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| 1 | Molecular detection of monocyte chemotactic protein-1 polymorphism in spontaneous bacterial peritonitis patients显示文摘AIM: To investigate the association of the functional monocyte chemotactic protein-1(MCP-1) promoter polymorphism(A-2518G) with spontaneous bacterial peritonitis(SBP).METHODS: Fifty patients with post-hepatitis C liver cirrhosis and ascites were categorized into two groups; group Ⅰ included 25 patients with SBP and group Ⅱ included 25 patients free from SBP. In addition, a group of 20 healthy volunteers were included. We assessed the MCP-1 gene polymorphism and gene expression as well as interleukin(IL)-10 levels in both blood and ascitic fluid. RESULTS: A significant MCP-1 gene polymorphism was detected in groups Ⅰ and Ⅱ(P = 0.001 and 0.02 respectively). Group Ⅰ was associated with a significantly higher frequency of AG genotype [control 8(40%) vs SBP 19(76.0%), P < 0.001], and group Ⅱ was associated with a significantly higher frequency of GG genotype when compared to healthy volunteers [control 1(5%) vs cirrhotic 16(64%), P < 0.001]. Accordingly, the frequency of G allele was significantly higher in both groups(Ⅰ and Ⅱ) [control 10(25%) vs SBP 27(54%), P < 0.001 and vs cirrhotic 37(74.0%), P < 0.001, respectively]. The total blood and ascetic fluid levels of IL-10 and MCP-1 gene expression were significantly higher in group Ⅰ than in group Ⅱ. Group Ⅰ showed significant reductions in the levels of MCP-1 gene expression and IL-10 in the whole blood and ascetic fluid after therapy. CONCLUSION: MCP-1 GG genotype and G allele may predispose HCV infected patients to a more progressive disease course, while AG genotype may increase the susceptibility to SBP. Patients carrying these genotypes should be under supervision to prevent or restrict further complications. | Maysa Kamal Salama Dina Sabry Mohamed AS Al-Ghussein Rasha Ahmed Sayed AbdAllah Fatma Mohamed Taha Wael Fathy Miriam Safwat Wadie Mona Nabih Amr Abul-Fotouh Tarneem Darwish | 2014 | World Journal of Gastroenterology2014，20，33： | 7 |
| 2 | Joint arthroplasties other than the hip in solid organ transplant recipients显示文摘 | Sayed - Noor AS | 2009 | Open Orthop J2009，3，： | 1 |
| 3 | Circulating microRNAs : a potential role in diagnosis and prognosis of acute myocardial Infarction 显示文摘 | Sayed AS Xia K Yang TL | 2013 | Dis Markers2013，35，5： | 1 |
| 4 | Arsenic in drinking water and pregnancy outcome显示文摘 | Ahmad AS Sayed SU Barua S | 2001 | Environ Health Perspect2001，109，： | 1 |
| 5 | Circulating microRNAs: a potential role in diagnosis and prognosis of acute myocardial infarction显示文摘 | Sayed AS Xia K Yang TL | 2013 | Dis Markers2013，35，5： | 1 |
| 6 | Diagnosis,prognosis and therapeutic role of circulating miRNAs in cardiovascular diseases显示文摘 | Sayed AS Xia K Salma U | 2014 | Heart Lung Circ2014，23，6： | 1 |
| 7 | Circulating microRNAs: a potential role in diagnosis and prognosis of acute myocardial infarction显示文摘 | Sayed AS Xia K Yang TL | 2013 | Dis Markers2013，35，5： | 1 |
| 8 | Efficacy of intrauterine devicein the treatment of intrauterine adhesions 显示文摘 | Salma U Xue M Md Sayed AS | 2014 | Biomed Res Int2014，2014，58： | 1 |
| 9 | Diagnosis, prognosis and therapeutic role of circulating miRNAs in cardiovascular diseases 显示文摘 | SAYED AS XIA K SALMA U | 2014 | Heart Lung Circ2014，23，6： | 1 |
| 10 | Circulating microRNAs: a potential role in diagnosis and prognosis of acute myocardial in-farction显示文摘 | SAYED AS XIA K YANG TL | 2013 | Dis Markers2013，35，5： | 1 |
| 11 | Circulating microRNAs :a potential role in diagnosis and prognosis of acute myocardialinfarction 显示文摘 | Sayed AS Xia K Yang TL | 2013 | Dis Markers2013，35，5： | 1 |
| 12 | A flavonol triglycoside from Chenopodium murale显示文摘 | Awaad AS Hifnawy MS | 1999 | Phytochemistry1999，51，4： | 1 |
| 13 | Biochemical changes in expermental diabetes before and after treatmengt with mangifera indica and psidium guava extracts显示文摘 | Sayed MR Iman MM Dawlat AS | 2011 | Pharm Biomed Sci2011，2，2： | 1 |
| 14 | Operative versus nonop-erative treatment of displaced intra - articular calcaneal fractures : aprospective, randomized, controlled multicenter trial 显示文摘 | Agren PH Wretenberg P Sayed - Noor AS | 2013 | J Bone JointSurg Am2013，95，15： | 1 |
| 15 | Diagnosis, prognosis and therapeutic role of circulating miRNAs in cardiovascular diseases 显示文摘 | Sayed AS Xia K Salma U | 2014 | Heart LungCirc2014，23，6： | 1 |
| 16 | Efficacy of intrauterinedevice in the treatment of intrauterine adhesions显示文摘 | Salma U Xue M Md Sayed AS etal | 2014 | BiomedResInt2014，2014，： | 1 |
| 17 | Biochemical changes in experi- mental diabetes before and after treatment with mangifera indica and psidium guava extracts 显示文摘 | Sayed MR Iman MM Dawlat AS | 2011 | Int J Pharm Biomed Sci2011，2，2： | 1 |
| 18 | Immunization of nonobese diabetic(NOD)mice with glutamic acid decarboxylase-derived peptide 524-543 reduces cyclophosphamide accelerated diabetes显示文摘 | Sai P Rivereau AS Granier C | 1996 | Clin Exp Immunol1996，105，： | 1 |
| 19 | Immunization of non-obese diabetic(NOD)mice with glutamic acid decarboxylase-derived peptide 524-543 reduces cyclophosphamide accelerated diabetes显示文摘 | Sai P Rivereau AS Granier C | 1996 | Clin Exp Immunol1996，105，： | 1 |
| 20 | Immunization of nonobese diabetic(NOD) mice with glutamic acid decarboxylase-derived peptide 524-43 reduces cyclophosphamide accelerated diabetes显示文摘 | Sai P Rivereau AS Granier C | | 0，，： | 1 |
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