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| 1 | The cellular labeling and pH-sensitive responsive-drug release of celastrol in cancer cells based on Cys-CdTe QDs显示文摘As one of the active compounds derived from Traditional Chinese Medicine,Celastrol(CSL)had cytotoxicity for human leukemia cancer cells K562 and its multidrug-resistant cell line K562/A02.Here,we introduced cysteamine-modified CdTe QDs as the labeling and drug carrier into CSL research and found that the self-assembly and conjugation of anticancer molecular CSL with the Cys-CdTe QDs could significantly increase the drug’s cytotoxicity for K562 cells.More important,these CSL-Cys-CdTe nanocomposites could overcome the multidrug resistance of K562/A02 cells and efficiently inhibit the cancer cell proliferation by realizing the pH-sensitive responsive release of CSL to cancer cells.The enhanced cytotoxicity was caused by the increase of the G2/M phase arrest for K562/A02 cells as well as for K562 cells.Cys-CdTe QDs can readily bind on the cell plasma membranes and be internalized into cancer cells to trace and detect human leukemia cancer cells in real time.In addition,these Cys-CdTe QDs can facilitate the inhibition of the multidrug resistance of K562/A02 cells and readily induce apoptosis.As a good photosensitizer for the therapy,labeling,and tracing of cancer cells,the combination of CSL with Cys-CdTe QDs can optimize the use of and a new potential therapy method for CSL and yield new tools to explore the mechanisms of active compounds from Traditional Chinese Medicine. | LI JingYuan SHI LiXin SHAO YiXiang SELKE Matthias CHEN BaoAn JIANG Hui WANG XueMei | 2014 | Science China Chemistry2014，57，6： | 6 |
| 2 | Enhanced in vitro anticancer activity of quercetin mediated by functionalized CdTe QDs显示文摘We report in this study the effects of red-emitting CdTe QDs capped with cysteamine(Cys-CdTe) on the in vitro anticancer activity of the well-known flavenoid quercetin(Qu). Various techniques, including the methylthiazolyldiphenyl-tetrazolium bromide assay, the real-time cell electronic sensing system, the optical and fluorescence imaging, and electrochemical methods have been utilized to study the potential interactions of Cys-CdTe QDs with Qu. The observations demonstrate that the safe-dosage Cys-CdTe QDs can greatly improve the drug uptake and enhance the inhibition efficiency of Qu towards the proliferation of cancer cells such as HepG2 cells. This study implies that Cys-CdTe QDs may be used for cancer therapy and that they exert a synergic anticancer effect when bound to drug molecules. | WU ChunHui SHI LiXin WU ChangYu GUO DaDong SELKE Matthias WANG XueMei | 2014 | Science China Chemistry2014，57，11： | 2 |
| 3 | Rapid and multimodal in vivo bioimaging of cancer cells through in situ biosynthesis of Zn&Fe nanoclusters显示文摘早诊断为有效癌症治疗仍然保持高度重要,并且因此,对有效成像策略的发展有重要兴趣。这个工作由介绍水的 Fe 2+ 和 Zn 2+ 离子进癌症房间为癌症房间的精确、快速的诊断报导一个新多模式的 bioimaging 方法(即, HeLa, U87,和 HepG2 癌症房间) 。我们发现 biocompatible 金属离子 Fe 2+ 和 Zn 2+ 强迫了癌症房间自发地综合荧光灯 ZnO nanoclusters 和磁性的 Fe 3 O 4 nanoclusters。这些簇然后能由把荧光成像与磁性的回声成像相结合被用于多模式的癌症成像并且计算断层摄影术成像。同时,为正常房间(即, L02 ) 并且纸巾,两荧光也不任何另外的明显的差别能在 preand 之间被检测注射以后。这多模式的 bioimaging 策略基于在里面 situ biosynthesized Zn&Fe 氧化物 nanoclusters 可能因此为早癌症诊断和治疗是有用的。 | Tianyu Du Chunqiu Zhao Fawad ur Rehman Lanmei Lai Xiaoqi Li Yi Sun Shouhua Luo Hui Jiang Matthias Selke Xuemei Wang | 2017 | Nano Research2017，10，8： | 1 |
| 4 | CdTe quantum dots with dauuorubicin induce apoptosis of muhidrug-resistant human hepa- toma HepG2/ADM cells: in vitro and in vivo evaluation 显示文摘 | Zhang Gen Shi Linxin Matthias Selke | 2011 | Nanoseale Research Letters2011，6，1： | 1 |
| 5 | Synergy and translation of allogenic bone marrow stem cells after photodynamic treatment of rheumatoid arthritis with tetra sulfonatophenyl porphyrin and TiO2 nanowhiskers显示文摘风湿性关节炎(RA ) 病原学和改善在现代治疗学仍然是挑战。此处,我们探索了 allogenic 的 synergistic 效果骨头髓干细胞(BMSC ) 翻译和有 tetra sulfonatophenyl 卟啉(TSPP ) 和 TiO 2 nanocomposites 的 RA 的光力学的处理作为为 RA theranostics 的新策略。有进在长骨头 photodynamic 以后治疗的感染的关节的 miRNAs 的 BMSC 的翻译对对待并且理解 RA pathophysiology 有用。我们在骨胶原观察了翻译显著地与 TSPP-TiO 2 nanocomposites 罐头相结合的那 allogenic BMSC ( p 和 interleukin-17 )导致的关节炎(中央情报局)鼠科的模型,在 vitro 并且在 vivo ,以及改进象关节炎 20 那样的另外的参数, BMSC 计数,完全的血计数,并且血小板,红血房间,和白血房间数。而且,一荧光灯脚里的 TSPP 和 RA 关节的 X 光检查 bioimaging 表明 BMSC 的临床的功效与 TSPP-TiO 2 nanocomposites 结合了。Microarray 数据分析说明了那 rno-mir-375-3p, rno-mir-196b-3p 由近似在有 TSPP-TiO 2 nanocomposites 的改善 RA photodynamic 以后治疗的 BMSC 的 100 褶层是起来调整的。我们的学习不仅为 RA theranostics 建议一条新途径,而且在理解 RA pathophysiology 帮助。 | Fawad U. Rehman Chunqiu Zhao Changyu Wu Xiaoqi Li Hui Jiang Matthias Selke Xuemei Wang | 2016 | Nano Research2016，9，11： | 1 |
| 6 | Titanium dioxide-tetra sulphonatophenyl porphyrin nanocomposites for target cellular bio-imaging and treatment of rheumatoid arthritis显示文摘Photodynamic therapy(PDT) is one of the latest biomedical technologies used for treatment of various neoplastic and non-neoplastic diseases. However, there still exist some well-known problems regarding its efficacy, e.g. effective concentration of the drug at the desired sites, the irradiation light dosimetry and biocompatibility of the photosensitizer. The introduction of nanotechnology and nanomaterial like biocompatible nano-titania(i.e., nano-TiO_2) may facilitate to solve some of these problems. In this study we have explored the possibility of combining tetra sulphonatophenyl porphyrin(TSPP) with nano-titania(PT) for efficient PDT with least adverse effects. The spectroscopic properties of these nano-composites were characterized by using fluorescence and UV-Vis absorption spectroscopic study. The singlet oxygen quantum yield was determined by using 2,5-diphenyl-3,4-benzofuran(DPBF), while the effect of nano TiO_2 with TSPP on the synovial fibroblast cells from human(HSC) and rat models(RSC) were investigated by confocal laser microscopy and 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide(MTT) assay. Our results suggest that nano TiO_2 with TSPP can be readily utilized for effective PDT treatment of Rheumatoid Arthritis(RA). | Chunqiu Zhao Fawad Ur Rehman Hui Jiang Matthias Selke Xuemei Wang Chong-Yang Liu | 2016 | Science China Chemistry2016，59，5： | 0 |
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