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| 1 | 帕博利珠单抗治疗伴脑转移NSCLC患者的一项非随机、开放Ⅱ期试验的长期随访结果和生物标志物分析显示文摘背景与目的我们开展了一项帕博利珠单抗用于伴未治疗脑转移的非小细胞肺癌(non-small cell lung cancer,NSCLC)或黑色素瘤患者的疗效和安全性的II期试验,旨在评估程序性死亡受体1(programmed cell death 1,PD-1)抑制剂在中枢神经系统(central nervous system,CNS)中的疗效。中期结果已发表,现报道对NSCLC队列的更新分析结果。方法这是一项开放性、单中心、II期试验。纳入标准:年龄≥18岁,诊断为晚期NSCLC并伴有≥1个5 mm-20 mm脑转移病灶,既往从未治疗或之前放疗后进展,无神经系统症状,不需要激素治疗且美国东部肿瘤协作组(Eastern Cooperative Oncology Group,ECOG)<2分。患者每2周接受一次帕博利珠单抗(10 mg/kg)治疗。队列1为程序性死亡配体1(programmed cell death ligand 1,PD-L1)≥1%的患者,队列2为PD-L1<1%或未评估的患者。主要终点是脑转移患者缓解比例。所有经治患者均纳入疗效与安全性终点的分析。该研究已结束入组,并于Clinicaltrials.gov登记注册,注册号为NCT02085070。结果2014年3月31日-2018年5月21日,共42例患者接受治疗。中位随访时间为8.3个月(IQR:4.5个月-26.2个月)。队列1的37例患者中11例有脑转移缓解[29.7%(95%CI:15.9%-47.0%)]。队列2未观察到缓解。治疗相关的3级-4级不良事件(adverse events,AEs)包括2例肺炎、1例全身症状、1例结肠炎、1例肾上腺皮质功能不全、1例高血糖症和1例低钾血症。6例(14%)患者发生了治疗相关的严重不良事件,包括肺炎、急性肾损伤、低钾血症和肾上腺皮质功能不全。没有观察到治疗相关死亡病例。结论帕博利珠单抗治疗PD-L1≥1%的NSCLC伴脑转移患者有效,且对所有纳入的未经治疗的脑转移患者安全。需要进一步探索免疫治疗用于NSCLC合并CNS转移。 | Sarah B GOLDBERG Kurt A SCHALPER Scott N GETTINGER Amit MAHAJAN Roy S HERBST Anne C CHANG Rogerio LILENBAUM Frederick H WILSON Sacit Bulent OMAY James B YU Lucia JILAVEANU Thuy TRAN Kira PAVLIK Elin ROWEN Heather GERRSH Annette KOMLO Richa GUPTA Hailey WYATT Matthew RIBEIRO Yuval KLUGER Geyu ZHOU Wei WEI Veronica L CHANG Harriet M KLUGER 董晓荣(翻译/校对) | 2021 | 中国肺癌杂志2021，24，9： | 34 |
| 2 | Thyroid hormone stimulates hepatic lipid catabolism via activation of autophagy显示文摘 | Sinha Rohit Anthony You Seo-Hee Zhou Jin Siddique Mobin M Bay Boon-Huat Zhu Xuguang Privalsky Martin L Cheng Sheue-Yann Stevens Robert D Summers Scott A Newgard Christopher B Lazar Mitchell A Yen Paul M | 2012 | EN2012，，7： | 2 |
| 3 | Cardiovascular physiology in the older adults显示文摘 | Xuming Dai Scott L Hummel Jorge B Salazar George E Taffet Susan Zieman Janice B Schwartz | 2015 | Journal of Geriatric Cardiology2015，12，3： | 2 |
| 4 | Mechanism of film growth during anodizing of A1-alloy-8090/SiC metal composites显示文摘 | Coleman S L Scott V D Mcenaney B | 1994 | J Mater Sci1994，29，： | 2 |
| 5 | Gold and trace element zonation in pyrite using a laser imaging technique: Implications for the timing of gold in orogenic and Carlin- style sediment- hosted deposits 显示文摘 | R R Large L Danyushevsky C Hollit V Maslennikov S Meffer S Gilbert S Bull R Scott P Emsbo H Thomas B Singh J Foster | 2009 | Economic Geology2009，104，5： | 1 |
| 6 | Governance:a review and synthesis of the literature显示文摘 | Ruhanen L Scott N Ritchie B | | 0，，04： | 1 |
| 7 | Calcium anidotrihydroborate:a hydrogen storage material显示文摘 | Diyabalanage H V K Shrestha R P Semelsberger TA Scott B L Bowden M E Davis B L Burrell A K | | 0，，47： | 1 |
| 8 | Development of coarsegrained facies in lacustrine rift basins, example from East of America 显示文摘 | Scholz C A Rosendahl B R Scott D L | 1990 | Geology1990，18，2： | 1 |
| 9 | Postoperative cognitive dys-function is independent of type of surgery and anesthetic显示文摘 | Evered L Scott DA Silbert B | 2011 | Anesth Analg2011，112，5： | 1 |
| 10 | Posttraumatic growth after cancer: the importance of health-related benefits and ne- wfound compassion for others 显示文摘 | Morris B A Shakespeare-Finch J Scott J L | 2012 | Support Care Cancer2012，20，4： | 1 |
| 11 | Standardly endmorphism algebras显示文摘 | Cline E Parshall B Scott L | 1996 | Mem Amer Math Soc1996，591，： | 1 |
| 12 | North Viking graben: an East African prospective 显示文摘 | Scott D L Rosendahl B R | 1989 | AAPG Bull1989，73，2： | 1 |
| 13 | Myeloablative vs nonmyeloablative allogeneic trans-plantation for patients with myelodysplastic syndromeor acute myelogenous leukemia with multilineaga dys-plasia:a retrospective analysis显示文摘 | SCOTT B L SANDMAIER B M STORER B | 2006 | Leukemia2006，20，： | 1 |
| 14 | Antioxidant actions of thymol, carvacrol, 6-gingerol, zingerone and hydroxytyrosol显示文摘 | Aeschbach R L liger J Scott B | 1994 | Food and Chemical Toxicolo- gy1994，32，1： | 1 |
| 15 | Persistence of cccDNA during the natural history of chronic hepatitis B and decline during Adefovir Dipivoxil therapy显示文摘 | Bettina WL Scott B Stephen L | 2004 | Gastroenterology2004，126，： | 1 |
| 16 | Postoperative cognitive dysfunc- tion is independent of type of surgery and anesthetic 显示文摘 | Evered L Scott DA Silbert B | 2011 | Anesth Analg2011，112，5： | 1 |
| 17 | Gene expression after freshwater transfer in gills and opercular epithelia of killifish: insight into divergent mechanisms of ion transport 显示文摘 | SCOTT G R CLAIBORNE J B EDWARDS S L | 2005 | Journal of Experimental Biology2005，208，14： | 1 |
| 18 | Failure of lymphopoiesis after adoptive transfer of NF-kappaB-deficient fetal liver cells显示文摘 | Horwitz B H Scott M L Cherry S R | 1997 | Immunity1997，6，6： | 1 |
| 19 | Estimation of solar radiation in Australia from rainfall and temperature observations显示文摘 | Liu D L Scott B J | 2001 | Agricultural and Forest Meteorology2001，10，6： | 1 |
| 20 | Closegenetic similarity between two sympatric species of tephritid fruit fly reproductively isolated by mating time显示文摘 | MORROW J SCOTT L CONGDON B | 2000 | Evolution Int J Org Evolution2000，54，3： | 1 |
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