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| 1 | Acute fatty liver of pregnancy associated with severe acute pancreatitis:A case report显示文摘Acute fatty liver of pregnancy is a rare disease that affects women in the third trimester of pregnancy. Although infrequent, the disease can cause maternal mortality. The diagnosis is not always clear until the pregnancy is terminated, and significant complications, such as acute pancreatitis, can occur. Pancreatic involvement typically only occurs in severe cases after the development of hepatic and renal impairment. To date, little knowledge is available regarding how the disease causes pancreatitis. Treatment involves supportive measures and pregnancy interruption. In this report, we describe a case of a previously healthy 26-year-old woman at a gestational age of 27 wk and 6 d who was admitted with severe abdominal pain and vomiting. This case illustrates the clinical and laboratory overlap between acute fatty liver of pregnancy and pancreatitis, highlighting the difficulties in differentiating each disease. Furthermore, the hypothesis for this overlapping is presented, and the therapeutic options are discussed. | Cássio Vieira de Oliveira Alecsro Moreira Julio P Baima Leticia de C Franzoni Talles B Lima Fabio da S Yamashiro Kunie Yabuki Rabelo Coelho Ligia Y Sassaki Carlos Antonio Caramori Ferno G Romeiro Giovanni F Silva | 2014 | World Journal of Hepatology2014，6，7： | 3 |
| 2 | Quality of life, work productivity impairment and healthcare resources in inflammatory bowel diseases in Brazil显示文摘BACKGROUND Inflammatory bowel diseases(IBD)have been associated with a low quality of life(QoL)and a negative impact on work productivity compared to the general population.Information about disease control,patient-reported outcomes(PROs),treatment patterns and use of healthcare resources is relevant to optimizing IBD management.AIM To describe QoL and work productivity and activity impairment(WPAI),treatment patterns and use of healthcare resources among IBD patients in Brazil.METHODS A multicenter cross-sectional study included adult outpatients who were previously diagnosed with moderate to severe Crohn’s disease(CD)or ulcerative colitis(UC).At enrolment,active CD and UC were defined as having a Harvey Bradshaw Index≥8 or a CD Activity Index≥220 or calprotectin>200μg/g or previous colonoscopy results suggestive of inadequate control(per investigator criteria)and a 9-point partial Mayo score≥5,respectively.The PRO assessment included the QoL questionnaires SF-36 and EQ-5D-5L,the Inflammatory Bowel Disease Questionnaire(IBDQ),and the WPAI questionnaire.Information about healthcare resources and treatment during the previous 3 years was collected from medical records.Chi-square,Fisher’s exact and Student’s t-/Mann-Whitney U tests were used to compare PROs,treatment patterns and the use of healthcare resources by disease activity(α=0.05).RESULTS Of the 407 patients in this study(CD/UC:64.9%/35.1%,mean age 42.9/45.9 years,54.2%/56.6%female,38.3%/37.1%employed),44.7%/25.2%presented moderate-to-severe CD/UC activity,respectively,at baseline.Expressed in median values for CD/UC,respectively,the SF-36 physical component was 46.6/44.7 and the mental component was 45.2/44.2,the EQ-visual analog scale score was 80.0/70.0,and the IBDQ overall score was 164.0/165.0.Moderate to severe activity,female gender,being unemployed,a lower educational level and lower income were associated with lower QoL(P<0.05).Median work productivity impairment was 20%and 5%for CD and UC patients,respectively,and activity impairment was 30%,the latter being higher among patients with moderate to severe disease activity compared to patients with mild or no disease activity(75.0%vs 10.0%,P<0.001).For CD/UC patients,respectively,25.4%/2.8%had at least one surgery,38.3%/19.6%were hospitalized,and 70.7%/77.6%changed IBD treatment at least once during the last 3 years.The most common treatments at baseline were biologics(75.3%)and immunosuppressants(70.9%)for CD patients and 5-ASA compounds(77.5%)for UC patients.CONCLUSION Moderate to severe IBD activity,especially among CD patients,is associated with a substantial impact on QoL,work productivity impairment and an increased number of IBD surgeries and hospitalizations in Brazil. | Rogerio Serafim Parra Julio MF Chebli Heda MBS Amarante Cristina Flores Jose ML Parente Odery Ramos Milene Fernandes Jose JR Rocha Marley R Feitosa Omar Feres Antonio S Scotton Rodrigo B Nones Murilo M Lima Cyrla Zaltman Carolina D Goncalves Isabella M Guimaraes Genoile O Santana Ligia Y Sassaki Rogerio S Hossne Mauro Bafutto Roberto LK Junior Mikaell AG Faria Sender J Miszputen Tarcia NF Gomes Wilson R Catapani Anderson A Faria Stella CS Souza Rosana F Caratin Juliana T Senra Maria LA Ferrari | 2019 | World Journal of Gastroenterology2019，25，38： | 2 |
| 3 | Distribution of cyclooxygensse-2 in eutopic and endometrin in endonetriosis and andnomyosis显示文摘 | Ota H Igarashi S Sassaki M | 2001 | Hum Reprod2001，16，3： | 1 |
| 4 | Angiotensin-converting enzyme inhibition, but not calcinum antagonism, improves a response of the renal vasculature to L-arginine in patients with essential hypertension显示文摘 | Higashi Y Oshima T Sassaki S | 1998 | Hypertension1998，32，： | 1 |
| 5 | Assignment of the porcine obese (leptin) gene to chromosome 18 by linkage analysis of a new PCR-based polymorphism显示文摘 | Sassaki S Clutter A C Pomp D | 1996 | Mammalian Genome1996，7，4： | 1 |
| 6 | Distribution of cyclooxygenase-2 in eutopic and endometrim in endometriosis and adenomyosis显示文摘 | Ota H Igarashi S Sassaki M | 2001 | Hum Reprod2001，16，3： | 1 |
| 7 | Isolation and characterization of microsatellite loci in tropical forage Stylosanthes capitata Vogel显示文摘 | Santos M O Sassaki R P Chiari L Resende R M S Souza A P | 2009 | Molecular Ecology Resources2009，9，1： | 1 |
| 8 | Sonodynamically induced antutumor effect of a gallium-porphyrin complex,ATX-70显示文摘 | Yumita N Sassaki K Umemura S | 1996 | Jpn J Cancer Res1996，87，3： | 1 |
| 9 | Sonodynamically induced antitumor effect of a gallium-porphyrin complex by focused ultrasound on experimental kidney tumor显示文摘 | Yumita N Sassaki K Umemura S | 1997 | Cancer Lett1997，112，1： | 1 |
| 10 | Distribution of cyclooxygenase- 2 in eutopic and endometrin in endonetriosis and andnomyosis 显示文摘 | Ota H Igarashi S Sassaki M | 2001 | Hum Reprod2001，16，3： | 1 |
| 11 | Molecular and structural characterization of the biosurfactant produced by Pseudornonas aeraginosa DAUPE 614 显示文摘 | Monteiro S A Sassaki G L de Souza L M | 2007 | Chem Phys Lipids2007，147，： | 1 |
| 12 | Assignment of the porcine obese (leptin) gene to chromosome 18 by linkage analysis of a new PCR-base polymorphism显示文摘 | SASSAKI S CLUTEER A C POMOP D | 1996 | Mammalian Genome1996，7，4： | 1 |
| 13 | The decay of the wet shear strength of adhesion and its application to metal/epoxy/metal joints 显示文摘 | MARUNO T SASSAKI S | 1987 | International Journal of Adhesion and Adhesives1987，7，2： | 1 |
| 14 | Distribution of cyclooxygenase- 2 in eutopic and endometrin ir endonetriosis and andnomyosis显示文摘 | Ota H Igarashi S Sassaki M | 2001 | Hum Reprod2001，16，3： | 1 |
| 15 | Sonodynamcalliyinduced antitumor effect of a gallium-porphyrin complex, ATX-70 显示文摘 | Yumita N Sassaki K Umemura S | 1996 | Jpn J Cancer Res1996，87，3： | 1 |
| 16 | Sonodynamical-ly induced antitumor effect of a gallium-porphyrin complex by focused ultrasound on experimental kidney tumor 显示文摘 | Yumita N Sassaki K Umemura S | 1997 | Cancer Lett1997，112，1： | 1 |
| 17 | Distribution of cyclooxygenase-2 in eutopic and endometrin in wndonetriosis and andomyosis显示文摘 | Ota H Igarashi S Sassaki M | 2001 | Hum Reprod2001，16，3： | 1 |
| 18 | Distribution of cyclooxygenase-2 in eutopic and ectopic endometrium in endometriosis and adenomyosis 显示文摘 | OTA H IGARASHI S SASSAKI M | 2001 | Hum Report2001，16，3： | 1 |
| 19 | Demonstration of de?creased posterior cingulated perfusion in mild Alzheimer's Dis?ease by means of H2150 positron emission tomography 显示文摘 | Ishii K Sassaki M Yamaji S | 1997 | Eur J Nucl Med1997，24，6： | 1 |
| 20 | Quality of care in patients with inflammatory bowel disease from a public health center in Brazil显示文摘BACKGROUND Inflammatory bowel diseases(IBDs)are chronic diseases that demand continuous interaction between patients and healthcare providers.Quality of care(QoC)is a factor that contributes to a patient’s adherence to treatment and its success.AIM To evaluate QoC in patients from a single IBD reference center.METHODS This cross-sectional study included 133 patients from a single Brazilian IBD public health center.QoC was evaluated through the QoC Through the Eyes of Patients with IBD(QUOTE-IBD)questionnaire(based on patient perspectives),which measures eight dimensions of care.We compared QoC among patients with Crohn’s disease and ulcerative colitis and analyzed the clinical and psychological factors associated with QoC satisfaction.Clinical evaluations assessed disease characteristics,quality of life,anxiety,and depression levels.RESULTS Sixty-nine patients with Crohn’s disease and 64 with ulcerative colitis were interviewed.The mean age was 37.26 years±13.05 years,and 63.91%of the patients were women.The mean duration of the disease was 8.44 years±7.59 years,where most patients were in remission(70.31%of patients with ulcerative colitis and 62.32%with Crohn’s disease).The total QoC score of the sample was 8.61 years±1.31 points,indicating that the QoC provided by the center was unsatisfactory.According to univariate logistic regression,patients with Crohn’s disease had higher satisfaction rates than those with ulcerative colitis[odds ratio(OR):2.746;95%confidence interval(CI):1.360-5.541;P=0.0048]and patients on infliximab(OR:2.175;95%CI:1.037-4.562;P=0.0398).CONCLUSION Patients from the IBD public center reported good doctor-patient relationships,but had problems related to the healthcare structure.Evaluation of healthcare centers is of paramount to improve QoC for the patients involved. | Debora Mayumi Takamune Giovana Signorelli Astolfi Cury Giulia Ferrás Giedre Soares Prates Herrerias Adriana Rivera Jaqueline Ribeiro Barros Julio Pinheiro Baima Rogerio Saad-Hossne Ligia Yukie Sassaki | 2022 | World Journal of Clinical Cases2022，10，33： | 0 |
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