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| 1 | Early effects of oral administration of omeprazole and roxatidine on intragastric pH显示文摘Objective:The ideal medication for the treatment of acid-related diseases,e.g.,peptic ulcers,stress-related gastric bleeding,functional dyspepsia,and gastroesophageal reflux disease,should have a rapid onset of action to promote hemostasis and relieve the symptoms.The aim of our study was to investigate the inhibitory effects on gastric acid secretion of a single oral administration of a proton pump inhibitor,omeprazole 20 mg,and an H2-receptor antagonist,roxatidine 75 mg.Methods:Ten Helicobacter pylori-negative male subjects participated in this randomized,two-way crossover study.Intragastric pH was monitored continuously for 6 h after single oral administration of omeprazole 20 mg and roxatidine 75 mg.Each administration was separated by a 7-d washout period.Results:During the 6-h study period,the average pH after administration of roxatidine was higher than that after administration of omeprazole(median:4.45 vs.2.65;P=0.0367).Also during the 6-h study period,a longer duration of maintenance at pH above 2,5,and 6 was observed after administration of roxatidine 75 mg than after administration of omeprazole 20 mg(median:90.6% vs.55.2%,P=0.0284;43.7% vs.10.6%,P=0.0125;40.3% vs.3.3%,P=0.0125;respectively).Conclusions:In Helicobacter pylori-negative healthy male subjects,oral administration of roxatidine 75 mg increased the intragastric pH more rapidly than that of omeprazole 20 mg. | Hiroshi IIDA Shingo KATO Yusuke SEKINO Eiji SAKAI Takashi UCHIYAMA Hiroki ENDO Kunihiro HOSONO Yasunari SAKAMOTO Koji FUJITA Masato YONEDA Tomoko KOIDE Hirokazu TAKAHASHI Chikako TOKORO Ayumu GOTO Yasunobu ABE Noritoshi KOBAYASHI Kensuke KUBOTA Eiji GOTOH Shin MAEDA Atsushi NAKAJIMA Masahiko INAMORI | 2012 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2012，13，1： | 6 |
| 2 | characteristics of intestinal pseudo-obstruction in patients with mitochondrial diseases显示文摘AIM: To reveal the frequency, characteristics and prognosis of chronic intestinal pseudo-obstruction (CIP) in mitochondrial disease patients. METHODS: Between January 2000 and December 2010, 31 patients (13 males and 18 females) were di-agnosed with mitochondrial diseases at our hospital. We conducted a retrospective review of the patients' sex, subclass of mitochondrial disease, age at onset of mitochondrial disease, frequency of CIP and the age at its onset, and the duration of survival. The age at onset or at the first diagnosis of the disorder that led to the clinical suspicion of mitochondrial disease was also examined. RESULTS: Twenty patients were sub-classified with mitochondrial encephalopathy with lactic acidosis and stroke-like episodes (MELAS), 8 with chronic progressive external ophthalmoplegia (CPEO), and 3 with myoclonus epilepsy associated with ragged-red fibers (MERRF). Nine patients were diagnosed with CIP, 8 of the 20 (40.0%) patients with MELAS, 0 of the 8 (0.0%) patients with CPEO, and 1 of the 3 (33.3%) patients with MERRF. The median age (range) at the diagnosis and the median age at onset of mitochondrial disease were 40 (17-69) and 25 (12-63) years in patients with CIP, and 49 (17-81) and 40 (11-71) years in patients without CIP. During the survey period, 5 patients (4 patients with MELAS and 1 with CPEO) died. The cause of death was cardiomyopathy in 2 patients with MELAS, cerebral infarction in 1 patient with MELAS, epilepsy and aspiration pneumonia in 1 patient with MELAS, and multiple metastases from gastric cancer and aspiration pneumonia in 1 patient with CPEO. CONCLUSION: Patients with CIP tend to have disorders that are suspected to be related to mitochondrial diseases at younger ages than are patients without CIP. | Yusuke Sekino Masahiko Inamori Eiji Yamada Hidenori Ohkubo Eiji Sakai Takuma Higurashi Hiroshi Iida Kunihiro Hosono Hiroki Endo Takashi Nonaka Hirokazu Takahashi Tomoko Koide Yasunobu Abe Eiji Gotoh Shigeru Koyano Yoshiyuki Kuroiwa Shin Maeda Atsushi Nakajima | 2012 | World Journal of Gastroenterology2012，18，33： | 3 |
| 3 | Contrast uptake in primary hepatic angiosarcoma on gadolinium-ethoxybenzyl-diethylenetriamine pentaacetic acid-enhanced magnetic resonance imaging in the hepatobiliary phase显示文摘Primary hepatic angiosarcoma is the most common malignant mesenchymal tumor of the liver. It has a poor prognosis and various appearances on magnetic resonance(MR) images. We report a case of hepatic angiosarcoma with a characteristic appearance on gadolinium-ethoxybenzyl-diethylenetriamine pentaacetic acid(Gd-EOB-DTPA)-enhanced MR imaging in the hepatobiliary phase. A 72-year-old man was admitted with a complaint of abdominal pain. Gd-EOBDTPA-enhanced MR imaging revealed a liver tumor that showed slight hyperintensity in the hepatobiliary phase. These findings suggested Gd-EOB-DTPA uptake in the tumor. An autopsy revealed the solid proliferation and sinusoidal spreading of hepatic angiosarcoma cells. Immunohistochemistry indicated that the tumor was negative for OATP1B3. Gd-EOB-DTPA uptake in the liver tumor in the hepatobiliary phase suggested sinusoidal tumor invasion with residual normal hepatocytes. | Manabu Hayashi Satoshi Kawana Hirofumi Sekino Kazumichi Abe Naoki Matsuoka Masahito Kashiwagi Ken Okai Yukiko Kanno Atsushi Takahashi Hiroshi Ito Yuko Hashimoto Hiromasa Ohira | 2018 | World Journal of Hepatology2018，10，1： | 3 |
| 4 | Solid propulsion for space applications: An updated roadmap显示文摘 | Jean-Francois Guery I-Shih Chang Toru Shimada Marilyn Glick Didier Boury Eric Robert John Napior Robert Wardle Christian Pérut Max Calabro Robert Glick Hiroto Habu Nobuhiro Sekino Gilles Vigier Bruno d’Andrea | 2009 | Acta Astronautica2009，，1： | 2 |
| 5 | CD24 induces apoptosis in human B cells via the glycolipid-enriched membrane domains/rafts-mediated signaling system显示文摘 | Suzuki T Kiyokawa N Taguchi T Sekino T Katagiri YU Fujimoto J | 2001 | J Immunol2001，166，： | 1 |
| 6 | Application of microsatellite markers to population genetics studies of Japanese flounder Paralichthys olivaceus显示文摘 | Sekino M Hara M | 2001 | Mar Bioteehnol2001，3，： | 1 |
| 7 | Properties of hot-pressed A1N/BN nanocomposites 显示文摘 | Kusunose T Sekino T Kim B S | 2003 | Materials Science Forum2003，439，： | 1 |
| 8 | Effect of ZrO2 addition on Microstructure and mechanical properties of MoSiz 显示文摘 | Suzuki Y Sekino Ti Niihara K | 1995 | Scripta Metallurgic of Materialia1995，，33： | 1 |
| 9 | Effects of strong static magnetic fields on nerve excitation 显示文摘 | Sekino M Tatsuoka H Yamaguchi S | 2006 | IEEE Transactions on Magnetics2006，42，10： | 1 |
| 10 | New thin lithium-ion batteries using a liquid electrolyte with thermal stability显示文摘 | Norio Takami Masahiro Sekino Takahisa Ohsaki | 2001 | J Power Sources2001，9798，： | 1 |
| 11 | Fabrication and microstructure of silicon nitride/boron nitride nanocomposites 显示文摘 | KUSUNOSE T SEKINO T CHOA Y H | 2002 | J Am Ceram Soc2002，85，11： | 1 |
| 12 | Linkage maps for the Pacific abalone (Genus Haliotis) based on microsatellite DNA markers显示文摘 | SEKINO M HARA M | 2007 | Genet- ics2007，175，： | 1 |
| 13 | Isolation and characterization microsatellite DNA loci in Japan flounder Paralichthys olivaceus 显示文摘 | Sekino M Hrara M | 2000 | Mol Ecol2000，9，： | 1 |
| 14 | Isolation and characterization of microsatellite DNA loci in Japanese flounder Paralichthys olivaceus (Pleuronectiformes, Pleuronectoidei, Paralichthyidae) 显示文摘 | Sekino M Hara M | 2000 | Mol Ecol2000，9，： | 1 |
| 15 | Synthesis and immunological effect of deacetyl-thymosi n alpha 11 on low E-rosette-forming cells of a rheumatoid arthritis patient显示文摘 | ABIKO T SEKINO H | 1985 | Chem Pharm Bull1985，33，2： | 1 |
| 16 | Development of novel microsatellite DNA markers from the Pacific oyster Crassostrea gigas显示文摘 | Sekino M Hamaguchi M Aranishi F Okoshi K | | 0，，3： | 1 |
| 17 | Photoluminescence of samarium-doped TiO2 nanotubes 显示文摘 | Park D J Sekino T Tsukuda S | 2011 | Solid State Chem2011，184，10： | 1 |
| 18 | Loss of microsatellite and mitoehondrial DNA variation in hatchery strains of Japanese flounder Paralichthys olivaceus 显示文摘 | Sekino M Hrara M Taniguchi N | 2002 | Aquaculture2002，213，： | 1 |
| 19 | Application of microsatellite markers to population genetics studies of Japanese flounder Paralichthys olivaceus 显示文摘 | Sekino M Hara M | 2001 | Marine Biotechnology2001，3，： | 1 |
| 20 | 查看详情显示文摘 | SEKINO H BARTLETT R J | | 0，，04： | 1 |
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