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| 1 | Impact of concomitant use of proton pump inhibitors and clopidogrel or ticagrelor on clinical outcomes in patients with acute coronary syndrome显示文摘BackgroundThere 是在质子泵禁止者(PPI ) 和 clopidogrel 之间的可能的不利相互作用上的大争论。另外, PPI 的使用是否少些影响 ticagrelor 遗体的临床的功效,知道。在经皮的冠的干预(一种总线标准) .MethodsWe 回顾地从 “ 分析了数据以后,我们试图与急性冠的症候群(交流)在病人在临床的结果上决定 PPI 和 clopidogrel 或 ticagrelor 的伴随物管理的影响;真实 world” ;,国际,在 2003 和 2014 之间的多中心登记( n = 15,401 )并且在1年的合成主要端点上估计了 PPI 和 clopidogrel 或 ticagrelor 的伴随物管理的影响(所有原因死亡收到 PPI 的病人更老,更经常女性,并且是更可能的有 comorbidities。没有协会为收到 clopidogrel 的病人在 PPI 使用和主要端点之间被观察(调整 HR:1.036;95% CI:0.903-1.189 ) 或 ticagrelor (调整 HR:2.320;95% CI:0.875-6.151 )(P 相互作用 = 0.2004 ) 。同样, PPI 的使用没与所有原因死亡,重新梗塞,或与交流后面的一种总线标准的为与任何一个 clopidogrel 对待的病人或 ticagrelor.ConclusionsIn 病人的严重流血的减少的风险的增加的风险被联系, PPI 的伴随物使用没在收到 clopidogrel 或 ticagrelor 的病人与不利结果的增加的风险被联系。我们的调查结果显示与 clopidogrel 或 ticagrelor 在联合使用 PPI 是合理的,特别在有胃肠的流血的更高的风险的病人。 | Yan YAN Xiao WANG Jing-Yao FAN Shao-Ping NIE Sergio Raposeiras-Roubin Emad Abu-Assi Jose P Simao Henriques Fabrizio D'Ascenzo Jorge Saucedo Jose R Gonzfilez-Juanatey Stephen B Wilton Wouter J Kikkert Ivlin Nufiez-Gil Albert Ariza-Sole Xian-Tao SONG Dimitrios Alexopoulos Christoph Liebetrau Tetsuma Kawaji Claudio Moretti Zenon Huczek Toshiharu Fujii Luis C Correia Masa-aki Kawashiril Sasko Kedev | 2016 | Journal of Geriatric Cardiology2016，13，3： | 12 |
| 2 | P2Y12受体抑制剂联合质子泵抑制剂对急性冠脉综合征患者缺血事件影响的临床分析显示文摘目的本研究旨在分析P2Y12受体抑制剂联合质子泵抑制剂(PPI)治疗对经皮冠状动脉介入(PCI)术后的急性冠脉综合征患者缺血事件的影响。方法基于国际多中心回顾性注册登记研究,纳入2003至2014年因急性冠脉综合征人院行PCI术的患者,分为PPI组及非PPI组并随访1年,主要临床终点为全因死亡/再发心肌梗死的复合终点。根据P2Y12受体抑制剂种类,将入组患者分为氯吡格雷组及替格瑞洛组,并比较不同药物与PPI联用发生临床终点事件的风险。结果研究入选9429例患者,PPI组占54.8%,具有更多高危因素。Cox回归结果提示PPI组较非PPI组全因死亡/再发心肌梗死复合事件的发生差异无统计学意义(HR1.00,95%CI 0.86—1.18)。根据P2Y12抑制剂种类不同分为氯吡格雷组和替格瑞洛组,不同P2Y12受体抑制剂联用PPI较未联用PPI患者的临床终点无差异,联用PPI的氯吡格雷组与替格瑞洛组的临床终点差异也无统计学意义。结论急性冠脉综合征患者PPI与P2Y12受体抑制剂联用不增加全因死亡和再发心肌梗死风险,尤其PPI联用氯吡格雷在患者的缺血事件上与替格瑞洛比较差异无统计学意义。 | 冯斯婷 严妍 范婧尧 王晓 郑文 聂绍平 Sergio Raposeiras-Roubin Emad Abu-Assi Jose P Simao Henriques Fabrizio D' Ascenzo Jorge Saucedo Jose R Conzalez-Juanatey Stephen B Wilton Wouter J Kikkert Ivan Nunez-Gil Albert Ariza-Sole Dimitrios Alexopoulos Christoph Liebetrau Tetsuma Kawaji Claudio Moretti Zenon Huczek Toshiharu Fujii Luis C Correia Masa-aki Kawashiri Sasko Kedev | 2016 | 中华医学杂志2016，96，33： | 6 |
| 3 | Endoscopic ultrasound-guided vs endoscopic retrograde cholangiopancreatography biliary drainage for obstructed distal malignant biliary strictures: A systematic review and meta-analysis显示文摘BACKGROUND For palliation of malignant biliary obstruction(MBO), the gold-standard method of biliary drainage is endoscopic retrograde cholangiopancreatography(ERCP)with the placement of metallic stents. Endoscopic ultrasound(EUS)-guided drainage is an alternative that is typically reserved for cases of ERCP failure.Recently, however, there have been robust randomized clinical trials(RCTs)comparing EUS-guided drainage and ERCP as primary approaches to MBO.AIM To compare EUS guidance and ERCP in terms of their effectiveness and safety in palliative biliary drainage for MBO.METHODS This was a systematic review and meta-analysis, in which we searched the MEDLINE, Excerpta Medica, and Cochrane Central Register of Controlled Trials databases. Only RCTs comparing EUS and ERCP for primary drainage of MBO were eligible. All of the studies selected provided data regarding the rates of technical and clinical success, as well as the duration of the procedure, adverse events, and stent patency. We assessed the risk of biases using the Jadad score and the quality of evidence using the Grading of Recommendations Assessment,Development and Evaluation criteria.RESULTS The database searches yielded 5920 records, from which we selected 3 RCTs involving a total of 222 patients(112 submitted to EUS and 110 submitted to ERCP). In the EUS and ERCP groups, the rate of technical success was 91.96%n and 91.81%, respectively, with a risk difference(RD) of 0.00%(95%CI:-0.07, 0.07;P = 0.97; I^2 = 0%). The clinical success was 84.81% and 85.53% in the EUS and ERCP groups, respectively, with an RD of-0.01%(95%CI:-0.12, 0.10; P = 0.90; I^2 =0%). The mean difference(MD) for the duration of the procedure was-0.12%(95%CI:-8.20, 7.97; P = 0.98; I^2 = 84%). In the EUS and ERCP groups, there were14 and 25 adverse events, respectively, with an RD of-0.06%(95%CI:-0.23, 0.12; P= 0.54; I^2 = 77%). The MD for stent patency was 9.32%(95%CI:-4.53, 23.18; P =0.19; I^2 = 44%). The stent dysfunction rate was significantly lower in the EUS t group(MD =-0.22%; 95 CI:-0.35,-0.08; P = 0.001; I^2 = 0%).CONCLUSION EUS represents an interesting alternative to ERCP for MBO drainage,demonstrating lower stent dysfunction rates compared with ERCP. Technical and clinical success, duration, adverse events and patency rates were similar. | Fernanda P Logiudice Wanderlei M Bernardo Facundo Galetti Vitor M Sagae Carolina O Matsubayashi Antonio C Madruga Neto Vitor O Brunaldi Diogo T H de Moura Tomazo Franzini Spencer Cheng Sergio E Matuguma Eduardo G H de Moura | 2019 | World Journal of Gastrointestinal Endoscopy2019，11，4： | 6 |
| 4 | The jack mackerel fishery and El Nino 1997-98 effects off Chile 显示文摘 | Dagoberto F A Luis A C Sergio P N | 2001 | Progress in Oceanography2001，，49： | 1 |
| 5 | Method development for the simultaneous determination of methylmercury and inorganic mercury in seafood显示文摘 | Ariane V Z Sergio C Carmen I P | 2014 | Food Control2014，46，1： | 1 |
| 6 | Hemodynamic effects of phos2phate in patients with congestive heart failure,A double-blind comparison trial versus placebo显示文摘 | Sergio F Linzia C Fibrazio P | 1996 | Clin Cardiol1996，19，9： | 1 |
| 7 | The jack mackerel fishery and EL Nino effeels of Chile显示文摘 | DAGOBERTO F A LUIS A C SERGIO P | 2001 | Progress in Oceangraphy2001，，49： | 1 |
| 8 | Cardiovascular risk as- sessment of pulmonary embolism with the GRACE Risk Score 显示文摘 | Luis V P Rui C P Sergio N B | 2013 | Am J Cardiol2013，111，2： | 1 |
| 9 | A comprehensive multilocus phylogeny for the wood-warblers and a revised classification of the Parulidae (Aves)显示文摘 | Irby J. Lovette Jorge L. Pérez-Emán John P. Sullivan Richard C. Banks Isabella Fiorentino Sergio Córdoba-Córdoba María Echeverry-Galvis F. Keith Barker Kevin J. Burns John Klicka Scott M. Lanyon Eldredge Bermingham | 2010 | Molecular Phylogenetics and Evolution2010，，2： | 1 |
| 10 | Modelling biological invasions:species traits,species interactions,and habitat heterogeneity显示文摘 | SERGIO A C DIANA E M SERGIO A P | 2003 | Mathematical Biosciences2003，183，： | 1 |
| 11 | Effect of maternal carbohydrate metabolism on fetal growth显示文摘 | Alessandro C Giancarlo P Sergio F | 1998 | Obstet Gynecol1998，92，： | 1 |
| 12 | The human serum paraoxonase/arylesterase gene(PON1) is one member of a multigene family显示文摘 | Sergio L Primo P Robert C | 1996 | Genomics1996，33，3： | 1 |
| 13 | Effect of maternal carbohydrate metabolism on fetal growth显示文摘 | Alessandro C Giancarlo P Sergio F | 1998 | Obstet Gynecol1998，92，： | 1 |
| 14 | Does angiotensin converting enzyme gene polymorphism affect blood pressure? Findings after 6 years of follow-up in healthy subjects显示文摘 | Pietro DP Sergio C Salvatore P | | 0，，01： | 1 |
| 15 | Parametric vs neural network models for the estimation of production costs:A case study in the automotive industry显示文摘 | Sergio C Paolo M Roberto P | 2004 | International Journal of Production Economics2004，91，： | 1 |
| 16 | The jack mackerel fishery and El Ni(n)o 1997-98 effects off Chile显示文摘 | Dagoberto F A Luis A C Sergio P N | 2001 | Progress in Oceanography2001，，49： | 1 |
| 17 | Hemodynamie effects of creatine phosphate in patients with congestive heart failure : A double-blind comparison trial versus placebo显示文摘 | Sergio F Cinzia C Fabrizio P | 1996 | Clinical Cardiology1996，19，13： | 1 |
| 18 | Propionyl coenzyme A is a common intermediate in the 1,2-propanediol and propionate catabolic pathways needed for expression of the prpBCDE operon during growth of Salmonella enterica on 1,2-propanediol显示文摘 | Sergio P Vincent J S Jorge C | 2003 | Journal of Bacteriology2003，185，9： | 1 |
| 19 | Centrality measures in spatial networks of urban streets 显示文摘 | Paolo C Vito L Sergio P | 2006 | Physics Review E2006，73，2： | 1 |
| 20 | Thermal body patterns for healthy Brazilian adults (male and female) 显示文摘 | JOAO C B M ALEX A F SERGIO P C | 2014 | Journal of Thermal Biology2014，42，1： | 1 |
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