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| 1 | FAIR Principles:Interpretations and Implementation Considerations显示文摘The FAIR principles have been widely cited,endorsed and adopted by a broad range of stakeholders since their publication in 2016.By intention,the 15 FAIR guiding principles do not dictate specific technological implementations,but provide guidance for improving Findability,Accessibility,Interoperability and Reusability of digital resources.This has likely contributed to the broad adoption of the FAIR principles,because individual stakeholder communities can implement their own FAIR solutions.However,it has also resulted in inconsistent interpretations that carry the risk of leading to incompatible implementations.Thus,while the FAIR principles are formulated on a high level and may be interpreted and implemented in different ways,for true interoperability we need to support convergence in implementation choices that are widely accessible and(re)-usable.We introduce the concept of FAIR implementation considerations to assist accelerated global participation and convergence towards accessible,robust,widespread and consistent FAIR implementations.Any self-identified stakeholder community may either choose to reuse solutions from existing implementations,or when they spot a gap,accept the challenge to create the needed solution,which,ideally,can be used again by other communities in the future.Here,we provide interpretations and implementation considerations(choices and challenges)for each FAIR principle. | Annika Jacobsen Ricardo de Miranda Azevedo Nick Juty Dominique Batista Simon Coles Ronald Cornet Melanie Courtot Merce Crosas Michel Dumontier Chris T.Evelo Carole Goble Giancarlo Guizzardi Karsten Kryger Hansen Ali Hasnain Kristina Hettne Jaap Heringa Rob W.W.Hooft Melanie Imming Keith G.Jeffery Rajaram Kaliyaperumal Martijn GKersloot Christine R.Kirkpatrick Tobias Kuhn Ignasi Labastida Barbara Magagna PeterMcQuilton Natalie Meyers Annalisa Montesanti Mirjam van Reisen Philippe Rocca-Serra Robert Pergl Susanna-Assunta Sansone Luiz Olavo Bonino da Silva Santos Juliane Schneider George Strawn Mark Thompson Andra Waagmeester Tobias Weigel Mark D.Wilkinson Egon L.Willighagen Peter Wittenburg Marco Roos Barend Mons Erik Schultes | 2020 | Data Intelligence2020，2，1： | 26 |
| 2 | Diagnostic and prognostic value of circulating micro RNAs in heart failure with preserved and reduced ejection fraction显示文摘micro RNAs(mi RNAs) are powerful regulators of posttranscriptional gene expression and play an important role in pathophysiological processes. Circulating mi RNAs can be quantified in body liquids and are promising biomarkers in numerous diseases. In cardiovascular disease mi RNAs have been proven to be reliable diagnostic biomarkers for different disease entities. In cardiac fibrosis(CF) and heart failure(HF) dysregulated circulating mi RNAs have been identified,indicating their promising applicability as diagnostic biomarkers. Some mi RNAs were successfully tested in risk stratification of HF implementing their potential use as prognostic biomarkers. In this respect mi RNAs might soon be implemented in diagnostic clinical routine. In the young field of mi RNA based research advances have been made in identifying mi RNAs as potential targets for the treatment of experimental CF and HF. Promising study results suggest their potential future application as therapeutic agents in treatment of cardiovascular disease. This article summarizes the current state of the various aspects of mi RNA research in the field of CF and HF with reduced ejection fraction as well as preserved ejection fraction. The review provides an overview of the application of circulating mi RNAs as biomarkers in CF and HF and current approaches to therapeutically utilize mi RNAs in this field of cardiovascular disease. | Christian Schulte Dirk Westermann Stefan Blankenberg Tanja Zeller | 2015 | World Journal of Cardiology2015，7，12： | 11 |
| 3 | 德国人文聚落区生态单元制图国家项目显示文摘联邦德国自然保护法、德国各州自然保护法要求在自然景观区和人文聚落区保护、管理和发展自然。实现这一法律要求 ,必须以现实的、全面的、高质量的、与自然保护原则相匹配的数据为基础。实践证明 ,城乡生态单元制图是获取和解释这些数据不可或缺的手段。德国人文聚落区生态单元制图始于 1 978年 ,同年组建成立了德国联邦与各州自然保护部门参加并联合协调的“人文聚落区生态单元制图工作组”。 1 986年工作组提出了德国人文聚落区生态单元制图基本方案 ,1 993年完成基本方案修订版。基本方案的目标是在全国范围建立标准制图方法 ,使获取的科学数据可以相互比较。至 2 0 0 0年 ,德国在人文聚落区生态单元制图项目上的投资约合 2亿马克 ;至 2 0 0 1年 3月 ,德国有 2 2 3个大中城市已经完成或正在实施生态单元制图 ,人文聚落区生态单元制图已经成为德国各级政府生态规划的基本工作内容。 | Wolfgang Schulte Herbert Sukopp 李建新 | 2003 | 生态学报2003，23，3： | 10 |
| 4 | Measurement of calprotectin in ascitic fluid to identify elevated polymorphonuclear cell count显示文摘AIM: To evaluate the diagnostic capability of calprotectin in ascitic fluid for detecting a polymorphonuclear (PMN) cell count > 250/μL ascites. METHODS: In this prospective observational study, a total of 130 ascites samples were analysed from 71 consecutive patients referred for paracentesis. Total and differential leukocyte cell counts were determined manually with a Neubauer chamber and gentianviolet stain. Calprotectin was measured in 1 mL ascetic fluid by enzyme-linked immunosorbent assay (ELISA) and a point-of-care (POC) lateral flow assay with the Quantum Blue Reader (Bühlmann Laboratories). All measurements were carried out in a central laboratory by senior personnel blinded to patient history. A PMN count > 250/μL was the primary endpoint of the study. The diagnostic value of ascitic calprotectin measurement was assessed by comparing to the final diagnosis of each patient that had been adjudicated by investigators blinded to calprotectin values. RESULTS: The PMN count was > 250/μL in 19 samples (14.6%) from 15 patients (21.1%) and varied widely among the study population (range 10-19 800/mL and 1-17 820/mL, respectively). Spontaneous bacterial peritonitis (SBP) was the final diagnosis in four patients (5.6%). All patients with PMN ≤ 250/μL had negative bacterial culture. PMN count was elevated in five patients with peritoneal carcinomatosis, three with lymphoma, one with neuroendocrine carcinoma, and two with secondary peritonitis due to abdominal perforation. PMN cell counts correlated with ascitic calprotectin values (Spearman's rho; r = 0.457 for ELISA, r = 0.473 for POC). A considerable range of ascitic calprotectin concentrations was detected by ELISA [median 0.43 μg/mL, interquartile range (IQR) 0.23-1.23 (range 0.10-14.93)] and POC [median 0.38 μg/mL, IQR 0.38-0.56 (range 0.38-13.31)]. Ascitic calprotectin levels were higher in samples with PMN > 250/μL, by both ELISA [median (IQR) 2.48 μg/mL (1.61-3.65) vs 0.10 μg/mL (0.10-0.36), P < 0.001] and POC [2.78 μg/mL (2.05-5.37) vs 0.38 μg/mL (0.38-0.41), P < 0.001]. The area under the receiver operating characteristics curve for identifying an elevated PMN count was 0.977 (95%CI: 0.933 to 0.995) for ELISA and 0.982 (95%CI: 0.942 to 0.997) for POC (P = 0.246 vs ELISA). Using the optimal cut-off value for ELISA (0.63 μg/mL), ascitic calprotectin had 94.8% sensitivity, 89.2% specificity, positive and negative likelihood ratios of 8.76 and 0.06 respectively, positive and negative predictive values of 60.0% and 99.0% respectively, and 90.0% overall accuracy. Using the optimal cut-off value for POC (0.51 μg/mL), the respective values were 100.0%, 84.7%, 6.53, 0.00, 52.8%, 100% and 87.7%. Correlation between ELISA and POC was excellent (r = 0.873, P < 0.001). The mean ± SD of the difference was -0.11 ± 0.48 μg/mL with limits of agreement of + 0.8 μg/mL (95%CI: 0.69 to 0.98) and -1.1 μg/mL (95%CI: -1.19 to -0.91). CONCLUSION: Ascitic calprotectin reliably predicts PMN count > 250/μL, which may prove useful in the diagnosis of SBP, especially with a readily available bedside testing device. | Emanuel Burri Felix Schulte Jürgen Muser Rémy Meier Christoph Beglinger | 2013 | World Journal of Gastroenterology2013，19，13： | 10 |
| 5 | Biology and control of the fruit borer, Conopomorpha sinensis Bradley on litchi (Litchi chinensis Sonn.) in northern Thailand显示文摘水果和叶由水果 borer, Conopomorpha sinensis 幼虫和 C 的自然地发生的人口荔枝(荔枝 chinensis ) 射击群袭。sinensis parasitization 率在高度在北泰国在荔枝果园被决定(ca。1 400 m ASL ) 并且低(ca。800 m ASL ) 举起与不同, non-over-lapping fruiting 季节。另外,喷洒杆菌 thuringiensis var 的应用。aizawai,自然复合 spinosad 和化学农药 imidacloprid 在这块地里被进行在 C 上测试这些代理人的效果。sinensis 水果群袭率。水果群袭率和水果生长,在一个低举起果园学习了,是 sigmoidal 并且显示出一道高度重要的正相关(Pp “ 0.01 ) 。在低举起果园的叶射击群袭率在 fruiting 季节期间减少了(前进直到 5 月) ,但是在高举起果园增加了,在没有水果在时间的一样的时期以内是在场的的地方。一起,这些结果显示那 C 的女性。sinensis 清楚地为产卵离子喜欢水果甚于射击。如果没有水果是可得到的,它在此期间是在高举起果园的盒子,他们被抑制在射击上生他们的鸡蛋。C 的 parasitization 率。在未经治疗的水果的 sinensis 幼虫是 54.3% 。parasitoid 种类是 Chelonus chailini (90.8%) 和 Phanerotoma sp。(9.2%) 。在叶射击, C。sinensis 被发现被 Phanerotoma sp 寄生于。并且 Apanteles briareus。不同活跃代理人的应用没在 C 上有重要效果。与未经治疗的控制相比的 sinensis 水果群袭。除幼虫的神秘生活以外,这被事实最可能解释那 C。sinensis 在 fruiting 季节期间有几代。因为记录的高 parasitization 率,一种选择和更有效的控制比杀虫剂的申请可能是 parasitoids 的有增加力的版本测量。 | MARIE JOY SCHULTE KONRAD MARTIN JOACHIM SAUERBORN | 2007 | Insect Science2007，14，6： | 5 |
| 6 | A Generic Workflow for the Data FAIRification Process显示文摘The FAIR guiding principles aim to enhance the Findability,Accessibility,Interoperability and Reusability of digital resources such as data,for both humans and machines.The process of making data FAIR(“FAIRification”)can be described in multiple steps.In this paper,we describe a generic step-by-step FAIRification workflow to be performed in a multidisciplinary team guided by FAIR data stewards.The FAIRification workflow should be applicable to any type of data and has been developed and used for“Bring Your Own Data”(BYOD)workshops,as well as for the FAIRification of e.g.,rare diseases resources.The steps are:1)identify the FAIRification objective,2)analyze data,3)analyze metadata,4)define semantic model for data(4a)and metadata(4b),5)make data(5a)and metadata(5b)linkable,6)host FAIR data,and 7)assess FAIR data.For each step we describe how the data are processed,what expertise is required,which procedures and tools can be used,and which FAIR principles they relate to. | Annika Jacobsen Rajaram Kaliyaperumal Luiz Olavo Bonino da Silva Santos Barend Mons Erik Schultes Marco Roos Mark Thompson | 2020 | Data Intelligence2020，2，1： | 5 |
| 7 | 缺血性脑卒中患者血压与住院临床结局的相关性显示文摘高血压是脑卒中的主要危险因素。研究表明,在缺血性脑卒中患者中,由于压力依赖性的脑血液流向缺血区域,脑卒中后高血压有益。然而,其他研究显示,脑卒中后的高血压与短期再发性脑卒中、脑出血性转化和脑水肿发生率升高有关。关于血压与脑卒中短期临床结局相关性的观察性研究结论相互矛盾。此外,关于血压的搏动组分(脉压)或稳定组分(平均动脉压)与临床结局相关性的数据有限。 | Bangalore S Schwamm L Smith EE Hellkamp AS Suter RE Xian Y Schulte PJ Fonarow GC Bhatt DL 练桂丽 叶鹏 | 2017 | 中华高血压杂志2017，25，11： | 5 |
| 8 | Partial external biliary diversion in bile salt export pump deficiency: Association between outcome and mutation显示文摘AIM To investigate the relation of two different mutations to the outcome of partial external biliary diversion(PEBD)in severe bile salt export pump(BSEP) deficiency.METHODS Mutations in the gene encoding BSEP leading to severe BSEP deficiency in two unrelated patients were identified by genomic sequencing. Native liver biopsies and transiently transfected human embryonic kidney(HEK) 293 cells expressing either wild-type or mutated BSEP were subjected to immunofluorescence analysis to assess BSEP transporter localization. Bile acid profiles of patient and control bile samples were generated by ultra-performance liquid chromatographytandem mass spectrometry. Wild-type and mutant BSEP transport of [~3H]-labeled taurocholate(TC) and taurochenodeoxycholate(TCDC) was assessed by vesicular transport assays.RESULTS A girl(at 2 mo) presented with pruritus, jaundice and elevated serum bile salts(BS). PEBD stabilized liver function and prevented liver transplantation. She was heterozygous for the BSEP deletion p.T919 del and the nonsense mutation p.R1235 X. At the age of 17 years relative amounts of conjugated BS in her bile were normal, while total BS were less than 3% as compared to controls. An unrelated boy(age 1.5 years) presenting with severe pruritus and elevated serum BS was heterozygous for the same nonsense and another missense mutation, p.G1032 R. PEBD failed to alleviate pruritus, eventually necessitating liver transplantation. BS concentration in bile was about 5% of controls. BS were mainly unconjugated with an unusual low amount of chenodeoxycholate derivatives(< 5%). The patients' native liver biopsies showed canalicular BSEP expression. Both BSEP p.T919 del and p.G1032 R were localized in the plasma membrane in HEK293 cells. In vitro transport assays showed drastic reduction of transport by both mutations. Using purified recombinant BSEP as quantifiable reference, per-molecule transport rates for TC and TCDC were determined to be 3 and 2 BS molecules per wild-type BSEP transporter per minute, respectively.CONCLUSION In summary, our findings suggest that residual function of BSEP as well as substrate specificity influence the therapeutic effectiveness of PEBD in progressive familial intrahepatic cholestasis type 2(PFIC-2). | Philipp Ellinger Jan Stindt Carola Droge Katharina Sattler Claudia Stross Stefanie Kluge Diran Herebian Sander HJ Smits Martin Burdelski Sebastian Schulz-Jürgensen Antje Ballauff Jan Schulte am Esch Ertan Mayatepek Dieter Haussinger Ralf Kubitz Lutz Schmitt | 2017 | World Journal of Gastroenterology2017，23，29： | 4 |
| 9 | FAIR Convergence Matrix:Optimizing the Reuse of Existing FAIR-Related Resources显示文摘The FAIR principles articulate the behaviors expected from digital artifacts that are Findable,Accessible,Interoperable and Reusable by machines and by people.Although by now widely accepted,the FAIR Principles by design do not explicitly consider actual implementation choices enabling FAIR behaviors.As different communities have their own,often well-established implementation preferences and priorities for data reuse,coordinating a broadly accepted,widely used FAIR implementation approach remains a global challenge.In an effort to accelerate broad community convergence on FAIR implementation options,the GO FAIR community has launched the development of the FAIR Convergence Matrix.The Matrix is a platform that compiles for any community of practice,an inventory of their self-declared FAIR implementation choices and challenges.The Convergence Matrix is itself a FAIR resource,openly available,and encourages voluntary participation by any self-identified community of practice(not only the GO FAIR Implementation Networks).Based on patterns of use and reuse of existing resources,the Convergence Matrix supports the transparent derivation of strategies that optimally coordinate convergence on standards and technologies in the emerging Internet of FAIR Data and Services. | Hana Pergl Sustkova Kristina Maria Hettne Peter Wittenburg Annika Jacobsen Tobias Kuhn Robert Pergl Jan Slifka Peter McQuilton Barbara Magagna Susanna-Assunta Sansone Markus Stocker Melanie Imming Larry Lannom Mark Musen Erik Schultes | 2020 | Data Intelligence2020，2，1： | 4 |
| 10 | Surgery in Castleman?s Disease: A Systematic Review of 404 Published Cases显示文摘 | Nadia Talat Ajay P. Belgaumkar Klaus-Martin Schulte | 2012 | Annals of Surgery2012，，4： | 3 |
| 11 | Early Results of the Swiss Multicentre Bypass or Sleeve Study (SM-BOSS): A Prospective Randomized Trial Comparing Laparoscopic Sleeve Gastrectomy and Roux-en-Y Gastric Bypass显示文摘 | Ralph Peterli Yves Borbély Beatrice Kern Markus Gass Thomas Peters Martin Thurnheer Bernd Schultes Kurt Laederach Marco Bueter Marc Schiesser | 2013 | Annals of Surgery2013，，5： | 3 |
| 12 | The FAIR Principles:First Generation Implementation Choices and Challenges显示文摘“FAIR enough”?...A question asked on a daily basis in the rapidly evolving field of open science and the underpinning data stewardship profession.After the publication of the FAIR principles in 2016,they have sparked theoretical debates,but some communities have already begun to implement FAIR-guided data and services.No-one really argues against the idea that data,as well as the accompanying workflows and services should be findable,accessible under well-defined conditions,interoperable without data munging,and thus optimally reusable.Being FAIR is not a goal in itself;FAIR Data and Services are needed to enable data intensive research and innovation and(thus)have to be“AI-ready”(=future proof for machines to optimally assist us).However,the fact that science and innovation becomes increasingly“machine-assisted”and hence the central role of machines,is still overlooked in some cases when people claim to implement FAIR. | Barend Mons Erik Schultes Fenghong Liu Annika Jacobsen | 2020 | Data Intelligence2020，2，1： | 2 |
| 13 | Natural Orifice Translumenal Endoscopic Surgery (NOTES) Transvaginal Cholecystectomy in a Morbidly Obese Patient显示文摘 | Luis DeCarli Ricardo Zorron Alcides Branco Fernando Cirme Lima Marcos Tang Sergio Ricardo Pioneer Idilio Zanin Alfredo Augusto Schulte André Vicente Bigolin Michel Gagner | 2008 | Obesity Surgery2008，，7： | 2 |
| 14 | 利用OH夜气辉反演原子氧数密度时输入参数的不确定度对反演结果的影响显示文摘借助OH夜气辉辐射的光化学模式,由OH夜气辉辐射反演中间层-低热层区域的原子氧数密度时,输入参数的不确定性将导致反演得到的原子氧数密度具有不确定性.以在sudden death猝灭模式下通过OH_((8-3))振动带体辐射率反演原子氧数密度为例,分别研究了大气参数和OH气辉辐射率的不确定度引起的反演不确定度、化学反应速率常数的不确定度引起的反演不确定度,以及所有输入参数的不确定度共同引起的反演不确定度,找出其不确定度对反演结果影响最大的参数.结果表明,三种反演不确定度均随着高度的升高而增大,温度和体辐射率的不确定度对第一种反演不确定度的贡献最大,反应速率常数b_((8))和A_((8-3))的不确定度对第二种反演不确定度的贡献最大. | 高红 徐寄遥 陈光明 袁韡 Schulte W Mikhalev A V Medvedeva I V | 2009 | 空间科学学报2009，29，3： | 2 |
| 15 | Glucagon-like peptide 1 increases secretory burst mass of pulsatile insulin secretion in patients with type 2 diabetes and impaired glucose tolerance显示文摘 | Ritzel R Schulte M Nauck M A | 2001 | Diabetes2001，50，： | 2 |
| 16 | In situ liver transection with portal vein ligation for rapid growth of the future liver remnant in two‐stage liver resection显示文摘 | W. T. Knoefel I. Gabor A. Rehders A. Alexander M. Krausch J. Schulte am Esch G. Fürst S. A. Topp | 2012 | Br J Surg2012，，3： | 2 |
| 17 | 新型VOC可再生成膜助剂显示文摘特殊的高纯度脂肪酸酯及其混合物可用于制备较低气味,无VOC,可再生的成膜助剂。这种成膜助荆可以提高极低VOC涂料中乳液的效果。实验证明:与非再生成膜助剂相比,该新产品不仅能降低配方的综合成本,还能明显提高性能。 | Anbu Natesh Vishnu Shah Heinz-Guenther Schulte Harald Frommelius Shailesh Shah 吴晓天(翻译整理) | 2008 | 上海涂料2008，46，10： | 2 |
| 18 | Role of senescence induction in cancer treatment显示文摘Cellular senescence is a form of permanent cell cycle arrest that can be triggered by a variety of cell-intrinsic and extrinsic stimuli, including telomere shortening,DNA damage, oxidative stress, and exposure to chemotherapeutic agents and ionizing radiation. Although the induction of apoptotic cell death is a desirable outcome in cancer therapy, mutations and/or deficiencies in the apoptotic signaling pathways have been frequently identified in many human cancer types,suggesting the importance of alternative apoptosis-independent therapeutic approaches for cancer treatment. A growing body of evidence has documented that senescence induction in tumor cells is a frequent response to many anticancer modalities including cyclin-dependent kinases 4/6 small molecule inhibitor-based targeted therapeutics and T helper-1 cytokine-mediated immunotherapy. This review discusses the recent advances and clinical relevance of therapy-induced senescence in cancer treatment. | Shenghui Qin Bradley A Schulte Gavin Y Wang | 2018 | World Journal of Clinical Oncology2018，9，8： | 2 |
| 19 | Characterization of gallium-doped CdS thin films grown by chemical bath deposition显示文摘 | Hani Khallaf Guangyu Chai Oleg Lupan Lee Chow S. Park Alfons Schulte | 2008 | Applied Surface Science2008，，7： | 2 |
| 20 | Simple Scoring Scheme for Calculating the Risk of Acute Coronary Events Based on the 10-Year Follow-Up of the Prospective Cardiovascular Münster (PROCAM) Study显示文摘 | Gerd Assmann Paul Cullen Helmut Schulte | 2002 | Circulation: Journal of the American Heart Association2002，，： | 2 |
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