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| 1 | Upregulation of CD81 in trophoblasts induces an imbalance of Treg/Th17 cells by promoting IL-6 expression in preeclampsia显示文摘The disturbance of maternal immune tolerance to a semiallogeneic fetus is recognized as one of the key pathologies of preeclampsia(PE),in which an imbalance between the inflammation-limiting regulatory T cells(Tregs)and the inflammationmediating Th17 cells plays an essential role.Previously,we reported that the abnormal upregulation of tetraspannin CD81 in trophoblast cells(fetal component)participated in the pathogenesis of PE.However,as one of the potential immune regulatory molecules,whether CD81 induces PE by interfering with the balance of the maternal immune system has not yet been clarified.Thus,we investigated the relationship between the upregulation of CD81 in trophoblast cells and the imbalance of Treg and Th17 cells in mothers.Here,we demonstrated that upregulation of CD81 in trophoblast cells was accompanied by a decrease in Treg cells and an increase in Th17 cells in both the basal plate(placental maternal side)and peripheral blood of patients with PE.In vitro culture of naïve T cells with medium from the CD81-overexpressing trophoblast cell line HTR-8 resulted in enhanced differentiation of T cells into Th17 cells and decreased the formation of Tregs,which was dependent on the paracrine signaling of IL-6 in trophocytes,induced by CD81.In a CD81-induced PE rat model,we found a significant shift of T cell differentiation towards Th17 cells,and administration of IL-6 antibody mitigated the PE phenotype and the imbalance of the Treg/Th17 cells.These results define a vital regulatory cascade involving trophocyte-derived CD81,IL-6,and maternal Treg/Th17 cells in the pathogenesis of PE and suggests new therapeutic approaches based on CD81 and IL-6 downregulation to prevent human PE. | Hailin Ding Yimin Dai Yi Lei Zhiyin Wang Dan Liu Ruotian Li Li Shen Ning Gu Mingming Zheng Xiangyu Zhu Guangfeng Zhao Yali Hu | 2019 | Cellular & Molecular Immunology2019，16，3： | 15 |
| 2 | Biochar-Induced Priming Effects in Young and Old Poplar Plantation Soils显示文摘The priming effect(PE)induced by biochar provides a basis for evaluating its carbon(C)sequestration potential in soils.A 60 days’laboratory incubation was conducted,which involved the amendment of biochar(1%of soil mass)produced from rice straw at 300℃(B300)and 500℃(B500)to young(Y)and old(O)poplar plantation soils,with the aim of studying the responses of biochar-induced PEs to poplar plantation ages.This incubation included six treatments:Y+CK(control),Y+B300,Y+B500,O+CK,O+B300,and O+B500.Carbon dioxide(CO_(2))emissions were significantly increased(p<0.05)in the B300 amended soils,while it was decreased in the B500 amended soils compared to the CK.The primed CO_(2) emissions were 2.35 times higher in the Y+B300 than the O+B300 treatments,which was measured to be 18.6 and 5.56 mg C·kg^(-1) with relative PEs of 12.4%and 3.35%,respectively.However,there was little difference between the primed CO_(2) emissions in Y+B500 and O+B500 treatments,which were measured to be-24.9 and-29.6 mg·C·kg^(-1) with relative PEs of-16.6%and-17.8%,respectively.Dissolved organic carbon(DOC)was significantly lower in the young poplar plantation soil than that in the old poplar plantation soil regardless of biochar amendment throughout the incubation,indicating greater C-limit of soil microorganisms in the young poplar plantation soil.Using ^(13)C isotope tracing,neither B300 nor B500 decreased native soil-derived DOC,which indicated that the negative B500-induced PEs were not due to a reduction in the availability of native soil-derived C.In conclusion,the response of biochar-induced PEs to poplar plantation age depends on biochar types while soil available C indirectly affects biochar-induced PEs.Further studies should focus on how the interactive effects between soil C availability and microbial community impacts biochar-induced PEs. | Weiwei Lu Yirui Zhang Yixian Yao Yuying Wu Han Y.H.Chen Hailin Zhang Jia Yu Caiqin Shen Qi Liu Honghua Ruan | 2020 | Phyton-International Journal of Experimental Botany2020，89，1： | 2 |
| 3 | Generalized PLS regression显示文摘 | XU Qingsong LIANG Yizeng SHEN Hailin | 2001 | Chemometrics2001，，15： | 1 |
| 4 | Local resolution of hyphenated chromatographic data显示文摘 | SHEN Hailin MANNE R XU Qingsong | 1999 | Chemometrics and Intelligent Laboratory Systems1999，45，12： | 1 |
| 5 | 显示文摘 | LU Hongmei DUNN W B SHEN Hailin | 2008 | Trac-Trends in Analytical Chemistry2008，27，： | 1 |
| 6 | Polymer–inorganic nanocomposite membranes for gas separation显示文摘 | Hailin Cong Maciej Radosz Brian Francis Towler Youqing Shen | 2007 | Separation and Purification Technology2007，，3： | 1 |
| 7 | Generalized PLS regression显示文摘 | Xu Qingsong Liang Yizeng Shen Hailin | 2001 | Journal of Chemometrics2001，15，3： | 1 |
| 8 | Ant-Colony Based Routing Algorithm in Wireless Sensor Networks显示文摘 | Shen Yulong Xu Qijian Pei Qingqi Feng Hailin Ma Jianfeng | 2010 | China Communications2010，7，5： | 1 |
| 9 | The potential clinical applications of radionuclide labeled/doped gold-based nanomaterials显示文摘Radionuclides have been widely used for multimodal imaging and radioisotope therapy of cancer.Various nanomaterials have been developed as excellent nanocarriers of radionuclides for the targeted delivery into tumors,in order to minimize the unnecessary side effect and enhance the therapeutic efficacy of radiotherapy.Among those nanomaterials,gold nanomaterials with tunable morphologies,easy modification,good biological safety,and radiation sensitization capability are excellent candidates for cancer theranostics.Given the superior performance of gold-based nanomaterials in biomedicine,we summary the recent advance of radionuclide labeled/doped gold-based nanomaterials for cancer theranostics.In this review article,we will discuss the methods for labelling or doping radionuclides onto gold nanomaterials,their applications for nuclear imaging and Cerenkov luminescence(CL)imaging,as well as the radioisotope therapy of cancer,and finally the toxicity evaluation of radionuclide labeled/doped gold-based nanomaterials.We hope that our review article would provide guidance for non-experts to design the radiolabeled nanomaterials for cancer imaging guided therapy. | Wenhao Shen Hailin Zhou Teng Liu Pei Pei Junxing Huang Xuan Yi Kai Yang | 2020 | Radiation Medicine and Protection2020，1，4： | 1 |
| 10 | Layered manganese phosphorus trisulfides for high-performance lithium-ion batteries and the storage mechanism显示文摘Although advanced anode materials for the lithium-ion battery have been investigated for decades,a reliable,high-capacity,and durable material that can enable a fast charge remains elusive.Herein,we report that a metal phosphorous trichalcogenide of MnPS_(3)(manganese phosphorus trisulfide),endowed with a unique and layered van der Waals structure,is highly beneficial for the fast insertion/extraction of alkali metal ions and can facilitate changes in the buffer volume during cycles with robust structural stability.The few-layered MnPS_(3)anodes displayed the desirable specific capacity and excellent rate chargeability owing to their good electronic and ionic conductivities.When assembled as a half-cell lithium-ion battery,a high reversible capacity of 380 mA h g^(−1)was maintained by the MnPS_(3)after 3000 cycles at a high current density of 4 A g^(−1),with a capacity retention of close to or above 100%.In full-cell testing,a reversible capacity of 450 mA h g^(−1)after 200 cycles was maintained as well.The results of in-situ TEM revealed that MnPS_(3)nanoflakes maintained a high structural integrity without exhibiting any pulverization after undergoing large volumetric expansion for the insertion of a large number of lithium ions.Their kinetics of lithium-ion diffusion,stable structure,and high pseudocapacitance contributed to their comprehensive performance,for example,a high specific capacity,rapid charge-discharge,and long cyclability.MnPS_(3)is thus an efficient anode for the next generation of batteries with a fast charge/discharge capability. | Hailin Shen Yueling Cai Zhongtao Ma Peng Wang Bingkun Guo Jipeng Cheng Qianqian Li Hongtao Wang Zhongyuan Liu Anmin Nie Jinsong Wu | 2023 | Carbon Energy2023，5，3： | 1 |
| 11 | Analysis of PAHs in air-borne particulates in Hong Kong City by heuristic evolving latent projections显示文摘 | Hailin Shen Yizeng Liang Ruqin Yu Xianchun Li Xinxi Sun | 1998 | Science in China Series B: Chemistry1998，，1： | 1 |
| 12 | Local resolution of hyphenated chromatographic data显示文摘 | Hailin Shen Rolf Manne Qingsong Xu | 1999 | Chemometrics and Intelligent Laboratory Systems1999，45，12： | 1 |
| 13 | Generalized PLS Regression显示文摘 | Qingsong xu Yizeng Liang and Hailin shen | 2001 | Joural of Chemometrcs2001，，15： | 1 |
| 14 | Carbon nanotube composite membranes of brominated poly(2,6-diphenyl-1,4-phenylene oxide) for gas separation显示文摘 | Hailin Cong Jianmin Zhang Maciej Radosz Youqing Shen | 2007 | Journal of Membrane Science2007，，1： | 1 |
| 15 | Peripheral body temperature rhythm is associated with suicide risk in major depressive disorder:a case-control study显示文摘Background Patients with major depressive disorder(MDD)may have an abnormal peripheral body temperature rhythm,but its relationship with suicidal risk and the response to treatment with antidepressants remain unknown.Aims This study aimed to investigate the feature of peripheral body temperature in patients with MDD and its relationship with suicide risk before and after treatment with antidepressants.Methods This is a prospective case-control study.Patients diagnosed as MDD were enrolled into MDD group.Healthy subjects who matched in terms of gender,age and body mass index were enrolled into normal control(NC)group.The 24-hour peripheral body temperatures were monitored by TM’Holter the next day after assessment.Patients with MDD were re-assessed after a 2-week treatment with antidepressants.All temperature data were fitted into cosine curves by Python.Result There were 41 patients with MDD,and 21 NC participants enrolled and completed the baseline assessments before the treatment.Patients with MDD were further divided into subgroup of with suicide risk or without suicide risk.In patients with MDD,the mesor of peripheral body temperature rhythm was higher in both patients with(36.17(0.30))and without suicide risk(36.22(0.27))than the mesor in NC participants before treatment(35.84(0.38),Z=11.82,p=0.003,Kruskal-Wallis test).The phase-delay of temperature before treatment was greater in patients with MDD with suicidal risk(4.71(1.68))in comparison with those without suicidal risk(3.05(2.19))and NC participants(3.19(1.82),Z=9.68,p=0.008,Kruskal-Wallis test).Moreover,phase-delay of temperature was associated with suicide risk in patients with MDD before treatment(OR=1.046,95%CI:1.009 to 1.085,p=0.015,unadjusted;OR=1.080,95%CI:1.020 to 1.144,p=0.009,adjusted by age and sex).Conclusion Patients with MDD might have abnormal peripheral body temperature.The abnormal phase-delay of peripheral body temperature may indicate suicide risk in patients with MDD,depending on validation in large-scale cohorts. | Xin Ma Jing Cao Hailin Zheng Xinchun Mei Meijuan Wang Haoran Wang Yu Shuai Yuan Shen | 2021 | General Psychiatry2021，34，1： | 1 |
| 16 | Local resolution of hypenated chromatographic data 显示文摘 | Shen Hailin Manne R Xu Qingsong | 1999 | Chernom Intell Lba Syst1999，45，12： | 1 |
| 17 | Preparation and anti-tumor application of hyaluronic acid-based material for disulfide and copper ions co-delivery显示文摘Disulfide(DSF) has been proved good anti-tumor effect and even better with coadministration of Cu^(2+). In this work, we report the use of hyaluronic acid(HA) based materials to construct vectors for the delivery of both DSF and Cu^(2+). HA was firstly modified with polyethylene glycol monomethyl ether(mPEG) and polycaprolactone(PCL) to synthesize an amphiphilic polymer(HA-PEG-PCL). DSF could be loaded in the hydrophobic core and Cu^(2+) could be cooperated to the negative hydrophilic segment. The Cu^(2+) also played a role as crosslinking agent, which prevented DSF leakage prematurely, avoiding the bad side effects to normal tissues. The interaction between HA and CD44 improved the distribution of nanodrugs in tumor cells. When the nanodrugs were delivered to the cancer cell, the acidic micro-environment would separate the Cu^(2+) from the surface, leading to the disintegration of the micelles, promoting the release of DSF from the micelle core. The results of in vitro and in vivo experiments showed that the DSF and Cu^(2+) co-delivery vector constructed in this work could enhance the antitumor effect and have low biological toxicity. | PANG Long ZHONG Wei WANG QiuBo FENG HaoHui DONG HaoNan WANG Song CONG HaiLin SHEN YouQing YU Bing | 2021 | Science China(Technological Sciences)2021，64，9： | 0 |
| 18 | A new approach for determination of component number in chemical system:Subspace comparison显示文摘A new approach is proposed to determine component number in mixture. In this procedure, base vectors of measurement matrix are extracted by two methods respectively. The discrepancy between subspaces spanned by two sets of base vectors is measured. Examples in this note show that the proposed procedure can correctly determine the number of components for systems even with very similar spectral profiles. It is applied in the study of the self-association behavior of alcohol in CCI4. | Hailin Shen Xiaoning Li Yizeng Liang | 2000 | Chinese Science Bulletin2000，45，15： | 0 |
| 19 | Analysis of Genetic Diversity of Vitis amurensis Rupr.(Vitaceae) Germplasm Resources显示文摘[Objective] This study aimed to explore the genetic diversity of Vitis amurensis Rupr. (Vitaceae) germplasm resources.[Method] Out of total 245 pairs of primers, 18 were selected for SSR amplification of 360V. amurensis experimental materials.[Result] The number of bands amplified by each primer ranged from 4 to 13 with a mean of 9.44. The length of bands ranged from 150 to 1000 bp, concentrated at 200-750bp. The 18 pairs of primers amplified 170 bands totally, of which 167 bands were polymorphic with a polymorphism ratio of 98.2%. The Shannon's diversity index (I) is 1.778 051. With the SSR-PCR amplification of 360V. amurensis varieties (strains), 5 specific bands were amplified by certain primers in several varieties(strains) accounting for 2.95% of the total bands.[Conclusion] SSR molecular marker technique was an efficient method to detect the genetic diversity of V. amurensis and thereby is an effective tool for pedigree analysis and variety identification of A. amurensis varieties(strains). | Jinghui WEN Hailin SHEN Liren ZOU Lei CHEN Hongzhang LIU | 2012 | Agricultural Biotechnology2012，1，5： | 0 |
| 20 | RNA 5-methylcytosine regulates YBX2-dependent liquid-liquid phase separation显示文摘5-Methylcytosine(m^(5)C)is one of the most prevalent internal modifications of messenger RNA(mRNA)in higher eukaryotes.Here we report that Y box protein 2(YBX2)serves as a novel mammalian m^(5)C binding protein to undergo liquid-liquid phase separation(LLPS)both in vivo and in vitro,and this YBX2-dependent LLPS is enhanced by m^(5)C marked RNA.Furthermore,the crystal structure assay revealed that W100,as a distinct m^(5)C binding site of YBX2,is critical in mediating YBX2 phase separation.Our study resolved the relationship between RNA m^(5)C and phase separation,providing a clue for a new regulatory layer of epigenetics. | Xiuzhi Wang Mengke Wang Xinyuan Dai Xiao Han Yu Zhou Weiyi Lai Liyuan Zhang Ying Yang Yusheng Chen Hailin Wang Yong Liang Zhao Bin Shen Yuhan Zhang Ying Huang Yun-Gui Yang | 2022 | Fundamental Research2022，2，1： | 0 |
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