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| 1 | Microstructure,Tensile and Impact Toughness Properties of Friction Stir Welded Mild Steel显示文摘Microstructure,tensile and impact toughness properties and fracture location of friction stir welded AISI 1018 mild steel were revealed.The AISI 1018 mild steel plates with thickness of 5 mm were friction stir welded by tungsten based alloy tool with tool rotational speed of 1000 r/min and welding speed of 50 mm/min.Tensile strength of stir zone is higher(8%)compared to that of the base metal.This may be due to the formation of finer grains in the weld nugget region under the stirring action of the rotating tool.The ductility and impact toughness of the joints are decreased compared to those of the base metal owing to the inclusion of tungsten particles in the weld region. | A K Lakshminarayanan V Balasubramanian M Salahuddin | 2010 | Journal of Iron and Steel Research(International)2010，17，10： | 10 |
| 2 | 落叶松人工林下红皮云杉和青海云杉的幼苗更新显示文摘落叶松幼苗在其人工林内难以更新。为探讨红皮云杉和青海云杉幼苗是否具有在落叶松人工林内成功定植并替代落叶松更新的潜力,采用红皮云杉和青海云杉幼苗在不同落叶松人工林(样地Ⅰ:1 300株·hm^(-2)的平地,样地Ⅱ,660株·hm^(-2)的平地;样地Ⅲ,330株·hm^(-2)的平地;样地Ⅳ,660株·hm^(-2)的坡地)下进行人工更新。结果表明:1)样地Ⅰ和样地Ⅱ更适宜红皮云杉和青海云杉幼苗的存活,且同一样地内,红皮云杉幼苗的成活率均高于青海云杉的;2)同一样地内,红皮云杉幼苗的地上生物量均高于青海云杉的,并且在样地Ⅰ和样地Ⅱ红皮云杉的地上生物量显著高于青海云杉的;3)在不同落叶松人工林样地,红皮云杉和青海云杉幼苗的1级根均有较好的外生菌根侵染;4)红皮云杉幼苗的1级根直径受环境影响较大,而青海云杉幼苗的1级根皮层厚度受环境影响较大。同一样地内,2种云杉幼苗的1级根解剖结构除在样地Ⅳ表现出明显的差异外,在其它样地基本无显著差异。红皮云杉和青海云杉幼苗均适宜在落叶松人工林内存活,但相对高密度的林分更适宜云杉幼苗的生长,且红皮云杉比青海云杉更具生长优势。 | Salahuddin 董慧 及利 杨立学 | 2019 | 中南林业科技大学学报2019，39，3： | 6 |
| 3 | Molecular study of HCV detection,genotypes and their routes of transmission in North West Frontier Province,Pakistan显示文摘Objective:To determine hepatitis C virus(HCV) genotypes and explore the associated risk factors in chronic HCY patients.Methods:A total of 116 patients with chronic hepatitis C were subjected to polymerase chain reaction(PCR) based detection out of which 112 chronic HCV patients[53 male(47.32%),59 female(52.68%);mean age(43.76±16.40) years;mean BMI(23.8± 3.9)kg]were enrolled in this study.The frequency of 6 HCV genotypes and associated risk factors were evaluated from five districts of North West Frontier Province(NWFP).Results:Genotype 3was the most prevalent in 73 samples(65.17%) followed by genotype 1 in 24(21.42%) and genotype2 in 13(11.60%) samples.Genotype3 had significantly high prevalence(P=0.0002).The results showed that 48(42.85%) samples were infected with HCV 3a:25(22.32%) with 3b;14(12.50%) with 1a;10(8.92%)with 1b;11(9.82%) with 2a;2(1.78%) with 2b;and 2 were untypable.The distribution of HCV genotypes in Murdan.Charsadda,Peshawar.Sawabi and Nowshehra districts was different.Use of unsterile equipment lor medication,barbers and previous history of hospitalization were the main risk factors for HCV transmission.Conclusions:Cenotype 3a and 3b.1a.1b and 2a are the common genotypes in NWFP.Genotype 4.5.and 6 can not be found in a single sample.The level of awareness about various modes ot transmission of HCV among the population is found to be verv low. | Asher Zaman Safi Yasir Waheed Joharia Sadat Solat-Ul-Islam Sadia Salahuddin Umar Saeed Muhammad Ashraf | 2012 | Asian Pacific Journal of Tropical Biomedicine2012，2，7： | 5 |
| 4 | Structural and Functional Analysis of NS1 and NS2 Proteins of H1N1 Subtype显示文摘Influenza A virus (H1N1), a genetic reassortment of endemic strains of human, avian and swine flu, has crossed species barrier to human and apparently acquired the capability of human to human transmission. Some strains of H5N1 subtype are highly virulent because NS1 protein inhibits antiviral interferon α/β production. Another protein NS2 mediates export of viral ribonucleoprotein from nucleus to the cytoplasm through export signal. In this paper, we have studied structure-function relationships of these proteins of H1N1 subtype and have determined the cause of their pathogenicity. Our results showed that non-conservative mutations slightly stabilized or destabi- lized structural domains of NS1 or NS1-dsRNA complex, hence slightly increased or decreased the function of NS1 protein and consequently enhanced or reduced the pathogenicity of the H1N1 virus. NS2 protein of different strains carried non-conservative mutations in different domains, resulting in slight loss of function. These mutations slightly decreased the pathogenicity of the virus. Thus, the results confirm the structure-function relationships of these viral proteins. | Parveen Salahuddin Asad U.Khan | 2010 | Genomics, Proteomics & Bioinformatics2010，8，3： | 5 |
| 5 | Sustained virological response based on rapid virological response in genotype-3 chronic hepatitis C treated with standard interferon in the Pakistani population显示文摘AIM:To document the sustained virological response (SVR) in rapid virological responders (RVR) of genotype-3 chronic hepatitis C with standard interferon (SdIF). METHODS:Hepatitis C genotype-3 patients during the period July 2006 and June 2007 were included. Complete blood counts, prothrombin time, ALT, albumin, qualitative HCV RNA were done. SdIF and ribavirin were given for 4 wk and qualitative HCV RNA was repeated. Those testing negative were allocated to group-A while the rest were allocated to group-B. Treatment was continued a total of 16 and 24 wk for group A and B respectively. HCV RNA was repeated after 24 wk of treatment. End virological and sustained virological responses were compared by χ2 test. ROC of pretreatment age, ALT and albumin were plotted for failure to achieve SVR. RESULTS:Of 74 patients treated, RCV RNA after 16 wk of therapy became undetectable in 34 (45.9%) and was detectable in 40 (54.1%) and were allocated to groups A and B respectively. SVR was achieved in 58.8% and 27.8% in groups A and B respectively. SVR rates were significantly higher in patients who had RVR as compared to those who did not (P = 0.0;γ = 2). Both groups combined ETR and SVR were 70% and 33% respectively. ROC plots of pretreatment age, ALT and albumin for SVR showed only ALT to have a significantly large area under the curve.CONCLUSION:SVR rates were higher in patients who had RVR with SdIF and high pre treatment ALT values correlated to probability of having RVR. | Bader Faiyaz Zuberi Faisal Faiyaz Zuberi Sajjad Ali Memon Muhammad Hafeez Qureshi Sheikh Zafar Ali Salahuddin Afsar | 2008 | World Journal of Gastroenterology2008，14，14： | 3 |
| 6 | Antidiabetic activity of aqueous fruit extract of Cucumis trigonus Roxb. in streptozotocin-induced-diabetic rats显示文摘 | Md. Salahuddin Sunil S. Jalalpure | 2009 | Journal of Ethnopharmacology2009，，2： | 3 |
| 7 | Suppression of monosodium urate crystal-induced inflammation by inhibiting TGF-β-activated kinase 1-dependent signaling:role of the ubiquitin proteasome system显示文摘Monosodium urate(MSU)crystals activate inflammatory pathways that overlap with interleukin-1β(IL-1β)signaling.However,the post-translational mechanisms involved and the role of signaling proteins in this activation are unknown.In the present study,we investigated the intracellular signaling mechanisms involved in MSU-induced activation of THP-1 macrophages and human nondiseased synovial fibroblasts(NLSFs)and the in vivo efficacy of an inhibitor of tumor grovArth factor-β(TGF-β)-activated kinase 1(TAK1),5Z-7-oxozeaenoI,in MSU-induced paw inflammation in C57BL76 mice.THP-1 macrophage activation with MSU crystals(25-200 ng/ml)resulted in the rapid and sustained phosphorylation of interleukin-1 receptor-activated kinase 1(IRAK1 Thr^(209))and TAK1(Thr^(184/187))and their association with the E3 ubiquitin ligase TRAF6.At the cellular level,MSU inhibited the deubiquitinases A20 and UCHL2 and increased 20s proteasomal activity,leading to a global decrease in K^(63)-linked ubiquitination and increase in K^(48)-linked ubiquitination in THP-1 macrophages.While MSU did not stimulate cytokine produaion in NLSFs,it significantly amplified IL-1β-induced IL-6,IL-8,and ENA-78/CXCL5 production.Docking studies and MD simulations followed by TAK1 in vitro kinase assays revealed that uric acid molecules are capable of arresting TAK1 in an active-state conformation,resulting in sustained TAK1 kinase activation.Importantly,MSU-induced proinflammatory cytokine production was completely inhibited by 5Z-7-oxozeaenol but not IRAK1/4 or TRAF6 inhibitors.Administration of 5Z-7-oxozeaenol(5 or 15 mg/kg;orally)significantly inhibited MSU-induced paw inflammation in C57BL/6 mice.Our study identifies a novel post-translational mechanism of TAK1 activation by MSU and suggests the therapeutic potential of TAK1 in regulating MSU-induced Inflammation. | Anil K.Singh Mahamudul Haque Kayla O'Sullivan Mukesh Chourasia Madhu M.Ouseph Salahuddin Ahmed | 2021 | Cellular & Molecular Immunology2021，18，1： | 2 |
| 8 | Dengue epidemiology and pathogenesis:images of the future viewed through a mirror of the past显示文摘Every year, millions of individuals throughout the world are seriously affected by dengue virus. The unavailability of a vaccine and of anti-viral drugs has made this mosquito-borne disease a serious health concern. Not only does dengue cause fatalities but it also has a profoundly negative economic impact. In recent decades, extensive research has been performed on epidemiology, vector biology, life cycle, pathogenesis, vaccine development and prevention. Although dengue research is still not at a stage to suggest definite hopes of a cure, encouraging significant advances have provided remarkable progress in the fight against infection. Recent developments indicate that both anti-viral drug and vaccine research should be pursued, in parallel with vector control programs. | Rashedul Islam Mohammed Salahuddin Md.Salahuddin Ayubi Tahmina Hossain Apurba Majumder Andrew W.Taylor-Robinson Abdullah Mahmud-Al-Rafat | 2015 | Virologica Sinica2015，30，5： | 2 |
| 9 | Angiogenic Factors and the Risk of Adverse Outcomes in Women With Suspected Preeclampsia显示文摘 | Sarosh Rana Camille E. Powe Saira Salahuddin Stefan Verlohren Frank H. Perschel Richard J. Levine Kee-Hak Lim Julia B. Wenger Ravi Thadhani S. Ananth Karumanchi | 2012 | Circulation2012，，7： | 2 |
| 10 | Role of macrophages and monocytes in hepatitis C virus infections显示文摘A number of studies conducted over many years have shown that hepatitis C virus(HCV)can infect a variety of cell types.In vivo infection of monocytes,macrophages,and dendritic cells by HCV has been frequently shown by a number of researchers.These studies have demonstrated replication of HCV by detecting the presence of both negative genomic strands and a variety of non-structural HCV proteins in infected cells.In addition,analyses of genome sequences have also shown that different cell types can harbor different HCV variants.Investigators have also done preliminary studies of which cellular genes are affected by HCV infection,but there have not yet been a sufficient number of these studies to understand the effects of infection on these cells.Analyses of in vitro HCV replication have shown that monocytes,macrophages and dendritic cells can be infected by HCV from patient sera or plasma.These studies suggest that entry and cellular locations may vary between different cell types.Some studies suggest that macrophages may preferentially allow HCV genotype 1 to replicate,but macrophages do not appear to select particular hypervariable regions.Overall,these studies agree with a model where monocytes and macrophages act as an amplification system,in which these cells are infected and show few cytopathic effects,but continuously produce HCV.This allows them to produce virus over an extended time and allows its spread to other cell types. | Dennis Revie Syed Zaki Salahuddin | 2014 | World Journal of Gastroenterology2014，20，11： | 2 |
| 11 | Layered silicate/epoxy nanocomposites : synthesis, characterization and properties 显示文摘 | Salahuddin N A | 2004 | Polymers for Advanced Technologies2004，15，5： | 1 |
| 12 | Spin hall effect clocking of nanomagnetic logic without a magnetic field 显示文摘 | Bhowmik D You L Salahuddin S | 2015 | Nature Nanotechnology2015，9，1： | 1 |
| 13 | Isolation of a new virus, HBLV, in patients with lymphoproliferative disorders显示文摘 | Salahuddin SZ Ablashi DV Markham PD | 1986 | Science1986，234，4776： | 1 |
| 14 | Angiogenic factors and the risk of adverse outcomes in women with suspected preeclampsia 显示文摘 | Rana S Powe CE Salahuddin S | 2012 | Circulation2012，125，7： | 1 |
| 15 | Generalized quasi-complementarity problems with fuzzy set-valued mappings显示文摘 | AHMAD R SALAHUDDIN IRFAN S S | 2003 | Int J Fuzzy Syst2003，5，： | 1 |
| 16 | Isolation of a new virus, FIBLV, in patients with lymphoproliferative disorders显示文摘 | Salahuddin S Z D V Ablashi P D Markham | 1986 | Science1986，234，： | 1 |
| 17 | Nanoscale highly filled epoxy nanocomposite显示文摘 | N Salahuddin A Moet A Hiltner | 2002 | European Polymer Journal2002，38，7： | 1 |
| 18 | A modified a priori SNR for speech enhancement using spectral subtraction rules显示文摘 | Hasan M K Salahuddin S Rezwan M | 2004 | IEEE Signal Processing Letters2004，11，4： | 1 |
| 19 | Reducing ventilatorassociated pneumonia rates through a staff education programme显示文摘 | Salahuddin N Zafar A Sukhyani L | 2004 | J Hosp Infect2004，57，3： | 1 |
| 20 | How good can monolayer MoSz transistors be? 显示文摘 | Yoon Y Ganapathi K Salahuddin S | 2011 | Nano Lett2011，11，9： | 1 |
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