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| 1 | New means to monitor the effect of glucocorticoid therapy in children显示文摘AIM:To study the individual effects of glucocorticoid (GC) therapy on the state ofimmune activation in patient serum.METHODS:We developed a novel assay in which the effect of corticosteroid-treated patient serum on healthy donor peripheral blood mononuclear cells (target cells) was studied,with a panel of markers for effector [interferon (IFN)γ and interleukin (IL)-5] and regulatory T cells (FOXP3 and glucocorticoid-induced tumor necrosis factor receptor,GITR).The study group comprised 19 children with inflammatory bowel disease.The individual effect of patient serum on target cells was analyzed prior to GC therapy and 2 wk later.RESULTS:The effect of GC therapy mediated by patient serum was seen as a decrease in the target cells expression of regulatory T-cell-related markers GITR (median suppression 24%,range of suppression 1%-63%,in 2 cases increase of 6% and 77%,P < 0.01 for mitogen-activated target cells) and FOXP3 (median suppression 33%,range of suppression 0%-79%,in one case an increase of 173%,P < 0.05 for resting cells),and secretion of IFNγ [from a mean of 87 700 pg/mL (SD 33 900 pg/mL) to 60 900 pg/mL (SD 44 200 pg/mL) in mitogen-activated target cells,13 of the cases showed a decrease,P < 0.01].The total or weight-related prednisolone dose did not correlate with the patient-seruminduced changes in the target cell markers.CONCLUSION:GC response could be monitored at an individual level by studying the effect of patient serum on signaling pathways of target immune cells. | Hanne Rintamki Harri M Salo Outi Vaarala Kaija-Leena Kolho | 2010 | World Journal of Gastroenterology2010，16，9： | 4 |
| 2 | Seasonal comparison of moss bag technique against vertical snow samples for monitoring atmospheric pollution显示文摘This is the first study seasonally applying Sphagnum papillosum moss bags and vertical snow samples for monitoring atmospheric pollution.Moss bags,exposed in January,were collected together with snow samples by early March 2012 near the Harjavalta Industrial Park in southwest Finland.Magnetic,chemical,scanning electron microscopy-energy dispersive X-ray spectroscopy(SEM-EDX),K-means clustering,and Tomlinson pollution load index(PLI)data showed parallel spatial trends of pollution dispersal for both materials.Results strengthen previous findings that concentrate and slag handling activities were important(dust)emission sources while the impact from Cu–Ni smelter's pipe remained secondary at closer distances.Statistically significant correlations existed between the variables of snow and moss bags.As a summary,both methods work well for sampling and are efficient pollutant accumulators.Moss bags can be used also in winter conditions and they provide more homogeneous and better controlled sampling method than snow samples. | Hanna Salo Anna-Kaisa Berisha Joni M?kinen | 2016 | Journal of Environmental Sciences2016，28，3： | 3 |
| 3 | Limiting Carleman weights and anisotropic inverse problems显示文摘 | Dos Santos Ferreira D Kenig C E Salo M | | 0，，： | 1 |
| 4 | Incipient angiogenesis in Barrett's epithelium and lymphangiogenesis in Barrett' s adenocarcinoma 显示文摘 | Ramo JO Bergman M Salo JA | 2002 | J Clin Oncol2002，20，13： | 1 |
| 5 | Histone deacetylase inhibitors induce apoptosis in human eosinophils and neutrophils显示文摘 | Kankaanranta H Janka -Junttila M Ilmarinen - Salo P | 2010 | J Inflamm (Lond)2010，7，： | 1 |
| 6 | Effects of propofol emulsion and thiopentone on T helper cell type-1/type-2 balance in vitro 显示文摘 | SALO M PIRTTIKANGAS C O PULKKI K | 1997 | Anaesthesia1997，52，： | 1 |
| 7 | An efficient approach for screening minimal PKS genes from Streptomyces显示文摘 | Metsg-Ketela M Salo V Halo L | 1999 | FEMS Microbiology Letters1999，180，1： | 1 |
| 8 | A new control system with a control delay compensation for a current-source active power filter显示文摘 | SALO M TUUSA H | 2005 | IEEE Trans on Industrial Electronics2005，56，6： | 1 |
| 9 | Effects of anesthesia and surgery on the immune response显示文摘 | Salo M | 1992 | Acta Anaesthesiol Scand1992，36，3： | 1 |
| 10 | Effects of anaesthesia and surgery on the immuneresponse显示文摘 | Salo M | | 0，，03： | 1 |
| 11 | Decreased isometric neck strength in women with chronic neck pain and the repeatabitity of neck strength measurements显示文摘 | Ylinen J Salo P Nykanen M | 2004 | Arch Phys Med Rehabil2004，85，8： | 1 |
| 12 | Effects of postoperative pain treatment using non-steroidal antiinflammatory analgesics,opioids or epidural blockade on systemic and local immune responses in children显示文摘 | Vuori A Salo M Viljanto J | 2004 | Acta Anaesthesiol Scand2004，48，6： | 1 |
| 13 | An efficient approach for screening minimal PKS genes from Streptomyces显示文摘 | Mets:i-Ketela M Salo V Halo L | 1999 | FEMS Microbiol Lett1999，180，： | 1 |
| 14 | A vector controlled current-source PWM rectifier with a novel current damping method 显示文摘 | SALO M TUSSA H | 2000 | IEEE Transactions on Power Electronics2000，15，6： | 1 |
| 15 | Distribution of the Product of Independent Rayleigh Random Variables显示文摘 | Salo J El-Sallabi H M Vainikainen P | 2006 | IEEE Trans Antennas and Propagation2006，54，2： | 1 |
| 16 | Effects of postoperative pain treatment using non-steroidal anti-inflammatory analgesics, opioids or epidural blockade Oilsystemie and local immune responses in children 显示文摘 | Vuori A Salo M Viljanto J | 2004 | Acta Anaesthesiol Scand2004，48，6： | 1 |
| 17 | HSP70 and Other Possible Heat Shock or Oxidative Stress Proteins are Induced in Skeletal Muscle,Heart,And Liver during Exercise显示文摘 | SALO D C DONOVAN C M DAVIES K J | 1991 | Free Radic Biol Med1991，11，3： | 1 |
| 18 | cDNA cloning of a Trichoderma reesei cellulase and demon- stration of endoglucanase activity by expression in yeast 显示文摘 | SALO~IEIMO M NAKARI-SETALA T TENKANEN M | 1997 | Eur J Biochem1997，249，： | 1 |
| 19 | A novel isolalion methtM for mac- rophage-like cells from mixed primary cuhures of aduh rat liver (:ells 显示文摘 | Kilani H Takenouehi T Salo M el al | 2010 | J lmmunol Methods2010，360，12： | 1 |
| 20 | Effects of propofol emulsion and the thiopentone on T helper cell type-i/type-2 balance in vitro显示文摘 | Salo M Miljevic C Djergovic D | 1997 | Anaesthesia1997，52，： | 1 |
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