Andrew H. S.Lee John F.Robertson Ian O.Ellis | 2006 | Cancer2006，，1： | 2 |
| 10 | Lifetime prevalence of suicide ideation, plan, and attempt in metropolitan China显示文摘 | S.Lee S. C.Fung A.Tsang Z. R.Liu Y. Q.Huang Y. L.He M. Y.Zhang Y. C.Shen M. K.Nock R. C.Kessler | 2007 | Acta Psychiatrica Scandinavica2007，，6： | 2 |
| 11 | High Viremia, Prolonged Lamivudine Therapy and Recurrent Hepatocellular Carcinoma Predict Posttransplant Hepatitis B Recurrence显示文摘 | J.Chun W.Kim B. G.Kim K. L.Lee K.‐S.Suh N.‐J.Yi K. U.Park Y. J.Kim J.‐H.Yoon H. S.Lee | 2010 | American Journal of Transplantation2010，，7： | 2 |
| 12 | Containment of herbicide resistance through genetic engineering of the chloroplast genome显示文摘 | Daniell H Datta R Varma S Gray S.Lee S.B | | 0，，： | 1 |
| 13 | Q‐Chem 2.0: a high‐performance ab initio electronic structure program package显示文摘 | JingKong Christopher A.White Anna I.Krylov DavidSherrill Ross D.Adamson Thomas R.Furlani Michael S.Lee Aaron M.Lee Steven R.Gwaltney Terry R.Adams ChristianOchsenfeld Andrew T. B.Gilbert Gary S.Kedziora Vitaly A.Rassolov David R.Maurice NikhilNair YihanSh | 2000 | J Comput Chem2000，，16： | 1 |
| 14 | Projectile Fragmentation in ^(20)Ne-^(165)Ho Reaction at 45 MeV/u | G.X.Dai J.B.Natowitz R.Wada K.Hagel Q.Z.Luo Z.Y.He J.Blackadar S.Lee J.T.Li Y.N.Lou D.Utley B.Xiao | 1995 | Chinese journal of nuclear physics1995，，3： | 1 |
| 15 | Abnormal cardiovascular reflex tests are predictors of mortality in Type 2 diabetes mellitus显示文摘 | H. S.Chen C. M.Hwu B. I.Kuo S. C.Chiang C. F.Kwok S. H.Lee Y. S.Lee M. J.Weih L. C.Hsiao S. H.Lin L. T.Ho | 2001 | Diabetic Medicine2001，，4： | 1 |
| 16 | Factors affecting the quality of life in patients with epilepsy in Seoul, South Korea显示文摘 | S.Choi‐Kwon C.Chung H.Kim S.Lee S.Yoon H.Kho J.Oh S.Lee | 2003 | Acta Neurologica Scandinavica2003，，6： | 1 |
| 17 | Using Building Information Modeling for Green Interior Simulations and Analyses显示文摘 | Young S.Lee | 2012 | Journal of Interior Design2012，，1： | 1 |
| 18 | Social connectedness,dysfunctional interpersonal behaviors,and psychological distress:Testing a mediator model显示文摘 | Lee R.M M.Draper S.Lee | | 0，，03： | 1 |
| 19 | Biochemical variations in the synaptic level of dopamine precede motor fluctuations in Parkinson’s disease: PET evidence of increased dopamine turnover显示文摘 | RaúlDe La Fuente‐Fernández Jian‐QiangLu VesnaSossi SalmaJivan MichaelSchulzer James E.Holden Chong S.Lee Thomas J.Ruth Donald B.Calne A. JonStoessl | 2001 | Ann Neurol2001，，： | 1 |
| 20 | Determinants of behavioral intention to mobile banking显示文摘 | Gu J S.Lee | | 0，，09： | 1 |
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