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| 1 | Osteoimmunomodulatory effects of biomaterial modification strategies on macrophage polarization and bone regeneration显示文摘Biomaterials as bone substitutes are always considered as foreign bodies that can trigger host immune responses.Traditional designing principles have been always aimed at minimizing the immune reactions by fabricating inert biomaterials.However,clinical evidence revealed that those methods still have limitations and many of which were only feasible in the laboratory.Currently,osteoimmunology,the very pioneering concept is drawing more and more attention-it does not simply regard the immune response as an obstacle during bone healing but emphasizes the intimate relationship of the immune and skeletal system,which includes diverse cells,cytokines,and signaling pathways.Properties of biomaterials like topography,wettability,surface charge,the release of cytokines,mediators,ions and other bioactive molecules can impose effects on immune responses to interfere with the skeletal system.Based on the bone formation mechanisms,the designing methods of the biomaterials change from immune evasive to immune reprogramming.Here,we discuss the osteoimmunomodulatory effects of the new modification strategies—adjusting properties of bone biomaterials to induce a favorable osteoimmune environment.Such strategies showed potential to benefit the development of bone materials and lay a solid foundation for the future clinical application. | Yajuan Xie Cheng Hu Yi Feng Danfeng Li Tingting Ai Yulei Huang Xiaodan Chen Lijia Huang Jiali Tan | 2020 | Regenerative Biomaterials2020，7，3： | 22 |
| 2 | Hierarchical 3D mesoporous silicon@graphene nanoarchitectures for lithium ion batteries with superior performance显示文摘硅为高能力锂离子电池作为最有希望的阳极材料被认出了。然而,大体积变化在骑车上在充电和分泌物期间导致 Si 电极和快能力损失的弄成粉。Si 电极的这个缺点能被联合与组织良好的 graphene 泡沫克服。在这个工作,层次三维的碳涂的 mesoporous Si nanospheres@graphene 泡沫(C@Si@GF ) nanoarchitectures 被热水泡喷射成功地综合帮助 chemical-vapor-deposition 和 magnesiothermic 减小方法。同样准备的 nanocomposites 的形态学和结构被扫描电子显微镜学,传播电子显微镜学和拉曼光谱学的地排放描绘。当在锂离子电池作为阳极材料采用了时, C@Si@GF nanocomposites 在 1 A/g,优秀的高率能力和突出的 cyclability 的当前的密度包括 1,200 mAh/g 的一个高特定的能力展出了优异电气化学的性能。验尸,分析鉴别在 200 个周期以后的 3D C@Si@GF 电极的形态学很好被维持。从 mesoporous Si nanospheres 和 graphene 泡沫 nanoarchitectures 的联合产生的 synergistic 效果可以处理 Si 电极的难处理的弄成粉问题。 | Shuangqiang Chen Peite Bao Xiaodan Huang Bing Sun Guoxiu Wang | 2014 | Nano Research2014，7，1： | 19 |
| 3 | Progress in Semi-arid Climate Change Studies in China显示文摘This article reviews recent progress in semi-arid climate change research in China.Results indicate that the areas of semiarid regions have increased rapidly during recent years in China,with an increase of 33%during 1994-2008 compared to 1948-62.Studies have found that the expansion rate of semi-arid areas over China is nearly 10 times higher than that of arid and sub-humid areas,and is mainly transformed from sub-humid/humid regions.Meanwhile,the greatest warming during the past 100 years has been observed over semi-arid regions in China,and mainly induced by radiatively forced processes.The intensity of the regional temperature response over semi-arid regions has been amplified by land-atmosphere interactions and human activities.The decadal climate variation in semi-arid regions is modulated by oceanic oscillations,which induce land-sea and north-south thermal contrasts and affect the intensities of westerlies,planetary waves and blocking frequencies.In addition,the drier climates in semi-arid regions across China are also associated with the weakened East Asian summer monsoon in recent years.Moreover,dust aerosols in semi-arid regions may have altered precipitation by affecting the local energy and hydrological cycles.Finally,semi-arid regions in China are projected to continuously expand in the 21st century,which will increase the risk of desertification in the near future. | Jianping HUANG Jieru MA Xiaodan GUAN Yue LI Yongli HE | 2019 | Advances in Atmospheric Sciences2019，36，9： | 15 |
| 4 | Species-dependent neuropathology in transgenic SOD' aigs显示文摘 | Huaqiang Yang Guohao Wang Haitao Sun Runzhe Shu Tao Liu Chuan-En Wang Zhaoming Liu Yu Zhao Bentian Zhao Zhen Ouyang Dongshan Yang Jiao Huang Yueling Zhou Shihua Li Xiaodan Jiang Zhicheng Xiao Xiao-Jiang Li Liangxue Lai | 2014 | Cell Research2014，24，4： | 13 |
| 5 | Fe-Mn-sepiolite as an effective heterogeneous Fenton-like catalyst for the decolorization of reactive brilliant blue显示文摘在把 Fe-Mn-sepiolite 用作异构的象 Fenton 一样催化剂的一个水的答案的反应灿烂的蓝色的 decolorization 的研究被执行了。Fourier 变换红外线(FTIR ) 催化剂的系列显示出 Fe-O 的弯曲颤动。催化剂的 X 射线衍射(XRD ) 模式显示出 -Fe2O3,-Fe2O3 和 MnO 的典型衍射山峰。中央合成设计(电荷耦合器件) 结合了的四个因素反应表面方法论(RSM ) 被使用评估并且优化重要变量(催化剂增加,氢过氧化物剂量,起始的 pH 值和起始的染料集中) 。反应什么时候调节,是催化剂剂量 = 0.4 g,[H 2 O 2]= 0.3 mL, pH = 2.5,[反应灿烂的蓝色] o = 50mg 愠摮琠瑯污 ?? 潣瑮湥 ? 愠摮攠' 乜畺 { 慥汢? 湡 ? 慣'R 湯瑡 ? 湍攠數瑲琠敨朠敲瑡獥 ? 湩汦敵据獥 ? 桷汩 ? 硥档湡 ??遤 吗?? | Chengyuan SU Weiguang LI Xingzhe LIU Xiaofei HUANG Xiaodan YU | 2016 | Frontiers of Environmental Science & Engineering2016，10，1： | 6 |
| 6 | Apelin-13 inhibits lipoprotein lipase expression via the APJ/PKCα/miR-361-5p signaling pathway in THP-1 macrophage-derived foam cells显示文摘动脉粥样硬化患者损害被丰富的类脂化合物和长期的发炎的累积描绘。以前的研究显示了导出巨噬细胞的脂蛋白脂肪分解酵素(LPL ) 由加速类脂化合物累积和支持 inflammatory cytokine 分泌物支持动脉粥样硬化前进。尽管 apelin-13 被认为是一个 atheroprotective 因素,它是否能调整 LPL 的表示,仍然保持不清楚。这研究的目的是在 THP-1 导出巨噬细胞的泡沫房间在 LPL 和内在的机制的表示上探索 apelin-13 的效果。Apelin-13 显著地减少了在 10 和 100 nM 的集中的全部的胆固醇,免费胆固醇,和胆固醇酉旨的细胞的层次。ELISA 分析证实有 apelin-13 的处理减少了支持 inflammatory cytokine 分泌物,例如 interleukin-6 (IL-6 ) , interleukin-1 (IL-1 ) 和肿瘤坏死 factor-alpha (TNF-) 。apelin-13 禁止了由西方的污点和即时 PCR 分析揭示了的 LPL 的表示,这也被发现。生物信息学分析和双酶的记者试金直接显示了那 miR-361-5p downregulated 由指向 LPL 的 3UTR 的 LPL 的表示。另外, apelin-13 + miR-361-5p 显著地模仿 downregulated 在房间的 LPL 的表示。最后,我们表明了那 apelin-13 downregulated 通过激活 PKC 的活动的 LPL 的表示。一起拿,我们的结果显示出那 apelin-13 downregulated 经由激活在 THP-1 导出巨噬细胞的泡沫房间表明小径的 APJ/PKC/miR-361-5p 的 LPL 的表示,导致类脂化合物累积和支持 inflammatory cytokine 分泌物的抑制。因此,我们的研究由 apelin-13 提供重要新卓见进类脂化合物累积和支持 inflammatory cytokine 分泌物的抑制,并且在动脉粥样硬化作为一个有希望的治疗学的目标加亮 apelin-13。 | Xin Zhang Qiong Ye Duo Gong Yuan Lv Haipeng Cheng Chong Huang Lingyan Chen Zhenwang Zhao Liang Li Xie Wei Min Zhang Xiaodan Xia Xiaohua Yu Xilong Zheng Shuzhi Wang Zongbao Wang Chaoke Tang | 2017 | Acta Biochimica et Biophysica Sinica2017，49，6： | 6 |
| 7 | Encapsulation of selenium sulfide in double-layered hollow carbon spheres as advanced electrode material for lithium storage显示文摘硒 sulfide/double-layered 空碳范围(SeS 2/DLHC) composites 为新奇 Li-SeS 2 电池作为高效的阴极材料被设计了。在里面构造合成, SeS 2 主要在 DLHC 的夹层空间被包含,高度(重量百分比)75% 装载并且为锂用作活跃部件存储。Se 在的存在合成并且碳框架不仅减轻 polysulfide 的 shuttling,而且改进电极的传导性。到在骑车以后的 DLHC 的空洞的从夹层虚空的活跃材料的移植,进一步减轻活跃材料和梭效果的损失,被观察。作为结果, SeS 2/DLHC 合成交付一个高特定的能力(930 mAed nanoparticles,有 81.8% 的轻发射度和 118.62ichia coli 的一个水接触角度(E。coli ) ,肠球菌(ENT ) 和全部的大肠菌(TC ) 被分析。除了 EC 和没有 3, ,结果揭示了低 concentrati 吗?? | Hongwei Zhang Liang Zhou Xiaodan Huang Hao Song Chengzhong Yu | 2016 | Nano Research2016，9，12： | 5 |
| 8 | Changes in Aridity in Response to the Global Warming Hiatus显示文摘The global warming slowdown or warming hiatus, began around the year 2000 and has persisted for nearly 15 years. Most studies have focused on the interpretation of the hiatus in temperature. In this study, changes in a global aridity index(AI) were analyzed by using a newly developed dynamical adjustment method that can successfully identify and separate dynamically induced and radiatively forced aridity changes in the raw data. The AI and Palmer Drought Severity Index produced a wetting zone over the mid-to-high latitudes of the Northern Hemisphere in recent decades. The dynamical adjustment analysis suggested that this wetting zone occurred in response to the global warming hiatus. The dynamically induced AI(DAI) played a major role in the AI changes during the hiatus period,and its relationships with the North Atlantic Oscillation(NAO), Pacific Decadal Oscillation(PDO), and Atlantic Multi-decadal Oscillation(AMO) also indicated that different phases of the NAO, PDO, and AMO contributed to different performances of the DAI over the Northern Hemisphere. Although the aridity wetting over the mid-to-high latitudes may relieve long-term drying in certain regions, the hiatus is temporary, and so is the relief. Accelerated global warming will return when the NAO, PDO, and AMO revert to their opposite phases in the future, and the wetting zone is likely to disappear. | Xiaodan GUAN Jianping HUANG Ruixia GUO | 2017 | Journal of Meteorological Research2017，31，1： | 5 |
| 9 | Impact of oceans on climate change in drylands显示文摘Drylands account for approximately 41% of the global total land area. Significant warming and rare precipitation in drylands result in a fragile ecology and deterioration of the living environment, making it more sensitive to global climate change. As an important regulator of the Earth's climate system, the oceans play a vital role in the process of climate change in drylands. In modern climate change in particular, the impact of marine activities on climate change in drylands cannot be neglected. This paper reviews the characteristics of climate change in drylands over the past 100 years, and summarizes the researches conducted on the impact of marine activities on these changes. The review focuses on the impact of the Pacific Decadal Oscillation(PDO), Atlantic Multidecadal Oscillation(AMO), El Ni?o and La Ni?a on climate change in drylands, and introduces the mechanisms by which different oceanic oscillation factors synergistically affect climate change in drylands.Studies have shown that global drylands have experienced a significant intensification in warming in the past 100 years, which shows obvious characteristics of interdecadal dry/wet variations. The characteristics of these changes are closely related to the oscillatory factors of the oceanic interdecadal scale. Different phase combinations of oceanic oscillation factors significantly change the land-sea thermal contrast, which in turn affects the westerly jet, planetary wave and blocking frequency, resulting in changes in the temperature and dry/wet characteristics of drylands. With the intensification of climate change in drylands, the impact of marine activities on these regions will reveal new characteristics in the future, which will increase the uncertainty of future climate change in drylands and intensify the impact of these drylands on global climate. | Xiaodan GUAN Jieru MA Jianping HUANG Ruixin HUANG Lei ZHANG Zhuguo MA | 2019 | Science China Earth Sciences2019，62，6： | 5 |
| 10 | Recognition of practical speech emotion using improved shuffled frog leaping algorithm显示文摘Due to the drawbacks in Support Vector Machine(SVM)parameter optimization,an Improved Shuffled Frog Leaping Algorithm(Im-SFLA)was proposed,and the learning ability in practical speech emotion recognition was improved.Firstly,we introduced Simulated Annealing(SA),Immune Vaccination(Iv),Gaussian mutation and chaotic disturbance into the basic SFLA,which bManced the search efficiency and population diversity effectively.Secondly,Im-SFLA Was applied to the optimization of SVM parameters,and an Im-SFLA-SVM method Was proposed.Thirdly,the acoustic features of practical speech emotion,such aS ridgetiness,were analyzed.The pitch frequency,short-term energy,formant frequency and chaotic characteristics were analyzed corresponding to different emotion categories,and we constructed a 144-dimensional emotion feature vector for recognition and reduced to 4-dimension by adopting Linear Discriminant Analysis(LDA) Finally,the Im-SFLA-SVM method Was tested on the practical speech emotion database,and the recognition results were compared with Shuffled Frog Leaping Algorithm optimization-SVM(SFLA-SVM)method,Particle Swarm Optimization algorithm optimization-SVM(PSo-SVM) method,basic SVM,Gaussian Mixture Model(GMM)method and Back Propagation(BP)neural network method.The experimentM resuits showed that the average recognition rate of Im-SFLA-SVM method was 77.8%,which had improved 1.7%,2.7%,3.4%,4.7%and 7.8%respectively,compared with the other methods.The recognition of fidgetiness was significantly improve,thus verifying that Im-SFLA was an effective SVM parameter selection method,and the Im-SFLA-SVM method may significantly improve the practical speech emotion recognition. | ZHANG Xiaodan HUANG Chengwei ZHAO Li ZOU Cairong | 2014 | Chinese Journal of Acoustics2014，33，4： | 4 |
| 11 | Potential-tuned selective electrosynthesis of azoxy-,azoand amino-aromatics over a CoP nanosheet cathode显示文摘Azoxy-, azo-and amino-aromatics are among the most widely used building blocks in materials science pharmaceuticals and synthetic chemistry, but their controllable and green synthesis has not yet been well established. Herein, a facile potential-tuned electrosynthesis of azoxy-, azo-and amino-aromatics via aqueous selective reduction of nitroarene feedstocks over a CoP nanosheet cathode is developed. A series of azoxy-, azo-and amino-compounds with excellent selectivity, good functional group tolerance and high yields are produced by applying different bias input. The synthetically significant and challenging asymmetric azoxy-aromatics can be controllably synthesized in moderate to good yields. The use of water as the hydrogen source makes this strategy remarkably fascinating and promising. In addition, deuterated aromatic amines with a high deuterium content can be readily obtained by using D2O. By pairing with anodic oxidation of aliphatic amines to nitriles, synthetically useful building blocks can be simultaneously produced in a CoP||Ni2 P two-electrode electrolyzer. Only 1.25 V is required to achieve a current density of 20 mA cm-2, which is much lower than that of overall water splitting(1.70 V). The paired oxidation and reduction reactions can also be driven using a 1.5 V battery to synthesize nitrile and azoxybenzene with good yields and selectivity, further emphasizing the flexibility and controllability of our method. This work paves the way for a promising approach to the green synthesis of valuable chemicals through potential-controlled electrosynthesis. | Xiaodan Chong Cuibo Liu Yi Huang Chenqi Huang Bin Zhang | 2020 | National Science Review2020，7，2： | 4 |
| 12 | Hybrid superhydrophilic-superhydrophobic micro/nanostructures fabricated by femtosecond laserinduced forward transfer for sub-femtomolar Raman detection显示文摘Raman spectroscopy plays a crucial role in biochemical analysis.Recently,superhydrophobic surface-enhanced Raman scattering(SERS)substrates have enhanced detection limits by concentrating target molecules into small areas.However,due to the wet transition phenomenon,further reduction of the droplet contact area is prevented,and the detection limit is restricted.This paper proposes a simple method involving femtosecond laser-induced forward transfer for preparing a hybrid superhydrophilic–superhydrophobic SERS(HS-SERS)substrate by introducing a superhydrophilic pattern to promote the target molecules to concentrate on it for ultratrace detection.Furthermore,the HS-SERS substrate is heated to promote a smaller concentrated area.The water vapor film formed by the contact of the solution with the substrate overcomes droplet collapse,and the target molecules are completely concentrated into the superhydrophilic region without loss during evaporation.Finally,the concentrated region is successfully reduced,and the detection limit is enhanced.The HS-SERS substrate achieved a final contact area of 0.013mm2,a 12.1-fold decrease from the unheated case.The reduction of the contact area led to a detection limit concentration as low as 10−16 M for a Rhodamine 6G solution.In addition,the HS-SERS substrate accurately controlled the size of the concentrated areas through the superhydrophilic pattern,which can be attributed to the favorable repeatability of the droplet concentration results.In addition,the preparation method is flexible and has the potential for fluid mixing,fluid transport,and biochemical sensors,etc. | Xiaodan Ma Lan Jiang Xiaowei Li Bohong Li Ji Huang Jiaxing Sun Zhi Wang Zhijie Xu Liangti Qu Yongfeng Lu Tianhong Cui | 2019 | Microsystems & Nanoengineering2019，5，1： | 3 |
| 13 | Advances in preimplantation genetic diagnosis/screening显示文摘Preimplantation genetic diagnosis(PGD)gives couples who have a high risk of transmitting genetic disorders to their baby the chance to have a healthy offspring through embryo genetic analysis and selection.Preimplantation genetic screening(PGS)is an effective method to select euploid embryos that may prevent repeated implantation failure or miscarriage.However,how and to whom PGS should be provided is a controversial topic.The first successful case of PGD of a human being was reported in 1990,and there have been tremendous improvements in this technology since then.Both embryo biopsy and genetic technologies have been improved dramatically,which increase the accuracy and expand the indications of PGD/PGS. | YAN LiYing WEI Yuan HUANG Jin ZHU XiaoHui SHI XiaoDan XIA Xi YAN Jie LU CuiLing LIAN Ying LI Rong LIU Ping QIAO Jie | 2014 | Science China(Life Sciences)2014，57，7： | 3 |
| 14 | Tailoring mesoporous-silica nanoparticles for robust immobilization of lipase and biocatalysis显示文摘nano 搬运人的合理设计为为先进 biocatalysis 的现代的酶固定是批评的。此处,我们与一个高 C18 内容报导修改 octadecylalkyl 的 mesoporous 硅石 nanoparticles (C18-MSNs ) 的合成(~ 19 wt.%) 并且悦耳的毛孔尺寸(1.6-13 nm ) 。增加的恐水病的内容和一个定制的毛孔缩放,这被表明(比脂肪分解酵素的尺寸稍微大) 为使不能调动的脂肪分解酵素的高效负责。优化 C18-MSNs 展览 711 mg/g 和比免费的酶的高 5.23 倍的一项特定的活动的一个装载能力。另外, 93% 起始的活动在复用以后被保留五次,它比性能迄今为止报导了的最好好。我们的调查结果为 biocatalytic 应用为脂肪分解酵素的柔韧的固定铺平道路。 | Mohammad Kalantari Meihua Yu Yannan Yang Ekaterina Strounina Zhengying Gu Xiaodan Huang Jun Zhang Hao Song Chengzhong Yu | 2017 | Nano Research2017，10，2： | 3 |
| 15 | The adaptive strategies of yaks to live in the Asian highlands显示文摘The yak(Bos grunniens),an indigenous herbivore raised at altitudes between 3,000 and 5,000 m above sea level,is closely linked to more than 40 ethnic communities and plays a vital role in the ecological stability,livelihood security,socio-economic development,and ethnic cultural traditions in the Asian highlands.They provide the highlanders with meat,milk,fibres,leather and dung(fuel).They are also used as pack animals to transport goods,for travel and ploughing,and are important in many religious and traditional ceremonies.The Asian highlands are known for an extremely,harsh environment,namely low air temperature and oxygen content and high ultraviolet light and winds.Pasture availability fluctuates greatly,with sparse pasture of poor quality over the long seven-month cold winter.After longterm natural and artificial selections,yaks have adapted excellently to the harsh conditions:1)by genomics,with positively selected genes involved in hypoxia response and energy metabolism;2)anatomically,including a short tongue with a weak sense of taste,and large lung and heart;3)physiologically,by insensitivity to hypoxic pulmonary vasoconstriction,maintaining foetal haemoglobin throughout life,and low heart rate and heat production in the cold season;4)behaviourlly,by efficient grazing and selecting forbs with high nutritional contents;5)by low nitrogen and energy requirements for maintenance and low methane emission and nitrogen excretion,namely,‘Low-Carbon’and‘Nitrogen-Saving’traits;6)by harboring unique rumen microbiota with a distinct maturation pattern,that has coevolved with host metabolism.This review aims to provide an overview of the comprehensive adaptive strategies of the yak to the severe conditions of the highlands.A better understanding of these strategies that yaks employ to adapt to the harsh environment could be used in improving their production,breeding and management,and gaining benefits in ecosystem service and a more resilient livelihood to climate change in the Asian highlands. | Xiaoping Jing Luming Ding Jianwei Zhou Xiaodan Huang Allan Degen Ruijun Long | 2022 | Animal Nutrition2022，，2： | 2 |
| 16 | 高原哺乳动物瘤胃微生物组的趋同进化显示文摘动物对极端环境的适应机制一直是物种适应性进化研究的热点。青藏高原土著动物牦牛为此提供了一个经典案例。通过解析牦牛基因组已阐明了其适应高原极端环境的遗传学机制。 | Zhigang Zhang Dongming Xu Li Wang Junjun Hao Jinfeng Wang Xin Zhou Weiwei Wang Qiang Qiu Xiaodan Huang Jianwei Zhou 龙瑞军 赵方庆 施鹏 | 2017 | 科学新闻2017，19，4： | 2 |
| 17 | GRP78 inhibits macrophage adhesion via SR-A显示文摘Class A scavenger receptor(SR-A)plays an important role in macrophage adhesion.However,the underlying mechanism remains unclear.We previously found that 78 kDa glucose-regulated protein(GRP78)inhibited SRA-mediated ligand internalization into macrophage by binding to SR-A.The aim of the study was to investigate whether GRP78 could regulate SR-A-mediated cell adhesion.We demonstrated that GRP78 bound directly to SR-A by fluorescence resonance energy transfer(FRET)assay.Overexpression of GRP78 inhibited macrophage adhesion via SR-A.These results suggest that GRP78 may act as an inhibitor of macrophage adhesion via SR-A. | Hui Bai Nan Li Xiaodan Zhou Chenchen Wang Yan Zhang Xudong Zhu Min Huang Yaoyu Chen Xiaoyu Li Qing Yang Chaojun Li Jingjing Ben Qi Chen | 2014 | The Journal of Biomedical Research2014，28，4： | 2 |
| 18 | Calcium-Impermeable NMDA Receptor:A Novel Target for Addiction显示文摘Drug addiction results in long-term synaptic potentiation at excitatory synapses in the brain reward circuitry,especially in the ventral tegmental area(VTA)and nucleus accumbens(NAc),central parts of the mesolimbic dopamine system,and then progresses to other cortical regions[1,2].It has been proposed that a drug-induced increase in | Xiaodan Huang Wei Ni Changzheng Zhang | 2017 | Neuroscience Bulletin2017，33，3： | 2 |
| 19 | Fe( Ⅵ )-assisted photocatalytic degradating of microcystin-LR using titanium dioxide显示文摘 | Yuan Baoling Li Yanbo Huang Xiaodan | 2006 | Journal of Photochemistry and Photobiology A: Chemistry2006，178，1： | 1 |
| 20 | Improvement of the sui'face biocompatibility of silicone intraocular lens by the plasma-induced tethering of phospholipid moieties显示文摘 | Yao Ke Huang Xiaodan Huang Xiaojun | 2006 | Journal of Biomedical Materials Research Part A2006，78，4： | 1 |
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