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| 1 | Novel interactions of mitochondria and reactive oxygen/nitrogen species in alcohol mediated liver disease显示文摘Mitochondrial dysfunction is known to be a contributing factor to a number of diseases including chronic alcohol induced liver injury. While there is a detailed understanding of the metabolic pathways and proteins of the liver mitochondrion, little is known regarding how changes in the mitochondrial proteome may contribute to the development of hepatic pathologies. Emerging evidence indicates that reactive oxygen and nitrogen species disrupt mitochondrial function through post-translational modifications to the mitochondrial proteome. Indeed, various new affinity labeling reagents are available to test the hypothesis that post-translational modification of proteins by reactive species contributes to mitochondrial dysfunction and alcoholic fatty liver disease. Specialized proteomic techniques are also now available, which allow for identification of defects in the assembly of multi-protein complexes in mitochondria and the resolution of the highly hydrophobic proteins of the inner membrane. In this review knowledge gained from the study of changes to the mitochondrial proteome in alcoholic hepatotoxicity will be described and placed into a mechanistic framework to increase understanding of the role of mitochondrial dysfunction in liver disease. | Sudheer K Mantena Adrienne L King Kelly K Andringa Aimee Landar Victor Darley-Usmar Shannon M Bailey | 2007 | World Journal of Gastroenterology2007，13，37： | 7 |
| 2 | Ammonia-oxidizing archaea and bacteria are structured by geography in biological soil crusts across North American arid lands显示文摘Introduction:Biological soil crusts(BSCs)can dominate surface cover in dry lands worldwide,playing an integral role in arid land biogeochemistry,particularly in N fertilization through fixation and cycling.Nitrification is a characteristic and universal N transformation in BSCs that becomes important for the export of N beyond the microscopic bounds of the crust itself.The contribution of ammonia-oxidizing bacteria(AOB)in BSCs has been shown,but the role and extent of the recently discovered ammonia-oxidizing archaea(AOA)have not.Methods:We sampled various types of crusts in four desert regions across the western United States and characterized the composition and size of ammonia-oxidizing communities using clone libraries and quantitative PCR targeting the amoA gene,which codes for the ammonia monooxygenase enzyme,universally present in ammonia-oxidizing microbes.Results:All archaeal amoA sequences retrieved from BSCs belonged to the Thaumarchaeota(Nitrososphaera associated Group I.1b).Sequences from the Sonoran Desert,Colorado Plateau,and Great Basin were indistinguishable from each other but distinct from those of the Chihuahuan Desert.Based on amoA gene abundances,archaeal and bacterial ammonia oxidizers were ubiquitous in our survey,but the ratios of archaeal to bacterial ammonia oxidizers shifted from bacterially dominated in northern,cooler deserts to archaeally dominated in southern,warmer deserts.Conclusions:Archaea are shown to be potentially important biogeochemical agents of biological soil crust N cycling.Conditions associated with different types of BSCs and biogeographical factors reveal a niche differentiation between AOA and AOB,possibly driven by temperature. | Yevgeniy Marusenko Scott T Bates Ian Anderson Shannon L Johnson Tanya Soule Ferran Garcia-Pichel | 2013 | Ecological Processes2013，2，1： | 4 |
| 3 | Client-level predictors of treatment engagement,outcome and dropout:moving beyond demographics显示文摘Background Despite the availability of evidence-based treatments for posttraumatic stress disorder(PTSD),significant heterogeneity in the effectiveness of PTSD treatment persists,especially in community settings.Client demographics used to understand this variability in treatment outcome and dropout have yielded mixed results.Despite increasing evidence for the importance of attending to treatment engagement in community settings,few studies have explored client-level predictors.Aim The purpose of this study is to explore client-level predictors of treatment outcome and dropout beyond client demographics,and to identify client-level predictors of treatment engagement in community settings.Method Secondary data analysis was conducted with data collected as part of an implementation-effectiveness hybrid study of cognitive processing therapy(CPT)for PTSD in a diverse community healthcentre.Providers(n=19)treated(n=52)clients as part of their routine clinical care.Non-demographic client-level predictors included barriers to treatment,quality of life,session-level language and employment history assessed at baseline.Treatment engagement included number of weeks in the study,number of sessions with repeated CPT content,number of unique CPT sessions attended,frequency of session attendance and consistency of session attendance.Results Results showed language as a significant predictor of treatment engagement.There were significant differences between Spanish and English-speaking clients,with the former having a tendency to repeat more session content than the latter(β=1.4 sessions,p=0.003),and also less likely to attend treatment frequently(r=0.62,p=0.009)and consistently(r=0.57,p=0.027)if high logistical and financial barriers were endorsed.Irrespective of language,clients who reported high quality of life at baseline were less likely to repeat CPT session content(β=-0.3,p=0.04),and those with increased baseline barriers to treatment had deceleration in PTSD symptom improvement over time(β=-0.62,p<0.05).In terms of treatment engagement moderators impacting treatment outcome,clients who repeated more session content were more likely to complete treatment(0R=1.84,p=0.037).Conclusion Identification of client-level predictors of treatment engagement,outcome and dropout is essential to optimise treatment,particularly in community settings. | Soo-jeong Youn Margaret-Anne Mackintosh Shannon Wiltsey Stirman Kay lie A Patrick Yesenia Aguilar Silvan Anna D Bartuska Derri L Shtasel Luana Marques | 2019 | General Psychiatry2019，32，6： | 2 |
| 4 | Peroxidase isoenzyme from horse radish roots: isolation and physical properties 显示文摘 | Shannon L M Kay E Law J Y | 1966 | J Biol Chem1966，241，： | 1 |
| 5 | Regulation of milk protein gene expression显示文摘 | Jeffrey M R Shannon L W Darryl H | 1999 | Annu Rev Nutr1999，19，： | 1 |
| 6 | Modeling non calamitous individual tree mortality using logistic regression, neural networks, and support vector methods 显示文摘 | SUSAN L KING KRISTIN P BENNETT SHANNON LIST | 2000 | Computers and Electronics in Agriculture2000，27，3： | 1 |
| 7 | Uncertainty and risk in financial markets显示文摘 | RIGOTTI L SHANNON C | 2005 | Econometrica2005，73，1： | 1 |
| 8 | Indentification of mutator insertional mutants of starch branching enzyme 2a in corn显示文摘 | Yuan Yao Klucinec J D Shannon J C Thompson D B Guilitinan M J | 2001 | plant physiol2001，125，： | 1 |
| 9 | Malignant and benign bone tumors显示文摘 | SHANNON L MILLER M S HOFFER M D | 2001 | Radiol Clin North Am2001，39，4： | 1 |
| 10 | Mitochondrial dysfunction and oxidative stress in the pathogenesis of alcohol - and obesity - induced fatty liver diseases 显示文摘 | Mantena Sudheer K King Adrienne L Andringa Kelly K Ec- cleston Heather B Bailey Shannon M | 2008 | Free radical biology & medi- cine2008，44，7： | 1 |
| 11 | Detection of five legume vi-ruses in one sensitive multiplex polymerase chain reaction test显示文摘 | Bariana H S Shannon A L Chu PW G | 1994 | Phytopathology1994，84，10： | 1 |
| 12 | Plant capture of free amino acids is maximized under high soil amino acid concentrations显示文摘 | JONES D L SHANNON D JUNVEE-FORTUNE T | 2005 | Soil Biology and Biochemistry2005，37，1： | 1 |
| 13 | Sediment transport and deposition in trickle irrigation laterals显示文摘 | Shannon W M James L G Bassett D L | 1982 | Transactions of the ASAE1982，25，1： | 1 |
| 14 | Role of dis- solved organic nitrogen (DON) in soil N cycling ingrassland soils显示文摘 | JONES D L SHANNON D MURPHY D V | 2004 | Soil Biology & Biochemistry2004，36，5： | 1 |
| 15 | Amino acid sequence and crystal structure of BaP1, a metalloproteinase from Bothrops asper snake venom that exerts multiple tissue-damaging activities 显示文摘 | Watanabe L Shannon J D Valente R H | 2003 | Protein Sci2003，12，10： | 1 |
| 16 | Affect general- ization to similar and dissimilar brand extensions显示文摘 | BOUSH D M SHANNONS BARBARA L | 1987 | Psycholo- gy and Marketing1987，，4： | 1 |
| 17 | Exploring the dynamics of ecological indicators using food web models fitted to time series of abundance and catch data显示文摘 | SHANNON L J COLL M NEIRA S | 2009 | Ecological Indicators2009，9，6： | 1 |
| 18 | Maternal Zinc Deficiency Reduces NMDA Receptor Expression in Neonatal Rat Brain,Which Persists into Early Adulthood显示文摘 | Winyoo C Shannon L Kelleher B L | 2005 | J Neuronchem2005，94，51： | 1 |
| 19 | Fracture toughness determination of Al2O3 using four-point-bend specimens with straight-through and chevron notches显示文摘 | MUNZ D BUBSEY R T SHANNON J L | 1979 | J Am Ceram Soc1979，63，56： | 1 |
| 20 | Effects of salinity on grainyield and yield components of rice at different seeding densities 显示文摘 | ZENG L H SHANNON M C | 2000 | Agronomy Journal2000，92，： | 1 |
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