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| 1 | Hepatitis B virus pathogenesis: Fresh insights into hepatitis B virus RNA显示文摘Hepatitis B virus(HBV) is still a worldwide health concern. While divergent factors are involved in its pathogenesis, it is now clear that HBV RNAs, principally templates for viral proteins and viral DNAs, have diverse biological functions involved in HBV pathogenesis. These functions include viral replication, hepatic fibrosis and hepatocarcinogenesis. Depending on the sequence similarities, HBV RNAs may act as sponges for host mi RNAs and may deregulate mi RNA functions, possibly leading to pathological consequences. Some parts of the HBV RNA molecule may function as viralderived mi RNA, which regulates viral replication. HBV DNA can integrate into the host genomic DNA and produce novel viral-host fusion RNA, which may have pathological functions. To date, elimination of HBVderived covalently closed circular DNA has not been achieved. However, RNA transcription silencing may be an alternative practical approach to treat HBVinduced pathogenesis. A full understanding of HBV RNA transcription and the biological functions of HBV RNA may open a new avenue for the development of novel HBV therapeutics. | Kazuma Sekiba Motoyuki Otsuka Motoko Ohno Mari Yamagami Takahiro Kishikawa Tatsunori Suzuki Rei Ishibashi Takahiro Seimiya Eri Tanaka Kazuhiko Koike | 2018 | World Journal of Gastroenterology2018，24，21： | 10 |
| 2 | Significance of a novel sucrose permeability test using serum in the diagnosis of early gastric cancer显示文摘AIM: To investigate the usefulness of sucrose permeability test using serum in the diagnosis of gastric diseases, with special reference to early gastric cancer (EGC).METHODS: A total of 63 subjects, including 11patients with gastric ulcer, 20 patients with gastric cancer (13, early; 7, advanced) and 32 healthy controls,were studied. Blood and urine samples were collected repeatedly for 5 h before and after the sucrose loading.Sucrose levels were measured by a newly developed enzymatic method.RESULTS: Serum sucrose levels started to increase15 min after loading, and peaked at 60 min in the gastric disease groups. The levels for gastric ulcer, EGC and advanced gastric cancer (AGC) at 60 min were significantly higher than that in the healthy controls(26.9±2.4, 34.4±5.0, and 71.8±15.6 vs 7.9±0.7 mol/L,respectively, P<0.01). The cut-off level set at 15.4 mol/L(60 min) offered the best distinction between EGC patients and healthy controls; and the sensitivity and specificity were 92.3% and 93.8%, respectively, while those of the urine method were 76.9% and 93.8%,respectively.CONCLUSIONS: The gastric permeability test using serum is reliable for the detection of EGC, and this test can provide results much earlier than the conventional urine method. This test may offer a useful alternative to more invasive tests for EGC. | Tadayuki Shishido Taketo Yamaguchi Takeo Odaka Masanori Seimiya Hiromitsu Saisho Fumio Nomura | 2005 | World Journal of Gastroenterology2005，11，44： | 5 |
| 3 | Fractionation of gamma-glutamyltransferase in patients with nonalcoholic fatty liver disease and alcoholic liver disease显示文摘AIM To assess how serum gamma-glutamyltransferase(GGT) fractions vary in patients with alcoholic liver disease(ALD) and non-alcoholic fatty liver disease(NAFLD). METHODS Serum samples were obtained from 14 patients with biopsy-proven alcoholic liver diseases and 9 patients with biopsy proven non-alcoholic fatty liver disease. In addition to these biopsy-proven cases, 16 obese(body mass index > 25) patients without any history of alcohol consumption but with a fatty liver on ultrasound examination and with elevated GGT were included for an additional analysis. Serum GGT fractionation was conducted by high-performance gel filtration liquid chromatography and was separated into the four fractions, big-GGT, medium-GGT, small-GGT(s-GGT), and free-GGT(f-GGT).RESULTS The results were expressed as a ratio of each fraction including the total GGT(t-GGT). The s-GGT/t-GGT ratioswere lowest for the control group and highest for the ALD group. The differences between the control and NAFLD groups and also between the NAFLD and ALD groups were statistically significant. In contrast, the f-GGT/t-GGT ratios were highest in the control group and lowest in the ALD group, with the differences being statistically significant. As a result, the s-GGT/f-GGT ratios were markedly increased in the NAFLD group as compared with the control group. The increase of the s-GGT/t-GGT ratios, the decrease of the f-GGT/t-GGT ratios, and the increase of s-GGT/F-GGT ratios as compared with the control group subjects were also found in obese patients with clinically diagnosed fatty change of the liver.CONCLUSION Serum GGT fractionation by high-performance gel filtration liquid chromatography is potentially useful for the differential diagnosis of ALD and NAFLD. | Shigeo Sueyoshi Setsu Sawai Mamoru Satoh Masanori Seimiya Kazuyuki Sogawa Atsushi Fukumura Mikihiro Tsutsumi Fumio Nomura | 2016 | World Journal of Hepatology2016，8，36： | 2 |
| 4 | Long period stacking structures observed in Mg 97 Zn 1 Y 2 alloy显示文摘 | T. Itoi T. Seimiya Y. Kawamura M. Hirohashi | 2004 | Scripta Materialia2004，，2： | 2 |
| 5 | Concentration dependence of micellar size and composition in mixed anionic/cationic surfac-tant solutions studied by light scattering and pulsed-gradient FT-NMR spectroscopy显示文摘 | KATO T TAKEUCHI H SEIMIYA T | | 0，，16： | 1 |
| 6 | Paradoxical effects of thyroid function on glomerular filtration rate estimated from serum ereatinine or standardized cystatin C in patients with Japanese Graves' disease 显示文摘 | Suzuki Y Matsushita K Seimiya M | 2015 | Clin Chim Acta2015，451，： | 1 |
| 7 | Long period stac- king structures observed in Mg97ZnlYz alloy显示文摘 | ITOI T SEIMIYA T KAWAMURA Y | 2004 | Scripta Materia- lia2004，51，2： | 1 |
| 8 | Serum cystatin C as a marker for early detection of chronic kidney disease and grade 2 nephropathy in Japanese patients with type 2 diabetes 显示文摘 | Suzuki Y Matsushita K Seimiya M | 2012 | Clin Chem Lab Med2012，50，10： | 1 |
| 9 | Long period stacking structures observed in Mg97Zn1Y2 alloy 显示文摘 | Itoi T Seimiya T Kawamura Y | 2004 | Scripta Materialia2004，51，2： | 1 |
| 10 | Effects of green tea intake on the development of coronary artery disease 显示文摘 | Junko Sano Shigenobu Inami Koji Seimiya | 2004 | Circ J2004，68，7： | 1 |
| 11 | Effects of green tea intake on the development of coronary artery disease显示文摘 | Sano J Inami S Seimiya k | 2004 | Circulation2004，68，10： | 1 |
| 12 | Telomerase inhibiton, telomere shortening and senescene of cancer cells by tea catecchin 显示文摘 | Nansani I Seimiya H Tsuruo T | 1998 | Biochem Biophy Res Commun1998，249，2： | 1 |
| 13 | Tankyrasel as a target for telomere-directed molecular cancer therapeutics 显示文摘 | Seimiya H Muramatsu Y Ohishi T | 2005 | Cancer Cell2005，7，1： | 1 |
| 14 | Telomer asae inhibition, telomere shortening, and senescence of cancer cells by tea catechins显示文摘 | Imad Naasani Hiroyudi Seimiya | 1998 | Biochemical and Biophysical Research Communications1998，249，： | 1 |
| 15 | Telomerase inhibition,telomere shortening,and senescence of cancer cells by tea catechins显示文摘 | Naasani I Seimiya H Tsuruo T | 1998 | Biochem Biophys Res Commun1998，249，2： | 1 |
| 16 | Long period stacking structures observed in Mg97Zn1Y2 alloy 显示文摘 | Itoi T Seimiya T Kawamura Y | 2004 | Scripta Materialia2004，51，2： | 1 |
| 17 | Telomeric repeat-containing RNA/G-quadruplex-forming sequences cause genome- wide alteration of gene expression in human cancer cells in vivo显示文摘 | Hirashima K Seimiya H | 2015 | Nucleic Acids Res2015，43，4： | 1 |
| 18 | Identification of homeobox-containing genes in the most primitive metazoa, sponge 显示文摘 | Watanabe Y Kurosawa Y | 1992 | Zool Sci1992，9，： | 1 |
| 19 | De nvo fatty-acid synlhesis and related pathways as molecular targets for cancer therapy 显示文摘 | Mashima T Seimiya H Tsuruo T | | Br J Cancer0，100，9： | 1 |
| 20 | Identification of novel immunohistochemical tumor markers for primary hepatocellular carcinoma; clathrin heavy chain and formiminotransferase cy- clodeaminase显示文摘 | Seimiya Masanori Tomonaga Takeshi Matsushita Kazuyu- ki | 2008 | Hepatology2008，48，2： | 1 |
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