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| 1 | Impacts of Urban Expansion on the Urban Thermal Environment:A Case Study of Changchun,China显示文摘Urbanization,especially urban land expansion,has a profound influence on the urban thermal environment.Cities in Northeast China face remarkably uneven development and environmental issues,and thus it is necessary to strengthen the diagnosis of thermal environmental pressure brought by urbanization.In this study,multi remote sensing imageries and statistical approaches,involving piecewise linear regression(PLR),were used to explore urban expansion and its effects on the thermal environment of Changchun City in Jilin Province,China.Results show that Changchun experienced rapid urban expansion from 2000 to 2020,with urban built-up areas increasing from 171.77 to 525.14 km^(2).The area of the city’s urban heat island(UHI)increased dramatically,during both day and night.Using PLR,a positive linear correlation of built-up density with land surface temperature(LST)was detected,with critical breakpoints of 70%-80%during the daytime and 40%-50%at nighttime.Above the thresholds,the magnitude of LST in response to built-up density significantly increased with intensifying urbanization,especially for nighttime LST.An analysis of the relative frequency distributions(RFDs)of LST reveals that rapid urbanization resulted in a significant increase of mean LST in newly urbanized areas,but had weak effects on daytime LST change in existing urban area.Urban expansion also contributed to a constant decrease of spatial heterogeneity of LST in existing urban area,especially at daytime.However,in newly urbanized areas,the spatial heterogeneity of LST was decreased during the daytime but increased at nighttime due to urbanization. | YANG Limin LI Xiaoyan SHANG Beibei | 2022 | Chinese Geographical Science2022，32，1： | 2 |
| 2 | Intercellular transfer of activated STING triggered by RAB22A-mediated non-canonical autophagy promotes antitumor immunity显示文摘STING,an endoplasmic reticulum(ER)transmembrane protein,mediates innate immune activation upon cGAMP stimulation and is degraded through autophagy.Here,we report that activated STING could be transferred between cells to promote antitumor immunity,a process triggered by RAB22A-mediated non-canonical autophagy.Mechanistically,RAB22A engages PI4K2A to generate PI4P that recruits the Atg12–Atg5–Atg16L1 complex,inducing the formation of ER-derived RAB22A-mediated non-canonical autophagosome,in which STING activated by agonists or chemoradiotherapy is packaged.This RAB22A-induced autophagosome fuses with RAB22A-positive early endosome,generating a new organelle that we name Rafeesome(RAB22A-mediated non-canonical autophagosome fused with early endosome).Meanwhile,RAB22A inactivates RAB7 to suppress the fusion of Rafeesome with lysosome,thereby enabling the secretion of the inner vesicle of the autophagosome bearing activated STING as a new type of extracellular vesicle that we define as R-EV(RAB22A-induced extracellular vesicle).Activated STING-containing R-EVs induce IFNβrelease from recipient cells to the tumor microenvironment,promoting antitumor immunity.Consistently,RAB22A enhances the antitumor effect of the STING agonist diABZI in mice,and a high RAB22A level predicts good survival in nasopharyngeal cancer patients treated with chemoradiotherapy.Our findings reveal that Rafeesome regulates the intercellular transfer of activated STING to trigger and spread antitumor immunity,and that the inner vesicle of non-canonical autophagosome originated from ER is secreted as R-EV,providing a new perspective for understanding the intercellular communication of organelle membrane proteins. | Ying Gao Xueping Zheng Boyang Chang Yujie Lin Xiaodan Huang Wen Wang Shirong Ding Weixiang Zhan Shang Wang Beibei Xiao Lanqing Huo Youhui Yu Yilin Chen Run Gong Yuanzhong Wu Ruhua Zhang Li Zhong Xin Wang Qiuyan Chen Song Gao Zhengfan Jiang Denghui Wei Tiebang Kang | 2022 | Cell Research2022，32，12： | 1 |
| 3 | Research Progress on Pathogenesis and Intervention Measures of Depression显示文摘With the wide spread of the epidemic,the long-term closed lifestyle and the sharp reduction of physical activities,many people have mental health problems such as panic,anxiety and depression.At present,there are few studies on the effect of exercise on depression.Therefore,the study selected exercise intervention therapy and other intervention methods to evaluate the intervention effect of depression,and explored the effect of exercise intervention by evaluating depression scale and effective indicators.Hope this can provide a new idea for exercise intervention as an adjunctive therapy for depression on drug treatment. | Yun Shang Beibei Ge Xiaolei Zhang | 2021 | Journal of Clinical and Nursing Research2021，5，5： | 0 |
| 4 | Atomically Dispersed Manganese Lewis Acid Sites Catalyze Electrohydrogenation of Nitrogen to Ammonia显示文摘Ambient electrochemical nitrogen fixation is a promising and environmentally benign route for producing sustainable ammonia,but has been limited by the poor performance of existing catalysts that promote the balanced chemisorption of N2 and subsequent electrochemical activation and hydrogenation.Herein,we describe the highly selective and efficient electrohydrogenation of nitrogen to ammonia using a hollow nanorod-based hierarchically graphitic carbon electrocatalyst with abundant atomically dispersed Mn sites.We discovered that the electron interactions strengthen the interfacial binding between nitrogen and active Mn Lewis acidic hotspots.The Lewis acid-base interactions promote the chemisorption and lock up nitrogen on the active sites and suppress proton adsorption.The proton-coupled electron transfer cleavage of the nitrogen triple bond through an associative mechanism was confirmed under lower overpotential,which delivered high ammonia yield of 67.5μg h−1 mgcat.−1 and Faradaic efficiency of 13.7% at−0.25 V versus the reversible hydrogen electrode,along with∼100% selectivity and significantly enhanced electrochemical stability(about 88.8% current retention over 50 h potentiostatic test)under mild conditions.Our strategy is versatile to tailor the nitrogen fixation performance of single-atom catalysts with atomic accuracy. | Zhoutai Shang Bin Song Hongbao Li Hong Zhang Fan Feng Jacob Kaelin Wenli Zhang Beibei Xie Yingwen Cheng Ke Lu Qianwang Chen | 2022 | CCS Chemistry2022，4，6： | 0 |
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