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| 1 | YTH Domain: A Family of N^6-methyladenosine (m^6A) Readers显示文摘Like protein and DNA, different types of RNA molecules undergo various modifications. Accumulating evidence suggests that these RNA modifications serve as sophisticated codes to mediate RNA behaviors and many important biological functions. N^6-methyladenosine(m^6 A)is the most abundant internal RNA modification found in a variety of eukaryotic RNAs, including but not limited to m RNAs, t RNAs, r RNAs, and long non-coding RNAs(lnc RNAs). In mammalian cells, m^6 A can be incorporated by a methyltransferase complex and removed by demethylases, which ensures that the m^6 A modification is reversible and dynamic. Moreover, m^6 A is recognized by the YT521-B homology(YTH) domain-containing proteins, which subsequently direct different complexes to regulate RNA signaling pathways, such as RNA metabolism, RNA splicing, RNA folding, and protein translation. Herein, we summarize the recent progresses made in understanding the molecular mechanisms underlying the m^6 A recognition by YTH domaincontaining proteins, which would shed new light on m^6 A-specific recognition and provide clues to the future identification of reader proteins of many other RNA modifications. | Shanhui Liao Hongbin Sun Chao Xu | 2018 | Genomics, Proteomics & Bioinformatics2018，16，2： | 29 |
| 2 | Noise-sidebands-free and ultra-low-RIN 1.5 μm single-frequency fiber laser towards coherent optical detection显示文摘A noise-sidebands-free and ultra-low relative intensity noise(RIN) 1.5 μm single-frequency fiber laser is demonstrated for the first time to our best knowledge. Utilizing a self-injection locking framework and a booster optical amplifier, the noise sidebands with relative amplitudes as high as 20 dB are completely suppressed.The RIN is remarkably reduced by more than 64 dB at the relaxation oscillation peak to retain below-150 dB∕Hz in a frequency range from 75 kHz to 50 MHz, while the quantum noise limit is -152.9 d B∕Hz.Furthermore, a laser linewidth narrower than 600 Hz, a polarization-extinction ratio of more than 23 dB, and an optical signal-to-noise ratio of more than 73 dB are acquired simultaneously. This noise-sidebands-free and ultralow-RIN single-frequency fiber laser is highly competitive in advanced coherent light detection fields including coherent Doppler wind lidar, high-speed coherent optical communication, and precise absolute distance coherent measurement. | QILAI ZHAO ZHITAO ZHANG BO WU TIANYI TAN CHANGSHENG YANG JIULIN GAN HUIHUI CHENG ZHOUMING FENG MINGYING PENG ZHONGMIN YANG SHANHUI XU | 2018 | Photonics Research2018，6，4： | 7 |
| 3 | Multi-functional bismuth-doped bioglasses: combining bioactivity and photothermal response for bone tumor treatment and tissue repair显示文摘Treatment of large bone defects derived from bone tumor surgery is typically performed in multiple separate operations,such as hyperthermia to extinguish residual malignant cells or implanting bioactive materials to initiate apatite remineralization for tissue repair;it is very challenging to combine these functions into a material.Herein,we report the first photothermal(PT)effect in bismuth(Bi)-doped glasses.On the basis of this discovery,we have developed a new type of Bi-doped bioactive glass that integrates both functions,thus reducing the number of treatment cycles.We demonstrate that Bi-doped bioglasses(BGs)provide high PT efficiency,potentially facilitating photoinduced hyperthermia and bioactivity to allow bone tissue remineralization.The PT effect of Bi-doped BGs can be effectively controlled by managing radiative and non-radiative processes of the active Bi species by quenching photoluminescence(PL)or depolymerizing glass networks.In vitro studies demonstrate that such glasses are biocompatible to tumor and normal cells and that they can promote osteogenic cell proliferation,differentiation,and mineralization.Upon illumination with near-infrared(NIR)light,the bioglass(BG)can efficiently kill bone tumor cells,as demonstrated via in vitro and in vivo experiments.This indicates excellent potential for the integration of multiple functions within the new materials,which will aid in the development and application of novel biomaterials. | Liping Wang Nicholas J.Long Lihua Li Yao Lu Mei Li Jiangkun Cao Yu Zhang Qinyuan Zhang Shanhui Xu Zhongmin Yang Chuanbin Mao Mingying Peng | 2018 | Light(Science & Applications)2018，7，1： | 6 |
| 4 | Experimental demonstration of transverse mode instability enhancement by a counter-pumped scheme in a 2 kW all-fiberized laser显示文摘Transverse mode instability(TMI)has become the major limitation for power scaling of fiber lasers with nearly diffraction-limited beam quality.Compared with a co-pumped fiber laser,a counter-pumped fiber laser reveals TMI threshold enhancement through a semi-analytical model calculation.We demonstrated a 2 kW high-power counter-pumped all-fiberized laser without observation of TMI.Compared with the co-pumped scheme,the TMI threshold is enhanced at least 50%in counter-pumped scheme,moreover,stimulated Raman scattering and four-wave mixing are suppressed simultaneously. | ZEBIAO LI ZHIHUA HUANG XIAOYU XIANG XIAOBAO LIANG HONGHUAN LIN SHANHUI XU ZHONGMIN YANG JIANJUN WANG FENG JING | 2017 | Photonics Research2017，5，2： | 6 |
| 5 | Characteristics of the Seismic Waves from a New Active Source Based on Methane Gaseous Detonation显示文摘Active seismic sources are critical for obtaining high resolution images of the subsurface.For active imaging in urban areas,environment friendly and green seismic sources are required.In present work,we introduce a new type of green active source based on the gaseous detonation of methane and oxygen.When fired in a closed container,the chemical reaction,i.e.gaseous detonation,will produce high pressure air over 150 MPa.Seismic waves are produced when high pressure air is quickly released to impact the surroundings.The first field experiment of this active source was carried out in December,2017 in Jingdezhen,Jiangxi Province,where a series of active sources were excited to explore their potential in mine exploration.In current work,we analyzed the seismic waves recorded by near-field accelerators and a dense short-period seismic array and compared them with those from a mobile airgun source,another kind of active source by releasing high pressure air into water.The results demonstrate that it can be used for high resolution near surface imaging.Firstly,the gaseous detonation productions are harmless CO2 and water,making it a green explosive source.Secondly,the dominant seismic frequencies are 10-80 Hz and a single shot can be recorded up to 15 km,making it suitable for local structure investigations.Thirdly,it can be excited in vertical wells,similar to traditional powder explosive sources.It can also act as an additional on-land active source to airgun sources,which requires a suitable water body as intermediate media to generate repeating signals.Moreover,the short duration and high frequency signature of the source signals make it safe with no damage to nearby buildings.These make it convenient to excite in urban areas.As a new explosive source,the excitation equipment and conditions,such as gas ratio,sink depth and air-releasing directions,need further investigation to improve seismic wave generation efficiency. | WANG Weitao WANG Xiang MENG Chuanmin DONG Shi WANG Zhigang XIE Junju WANG Baoshan YANG Wei XU Shanhui WANG Tao | 2019 | Earthquake Research in China2019，33，2： | 6 |
| 6 | High-efficiency and high-power single-frequency fiber laser at 1.6μm based on cascaded energy-transfer pumping显示文摘In this paper,a technique combining the cascaded energy-transfer pumping(CEP)method and master-oscillator power-amplifier(MOPA)configuration is proposed for power scaling of 1.6-μm-band single-frequency fiber lasers(SFFLs),where the Er^(3+)ion has a limited gain.The CEP technique is fulfilled by coupling a primary signal light at 1.6μm and a C-band auxiliary laser.The numerical model of the fiber amplifier with the CEP technique reveals that the energy transfer process involves the pump competition and the in-band particle transition between the signal and auxiliary lights.Moreover,for the signal emission,the population density in the upper level is enhanced,and the effective population inversion is achieved thanks to the CEP.A single-frequency MOPA laser at 1603 nm with an output power of 52.6 W and an improved slope efficiency of 30.4%is experimentally obtained through the CEP technique.Besides,a laser linewidth of 5.2 k Hz and a signal-to-auxiliary laser ratio of 60.7 d B are obtained at the maximum output power.The proposed technique is anticipated to be promising for increasing the slope efficiency and power scaling for fiber lasers operating at L band. | XIANCHAO GUAN QILAI ZHAO WEI LIN TIANYI TAN CHANGSHENG YANG PENGFEI MA ZHONGMIN YANG SHANHUI XU | 2020 | Photonics Research2020，8，3： | 5 |
| 7 | Active Source Seismic Identification and Automatic Picking of the P-wave First Arrival Using a Convolutional Neural Network显示文摘In seismic data processing,picking of the P-wave first arrivals takes up plenty of time and labor,and its accuracy plays a key role in imaging seismic structures.Based on the convolution neural network(CNN),we propose a new method to pick up the P-wave first arrivals automatically.Emitted from MINI28 vibroseis in the Jingdezhen seismic experiment,the vertical component of seismic waveforms recorded by EPS 32-bit portable seismometers are used for manually picking up the first arrivals(a total of 7242).Based on these arrivals,we establish the training and testing sets,including 25,290 event samples and 710,616 noise samples(length of each sample:2 s).After 3,000 steps of training,we obtain a convergent CNN model,which can automatically classify seismic events and noise samples with high accuracy(>99%).With the trained CNN model,we scan continuous seismic records and take the maximum output(probability of a seismic event)as the P-wave first arrival time.Compared with STA/LTA(short time average/long time average),our method shows higher precision and stronger anti-noise ability,especially with the low SNR seismic data.This CNN method is of great significance for promoting the intellectualization of seismic data processing,improving the resolution of seismic imaging,and promoting the joint inversion of active and passive sources. | XU Zhen WANG Tao XU Shanhui WANG Baoshan FENG Xuping SHI Jing YANG Minghan | 2019 | Earthquake Research in China2019，33，2： | 3 |
| 8 | Molecular basis of vasohibins-mediated detyrosination and its impact on spindle function and mitosis显示文摘α-Tubulin detyrosination, largely catalyzed by vasohibins, is involved in many microtubule (MT)-related cellular events. In this study, we identified a core heterodimeric complex of human small vasohibin-binding protein (SVBP) and vasohibin 1 (VASH1)(hereafter denoted as SVBP-VASH1) that catalyzes the detyrosination of a peptide derived from C-terminus of α-tubulin. We further solved the crystal structures of the SVBP-VASH1 heterodimer alone and in complex with either an inhibitor or a mutant substrate peptide. Our structural research, complemented by biochemical and mutagenesis experiments, resulted in identification of the key residues for VASH1 binding to SVBP and α-tubulin substrate. Our in vivo experiments reveal that MT detyrosination in general, as well as the interactions between SVBP, VASH1, and α-tubulin, are critical for spindle function and accurate chromosome segregation during mitosis. Furthermore, we found that the phenotypes caused by the depletion of vasohibins were largely rescued upon co-depletion of kinesin13/MCAK, suggesting the coordination between the MT depolymerase and MT detyrosination during mitosis. Thus our work not only provides structural insights into the molecular mechanism of α-tubulin detyrosination catalyzed by SVBP-bound vasohibins, but also uncovers the key role of vasohibins-mediated MT detyrosination in spindle morphology and chromosome segregation during mitosis. | Shanhui Liao Girish Rajendraprasad Na Wang Susana Eibes Jun Gao Huijuan Yu Gao Wu Xiaoming Tu Hongda Huang Marin Barisic Chao Xu | 2019 | Cell Research2019，29，7： | 2 |
| 9 | In situ instant generation of an ultrabroadband near-infrared emission center in bismuth-doped borosilicate glasses via a femtosecond laser显示文摘Bismuth(Bi)-doped photonic materials, which exhibit broadband near-infrared(NIR) luminescence(1000–1600 nm), are evolving into interesting gain media. However, the traditional methods have shown their limitations in enhancing Bi NIR emission, especially in the microregion. Consequently, the typical NIR emission has seldom been achieved in Bi-doped waveguides, which highly restricts the application of Bi-activated materials.Here, superbroadband Bi NIR emission is induced in situ instantly in the grating region by a femtosecond(fs)laser inside borosilicate glasses. A series of structural and spectroscopic characterizations are summoned to probe the generation mechanism. And we show how this novel NIR emission in the grating region can be enhanced significantly and erased reversibly. Furthermore, we successfully demonstrate Bi-activated optical waveguides.These results present new insights into Bi-doped materials and push the development of broadband waveguide amplification. | LIPING WANG JIANGKUN CAO YAO LU XIAOMAN LI SHANHUI XU QINYUAN ZHANG ZHONGMIN YANG MINGYING PENG | 2019 | Photonics Research2019，7，3： | 2 |
| 10 | Judd-Ofelt and laser parameterization of Tm^3+-doped barium gallo-germanate glass fabricated with efficient dehydration methods显示文摘 | YU Shenlei YANG Zhongmin XU Shanhui | 2009 | Opt Mater2009，31，： | 1 |
| 11 | The Hausdorff measure of the self-sifiailar set--a class of Sierpinski gasket显示文摘 | XU Shaoyuan SUN Shanhui LIU Juan | 2007 | Journal of Huaihei Coal Industry Teachers College (Natural Sciences Edition)2007，28，2： | 1 |
| 12 | Low noise single-frequency sin-gle-polarization ytterbium-doped phosphate fiber laser at 1083 nm显示文摘 | Shanhui Xu Can Li Weinan | | 0，，04： | 1 |
| 13 | Publisher Correction: Molecular basis of vasohibins-mediated detyrosination and its impact on spindle function and mitosis显示文摘In the initial published version of this article,there was an inadvertent omission from the Acknowledgements that work in the lab of MB is supported by grants from Danish Cancer Society Scientific Committee(KBVU;R146-A9322) and the Lundbeck Foundation (R215-2015-4081).This omission does not affect the description of the resuits or the conclusions of this work. The publisher apologizes for any inconvenience this has caused to the readers. | Shanhui Liao Girish Rajendraprasad Na Wang Susana Eibes Jun Gao Huijuan Yu Gao Wu Xiaoming Tu Hongda Huang Marin Barisic Chao Xu | 2019 | Cell Research2019，29，9： | 0 |
| 14 | Correction:Multi-functional bismuth-doped bioglasses:combining bioactivity and photothermal response for bone tumor treatment and tissue repair显示文摘In this originally published article,we have noticed several mistakes.They should be corrected as follows:1.On page 1,the second affiliation(No.5)of the author“Chuanbin Mao”should be deleted as he does not belong to that affiliation.Namely,he should be only listed with(Department of Chemistry and Biochemistry Stephenson Life Sciences Research Center,University of Oklahoma,Norman,OK 73072,USA). | Liping Wang Nicholas JLong Lihua Li Yao Lu Mei Li Jiangkun Cao Yu Zhang Qinyuan Zhang Shanhui Xu Zhongmin Yang Chuanbin Mao Mingying Peng | 2019 | Light(Science & Applications)2019，8，1： | 0 |
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